Danio rerio

7 known processes

ptpn6

protein tyrosine phosphatase, non-receptor type 6

(Aliases: fj22f05,zgc:55501,wu:fj22f05,SHP1,Hcph)

ptpn6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of cellular extravasationGO:000269310.993
neutrophil mediated immunityGO:000244610.661
superoxide metabolic processGO:000680120.645
response to biotic stimulusGO:0009607970.576
cellular component morphogenesisGO:00329893360.486
regulation of cellular extravasationGO:000269110.483
cell motilityGO:00488702440.441
defense response to other organismGO:0098542330.421
cellular extravasationGO:004512310.395
cell morphogenesisGO:00009022890.374
response to other organismGO:0051707970.359
neuron developmentGO:00486662620.342
immune system processGO:00023762410.341
protein polymerizationGO:005125840.341
response to chemicalGO:00422213200.337
localization of cellGO:00516742440.321
cell part morphogenesisGO:00329902460.318
response to external stimulusGO:00096052640.314
immune responseGO:0006955280.311
positive regulation of apoptotic signaling pathwayGO:200123510.299
gastrulationGO:00073692080.296
cell projection organizationGO:00300302840.290
positive regulation of neutrophil extravasationGO:200039110.270
signal transductionGO:00071654550.267
response to stressGO:00069502630.266
axon developmentGO:00615641660.266
regulation of primary metabolic processGO:00800903110.264
regulation of multicellular organismal processGO:00512392770.264
neuron projection developmentGO:00311751800.263
cell projection morphogenesisGO:00488582440.260
cell morphogenesis involved in neuron differentiationGO:00486671630.256
neutrophil migrationGO:1990266100.239
defense responseGO:0006952470.235
cellular macromolecule metabolic processGO:00442603910.232
generation of neuronsGO:00486993850.222
cell migrationGO:00164772370.222
leukocyte homeostasisGO:000177620.209
morphogenesis of an epitheliumGO:00020093330.206
angiogenesisGO:00015251580.202
neuron differentiationGO:00301823530.202
cell substrate adhesionGO:003158940.195
cell surface receptor signaling pathwayGO:00071663250.193
single organism metabolic processGO:00447102170.193
tube morphogenesisGO:00352393490.190
regulation of metabolic processGO:00192223590.186
positive regulation of protein polymerizationGO:003227320.182
taxisGO:00423301090.179
cellular component movementGO:00069283350.178
regulation of response to stimulusGO:00485832690.174
tissue regenerationGO:0042246740.172
regulation of multicellular organismal developmentGO:20000262230.167
regulation of cell activationGO:005086510.167
regulation of synapse organizationGO:005080730.165
regulation of protein polymerizationGO:003227120.159
positive regulation of biological processGO:00485182530.157
striated muscle cell developmentGO:00550021080.148
cellular component assemblyGO:00226071700.146
regulation of macromolecule metabolic processGO:00602553170.145
immune effector processGO:0002252230.143
muscle structure developmentGO:00610611960.140
organic acid metabolic processGO:0006082310.138
granulocyte migrationGO:0097530110.138
axonogenesisGO:00074091520.133
regulation of signal transductionGO:00099662250.130
digestive tract developmentGO:00485652650.128
single organism organelle organizationGO:19025891990.127
locomotionGO:00400113130.126
actin cytoskeleton organizationGO:0030036630.125
regulation of protein complex assemblyGO:004325430.124
sensory organ developmentGO:00074233930.123
myeloid leukocyte migrationGO:0097529120.121
cytoskeleton organizationGO:0007010960.119
neutrophil chemotaxisGO:0030593100.119
regulation of cell motilityGO:2000145460.116
oxoacid metabolic processGO:0043436310.116
regulation of establishment of protein localizationGO:007020140.114
larval developmentGO:000216420.114
regulation of nitrogen compound metabolic processGO:00511712510.113
regulation of immune system processGO:0002682340.112
cell morphogenesis involved in differentiationGO:00009041950.111
cellular amino acid metabolic processGO:000652070.108
small molecule metabolic processGO:0044281770.106
hematopoietic stem cell migrationGO:003570140.103
cellular nitrogen compound metabolic processGO:00346412900.102
regulation of neutrophil migrationGO:190262260.101
regulation of developmental processGO:00507932470.100
positive regulation of cellular component biogenesisGO:004408930.099
regulation of signalingGO:00230512350.099
positive regulation of response to stimulusGO:0048584800.097
regulation of cellular component movementGO:0051270550.096
negative regulation of biological processGO:00485193040.095
regulation of cell developmentGO:00602841000.094
neuron projection morphogenesisGO:00488121610.091
blood vessel morphogenesisGO:00485142160.091
positive regulation of cellular processGO:00485222010.091
multi organism processGO:00517041340.090
organonitrogen compound metabolic processGO:1901564740.086
cellular response to chemical stimulusGO:00708871570.084
heterocycle metabolic processGO:00464832900.082
chemotaxisGO:00069351040.082
regulation of anatomical structure morphogenesisGO:00226031300.081
regulation of cell communicationGO:00106462320.080
cellular component biogenesisGO:00440851780.078
g protein coupled receptor signaling pathwayGO:0007186740.077
lateral inhibitionGO:004633110.076
organelle fusionGO:004828430.076
actin filament polymerizationGO:003004120.076
guanosine containing compound catabolic processGO:190106920.076
regulation of establishment or maintenance of cell polarityGO:003287820.076
positive regulation of cell activationGO:005086710.074
regulation of cell differentiationGO:00455951420.074
myotube differentiationGO:0014902450.074
release of sequestered calcium ion into cytosolGO:005120930.074
reactive oxygen species metabolic processGO:007259360.073
negative regulation of sequestering of calcium ionGO:005128340.073
regulation of cell migrationGO:0030334400.072
actin polymerization or depolymerizationGO:000815420.072
defense response to fungusGO:005083220.071
regulation of cellular component organizationGO:0051128860.071
regulation of metal ion transportGO:001095940.070
positive regulation of response to external stimulusGO:003210390.070
organelle organizationGO:00069962270.070
regulation of apoptotic processGO:0042981980.069
sequestering of calcium ionGO:005120830.069
axonal defasciculationGO:000741420.069
digestive system developmentGO:00551232890.069
positive regulation of catabolic processGO:000989640.068
establishment of localizationGO:00512342440.067
response to bacteriumGO:0009617580.066
carboxylic acid metabolic processGO:0019752220.065
regulation of localizationGO:00328791040.065
single organism membrane fusionGO:004480120.065
regulation of synapse assemblyGO:005196330.063
cation transportGO:0006812810.063
regulation of cell shapeGO:000836010.063
muscle cell developmentGO:00550011150.063
maintenance of locationGO:005123540.063
guanosine containing compound metabolic processGO:190106840.062
leukocyte chemotaxisGO:0030595120.061
nitrogen compound metabolic processGO:00068073190.061
calcium ion transport into cytosolGO:006040230.060
transportGO:00068102200.060
regulation of nervous system developmentGO:0051960900.059
leukocyte proliferationGO:007066110.059
regulation of peptidyl tyrosine phosphorylationGO:005073010.059
regulation of sequestering of calcium ionGO:005128240.058
eye developmentGO:00016542770.057
homeostatic processGO:00425921420.056
motor neuron axon guidanceGO:0008045230.056
retina development in camera type eyeGO:00600411460.056
hydrogen peroxide metabolic processGO:004274320.056
organic substance biosynthetic processGO:19015762890.055
cellular component maintenanceGO:004395430.055
cell projection assemblyGO:0030031640.055
organic cyclic compound metabolic processGO:19013603010.053
regulation of locomotionGO:0040012550.052
central nervous system developmentGO:00074173870.052
developmental growthGO:00485891660.052
killing of cells in other organism involved in symbiotic interactionGO:005188310.051
ameboidal type cell migrationGO:00016671430.051
leukocyte mediated immunityGO:000244360.051
regulation of leukocyte migrationGO:000268580.050
response to external biotic stimulusGO:0043207970.050
regulation of cellular amine metabolic processGO:003323800.050
actin filament based processGO:0030029640.050
regulation of cellular component sizeGO:0032535300.049
regulation of cell projection organizationGO:0031344440.049
negative regulation of protein phosphorylationGO:000193340.049
embryonic organ morphogenesisGO:00485622740.049
agingGO:000756820.048
neutrophil extravasationGO:007267210.048
regulation of nucleobase containing compound metabolic processGO:00192192500.048
positive regulation of protein complex assemblyGO:003133420.048
amine metabolic processGO:000930820.047
nucleobase containing compound metabolic processGO:00061392740.047
maternal determination of anterior posterior axis embryoGO:000835840.047
regulation of cellular amino acid metabolic processGO:000652100.047
positive regulation of metabolic processGO:00098931080.047
regulation of nucleoside metabolic processGO:000911820.046
sprouting angiogenesisGO:0002040530.046
regulation of dendrite morphogenesisGO:004881430.046
regulation of biological qualityGO:00650082630.046
regulation of synaptic growth at neuromuscular junctionGO:000858210.046
organelle assemblyGO:00709251100.046
negative regulation of cytokine mediated signaling pathwayGO:000196020.046
positive regulation of cell killingGO:003134320.045
response to woundingGO:00096111160.045
carbohydrate derivative metabolic processGO:1901135610.043
regulation of muscle contractionGO:000693730.043
cellular ketone metabolic processGO:0042180110.043
lymphangiogenesisGO:0001946250.042
regulation of neutrophil chemotaxisGO:009002250.042
phagocytosisGO:000690930.042
camera type eye developmentGO:00430102220.042
leukocyte migrationGO:0050900150.042
multicellular organismal reproductive processGO:0048609350.042
negative regulation of cellular processGO:00485232830.041
defense response to bacteriumGO:0042742220.041
single organism localizationGO:19025782250.041
lymph vessel morphogenesisGO:0036303250.041
positive regulation of neutrophil migrationGO:190262400.041
adherens junction organizationGO:003433240.040
symbiosis encompassing mutualism through parasitismGO:004440340.040
negative regulation of synapse assemblyGO:005196420.040
head developmentGO:00603223030.039
positive regulation of secretion by cellGO:190353210.039
regulation of transcription dna templatedGO:00063552130.039
muscle organ developmentGO:00075171010.039
homeostasis of number of cells within a tissueGO:004887340.039
phosphate containing compound metabolic processGO:00067961080.039
cell migration involved in gastrulationGO:0042074790.038
positive regulation of wound healingGO:009030310.038
myeloid leukocyte mediated immunityGO:000244410.038
epithelial cell migrationGO:0010631250.038
phagosome maturationGO:009038210.037
skeletal system developmentGO:00015011810.037
positive regulation of cell motilityGO:2000147110.036
modification dependent macromolecule catabolic processGO:004363230.036
germ cell developmentGO:0007281220.036
regulation of cell morphogenesisGO:0022604420.036
granulocyte chemotaxisGO:0071621110.035
macrophage chemotaxisGO:004824630.035
phagolysosome assemblyGO:000184510.035
smooth muscle contractionGO:000693920.035
positive regulation of gtp catabolic processGO:003312610.035
response to organic substanceGO:00100331530.035
i kappab kinase nf kappab signalingGO:000724940.034
rna metabolic processGO:00160702190.034
synaptic growth at neuromuscular junctionGO:005112420.034
phosphorus metabolic processGO:00067931090.033
cellular localizationGO:0051641970.033
cellular component assembly involved in morphogenesisGO:00109271070.033
positive regulation of cellular component movementGO:0051272110.033
interspecies interaction between organismsGO:004441940.033
tissue migrationGO:0090130370.033
neuron projection guidanceGO:0097485860.033
t cell differentiationGO:003021760.033
protein modification processGO:00362111000.032
system processGO:00030081850.032
cellular amine metabolic processGO:004410620.032
regulation of gtp catabolic processGO:003312420.032
nucleobase containing compound biosynthetic processGO:00346542050.032
sequestering of metal ionGO:005123830.031
convergent extension involved in gastrulationGO:0060027710.031
gtp catabolic processGO:000618420.031
gtp metabolic processGO:004603940.031
regulation of programmed cell deathGO:00430671010.031
muscle cell differentiationGO:00426921390.031
regulation of purine nucleotide catabolic processGO:003312120.031
stem cell differentiationGO:00488631170.030
cellular aromatic compound metabolic processGO:00067252950.030
cellular modified amino acid metabolic processGO:000657530.030
regulation of neurogenesisGO:0050767870.030
negative regulation of immune responseGO:005077720.030
brain developmentGO:00074202930.030
cell killingGO:000190620.030
response to drugGO:004249330.029
regulation of nucleotide catabolic processGO:003081120.029
positive regulation of transportGO:005105020.029
vasculature developmentGO:00019442780.029
regulation of stem cell proliferationGO:007209120.029
positive regulation of cytoskeleton organizationGO:005149530.029
chemosensory behaviorGO:000763510.029
aromatic compound biosynthetic processGO:00194382170.029
protein phosphorylationGO:0006468470.028
regulation of gtpase activityGO:004308720.028
microtubule based processGO:0007017600.028
protein metabolic processGO:00195381830.028
rho protein signal transductionGO:000726650.028
purine nucleotide metabolic processGO:0006163270.028
cell cycle processGO:0022402530.028
single organism transportGO:00447652060.028
regulation of cellular ketone metabolic processGO:001056570.028
positive regulation of cytosolic calcium ion concentrationGO:000720440.028
positive regulation of cell communicationGO:0010647560.027
retinal ganglion cell axon guidanceGO:0031290350.027
cellular biosynthetic processGO:00442492860.027
negative regulation of cell communicationGO:0010648960.027
cell growthGO:0016049570.027
positive regulation of cellular catabolic processGO:003133130.027
positive regulation of molecular functionGO:0044093330.027
divalent metal ion transportGO:0070838200.027
regulation of cell projection assemblyGO:006049140.026
protein localizationGO:0008104400.026
regulation of wound healingGO:006104120.026
proteolysis involved in cellular protein catabolic processGO:005160330.025
mononuclear cell proliferationGO:003294310.025
nucleic acid metabolic processGO:00903042440.025
regulation of protein localization to plasma membraneGO:190307610.024
endosomal transportGO:001619720.024
embryo development ending in birth or egg hatchingGO:00097922710.024
digestive tract morphogenesisGO:00485462310.024
regulation of tyrosine phosphorylation of stat proteinGO:004250910.024
neuron recognitionGO:0008038180.024
negative regulation of response to stimulusGO:00485851040.024
tissue remodelingGO:004877140.024
axon extensionGO:0048675450.024
regenerationGO:0031099910.023
macromolecule biosynthetic processGO:00090592270.023
programmed cell deathGO:00125011190.023
cell proliferationGO:0008283800.023
positive regulation of map kinase activityGO:004340630.023
neuromast primordium migrationGO:0048883120.023
oocyte anterior posterior axis specificationGO:000731440.023
regulation of protein catabolic processGO:004217610.023
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.023
stem cell proliferationGO:007208940.022
cytosolic calcium ion transportGO:006040130.022
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.022
divalent inorganic cation transportGO:0072511210.022
organic cyclic compound biosynthetic processGO:19013622230.022
positive regulation of nucleoside metabolic processGO:004597910.022
positive regulation of dna metabolic processGO:005105410.022
regulation of response to cytokine stimulusGO:006075930.022
positive regulation of locomotionGO:0040017140.022
oxidoreduction coenzyme metabolic processGO:000673310.022
positive regulation of multicellular organismal processGO:0051240520.022
positive regulation of cellular metabolic processGO:0031325940.022
blood circulationGO:0008015870.022
central nervous system projection neuron axonogenesisGO:0021952150.022
protein localization to membraneGO:007265790.021
wound healingGO:0042060900.021
regulation of cell morphogenesis involved in differentiationGO:0010769380.021
positive regulation of signalingGO:0023056560.021
homeostasis of number of cellsGO:0048872620.021
multicellular organismal metabolic processGO:004423620.021
positive regulation of purine nucleotide catabolic processGO:003312310.021
developmental cell growthGO:0048588520.021
single organism cell adhesionGO:0098602290.021
cellular component disassemblyGO:002241110.021
growthGO:00400071740.021
regulation of cell adhesionGO:0030155150.021
negative regulation of macromolecule metabolic processGO:0010605760.021
deathGO:00162651210.021
lymphocyte proliferationGO:004665110.020
cellular protein catabolic processGO:004425740.020
t cell mediated immunityGO:000245610.020
regulation of dendrite developmentGO:005077330.020
organic substance transportGO:0071702580.020
cell deathGO:00082191210.020
response to amino acidGO:004320020.020
myoblast fusionGO:0007520100.020
regulation of macromolecule biosynthetic processGO:00105562250.020
cell chemotaxisGO:0060326170.020
regulation of catalytic activityGO:0050790550.020
negative regulation of nitrogen compound metabolic processGO:0051172590.020
positive regulation of cell differentiationGO:0045597300.020
skeletal muscle organ developmentGO:0060538780.020
ribonucleotide metabolic processGO:0009259270.020
multicellular organism growthGO:003526440.019
positive regulation of signal transductionGO:0009967560.019
intracellular signal transductionGO:0035556850.019
response to fungusGO:0009620250.019
regulation of response to external stimulusGO:0032101310.019
lamellipodium organizationGO:009758110.019
leukocyte mediated cytotoxicityGO:000190910.019
monoamine transportGO:001584410.019
pole plasm assemblyGO:000731540.019
ion transportGO:00068111140.019
embryonic digestive tract morphogenesisGO:004855730.019
response to alkaloidGO:004327920.019
cellular protein modification processGO:00064641000.019
regulation of chemotaxisGO:0050920180.019
calcium ion transportGO:0006816180.018
positive regulation of cell adhesionGO:004578510.018
tissue homeostasisGO:0001894250.018
regulation of leukocyte mediated immunityGO:000270310.018
negative regulation of multicellular organismal processGO:0051241690.018
positive regulation of nucleotide catabolic processGO:003081310.018
cellular aldehyde metabolic processGO:000608140.018
lytic vacuole organizationGO:008017110.018
cell adhesionGO:0007155400.018
regulation of developmental growthGO:0048638380.018
metal ion transportGO:0030001580.018
cell fate commitmentGO:0045165990.018
nucleic acid templated transcriptionGO:00976591810.017
positive regulation of developmental processGO:0051094500.017
positive regulation of nitrogen compound metabolic processGO:0051173690.017
rna biosynthetic processGO:00327741810.017
protein dephosphorylationGO:000647030.017
b cell differentiationGO:003018310.017
membrane organizationGO:0061024210.017
negative regulation of signalingGO:0023057960.017
heterocycle biosynthetic processGO:00181302150.017
modification dependent protein catabolic processGO:001994130.017
protein secretionGO:000930610.017
neuron migrationGO:0001764220.017
regulation of rho protein signal transductionGO:003502320.017
positive regulation of gtpase activityGO:004354710.017
tyrosine phosphorylation of stat proteinGO:000726010.016
regulation of neuron differentiationGO:0045664560.016
neuron deathGO:0070997210.016
killing of cells of other organismGO:003164010.016
regulation of establishment of protein localization to plasma membraneGO:009000310.016
cell cell signaling involved in cell fate commitmentGO:0045168120.016
collagen metabolic processGO:003296320.016
multi organism reproductive processGO:0044703360.016
phosphorylationGO:0016310690.016
negative regulation of protein kinase activityGO:000646940.016
membrane fusionGO:006102520.016
striated muscle tissue developmentGO:00147061100.016
lymphocyte homeostasisGO:000226010.016
regulation of gene expressionGO:00104682650.016
regulation of cell deathGO:00109411030.016
oxidation reduction processGO:0055114410.016
establishment of protein localization to plasma membraneGO:009000210.016
transcription dna templatedGO:00063511810.016
regulation of molecular functionGO:0065009700.015
regulation of extrinsic apoptotic signaling pathwayGO:200123630.015
blood vessel developmentGO:00015682460.015
regulation of apoptotic signaling pathwayGO:2001233120.015
positive regulation of leukocyte migrationGO:000268720.015
apoptotic processGO:00069151160.015
actin filament organizationGO:0007015150.015
regulation of anatomical structure sizeGO:0090066330.015
regulation of axonogenesisGO:0050770320.015
syncytium formationGO:0006949120.015
negative regulation of leukocyte chemotaxisGO:000268930.015
positive regulation of cellular amine metabolic processGO:003324000.015
divalent inorganic cation homeostasisGO:0072507220.015
positive regulation of i kappab kinase nf kappab signalingGO:004312330.015
small gtpase mediated signal transductionGO:000726480.015
biosynthetic processGO:00090582940.015
anatomical structure homeostasisGO:0060249360.015
immune system developmentGO:00025201910.015
epithelium migrationGO:0090132250.015
gene expressionGO:00104672520.015
regulation of cellular biosynthetic processGO:00313262450.015
regulation of protein modification processGO:0031399290.015
protein import into nucleusGO:000660630.014
regulation of jak stat cascadeGO:004642530.014
germ cell migrationGO:000835480.014
vasculogenesisGO:0001570410.014
macromolecule methylationGO:0043414190.014
regulation of protein transportGO:005122330.014
cellular protein complex assemblyGO:0043623190.014
reactive oxygen species biosynthetic processGO:190340910.014
positive regulation of leukocyte mediated cytotoxicityGO:000191210.014
single organism membrane organizationGO:0044802200.014
cellular protein metabolic processGO:00442671290.014
striated muscle cell differentiationGO:00511461290.014
positive regulation of striated muscle cell differentiationGO:005115510.014
regulation of filopodium assemblyGO:005148920.014
regulation of reproductive processGO:200024140.014
peptidyl lysine acetylationGO:001839420.014
regulation of cytokine mediated signaling pathwayGO:000195930.013
astrocyte differentiationGO:004870810.013
positive regulation of rna biosynthetic processGO:1902680570.013
protein complex subunit organizationGO:0071822460.013
regulation of multicellular organism growthGO:004001440.013
cellular response to endogenous stimulusGO:0071495680.013
ubiquitin dependent protein catabolic processGO:000651130.013
regulation of organelle organizationGO:0033043290.013
regulation of behaviorGO:0050795240.013
neutrophil homeostasisGO:000178010.013
positive regulation of cell migrationGO:0030335110.013
negative regulation of neutrophil chemotaxisGO:009002430.013
regulation of growthGO:0040008420.013
cell adhesion mediated by integrinGO:003362710.013
intracellular mrna localizationGO:000829810.013
regulation of cellular component biogenesisGO:0044087120.013
leukocyte activationGO:0045321120.013
macromolecular complex subunit organizationGO:0043933740.013
extrinsic apoptotic signaling pathwayGO:009719130.013
skeletal muscle fiber developmentGO:0048741350.013
regulation of system processGO:0044057400.013
immune response regulating signaling pathwayGO:000276450.012
positive regulation of secretionGO:005104710.012
actomyosin structure organizationGO:0031032530.012
cofactor metabolic processGO:0051186150.012
negative regulation of chemotaxisGO:005092240.012
regulation of phosphate metabolic processGO:0019220430.012
intracellular transportGO:0046907320.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
chloride transmembrane transportGO:190247640.012
ras protein signal transductionGO:000726570.012
spindle localizationGO:0051653120.012
regulation of cellular metabolic processGO:00313233200.012
immunoglobulin mediated immune responseGO:001606430.012
regulation of neutrophil extravasationGO:200038910.012
single organism intracellular transportGO:1902582250.012
macromolecule modificationGO:00434121110.012
biological adhesionGO:0022610400.012
cellular macromolecule biosynthetic processGO:00346452240.012
regulation of nucleic acid templated transcriptionGO:19035062130.012
positive regulation of apoptotic processGO:0043065290.012
negative regulation of kinase activityGO:003367340.012
modification of morphology or physiology of other organismGO:003582140.012
organophosphate metabolic processGO:0019637370.012
axon guidanceGO:0007411860.012
positive regulation of lymphocyte mediated immunityGO:000270810.012
regulation of protein metabolic processGO:0051246560.012
regulation of cytoplasmic transportGO:190364940.012

ptpn6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
amyloidosisDOID:912000.040
acquired metabolic diseaseDOID:006015800.040
disease of metabolismDOID:001466700.040
immune system diseaseDOID:291400.027
disease of anatomical entityDOID:700.027
primary immunodeficiency diseaseDOID:61200.027