Danio rerio

7 known processes

chek2

CHK2 checkpoint homolog (S. pombe)

(Aliases: fa66f08,zgc:55865,wu:fa66f08)

chek2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular nitrogen compound metabolic processGO:00346412900.328
Human Fly
regulation of dna replicationGO:000627530.173
Human
double strand break repair via homologous recombinationGO:000072410.111
organic cyclic compound metabolic processGO:19013603010.109
Human Fly
nitrogen compound metabolic processGO:00068073190.102
Human Fly
larval developmentGO:000216420.097
cellular biosynthetic processGO:00442492860.086
Human Fly
dna alkylationGO:000630580.079
organelle organizationGO:00069962270.078
Human Worm
dna catabolic processGO:000630810.078
transcription dna templatedGO:00063511810.076
Human Fly
gene expressionGO:00104672520.075
Human Fly
regulation of gene expressionGO:00104682650.074
Human Fly
mitotic dna integrity checkpointGO:004477440.072
Human Fly
recombinational repairGO:000072510.070
response to chemicalGO:00422213200.064
dna metabolic processGO:0006259270.058
Human Fly
microtubule organizing center organizationGO:003102310.055
regulation of nucleobase containing compound metabolic processGO:00192192500.054
Human Fly
nucleobase containing compound metabolic processGO:00061392740.053
Human Fly
positive regulation of catabolic processGO:000989640.047
negative regulation of histone methylationGO:003106110.047
locomotionGO:00400113130.046
g2 m transition of mitotic cell cycleGO:000008640.046
Human
immunoglobulin mediated immune responseGO:001606430.045
response to biotic stimulusGO:0009607970.045
regulation of multicellular organism growthGO:004001440.045
neuron developmentGO:00486662620.044
positive regulation of chromatin modificationGO:190331010.043
biosynthetic processGO:00090582940.042
Human Fly
meiotic chromosome segregationGO:004513230.041
Worm
positive regulation of cell cycleGO:004578730.041
regulation of dna metabolic processGO:0051052110.041
Human Fly
oocyte maturationGO:000155640.040
cellular nitrogen compound biosynthetic processGO:00442712180.040
Human Fly
regulation of transcription dna templatedGO:00063552130.039
Human Fly
regulation of chromosome segregationGO:005198310.039
regulation of protein ubiquitinationGO:003139630.039
organic cyclic compound biosynthetic processGO:19013622230.038
Human Fly
cell cycle g2 m phase transitionGO:004483940.038
Human
organic substance biosynthetic processGO:19015762890.038
Human Fly
cell cycleGO:0007049930.038
Human Worm Fly
mitotic recombinationGO:000631220.037
heterocycle metabolic processGO:00464832900.037
Human Fly
double strand break repairGO:000630230.036
Human
positive regulation of histone modificationGO:003105810.036
histone phosphorylationGO:001657220.036
cellular macromolecule metabolic processGO:00442603910.035
Human Fly
response to external stimulusGO:00096052640.035
cellular macromolecule biosynthetic processGO:00346452240.035
Human Fly
regulation of protein catabolic processGO:004217610.035
Human
cellular aromatic compound metabolic processGO:00067252950.035
Human Fly
signal transductionGO:00071654550.034
Human Mouse Fly
negative regulation of chromosome organizationGO:200125110.034
nucleic acid metabolic processGO:00903042440.033
Human Fly
regulation of nitrogen compound metabolic processGO:00511712510.032
Human Fly
aromatic compound biosynthetic processGO:00194382170.032
Human Fly
regulation of metabolic processGO:00192223590.032
Human Fly
dna modificationGO:000630480.032
positive regulation of cellular catabolic processGO:003133130.032
negative regulation of mitosisGO:004583930.031
establishment of localizationGO:00512342440.031
reciprocal dna recombinationGO:003582510.031
dna methylationGO:000630680.031
protein metabolic processGO:00195381830.031
Human Fly
modification dependent protein catabolic processGO:001994130.030
rna metabolic processGO:00160702190.030
Human Fly
regulation of rna metabolic processGO:00512522240.029
Human Fly
response to uvGO:000941130.029
dna methylation or demethylationGO:004472880.028
sex determinationGO:000753010.027
b cell activationGO:004211320.026
embryo development ending in birth or egg hatchingGO:00097922710.026
Worm
negative regulation of metabolic processGO:0009892860.026
Human
regulation of histone h3 k9 methylationGO:005157020.026
chromatin organizationGO:0006325220.025
macromolecule biosynthetic processGO:00090592270.024
Human Fly
response to organic substanceGO:00100331530.023
nucleobase containing compound biosynthetic processGO:00346542050.023
Human Fly
programmed cell deathGO:00125011190.023
Human Mouse Fly
regulation of macromolecule metabolic processGO:00602553170.023
Human Fly
pancreas developmentGO:0031016840.022
histone modificationGO:0016570200.022
neuron differentiationGO:00301823530.022
cell cycle g1 s phase transitionGO:004484310.022
sensory organ developmentGO:00074233930.022
cellular response to chemical stimulusGO:00708871570.021
b cell mediated immunityGO:001972430.021
growthGO:00400071740.021
dna biosynthetic processGO:007189730.021
regulation of apoptotic processGO:0042981980.021
Fly
regulation of rna biosynthetic processGO:20011412130.021
Human Fly
regulation of protein import into nucleusGO:004230620.020
neuroblast fate commitmentGO:001401710.020
meiosis iGO:000712710.019
histone h3 k4 methylationGO:005156820.019
response to stressGO:00069502630.019
g1 s transition of mitotic cell cycleGO:000008210.019
peptidyl serine phosphorylationGO:001810510.018
regulation of macromolecule biosynthetic processGO:00105562250.018
Human Fly
vasculature developmentGO:00019442780.018
intracellular mrna localizationGO:000829810.018
rna localizationGO:000640340.018
humoral immune response mediated by circulating immunoglobulinGO:000245530.018
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.018
negative regulation of nucleobase containing compound metabolic processGO:0045934590.018
Human
male meiosisGO:000714020.018
negative regulation of cellular processGO:00485232830.018
Human Fly
multicellular organism growthGO:003526440.017
response to drugGO:004249330.017
regulation of bindingGO:005109830.017
microtubule based processGO:0007017600.017
Human
stem cell maintenanceGO:001982740.017
centrosome organizationGO:005129710.017
regulation of histone methylationGO:003106030.017
meiosis iiGO:000713510.017
mitotic cell cycle embryonicGO:004544820.017
immunoglobulin productionGO:000237710.017
transportGO:00068102200.017
methylationGO:0032259220.017
phagocytosisGO:000690930.016
regulation of transcription from rna polymerase ii promoterGO:00063571140.016
Fly
covalent chromatin modificationGO:0016569200.016
cellular component movementGO:00069283350.016
gtp catabolic processGO:000618420.016
regulation of nucleoside metabolic processGO:000911820.016
establishment of protein localization to organelleGO:007259440.016
somatic cell dna recombinationGO:001644410.016
single organism metabolic processGO:00447102170.016
Human Fly
macromolecule modificationGO:00434121110.016
Human Fly
positive regulation of cellular metabolic processGO:0031325940.016
Human Fly
regulation of purine nucleotide catabolic processGO:003312120.016
positive regulation of purine nucleotide catabolic processGO:003312310.016
regulation of biosynthetic processGO:00098892500.016
Human Fly
protein modification processGO:00362111000.016
Human Fly
adult behaviorGO:003053420.015
cell morphogenesisGO:00009022890.015
heart developmentGO:00075073130.015
organelle fissionGO:0048285230.015
Human Worm
meiotic cell cycle processGO:190304630.015
Worm
macromolecule localizationGO:0033036540.015
response to endogenous stimulusGO:0009719830.015
leukocyte proliferationGO:007066110.015
negative regulation of dna replicationGO:000815620.015
Human
chromosome organizationGO:0051276310.015
regulation of gene silencingGO:006096810.015
multi organism processGO:00517041340.015
Fly
cellular response to oxygen levelsGO:007145310.015
positive regulation of chromosome organizationGO:200125210.015
g2 dna damage checkpointGO:003157230.015
modification dependent macromolecule catabolic processGO:004363230.014
production of molecular mediator of immune responseGO:000244020.014
organonitrogen compound metabolic processGO:1901564740.014
negative regulation of biological processGO:00485193040.014
Human Fly
negative regulation of dna metabolic processGO:005105340.014
Human
dna recombinationGO:000631050.014
cellular protein modification processGO:00064641000.014
Human Fly
sister chromatid cohesionGO:000706220.014
developmental process involved in reproductionGO:0003006270.014
Fly
cytokinesisGO:000091030.013
nucleocytoplasmic transportGO:000691340.013
organic acid metabolic processGO:0006082310.013
hatchingGO:003518840.013
heterocycle biosynthetic processGO:00181302150.013
Human Fly
negative regulation of nitrogen compound metabolic processGO:0051172590.013
Human
cellular amino acid metabolic processGO:000652070.013
reciprocal meiotic recombinationGO:000713110.013
carboxylic acid metabolic processGO:0019752220.013
cell part morphogenesisGO:00329902460.013
negative regulation of nucleocytoplasmic transportGO:004682320.013
chordate embryonic developmentGO:00430092710.013
organism emergence from protective structureGO:007168440.013
neuron projection morphogenesisGO:00488121610.013
chromosome organization involved in meiosisGO:007019210.013
regulation of gene expression epigeneticGO:0040029110.013
germ cell developmentGO:0007281220.013
Fly
morphogenesis of an epitheliumGO:00020093330.013
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.012
sensory organ morphogenesisGO:00905962000.012
response to external biotic stimulusGO:0043207970.012
oxoacid metabolic processGO:0043436310.012
negative regulation of biosynthetic processGO:0009890550.012
Human
negative regulation of cellular metabolic processGO:0031324770.012
Human
negative regulation of cytoplasmic transportGO:190365020.012
heme metabolic processGO:004216890.012
reproductionGO:0000003400.012
Worm Fly
somatic stem cell maintenanceGO:003501910.012
cellular response to endogenous stimulusGO:0071495680.012
regulation of protein complex assemblyGO:004325430.012
nucleic acid templated transcriptionGO:00976591810.012
Human Fly
regulation of mitotic cell cycle phase transitionGO:190199080.012
Human Fly
negative regulation of protein transportGO:005122430.012
determination of left right symmetryGO:00073681790.012
positive regulation of cellular component biogenesisGO:004408930.012
response to amino acidGO:004320020.011
negative regulation of intracellular transportGO:003238730.011
reproductive processGO:0022414400.011
Fly
centrosome cycleGO:000709810.011
cellular response to stressGO:0033554620.011
negative regulation of nuclear divisionGO:005178430.011
single organism organelle organizationGO:19025891990.011
Human
regulation of cellular protein catabolic processGO:190336210.011
cell projection morphogenesisGO:00488582440.011
amine metabolic processGO:000930820.011
ribonucleoside monophosphate catabolic processGO:000915840.011
phosphorus metabolic processGO:00067931090.011
Human Fly
cellular response to hypoxiaGO:007145610.011
anterior posterior pattern specificationGO:00099521520.011
regulation of cellular biosynthetic processGO:00313262450.011
Human Fly
cellular amine metabolic processGO:004410620.011
negative regulation of protein localization to nucleusGO:190018120.011
regulation of meiotic cell cycleGO:005144510.011
rna biosynthetic processGO:00327741810.011
Human Fly
apoptotic processGO:00069151160.011
Human Mouse Fly
negative regulation of protein import into nucleusGO:004230820.011
agingGO:000756820.010
regulation of cellular amino acid metabolic processGO:000652100.010
regulation of nucleotide catabolic processGO:003081120.010
cellular component morphogenesisGO:00329893360.010
urogenital system developmentGO:0001655970.010
positive regulation of nucleoside metabolic processGO:004597910.010
regionalizationGO:00030022740.010
regulation of cellular amine metabolic processGO:003323800.010
negative regulation of macromolecule metabolic processGO:0010605760.010
Human
gtp metabolic processGO:004603940.010
cellular protein catabolic processGO:004425740.010
Human

chek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.078
Human
disease of cellular proliferationDOID:1456600.078
Human
disease of anatomical entityDOID:700.028
bone marrow diseaseDOID:496100.028
immune system diseaseDOID:291400.028
hematopoietic system diseaseDOID:7400.028
gastrointestinal system cancerDOID:311900.027
organ system cancerDOID:005068600.027
Human
intestinal cancerDOID:1015500.027
large intestine cancerDOID:567200.027
colorectal cancerDOID:925600.027
nervous system diseaseDOID:86300.013
disease of metabolismDOID:001466700.011