Danio rerio

0 known processes

pcsk5b

proprotein convertase subtilisin/kexin type 5b

(Aliases: zgc:165659,pcsk5)

pcsk5b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
connective tissue developmentGO:0061448990.848
appendage morphogenesisGO:0035107560.770
embryonic organ morphogenesisGO:00485622740.765
heart developmentGO:00075073130.763
skeletal system developmentGO:00015011810.693
chordate embryonic developmentGO:00430092710.654
neuromast developmentGO:0048884460.639
embryonic cranial skeleton morphogenesisGO:0048701900.635
regulation of biological qualityGO:00650082630.630
embryonic skeletal system developmentGO:0048706970.623
regulation of response to stimulusGO:00485832690.595
appendage developmentGO:0048736800.586
embryonic viscerocranium morphogenesisGO:0048703520.514
cartilage developmentGO:0051216960.501
regulation of multicellular organismal processGO:00512392770.497
determination of bilateral symmetryGO:00098552040.459
protein metabolic processGO:00195381830.446
regulation of macromolecule metabolic processGO:00602553170.433
sensory organ developmentGO:00074233930.424
central nervous system developmentGO:00074173870.419
immunoglobulin mediated immune responseGO:001606430.413
lateral line system developmentGO:0048925760.387
forebrain developmentGO:0030900960.359
cell matrix adhesionGO:000716040.345
plasminogen activationGO:003163930.327
determination of left right symmetryGO:00073681790.305
negative regulation of sequestering of calcium ionGO:005128340.301
gene expressionGO:00104672520.292
regulation of rna metabolic processGO:00512522240.287
fin morphogenesisGO:0033334530.282
embryonic skeletal system morphogenesisGO:0048704930.278
regulation of developmental processGO:00507932470.277
urogenital system developmentGO:0001655970.266
cellular component movementGO:00069283350.260
rna biosynthetic processGO:00327741810.258
homeostatic processGO:00425921420.256
locomotionGO:00400113130.246
fin developmentGO:0033333770.243
localization of cellGO:00516742440.241
protein processingGO:0016485120.235
response to chemicalGO:00422213200.231
heart loopingGO:0001947940.224
single organism metabolic processGO:00447102170.219
embryo development ending in birth or egg hatchingGO:00097922710.219
cellular nitrogen compound metabolic processGO:00346412900.216
specification of symmetryGO:00097992040.216
cartilage morphogenesisGO:0060536130.208
agingGO:000756820.203
embryonic heart tube morphogenesisGO:00031431080.195
regulation of cell differentiationGO:00455951420.192
regulation of gene expressionGO:00104682650.187
heart morphogenesisGO:00030071560.183
cell migrationGO:00164772370.173
embryonic organ developmentGO:00485683810.169
cellular response to endogenous stimulusGO:0071495680.166
negative regulation of nuclear divisionGO:005178430.166
skeletal system morphogenesisGO:00487051020.162
signal transductionGO:00071654550.160
embryonic limb morphogenesisGO:003032620.160
otolith developmentGO:0048840320.159
pericardium developmentGO:006003910.152
embryonic heart tube developmentGO:00350501330.149
positive regulation of cellular processGO:00485222010.143
cellular component morphogenesisGO:00329893360.143
mesoderm morphogenesisGO:0048332510.141
mesoderm developmentGO:0007498880.139
negative regulation of cell communicationGO:0010648960.139
female sex differentiationGO:004666040.138
biosynthetic processGO:00090582940.133
regulation of metabolic processGO:00192223590.129
sensory system developmentGO:0048880760.126
cellular response to chemical stimulusGO:00708871570.126
positive regulation of map kinase activityGO:004340630.124
cytosolic calcium ion transportGO:006040130.124
immune system processGO:00023762410.123
pericardium morphogenesisGO:000334410.120
negative regulation of mitotic cell cycleGO:0045930110.120
regulation of signal transductionGO:00099662250.118
negative regulation of biological processGO:00485193040.117
muscle cell migrationGO:001481240.114
response to biotic stimulusGO:0009607970.113
cellular component assemblyGO:00226071700.113
response to endogenous stimulusGO:0009719830.111
regulation of cell substrate adhesionGO:001081010.110
cellular protein metabolic processGO:00442671290.109
positive regulation of cytokine productionGO:000181920.109
axon midline choice point recognitionGO:001619940.108
cell migration involved in gastrulationGO:0042074790.106
determination of heart left right asymmetryGO:00613711170.106
cell part morphogenesisGO:00329902460.105
regulation of multicellular organismal developmentGO:20000262230.105
morphogenesis of an epitheliumGO:00020093330.104
inner ear developmentGO:00488391260.104
heterocycle biosynthetic processGO:00181302150.103
nucleic acid templated transcriptionGO:00976591810.101
multi organism cellular processGO:004476420.100
programmed cell deathGO:00125011190.099
synaptic target recognitionGO:000803910.098
regulation of rna biosynthetic processGO:20011412130.098
kupffer s vesicle developmentGO:0070121500.098
response to organic substanceGO:00100331530.098
regulation of hormone secretionGO:004688320.097
actomyosin structure organizationGO:0031032530.097
cell surface receptor signaling pathwayGO:00071663250.095
muscle structure developmentGO:00610611960.094
regulation of cytoplasmic transportGO:190364940.093
negative regulation of cellular processGO:00485232830.093
muscle tissue developmentGO:00605371100.091
negative regulation of mitosisGO:004583930.091
regulation of transcription dna templatedGO:00063552130.091
cell proliferationGO:0008283800.091
regulation of nucleobase containing compound metabolic processGO:00192192500.091
ameboidal type cell migrationGO:00016671430.090
regulation of cell cycleGO:0051726520.088
cell deathGO:00082191210.087
neuron developmentGO:00486662620.086
lateral line developmentGO:0048882660.086
regulation of organ morphogenesisGO:2000027350.086
metal ion homeostasisGO:0055065260.085
collagen metabolic processGO:003296320.084
tube morphogenesisGO:00352393490.083
regulation of cell communicationGO:00106462320.083
enzyme linked receptor protein signaling pathwayGO:00071671060.082
cellular component biogenesisGO:00440851780.082
blood circulationGO:0008015870.081
regulation of cellular protein metabolic processGO:0032268520.080
stem cell developmentGO:0048864820.078
regulation of protein metabolic processGO:0051246560.078
heterocycle metabolic processGO:00464832900.078
eye morphogenesisGO:00485921440.077
positive regulation of macromolecule metabolic processGO:0010604930.077
skeletal muscle organ developmentGO:0060538780.076
eye developmentGO:00016542770.076
kidney epithelium developmentGO:0072073230.076
cell substrate adhesionGO:003158940.075
mechanosensory lateral line system developmentGO:0048881490.075
neuron projection extensionGO:1990138450.075
stem cell differentiationGO:00488631170.074
blood vessel developmentGO:00015682460.074
negative regulation of ras protein signal transductionGO:004658010.073
regulation of transferase activityGO:0051338160.072
regulation of extrinsic apoptotic signaling pathwayGO:200123630.072
viral processGO:001603210.072
carboxylic acid metabolic processGO:0019752220.071
cell motilityGO:00488702440.071
neuron projection morphogenesisGO:00488121610.070
brain developmentGO:00074202930.070
cellular response to organic substanceGO:00713101050.070
myeloid cell differentiationGO:0030099860.069
regulation of glucose importGO:004632410.069
anion transportGO:0006820380.069
cellular macromolecule metabolic processGO:00442603910.068
response to ketoneGO:190165410.067
multi organism processGO:00517041340.067
extrinsic apoptotic signaling pathwayGO:009719130.067
epithelial tube morphogenesisGO:00605621480.067
regulation of nitrogen compound metabolic processGO:00511712510.066
maintenance of locationGO:005123540.066
negative regulation of peptidase activityGO:0010466100.066
nucleobase containing compound metabolic processGO:00061392740.066
negative regulation of protein phosphorylationGO:000193340.065
skeletal muscle tissue developmentGO:0007519670.064
cell cycleGO:0007049930.062
negative regulation of cell differentiationGO:0045596460.062
heart contractionGO:0060047710.062
kidney developmentGO:0001822920.062
muscle cell differentiationGO:00426921390.061
regulation of programmed cell deathGO:00430671010.061
organelle organizationGO:00069962270.060
organonitrogen compound metabolic processGO:1901564740.060
system processGO:00030081850.060
neuron projection guidanceGO:0097485860.059
regenerationGO:0031099910.059
regulation of signalingGO:00230512350.059
response to external stimulusGO:00096052640.059
deathGO:00162651210.059
multicellular organismal macromolecule metabolic processGO:004425920.058
response to vitaminGO:003327330.058
sequestering of metal ionGO:005123830.058
regulation of peptidase activityGO:0052547230.058
anterior lateral line system developmentGO:004889890.058
anatomical structure homeostasisGO:0060249360.058
positive regulation of cell developmentGO:0010720250.057
cell projection morphogenesisGO:00488582440.057
cell morphogenesisGO:00009022890.056
intracellular signal transductionGO:0035556850.056
regulation of protein phosphorylationGO:0001932180.056
regulation of cell deathGO:00109411030.056
nuclear transportGO:005116940.056
positive regulation of neurogenesisGO:0050769240.056
regulation of catalytic activityGO:0050790550.055
dorsal ventral pattern formationGO:00099531250.054
response to corticosteroidGO:003196010.054
hormone transportGO:000991420.054
female gonad developmentGO:000858540.054
negative regulation of cell divisionGO:005178240.053
positive regulation of nitrogen compound metabolic processGO:0051173690.053
nitrogen compound metabolic processGO:00068073190.053
cellular amine metabolic processGO:004410620.053
regulation of kinase activityGO:0043549150.052
muscle organ developmentGO:00075171010.052
meiotic cell cycle processGO:190304630.051
mitotic cell cycle processGO:1903047480.051
positive regulation of canonical wnt signaling pathwayGO:009026340.051
cellular localizationGO:0051641970.051
modulation by virus of host morphology or physiologyGO:001904810.051
macromolecule biosynthetic processGO:00090592270.051
cellular nitrogen compound biosynthetic processGO:00442712180.051
negative regulation of catalytic activityGO:0043086210.050
stem cell maintenanceGO:001982740.050
mesoderm formationGO:0001707430.050
pectoral fin morphogenesisGO:0035138290.049
macromolecule modificationGO:00434121110.049
endoderm developmentGO:0007492490.049
negative regulation of endopeptidase activityGO:0010951100.048
cellular macromolecule biosynthetic processGO:00346452240.048
multicellular organism reproductionGO:0032504350.048
growthGO:00400071740.048
regulation of stem cell proliferationGO:007209120.048
hematopoietic or lymphoid organ developmentGO:00485341910.047
cellular protein modification processGO:00064641000.047
digestive tract developmentGO:00485652650.047
protein modification processGO:00362111000.046
gland developmentGO:00487321430.046
negative regulation of signal transductionGO:0009968940.046
positive regulation of reproductive processGO:200024320.046
organelle assemblyGO:00709251100.045
blood vessel endothelial cell migrationGO:0043534180.045
apoptotic processGO:00069151160.045
cellular component assembly involved in morphogenesisGO:00109271070.045
ovulation cycle processGO:002260220.045
negative regulation of cellular protein metabolic processGO:0032269160.045
regulation of reproductive processGO:200024140.045
multicellular organismal metabolic processGO:004423620.044
transportGO:00068102200.044
negative regulation of apoptotic processGO:0043066550.044
regulation of nucleic acid templated transcriptionGO:19035062130.044
regulation of cell developmentGO:00602841000.044
positive regulation of transportGO:005105020.044
interspecies interaction between organismsGO:004441940.043
striated muscle cell differentiationGO:00511461290.043
rna metabolic processGO:00160702190.043
anterior lateral line developmentGO:004889950.043
positive regulation of cellular component biogenesisGO:004408930.043
regulation of cellular biosynthetic processGO:00313262450.043
cell proliferation in forebrainGO:002184630.043
organic substance biosynthetic processGO:19015762890.043
regulation of locomotionGO:0040012550.042
phosphorylationGO:0016310690.042
ion homeostasisGO:0050801410.042
response to alkaloidGO:004327920.042
proteolysisGO:0006508380.042
regulation of chemotaxisGO:0050920180.042
regulation of anatomical structure morphogenesisGO:00226031300.042
regulation of muscle organ developmentGO:004863490.041
negative regulation of kinase activityGO:003367340.041
regulation of cellular ketone metabolic processGO:001056570.041
embryonic appendage morphogenesisGO:0035113300.041
neural plate anterior posterior regionalizationGO:002199980.041
tissue regenerationGO:0042246740.041
meiotic nuclear divisionGO:000712640.041
response to light stimulusGO:0009416460.041
single organism nuclear importGO:190259330.041
cell projection organizationGO:00300302840.040
establishment of localizationGO:00512342440.040
positive regulation of cellular metabolic processGO:0031325940.040
regulation of carbohydrate metabolic processGO:000610940.040
negative regulation of axon extension involved in axon guidanceGO:004884310.040
carbohydrate homeostasisGO:003350010.039
release of sequestered calcium ion into cytosolGO:005120930.039
positive regulation of response to stimulusGO:0048584800.039
regulation of nuclear divisionGO:005178390.039
single organism transportGO:00447652060.039
positive regulation of cell adhesionGO:004578510.039
regulation of organelle organizationGO:0033043290.038
developmental growth involved in morphogenesisGO:0060560860.038
cellular divalent inorganic cation homeostasisGO:0072503130.038
hemopoiesisGO:00300971830.038
regulation of cellular amine metabolic processGO:003323800.038
axon extensionGO:0048675450.038
cilium morphogenesisGO:0060271850.038
regulation of apoptotic processGO:0042981980.038
regulation of bindingGO:005109830.038
symbiosis encompassing mutualism through parasitismGO:004440340.037
regulation of primary metabolic processGO:00800903110.037
protein activation cascadeGO:007237660.036
heart processGO:0003015710.036
hepaticobiliary system developmentGO:0061008980.036
modification by symbiont of host morphology or physiologyGO:004400340.036
cell cycle g1 s phase transitionGO:004484310.036
positive regulation of rna biosynthetic processGO:1902680570.036
convergent extensionGO:00600261180.036
mitotic nuclear divisionGO:0007067180.035
positive regulation of biological processGO:00485182530.035
liver developmentGO:0001889960.035
regionalizationGO:00030022740.035
negative regulation of small gtpase mediated signal transductionGO:005105810.035
response to stressGO:00069502630.035
positive regulation of cell cycleGO:004578730.035
negative regulation of cell cycle processGO:001094890.035
protein localization to nucleusGO:003450430.034
regulation of collagen metabolic processGO:001071220.034
response to nutrientGO:000758430.034
positive regulation of epithelial cell differentiationGO:003085820.034
regulation of intracellular signal transductionGO:1902531570.034
negative regulation of protein kinase activityGO:000646940.034
response to other organismGO:0051707970.034
renal system developmentGO:0072001940.034
cellular ketone metabolic processGO:0042180110.033
axon developmentGO:00615641660.033
regulation of cell divisionGO:0051302120.033
regulation of nucleocytoplasmic transportGO:004682220.033
regulation of protein import into nucleusGO:004230620.033
regulation of dna replicationGO:000627530.033
epithelial cell differentiationGO:00308551160.033
regulation of fatty acid metabolic processGO:001921710.033
multicellular organismal reproductive processGO:0048609350.032
endochondral bone morphogenesisGO:006035080.032
gastrulationGO:00073692080.032
nuclear divisionGO:0000280230.032
stem cell proliferationGO:007208940.032
innate immune responseGO:0045087130.032
regulation of cellular amino acid metabolic processGO:000652100.032
regulation of mrna processingGO:005068430.032
hard palate developmentGO:006002240.032
divalent inorganic cation homeostasisGO:0072507220.032
regulation of mitotic cell cycleGO:0007346250.031
mediolateral intercalationGO:006003130.031
peptidyl serine modificationGO:001820920.031
positive regulation of macromolecule biosynthetic processGO:0010557590.031
response to fluid shear stressGO:003440520.031
organic cyclic compound metabolic processGO:19013603010.031
positive regulation of rna metabolic processGO:0051254590.031
regulation of cellular metabolic processGO:00313233200.031
peptidyl serine phosphorylationGO:001810510.031
negative regulation of hydrolase activityGO:0051346100.031
cellular biosynthetic processGO:00442492860.031
negative regulation of mapk cascadeGO:004340940.031
single organism localizationGO:19025782250.031
circulatory system processGO:0003013870.030
pectoral fin developmentGO:0033339500.030
protein importGO:001703830.030
negative regulation of cell deathGO:0060548600.030
cellular response to external stimulusGO:007149620.030
positive regulation of cytosolic calcium ion concentrationGO:000720440.030
zymogen activationGO:003163830.030
striated muscle cell developmentGO:00550021080.030
negative regulation of gene expressionGO:0010629650.030
regulation of neurogenesisGO:0050767870.030
calcium ion transport into cytosolGO:006040230.030
organic acid metabolic processGO:0006082310.030
phosphate containing compound metabolic processGO:00067961080.030
negative regulation of cell migrationGO:0030336170.029
regulation of cell adhesionGO:0030155150.029
phosphorus metabolic processGO:00067931090.029
regulation of immune system processGO:0002682340.029
negative regulation of cell cycleGO:0045786140.029
vasculature developmentGO:00019442780.029
cell divisionGO:0051301200.029
convergent extension involved in gastrulationGO:0060027710.029
positive regulation of metabolic processGO:00098931080.029
positive regulation of stress activated mapk cascadeGO:003287430.029
regulation of cellular response to growth factor stimulusGO:0090287350.029
negative regulation of macromolecule metabolic processGO:0010605760.029
negative regulation of multicellular organismal processGO:0051241690.028
positive regulation of nucleobase containing compound metabolic processGO:0045935690.028
organic cyclic compound biosynthetic processGO:19013622230.028
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.028
regulation of mapk cascadeGO:0043408140.028
regulation of cellular component movementGO:0051270550.028
regulation of cell motilityGO:2000145460.027
regulation of behaviorGO:0050795240.027
ovulation cycleGO:004269820.027
morphogenesis of an epithelial foldGO:006057110.027
organonitrogen compound biosynthetic processGO:1901566470.027
membrane invaginationGO:001032410.027
fin regenerationGO:0031101510.027
cellular ion homeostasisGO:0006873170.027
transcription from rna polymerase ii promoterGO:0006366800.027
nucleocytoplasmic transportGO:000691340.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.027
nephron tubule morphogenesisGO:007207810.027
optic placode formationGO:000174340.027
protein localization to plasma membraneGO:007265910.027
mitotic cell cycleGO:0000278640.026
g1 s transition of mitotic cell cycleGO:000008210.026
cell morphogenesis involved in neuron differentiationGO:00486671630.026
regulation of biosynthetic processGO:00098892500.026
regulation of protein catabolic processGO:004217610.026
larval developmentGO:000216420.026
negative regulation of reproductive processGO:200024230.026
positive regulation of cellular protein metabolic processGO:0032270220.026
cellular homeostasisGO:0019725260.026
adherens junction organizationGO:003433240.026
protein localizationGO:0008104400.026
cell substrate junction assemblyGO:000704420.026
cellular amino acid metabolic processGO:000652070.026
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.025
establishment of localization in cellGO:0051649770.025
response to organic cyclic compoundGO:0014070510.025
positive regulation of cellular amine metabolic processGO:003324000.025
phagocytosisGO:000690930.025
positive regulation of gene expressionGO:0010628710.025
hindbrain developmentGO:0030902910.025
protein phosphorylationGO:0006468470.025
blood vessel morphogenesisGO:00485142160.025
larval heart developmentGO:000750820.024
chemical homeostasisGO:0048878490.024
invagination involved in gastrulation with mouth forming secondGO:005510910.024
macromolecular complex subunit organizationGO:0043933740.024
metal ion transportGO:0030001580.024
regulation of mitosisGO:000708890.024
cellular response to stressGO:0033554620.024
leukocyte homeostasisGO:000177620.024
regulation of protein targetingGO:190353320.024
negative regulation of chemotaxisGO:005092240.024
ear developmentGO:00435831270.024
cellular response to lipidGO:0071396390.024
regulation of cellular protein catabolic processGO:190336210.023
regulation of peptidyl tyrosine phosphorylationGO:005073010.023
negative regulation of developmental processGO:0051093650.023
neural plate pattern specificationGO:0060896120.023
development of primary female sexual characteristicsGO:004654540.023
convergent extension involved in axis elongationGO:0060028260.023
digestive system developmentGO:00551232890.023
negative regulation of programmed cell deathGO:0043069580.023
cell fate commitmentGO:0045165990.022
neuron differentiationGO:00301823530.022
reproductionGO:0000003400.022
cell cycle arrestGO:000705010.022
protein maturationGO:0051604120.022
regulation of endocytosisGO:003010070.022
nucleic acid metabolic processGO:00903042440.022
cellular amide metabolic processGO:004360340.022
regulation of protein transportGO:005122330.022
i kappab kinase nf kappab signalingGO:000724940.022
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.022
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.021
positive regulation of cell deathGO:0010942290.021
oxoacid metabolic processGO:0043436310.021
regulation of cytokine productionGO:000181730.021
establishment of blood brain barrierGO:006085620.021
amine metabolic processGO:000930820.021
regulation of cellular component organizationGO:0051128860.021
angiogenesisGO:00015251580.021
positive regulation of immune responseGO:0050778110.020
regulation of multicellular organism growthGO:004001440.020
cardiac muscle tissue developmentGO:0048738480.020
phagocytosis engulfmentGO:000691110.020
response to woundingGO:00096111160.020
sarcomere organizationGO:0045214260.020
peptide metabolic processGO:000651810.020
response to monosaccharideGO:003428430.020
immune system developmentGO:00025201910.020
complement activationGO:000695630.020
positive regulation of epithelial cell proliferationGO:005067910.020
head developmentGO:00603223030.020
establishment of protein localization to organelleGO:007259440.020
bone developmentGO:0060348140.020
superoxide metabolic processGO:000680120.020
regulation of macromolecule biosynthetic processGO:00105562250.020
single organism organelle organizationGO:19025891990.020
negative regulation of signalingGO:0023057960.019
macromolecule localizationGO:0033036540.019
regulation of membrane potentialGO:0042391230.019
positive regulation of signalingGO:0023056560.019
generation of neuronsGO:00486993850.019
cellular component disassemblyGO:002241110.019
nucleobase containing compound biosynthetic processGO:00346542050.019
taxisGO:00423301090.019
embryonic skeletal joint developmentGO:007249830.019
cardiocyte differentiationGO:0035051440.019
positive regulation of multicellular organismal processGO:0051240520.019
positive regulation of apoptotic processGO:0043065290.019
regulation of molecular functionGO:0065009700.019
single organism cellular localizationGO:1902580460.019
regulation of i kappab kinase nf kappab signalingGO:004312240.019
hormone secretionGO:004687920.019
regulation of localizationGO:00328791040.019
positive regulation of cell substrate adhesionGO:001081110.019
negative regulation of homeostatic processGO:003284550.019
negative regulation of behaviorGO:004852160.019
lipid storageGO:001991510.019
tissue remodelingGO:004877140.019
otic vesicle formationGO:0030916270.019
post embryonic organ developmentGO:004856940.018
response to bacteriumGO:0009617580.018
cellular aromatic compound metabolic processGO:00067252950.018
microtubule organizing center organizationGO:003102310.018

pcsk5b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.038
disease of cellular proliferationDOID:1456600.038
large intestine cancerDOID:567200.038
intestinal cancerDOID:1015500.038
organ system cancerDOID:005068600.038
gastrointestinal system cancerDOID:311900.038
connective tissue diseaseDOID:6500.037
musculoskeletal system diseaseDOID:1700.037
bone diseaseDOID:008000100.037
disease of anatomical entityDOID:700.037