Danio rerio

66 known processes

chek1

CHK1 checkpoint homolog (S. pombe)

(Aliases: zgc:56093,MGC56093,id:ibd2720)

chek1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular biosynthetic processGO:00442492860.487
Mouse Rat
organic cyclic compound biosynthetic processGO:19013622230.445
Mouse Rat
cellular macromolecule metabolic processGO:00442603910.415
cellular nitrogen compound metabolic processGO:00346412900.387
Human Mouse Rat
nucleobase containing compound metabolic processGO:00061392740.346
Human Mouse Rat
positive regulation of dna metabolic processGO:005105410.271
positive regulation of biological processGO:00485182530.268
Mouse
regulation of transcription dna templatedGO:00063552130.254
Mouse
regulation of cellular metabolic processGO:00313233200.253
Human Mouse Rat
organic cyclic compound metabolic processGO:19013603010.243
Human Mouse Rat
transcription dna templatedGO:00063511810.229
Mouse
cellular macromolecule biosynthetic processGO:00346452240.228
Mouse Rat
nucleobase containing compound biosynthetic processGO:00346542050.226
Mouse Rat
mitotic dna integrity checkpointGO:004477440.225
rna biosynthetic processGO:00327741810.218
Mouse
organic substance biosynthetic processGO:19015762890.211
Mouse Rat
mitotic dna damage checkpointGO:004477340.210
cellular aromatic compound metabolic processGO:00067252950.209
Human Mouse Rat
regulation of primary metabolic processGO:00800903110.200
Human Mouse Rat
protein modification processGO:00362111000.191
nitrogen compound metabolic processGO:00068073190.189
Human Mouse Rat
nucleic acid templated transcriptionGO:00976591810.188
Mouse
regulation of cellular biosynthetic processGO:00313262450.185
Mouse Rat
regulation of macromolecule biosynthetic processGO:00105562250.182
Mouse Rat
regulation of nitrogen compound metabolic processGO:00511712510.180
Human Mouse Rat
protein metabolic processGO:00195381830.167
heterocycle biosynthetic processGO:00181302150.154
Mouse Rat
negative regulation of cellular processGO:00485232830.154
macromolecule biosynthetic processGO:00090592270.143
Mouse Rat
small gtpase mediated signal transductionGO:000726480.140
regulation of nucleic acid templated transcriptionGO:19035062130.137
Mouse
transcription from rna polymerase ii promoterGO:0006366800.137
Mouse
regulation of metabolic processGO:00192223590.136
Human Mouse Rat
aromatic compound biosynthetic processGO:00194382170.134
Mouse Rat
nucleic acid metabolic processGO:00903042440.133
Human Mouse Rat
biosynthetic processGO:00090582940.131
Mouse Rat
regulation of macromolecule metabolic processGO:00602553170.125
Human Mouse Rat
embryo development ending in birth or egg hatchingGO:00097922710.116
regulation of response to stimulusGO:00485832690.115
Human
meiotic cell cycle processGO:190304630.111
regulation of dna metabolic processGO:0051052110.110
Human Rat
meiotic nuclear divisionGO:000712640.108
macromolecule modificationGO:00434121110.107
apoptotic processGO:00069151160.104
dna biosynthetic processGO:007189730.103
Rat
response to alkaloidGO:004327920.102
Rat
cellular response to stressGO:0033554620.101
immune system processGO:00023762410.098
regulation of gene expressionGO:00104682650.097
Mouse
response to abiotic stimulusGO:00096281220.097
Human Mouse
cellular nitrogen compound biosynthetic processGO:00442712180.094
Mouse Rat
heterocycle metabolic processGO:00464832900.091
Human Mouse Rat
regulation of biosynthetic processGO:00098892500.091
Mouse Rat
protein acetylationGO:000647320.088
Mouse
mitotic cell cycle embryonicGO:004544820.088
dna repairGO:000628160.087
Human Mouse
gene expressionGO:00104672520.087
Mouse
regulation of cellular macromolecule biosynthetic processGO:20001122220.085
Mouse Rat
signal transductionGO:00071654550.085
cellular component biogenesisGO:00440851780.085
chromosome organization involved in meiosisGO:007019210.082
cellular protein modification processGO:00064641000.080
phosphate containing compound metabolic processGO:00067961080.080
programmed cell deathGO:00125011190.079
intracellular signal transductionGO:0035556850.074
regulation of multicellular organismal developmentGO:20000262230.074
positive regulation of metabolic processGO:00098931080.074
Mouse
mitotic g2 m transition checkpointGO:004481830.074
negative regulation of nucleobase containing compound metabolic processGO:0045934590.073
Rat
regulation of developmental processGO:00507932470.069
positive regulation of cellular processGO:00485222010.068
Mouse
phosphorus metabolic processGO:00067931090.068
chromosome organizationGO:0051276310.067
Human Mouse
response to drugGO:004249330.067
regulation of signal transductionGO:00099662250.067
regulation of rna biosynthetic processGO:20011412130.064
Mouse
agingGO:000756820.063
negative regulation of transcription dna templatedGO:0045892450.063
cellular response to dna damage stimulusGO:0006974240.060
chromatin modificationGO:0016568210.060
Human Mouse
deathGO:00162651210.060
immune system developmentGO:00025201910.059
peptidyl serine phosphorylationGO:001810510.059
cellular protein metabolic processGO:00442671290.058
cellular amine metabolic processGO:004410620.058
organism emergence from protective structureGO:007168440.056
cellular ketone metabolic processGO:0042180110.056
regulation of rna metabolic processGO:00512522240.056
Mouse
regulation of cellular amino acid metabolic processGO:000652100.056
positive regulation of cellular biosynthetic processGO:0031328680.055
Mouse
peptidyl serine modificationGO:001820920.055
multicellular organism growthGO:003526440.054
regulation of cell cycleGO:0051726520.053
regulation of transcription from rna polymerase ii promoterGO:00063571140.051
Mouse
negative regulation of biological processGO:00485193040.051
regulation of dna replicationGO:000627530.051
positive regulation of rna metabolic processGO:0051254590.050
Mouse
rna metabolic processGO:00160702190.050
Mouse
positive regulation of histone modificationGO:003105810.050
mitotic g2 dna damage checkpointGO:000709530.049
regulation of multicellular organismal processGO:00512392770.048
positive regulation of transcription dna templatedGO:0045893570.048
Mouse
positive regulation of cellular catabolic processGO:003133130.048
embryonic organ developmentGO:00485683810.048
histone h3 k4 methylationGO:005156820.047
response to chemicalGO:00422213200.047
Rat
protein acylationGO:004354330.045
Mouse
modification dependent protein catabolic processGO:001994130.045
regulation of multicellular organism growthGO:004001440.044
organelle organizationGO:00069962270.043
Human Mouse
meiotic chromosome segregationGO:004513230.043
cell deathGO:00082191210.043
positive regulation of nitrogen compound metabolic processGO:0051173690.041
Mouse
carboxylic acid metabolic processGO:0019752220.041
positive regulation of gene expressionGO:0010628710.041
Mouse
reciprocal dna recombinationGO:003582510.040
developmental growthGO:00485891660.040
cell morphogenesisGO:00009022890.040
positive regulation of cellular amino acid metabolic processGO:004576400.039
localization of cellGO:00516742440.039
positive regulation of rna biosynthetic processGO:1902680570.038
Mouse
negative regulation of nitrogen compound metabolic processGO:0051172590.038
Rat
cytokinesisGO:000091030.038
single organism metabolic processGO:00447102170.037
Human Mouse Rat
ubiquitin dependent protein catabolic processGO:000651130.036
cellular component assemblyGO:00226071700.036
signal transduction by p53 class mediatorGO:0072331130.036
catabolic processGO:0009056320.036
meiosis iGO:000712710.036
regulation of programmed cell deathGO:00430671010.036
small molecule metabolic processGO:0044281770.036
response to stressGO:00069502630.036
modification dependent macromolecule catabolic processGO:004363230.035
regulation of cell deathGO:00109411030.035
regulation of meiotic cell cycleGO:005144510.035
sensory organ developmentGO:00074233930.035
cellular protein catabolic processGO:004425740.035
regulation of cellular ketone metabolic processGO:001056570.035
regulation of apoptotic processGO:0042981980.035
cellular component movementGO:00069283350.035
digestive system developmentGO:00551232890.034
positive regulation of cell cycleGO:004578730.034
proteolysis involved in cellular protein catabolic processGO:005160330.033
mitotic cell cycleGO:0000278640.032
ras protein signal transductionGO:000726570.032
regulation of protein ubiquitinationGO:003139630.032
positive regulation of catabolic processGO:000989640.031
double strand break repair via homologous recombinationGO:000072410.031
Human
regulation of protein modification by small protein conjugation or removalGO:190332030.031
growthGO:00400071740.031
positive regulation of nucleic acid templated transcriptionGO:1903508570.031
Mouse
heart developmentGO:00075073130.030
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.029
regulation of establishment of protein localizationGO:007020140.029
morphogenesis of an epitheliumGO:00020093330.029
single organism organelle organizationGO:19025891990.028
Human Mouse
hatchingGO:003518840.028
nucleotide metabolic processGO:0009117280.028
positive regulation of nucleobase containing compound metabolic processGO:0045935690.028
Mouse
histone phosphorylationGO:001657220.027
Human Mouse
cellular component morphogenesisGO:00329893360.027
cellular catabolic processGO:0044248270.027
positive regulation of chromatin modificationGO:190331010.027
regulation of bindingGO:005109830.027
internal protein amino acid acetylationGO:000647520.027
Mouse
negative regulation of cellular biosynthetic processGO:0031327550.027
Rat
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.026
Rat
regulation of nucleobase containing compound metabolic processGO:00192192500.026
Human Mouse Rat
regulation of growthGO:0040008420.026
blood vessel morphogenesisGO:00485142160.026
g2 m transition of mitotic cell cycleGO:000008640.026
Mouse Rat
dna alkylationGO:000630580.026
negative regulation of rna biosynthetic processGO:1902679450.026
cognitionGO:005089010.026
vasculature developmentGO:00019442780.025
cellular nitrogen compound catabolic processGO:0044270150.025
dna metabolic processGO:0006259270.024
Human Mouse Rat
positive regulation of biosynthetic processGO:0009891680.024
Mouse
guanosine containing compound catabolic processGO:190106920.024
determination of bilateral symmetryGO:00098552040.024
mitotic cell cycle checkpointGO:000709350.024
cell part morphogenesisGO:00329902460.023
phosphorylationGO:0016310690.023
mitotic cell cycle processGO:1903047480.022
reciprocal meiotic recombinationGO:000713110.022
positive regulation of cellular amine metabolic processGO:003324000.022
response to organic substanceGO:00100331530.022
Rat
oxoacid metabolic processGO:0043436310.022
locomotionGO:00400113130.022
regulation of protein transportGO:005122330.021
response to other organismGO:0051707970.021
cell cycle g1 s phase transitionGO:004484310.021
amine metabolic processGO:000930820.021
cell cycle g2 m phase transitionGO:004483940.021
Mouse Rat
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.021
regulation of response to stressGO:0080134360.021
Human
cellular response to radiationGO:007147840.020
Mouse
cell projection morphogenesisGO:00488582440.020
cell motilityGO:00488702440.020
hematopoietic or lymphoid organ developmentGO:00485341910.020
camera type eye developmentGO:00430102220.020
negative regulation of metabolic processGO:0009892860.020
Rat
synapsisGO:000712910.020
negative regulation of gene expressionGO:0010629650.020
g1 s transition of mitotic cell cycleGO:000008210.019
guanosine containing compound metabolic processGO:190106840.019
specification of symmetryGO:00097992040.019
cell cycleGO:0007049930.019
multi organism processGO:00517041340.019
negative regulation of cell communicationGO:0010648960.019
dna modificationGO:000630480.019
response to ionizing radiationGO:001021260.018
establishment of protein localization to organelleGO:007259440.018
urogenital system developmentGO:0001655970.018
response to uvGO:000941130.018
Mouse
retina morphogenesis in camera type eyeGO:0060042790.018
positive regulation of protein complex assemblyGO:003133420.018
covalent chromatin modificationGO:0016569200.018
Human Mouse
regulation of cell communicationGO:00106462320.018
response to endogenous stimulusGO:0009719830.018
Rat
regulation of protein catabolic processGO:004217610.017
multicellular organism reproductionGO:0032504350.017
regulation of production of molecular mediator of immune responseGO:000270010.017
recombinational repairGO:000072510.017
Human
protein complex biogenesisGO:0070271300.017
connective tissue developmentGO:0061448990.017
response to metal ionGO:0010038340.016
regulation of biological qualityGO:00650082630.016
methylationGO:0032259220.016
regulation of lipid catabolic processGO:005099420.016
response to oxygen containing compoundGO:1901700550.016
regionalizationGO:00030022740.016
b cell activationGO:004211320.016
establishment of localizationGO:00512342440.016
negative regulation of rna metabolic processGO:0051253480.016
regulation of circadian rhythmGO:004275240.016
central nervous system developmentGO:00074173870.016
regulation of cellular amine metabolic processGO:003323800.016
cell migrationGO:00164772370.016
regulation of protein import into nucleusGO:004230620.016
cellular response to external stimulusGO:007149620.016
Human
positive regulation of macromolecule metabolic processGO:0010604930.016
Mouse
negative regulation of macromolecule metabolic processGO:0010605760.016
Rat
larval developmentGO:000216420.016
embryonic organ morphogenesisGO:00485622740.015
anterior posterior pattern specificationGO:00099521520.015
response to external stimulusGO:00096052640.015
Human
non recombinational repairGO:000072620.015
carbohydrate derivative metabolic processGO:1901135610.015
negative regulation of biosynthetic processGO:0009890550.015
Rat
tube morphogenesisGO:00352393490.015
regulation of signalingGO:00230512350.015
regulation of cellular component organizationGO:0051128860.015
Human Mouse
negative regulation of cellular metabolic processGO:0031324770.015
Rat
mitotic recombinationGO:000631220.015
internal peptidyl lysine acetylationGO:001839320.015
Mouse
positive regulation of response to stimulusGO:0048584800.015
negative regulation of cell cycleGO:0045786140.015
cellular response to endogenous stimulusGO:0071495680.015
Rat
exocrine system developmentGO:0035272280.014
immune responseGO:0006955280.014
positive regulation of transportGO:005105020.014
organic acid metabolic processGO:0006082310.014
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.014
regulation of cell sizeGO:0008361290.014
double strand break repairGO:000630230.014
Human
oocyte maturationGO:000155640.014
regulation of protein bindingGO:004339330.014
ribonucleoside monophosphate catabolic processGO:000915840.014
brain developmentGO:00074202930.014
dna catabolic processGO:000630810.014
positive regulation of cellular metabolic processGO:0031325940.014
Mouse
eye developmentGO:00016542770.014
digestive tract developmentGO:00485652650.014
organic substance catabolic processGO:1901575280.014
macromolecule methylationGO:0043414190.014
regulation of intracellular protein transportGO:003315730.014
cellular macromolecule catabolic processGO:0044265120.013
gtp metabolic processGO:004603940.013
membrane invaginationGO:001032410.013
production of molecular mediator of immune responseGO:000244020.013
dna recombinationGO:000631050.013
Human
head developmentGO:00603223030.013
negative regulation of nucleic acid templated transcriptionGO:1903507450.013
maintenance of locationGO:005123540.013
nucleobase containing compound catabolic processGO:0034655150.013
purine nucleotide metabolic processGO:0006163270.013
male meiosisGO:000714020.013
single organism reproductive processGO:0044702400.013
regulation of protein complex assemblyGO:004325430.013
homeostatic processGO:00425921420.013
nuclear transportGO:005116940.013
chromatin organizationGO:0006325220.013
Human Mouse
embryonic heart tube morphogenesisGO:00031431080.013
regulation of cell developmentGO:00602841000.012
apoptotic signaling pathwayGO:0097190230.012
determination of heart left right asymmetryGO:00613711170.012
response to external biotic stimulusGO:0043207970.012
proteolysisGO:0006508380.012
positive regulation of macromolecule biosynthetic processGO:0010557590.012
Mouse
negative regulation of response to stimulusGO:00485851040.012
lipid catabolic processGO:001604240.012
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.012
negative regulation of programmed cell deathGO:0043069580.012
cellular localizationGO:0051641970.012
regulation of cell activationGO:005086510.012
response to radiationGO:0009314510.012
Mouse
gtp catabolic processGO:000618420.012
nucleocytoplasmic transportGO:000691340.012
multicellular organismal reproductive processGO:0048609350.012
cellular response to organic substanceGO:00713101050.012
Rat
regulation of developmental growthGO:0048638380.012
purine containing compound metabolic processGO:0072521290.012
response to monosaccharideGO:003428430.012
positive regulation of nucleotide catabolic processGO:003081310.012
lymphocyte proliferationGO:004665110.012
intrinsic apoptotic signaling pathway by p53 class mediatorGO:007233290.012
system processGO:00030081850.012
dorsal ventral pattern formationGO:00099531250.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.011
regulation of dna recombinationGO:000001820.011
Human
negative regulation of macromolecule biosynthetic processGO:0010558480.011
Rat
hemopoiesisGO:00300971830.011
blood vessel developmentGO:00015682460.011
transportGO:00068102200.011
spermatid developmentGO:000728620.011
histone h3 k36 methylationGO:001045220.011
mrna metabolic processGO:0016071200.011
organonitrogen compound metabolic processGO:1901564740.011
immunoglobulin mediated immune responseGO:001606430.011
cell agingGO:000756920.011
regulation of endopeptidase activityGO:0052548230.011
regulation of protein targetingGO:190353320.011
development of primary female sexual characteristicsGO:004654540.011
lymphocyte activationGO:0046649100.011
protein localizationGO:0008104400.011
response to inorganic substanceGO:0010035380.011
cellular component assembly involved in morphogenesisGO:00109271070.011
regulation of stem cell proliferationGO:007209120.011
epithelial tube morphogenesisGO:00605621480.010
positive regulation of apoptotic processGO:0043065290.010
hematopoietic stem cell migrationGO:003570140.010
response to biotic stimulusGO:0009607970.010
b cell mediated immunityGO:001972430.010
ribonucleotide metabolic processGO:0009259270.010
spermatid differentiationGO:004851520.010
protein polymerizationGO:005125840.010
cell cycle arrestGO:000705010.010
retina development in camera type eyeGO:00600411460.010
purine ribonucleoside monophosphate catabolic processGO:000916940.010
positive regulation of chromosome organizationGO:200125210.010
microtubule polymerizationGO:004678520.010

chek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.047
nervous system diseaseDOID:86300.020
disease of cellular proliferationDOID:1456600.019
cancerDOID:16200.019
disease of metabolismDOID:001466700.019
thoracic cancerDOID:509300.011
organ system cancerDOID:005068600.011
breast cancerDOID:161200.011