Danio rerio

19 known processes

pcsk5a

proprotein convertase subtilisin/kexin type 5a

(Aliases: pc5.1,si:dkey-267i17.1,pcsk5/6a,pcsk5.1)

pcsk5a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuromast developmentGO:0048884460.997
mechanosensory lateral line system developmentGO:0048881490.985
sensory organ developmentGO:00074233930.984
lateral line system developmentGO:0048925760.901
lateral line developmentGO:0048882660.781
determination of bilateral symmetryGO:00098552040.746
sensory system developmentGO:0048880760.737
peptide metabolic processGO:000651810.670
chordate embryonic developmentGO:00430092710.649
Zebrafish
anterior lateral line system developmentGO:004889890.607
embryonic skeletal system morphogenesisGO:0048704930.559
Zebrafish
inner ear developmentGO:00488391260.556
regulation of response to stimulusGO:00485832690.410
embryonic organ developmentGO:00485683810.339
Zebrafish
regulation of extrinsic apoptotic signaling pathwayGO:200123630.332
cellular nitrogen compound metabolic processGO:00346412900.307
appendage morphogenesisGO:0035107560.307
Zebrafish
stem cell proliferationGO:007208940.266
regulation of biological qualityGO:00650082630.253
female sex differentiationGO:004666040.246
defense responseGO:0006952470.227
embryonic skeletal system developmentGO:0048706970.226
Zebrafish
embryonic cranial skeleton morphogenesisGO:0048701900.219
Zebrafish
embryonic organ morphogenesisGO:00485622740.213
Zebrafish
innate immune responseGO:0045087130.199
regulation of epithelial cell proliferationGO:005067830.184
regulation of gene expressionGO:00104682650.171
multi organism cellular processGO:004476420.165
liver developmentGO:0001889960.161
posterior lateral line system developmentGO:0048915460.151
kidney epithelium developmentGO:0072073230.149
urogenital system developmentGO:0001655970.142
posterior lateral line neuromast developmentGO:0048919200.139
regulation of multicellular organismal processGO:00512392770.135
cartilage morphogenesisGO:0060536130.135
Zebrafish
heart developmentGO:00075073130.134
posterior lateral line developmentGO:0048916380.130
neuromuscular process controlling balanceGO:005088530.129
organelle organizationGO:00069962270.129
otolith developmentGO:0048840320.126
hepaticobiliary system developmentGO:0061008980.123
cellular ketone metabolic processGO:0042180110.123
mitochondrion organizationGO:000700540.122
ear developmentGO:00435831270.121
dicarboxylic acid transportGO:000683510.121
cellular amide metabolic processGO:004360340.115
epithelial cell differentiationGO:00308551160.115
regulation of transmembrane transporter activityGO:002289820.110
protein processingGO:0016485120.109
membrane fusionGO:006102520.109
regulation of nitrogen compound metabolic processGO:00511712510.107
ion transmembrane transportGO:0034220910.105
cytokine mediated signaling pathwayGO:001922170.105
organic substance biosynthetic processGO:19015762890.100
cellular response to topologically incorrect proteinGO:003596720.100
establishment of localizationGO:00512342440.098
determination of left right symmetryGO:00073681790.098
embryo development ending in birth or egg hatchingGO:00097922710.098
Zebrafish
response to corticosteroidGO:003196010.096
myotome developmentGO:006105510.095
regulation of stem cell proliferationGO:007209120.094
agingGO:000756820.094
response to dexamethasoneGO:007154810.093
regulation of tyrosine phosphorylation of stat proteinGO:004250910.093
cellular macromolecule metabolic processGO:00442603910.093
ear morphogenesisGO:0042471640.090
cell death in response to oxidative stressGO:003647320.090
symbiosis encompassing mutualism through parasitismGO:004440340.089
multicellular organism growthGO:003526440.087
membrane repolarizationGO:008600920.085
membrane organizationGO:0061024210.084
negative regulation of reproductive processGO:200024230.082
cation transmembrane transportGO:0098655650.077
negative regulation of biological processGO:00485193040.077
negative regulation of multicellular organismal processGO:0051241690.076
regulation of vitamin metabolic processGO:003065660.075
central nervous system developmentGO:00074173870.075
melanin metabolic processGO:000658220.074
striated muscle cell developmentGO:00550021080.073
developmental programmed cell deathGO:001062340.073
detection of mechanical stimulusGO:0050982110.072
specification of symmetryGO:00097992040.072
anterior lateral line developmentGO:004889950.071
modification of morphology or physiology of other organismGO:003582140.070
endoplasmic reticulum unfolded protein responseGO:003096820.065
nitrogen compound metabolic processGO:00068073190.063
single organism localizationGO:19025782250.062
response to alkaloidGO:004327920.062
cellular amine metabolic processGO:004410620.062
carboxylic acid metabolic processGO:0019752220.061
striated muscle cell differentiationGO:00511461290.060
blood vessel endothelial cell migrationGO:0043534180.059
locomotionGO:00400113130.059
homeostatic processGO:00425921420.058
regulation of cellular ketone metabolic processGO:001056570.058
regulation of developmental processGO:00507932470.058
organonitrogen compound metabolic processGO:1901564740.058
regulation of membrane repolarizationGO:006030610.058
glial cell migrationGO:000834730.057
biosynthetic processGO:00090582940.056
immune system processGO:00023762410.056
connective tissue developmentGO:0061448990.056
Zebrafish
notch signaling pathwayGO:0007219350.055
sensory organ morphogenesisGO:00905962000.055
epithelial cell developmentGO:0002064420.055
response to drugGO:004249330.054
negative regulation of cellular processGO:00485232830.054
amide biosynthetic processGO:004360410.054
nephron epithelium morphogenesisGO:007208810.053
retina development in camera type eyeGO:00600411460.052
determination of heart left right asymmetryGO:00613711170.052
signal transductionGO:00071654550.051
regulation of rna metabolic processGO:00512522240.051
nucleic acid templated transcriptionGO:00976591810.051
nucleobase containing compound metabolic processGO:00061392740.051
regulation of tyrosine phosphorylation of stat3 proteinGO:004251610.051
neuron developmentGO:00486662620.051
fluid transportGO:0042044170.050
cellular response to lipopolysaccharideGO:007122230.050
hatchingGO:003518840.050
transportGO:00068102200.050
negative regulation of cell deathGO:0060548600.049
cellular pigmentationGO:0033059300.049
muscle cell migrationGO:001481240.049
heterocycle metabolic processGO:00464832900.049
cilium organizationGO:0044782710.048
protein metabolic processGO:00195381830.048
regulation of response to cytokine stimulusGO:006075930.048
cellular biosynthetic processGO:00442492860.047
regulation of jak stat cascadeGO:004642530.047
regulation of ion transmembrane transporter activityGO:003241220.047
regionalizationGO:00030022740.047
positive regulation of macromolecule metabolic processGO:0010604930.046
regulation of cell developmentGO:00602841000.046
regulation of notch signaling pathwayGO:0008593160.045
innervationGO:006038430.045
equilibrioceptionGO:005095720.045
cellular response to organic substanceGO:00713101050.044
adult behaviorGO:003053420.044
neuron differentiationGO:00301823530.044
organic acid metabolic processGO:0006082310.044
regulation of cellular amino acid metabolic processGO:000652100.043
cellular component movementGO:00069283350.042
regulation of cellular biosynthetic processGO:00313262450.042
myotube differentiationGO:0014902450.041
gland developmentGO:00487321430.041
cellular response to chemical stimulusGO:00708871570.041
negative regulation of response to stimulusGO:00485851040.040
regulation of nucleobase containing compound metabolic processGO:00192192500.040
positive regulation of innate immune responseGO:004508980.040
single organism membrane fusionGO:004480120.040
phosphate containing compound metabolic processGO:00067961080.040
negative regulation of protein phosphorylationGO:000193340.039
dorsal ventral pattern formationGO:00099531250.039
negative regulation of peptidase activityGO:0010466100.039
positive regulation of cellular amine metabolic processGO:003324000.039
response to glucocorticoidGO:005138410.039
system processGO:00030081850.039
organonitrogen compound biosynthetic processGO:1901566470.038
tyrosine phosphorylation of stat3 proteinGO:004250310.038
carbohydrate homeostasisGO:003350010.038
eye developmentGO:00016542770.038
negative regulation of mitosisGO:004583930.037
positive regulation of catabolic processGO:000989640.037
primitive erythrocyte differentiationGO:006031950.037
epithelium migrationGO:0090132250.037
cellular localizationGO:0051641970.037
negative regulation of epithelial cell proliferationGO:005068010.036
cellular component assembly involved in morphogenesisGO:00109271070.035
generation of neuronsGO:00486993850.035
negative regulation of signal transductionGO:0009968940.035
phagocytosisGO:000690930.035
response to organic substanceGO:00100331530.035
peptidyl serine modificationGO:001820920.034
cellular response to unfolded proteinGO:003462020.034
organism emergence from protective structureGO:007168440.034
positive regulation of mesenchymal cell proliferationGO:000205310.034
response to topologically incorrect proteinGO:003596620.034
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.033
response to unfolded proteinGO:000698620.033
fin morphogenesisGO:0033334530.033
Zebrafish
cellular amino acid metabolic processGO:000652070.033
membrane invaginationGO:001032410.033
negative regulation of metabolic processGO:0009892860.033
camera type eye developmentGO:00430102220.033
erythrocyte differentiationGO:0030218540.033
cellular response to extracellular stimulusGO:003166820.032
protein dephosphorylationGO:000647030.031
cellular response to lipidGO:0071396390.031
renal tubule morphogenesisGO:006133310.031
calcium mediated signalingGO:001972220.031
response to ketoneGO:190165410.031
cell surface receptor signaling pathwayGO:00071663250.031
positive regulation of embryonic developmentGO:004001930.030
detection of mechanical stimulus involved in sensory perception of soundGO:005091030.030
skeletal system morphogenesisGO:00487051020.030
Zebrafish
fat soluble vitamin metabolic processGO:000677540.030
regulation of bindingGO:005109830.030
ovulation cycle processGO:002260220.030
female gonad developmentGO:000858540.030
hormone transportGO:000991420.030
regulation of cellular metabolic processGO:00313233200.029
positive regulation of tyrosine phosphorylation of stat3 proteinGO:004251710.029
peripheral nervous system developmentGO:0007422550.029
regulation of cell substrate adhesionGO:001081010.029
larval behaviorGO:003053750.029
regulation of signal transductionGO:00099662250.029
development of primary female sexual characteristicsGO:004654540.029
cell part morphogenesisGO:00329902460.028
response to steroid hormoneGO:0048545350.028
cellular monovalent inorganic cation homeostasisGO:003000420.028
regulation of reproductive processGO:200024140.028
synaptic target recognitionGO:000803910.028
single organism transportGO:00447652060.028
regulation of cellular ph reductionGO:003284710.028
regulation of cell communicationGO:00106462320.027
regulation of multicellular organism growthGO:004001440.027
nucleoside monophosphate catabolic processGO:000912540.027
single organism organelle organizationGO:19025891990.027
actin filament based processGO:0030029640.027
cellular carbohydrate metabolic processGO:004426240.027
mitochondrial transportGO:000683920.027
regulation of rna biosynthetic processGO:20011412130.027
reproductionGO:0000003400.027
oxoacid metabolic processGO:0043436310.027
regulation of protein phosphorylationGO:0001932180.027
viral processGO:001603210.027
regulation of molecular functionGO:0065009700.026
epithelial cell proliferationGO:0050673170.026
homeostasis of number of cellsGO:0048872620.026
response to amino acidGO:004320020.026
calcium ion importGO:007050940.026
inner ear morphogenesisGO:0042472630.026
regulation of transporter activityGO:003240920.026
atp catabolic processGO:000620040.026
regulation of phosphorus metabolic processGO:0051174430.026
cell cell signalingGO:0007267520.025
localization of cellGO:00516742440.025
proteolysisGO:0006508380.025
response to uvGO:000941130.025
nephron tubule morphogenesisGO:007207810.025
regulation of peptidase activityGO:0052547230.025
small molecule metabolic processGO:0044281770.025
inorganic ion transmembrane transportGO:0098660570.025
transmembrane transportGO:00550851200.025
positive regulation of transportGO:005105020.025
regulation of retina development in camera type eyeGO:190286620.025
lymph vessel developmentGO:0001945270.025
regulation of metabolic processGO:00192223590.024
mesenchyme developmentGO:00604851270.024
anatomical structure homeostasisGO:0060249360.024
interspecies interaction between organismsGO:004441940.024
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.023
programmed cell deathGO:00125011190.023
pigment metabolic processGO:0042440120.023
organelle fusionGO:004828430.023
regulation of behaviorGO:0050795240.023
regulation of cytoplasmic transportGO:190364940.023
regulation of nucleic acid templated transcriptionGO:19035062130.023
cellular aromatic compound metabolic processGO:00067252950.023
secondary metabolic processGO:001974830.023
heart contractionGO:0060047710.023
forebrain developmentGO:0030900960.023
rna biosynthetic processGO:00327741810.022
negative regulation of protein serine threonine kinase activityGO:007190120.022
phosphorus metabolic processGO:00067931090.022
regulation of carbohydrate metabolic processGO:000610940.022
negative regulation of cell communicationGO:0010648960.022
nik nf kappab signalingGO:003806110.022
cytoskeleton organizationGO:0007010960.022
positive regulation of cellular amino acid metabolic processGO:004576400.022
guanosine containing compound metabolic processGO:190106840.022
regulation of neural retina developmentGO:006107420.022
actin filament based movementGO:003004810.022
skeletal muscle organ developmentGO:0060538780.022
organic substance catabolic processGO:1901575280.022
cellular response to molecule of bacterial originGO:007121930.022
er nucleus signaling pathwayGO:000698420.022
response to chemicalGO:00422213200.021
inorganic cation transmembrane transportGO:0098662500.021
organic cyclic compound metabolic processGO:19013603010.021
venous endothelial cell migration involved in lymph vessel developmentGO:006085540.021
zymogen activationGO:003163830.021
regulation of cellular amine metabolic processGO:003323800.021
response to bacteriumGO:0009617580.021
single organism metabolic processGO:00447102170.021
multicellular organismal response to stressGO:003355520.021
positive regulation of apoptotic signaling pathwayGO:200123510.021
negative regulation of macromolecule metabolic processGO:0010605760.021
hormone secretionGO:004687920.020
regulation of neurogenesisGO:0050767870.020
purine ribonucleoside monophosphate catabolic processGO:000916940.020
transcription dna templatedGO:00063511810.020
regulation of system processGO:0044057400.020
positive regulation of notch signaling pathwayGO:004574730.020
regulation of cellular phGO:003064110.020
tyrosine phosphorylation of stat proteinGO:000726010.020
myeloid cell differentiationGO:0030099860.020
regulation of locomotionGO:0040012550.020
single organism membrane organizationGO:0044802200.019
neuron cellular homeostasisGO:007005030.019
regulation of neuron differentiationGO:0045664560.019
neuromast depositionGO:004888590.019
macromolecular complex disassemblyGO:003298410.019
organic cyclic compound biosynthetic processGO:19013622230.019
response to hormoneGO:0009725480.019
lipid metabolic processGO:0006629520.019
hair cell differentiationGO:0035315320.019
regulation of biosynthetic processGO:00098892500.019
response to carbohydrateGO:000974330.019
regulation of programmed cell deathGO:00430671010.019
diencephalon developmentGO:0021536580.019
negative regulation of nucleic acid templated transcriptionGO:1903507450.019
ovarian follicle developmentGO:000154120.019
homeostasis of number of cells within a tissueGO:004887340.019
cytokinesisGO:000091030.019
primitive hemopoiesisGO:0060215270.019
cellular response to stressGO:0033554620.019
apoptotic process involved in developmentGO:190274220.019
cell cycle g2 m phase transitionGO:004483940.019
regulation of metal ion transportGO:001095940.019
cellular cation homeostasisGO:0030003170.019
negative regulation of protein kinase activityGO:000646940.019
gliogenesisGO:0042063450.018
regulation of calcium ion transportGO:005192420.018
ribonucleoside monophosphate catabolic processGO:000915840.018
response to external stimulusGO:00096052640.018
cilium morphogenesisGO:0060271850.018
cellular component disassemblyGO:002241110.018
apoptotic process involved in morphogenesisGO:006056120.018
somatic stem cell maintenanceGO:003501910.018
negative regulation of programmed cell deathGO:0043069580.018
regulation of purine nucleotide catabolic processGO:003312120.018
mitotic cell cycle processGO:1903047480.018
skin developmentGO:0043588540.018
skeletal system developmentGO:00015011810.018
Zebrafish
positive regulation of lipase activityGO:006019310.018
regulation of phosphate metabolic processGO:0019220430.018
golgi vesicle transportGO:004819330.017
leukocyte migrationGO:0050900150.017
negative regulation of behaviorGO:004852160.017
positive regulation of epithelial cell proliferationGO:005067910.017
ovulation cycleGO:004269820.017
retinal cell programmed cell deathGO:004666620.017
otic vesicle developmentGO:0071599420.017
cell proliferation involved in heart morphogenesisGO:006132320.017
regulation of anatomical structure morphogenesisGO:00226031300.017
response to cytokineGO:003409770.017
muscle cell developmentGO:00550011150.017
regulation of collagen metabolic processGO:001071220.016
regulation of circadian rhythmGO:004275240.016
carboxylic acid transportGO:004694280.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.016
leukocyte chemotaxisGO:0030595120.016
endosomal transportGO:001619720.016
positive regulation of cellular catabolic processGO:003133130.016
renal system developmentGO:0072001940.016
guanosine containing compound catabolic processGO:190106920.016
amine metabolic processGO:000930820.016
regulation of membrane potentialGO:0042391230.016
camera type eye morphogenesisGO:00485931080.016
pectoral fin morphogenesisGO:0035138290.016
multi organism processGO:00517041340.016
canonical wnt signaling pathwayGO:0060070480.016
regulation of cell deathGO:00109411030.016
regulation of cysteine type endopeptidase activityGO:2000116210.016
larval developmentGO:000216420.016
regulation of cellular protein catabolic processGO:190336210.016
sodium ion transmembrane transportGO:0035725210.016
protein maturationGO:0051604120.015
extrinsic apoptotic signaling pathwayGO:009719130.015
amino acid transportGO:000686520.015
axon developmentGO:00615641660.015
gtp metabolic processGO:004603940.015
nephron morphogenesisGO:007202820.015
sexual reproductionGO:0019953360.015
regulation of cellular response to oxidative stressGO:190040720.015
regulation of cell shapeGO:000836010.015
negative regulation of developmental processGO:0051093650.015
erythrocyte homeostasisGO:0034101550.015
phagocytosis engulfmentGO:000691110.015
embryonic heart tube morphogenesisGO:00031431080.015
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.015
catabolic processGO:0009056320.015
epithelial tube morphogenesisGO:00605621480.015
morphogenesis of an epitheliumGO:00020093330.015
regulation of cytokine mediated signaling pathwayGO:000195930.015
metal ion transportGO:0030001580.015
regulation of multicellular organismal developmentGO:20000262230.015
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.015
startle responseGO:000196440.015
adherens junction organizationGO:003433240.015
organic acid transportGO:001584990.015
regulation of phGO:000688530.014
granulocyte migrationGO:0097530110.014
regulation of glial cell proliferationGO:006025140.014
cell proliferationGO:0008283800.014
posterior lateral line neuromast depositionGO:004892250.014
heart morphogenesisGO:00030071560.014
gtp catabolic processGO:000618420.014
lipid storageGO:001991510.014
response to stressGO:00069502630.014
negative regulation of multi organism processGO:004390130.014
response to monosaccharideGO:003428430.014
regulation of intracellular signal transductionGO:1902531570.014
rna metabolic processGO:00160702190.014
vasculogenesisGO:0001570410.014
cell deathGO:00082191210.014
cartilage developmentGO:0051216960.014
Zebrafish
reactive oxygen species metabolic processGO:007259360.014
response to lipidGO:0033993600.014
regulation of protein complex assemblyGO:004325430.014
negative regulation of signalingGO:0023057960.014
ribonucleotide metabolic processGO:0009259270.014
otic vesicle formationGO:0030916270.014
apoptotic processGO:00069151160.014
retina morphogenesis in camera type eyeGO:0060042790.014
brain developmentGO:00074202930.013
detection of mechanical stimulus involved in sensory perceptionGO:0050974110.013
negative regulation of cell differentiationGO:0045596460.013
mitotic nuclear divisionGO:0007067180.013
regulation of primary metabolic processGO:00800903110.013
regulation of myotube differentiationGO:001083020.013
eye morphogenesisGO:00485921440.013
enzyme linked receptor protein signaling pathwayGO:00071671060.013
nucleic acid metabolic processGO:00903042440.013
regulation of nik nf kappab signalingGO:190122210.013
organelle membrane fusionGO:009017420.013
protein complex disassemblyGO:004324110.013
regulation of cellular macromolecule biosynthetic processGO:20001122220.013
hormone metabolic processGO:0042445190.013
positive regulation of map kinase activityGO:004340630.013
regulation of inner ear receptor cell differentiationGO:200098010.013
action potentialGO:0001508190.013
regulation of signalingGO:00230512350.013
response to oxygen radicalGO:000030520.013
negative regulation of translationGO:001714810.013
purine nucleoside triphosphate biosynthetic processGO:000914520.013
regulation of immune system processGO:0002682340.013
granulocyte chemotaxisGO:0071621110.013
metal ion homeostasisGO:0055065260.013
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.013
head developmentGO:00603223030.013
regulation of oxidative stress induced cell deathGO:190320120.013
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.013
positive regulation of gliogenesisGO:001401520.013
hematopoietic or lymphoid organ developmentGO:00485341910.012
response to inorganic substanceGO:0010035380.012
ion transportGO:00068111140.012
cellular component assemblyGO:00226071700.012
muscle cell differentiationGO:00426921390.012
neuroblast proliferationGO:000740520.012
activation of mapk activityGO:000018730.012
cellular metal ion homeostasisGO:0006875160.012
anion transportGO:0006820380.012
negative regulation of gene expressionGO:0010629650.012
nucleotide metabolic processGO:0009117280.012
regulation of cell proliferation involved in heart morphogenesisGO:200013620.012
cell morphogenesisGO:00009022890.012
cellular component morphogenesisGO:00329893360.012
cellular nitrogen compound biosynthetic processGO:00442712180.012
stem cell divisionGO:001714510.012
cellular component biogenesisGO:00440851780.012
protein targeting to nucleusGO:004474430.012
response to oxygen containing compoundGO:1901700550.012
hemopoiesisGO:00300971830.012
lipid digestionGO:004424130.012
multicellular organismal signalingGO:0035637220.012
regulation of intracellular phGO:005145310.012
regulation of protein metabolic processGO:0051246560.011
regulation of canonical wnt signaling pathwayGO:0060828340.011
negative regulation of mapk cascadeGO:004340940.011
cellular protein metabolic processGO:00442671290.011
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.011
regulation of skeletal muscle tissue developmentGO:004864140.011
pharyngeal muscle developmentGO:004328240.011
immune system developmentGO:00025201910.011
antimicrobial humoral responseGO:001973020.011
regulation of protein modification by small protein conjugation or removalGO:190332030.011
regulation of protein bindingGO:004339330.011
positive regulation of signal transductionGO:0009967560.011
glial cell proliferationGO:001400940.011
radial glial cell differentiationGO:006001920.011
positive regulation of dna metabolic processGO:005105410.011
modification by symbiont of host morphology or physiologyGO:004400340.011

pcsk5a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
auditory system diseaseDOID:274200.491
nonsyndromic deafnessDOID:005056300.491
autosomal dominant nonsyndromic deafnessDOID:005056400.491
nervous system diseaseDOID:86300.491
sensory system diseaseDOID:005015500.491
disease of anatomical entityDOID:700.491
hematopoietic system diseaseDOID:7400.064
immune system diseaseDOID:291400.064
cancerDOID:16200.016
organ system cancerDOID:005068600.016
disease of cellular proliferationDOID:1456600.016
eye and adnexa diseaseDOID:149200.016