IMP: Integrative Multi-species Prediction

Danio rerio

86 known processes

smad9

MAD homolog 9 (Drosophila)

(Aliases: sma8,MGC103407,zgc:103407)

ZFIN: ZDB-GENE-031014-1
Entrez: 445564
Ensembl: ENSDARG00000021938
UniProtKB: F1QXZ9
UniProtKB: Q6A3P7

Process Predictions
Disease Predictions

smad9 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
digestive system development	GO:0055123	289	0.983	Zebrafish Fly
embryonic heart tube morphogenesis	GO:0003143	108	0.924	Zebrafish
determination of bilateral symmetry	GO:0009855	204	0.922	Zebrafish
digestive tract morphogenesis	GO:0048546	231	0.912	Zebrafish Fly
digestive tract development	GO:0048565	265	0.889	Zebrafish Fly
heart morphogenesis	GO:0003007	156	0.887	Zebrafish
embryonic organ morphogenesis	GO:0048562	274	0.855	Zebrafish
regulation of multicellular organismal development	GO:2000026	223	0.832	Zebrafish Fly
convergent extension involved in gastrulation	GO:0060027	71	0.815	Zebrafish
determination of left right symmetry	GO:0007368	179	0.795	Zebrafish
convergent extension	GO:0060026	118	0.792	Zebrafish
tube morphogenesis	GO:0035239	349	0.765	Zebrafish Fly
determination of heart left right asymmetry	GO:0061371	117	0.752	Zebrafish
heart looping	GO:0001947	94	0.746	Zebrafish
positive regulation of cellular process	GO:0048522	201	0.739	Zebrafish Worm Fly
heart development	GO:0007507	313	0.736	Zebrafish
signal transduction	GO:0007165	455	0.689	Zebrafish Mouse Fly
gastrulation	GO:0007369	208	0.686	Zebrafish Fly
neuron differentiation	GO:0030182	353	0.672
neuron development	GO:0048666	262	0.657
specification of symmetry	GO:0009799	204	0.636	Zebrafish
regulation of synapse organization	GO:0050807	3	0.589	Fly
regulation of synapse assembly	GO:0051963	3	0.582	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.559	Zebrafish Mouse Fly
regulation of response to stimulus	GO:0048583	269	0.523	Zebrafish
rna biosynthetic process	GO:0032774	181	0.510
cell part morphogenesis	GO:0032990	246	0.508
positive regulation of macromolecule metabolic process	GO:0010604	93	0.493	Zebrafish Fly
skeletal system development	GO:0001501	181	0.491	Mouse
cell migration involved in gastrulation	GO:0042074	79	0.485	Zebrafish
ameboidal type cell migration	GO:0001667	143	0.483	Zebrafish
cell projection organization	GO:0030030	284	0.470
cell cycle	GO:0007049	93	0.444	Worm Fly
regulation of macromolecule metabolic process	GO:0060255	317	0.430
epithelial tube morphogenesis	GO:0060562	148	0.429	Zebrafish Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.410
morphogenesis of an epithelium	GO:0002009	333	0.405	Zebrafish Fly
response to lipid	GO:0033993	60	0.400
embryonic limb morphogenesis	GO:0030326	2	0.399
protein targeting to nucleus	GO:0044744	3	0.398
establishment of spindle orientation	GO:0051294	10	0.391
protein localization to nucleus	GO:0034504	3	0.384
single organism organelle organization	GO:1902589	199	0.375
positive regulation of biological process	GO:0048518	253	0.373	Zebrafish Worm Fly
phosphorylation	GO:0016310	69	0.370	Mouse
nuclear transport	GO:0051169	4	0.367
negative regulation of cell cycle process	GO:0010948	9	0.363	Fly
hematopoietic or lymphoid organ development	GO:0048534	191	0.362
sulfur compound metabolic process	GO:0006790	13	0.358
regulation of blood circulation	GO:1903522	32	0.348
heart jogging	GO:0003146	40	0.339	Zebrafish
dorsal ventral pattern formation	GO:0009953	125	0.337
regulation of developmental process	GO:0050793	247	0.336	Zebrafish Worm Fly
cell motility	GO:0048870	244	0.334	Zebrafish Fly
protein import into nucleus	GO:0006606	3	0.325
chordate embryonic development	GO:0043009	271	0.321
embryonic heart tube development	GO:0035050	133	0.308	Zebrafish
regulation of signaling	GO:0023051	235	0.306	Zebrafish
axon development	GO:0061564	166	0.296
proteasomal protein catabolic process	GO:0010498	2	0.295
cellular nitrogen compound metabolic process	GO:0034641	290	0.294
nuclear import	GO:0051170	3	0.279
nucleocytoplasmic transport	GO:0006913	4	0.279
cell morphogenesis involved in differentiation	GO:0000904	195	0.278
organonitrogen compound metabolic process	GO:1901564	74	0.277
cellular amine metabolic process	GO:0044106	2	0.272
positive regulation of map kinase activity	GO:0043406	3	0.271
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.266	Zebrafish
single organism transport	GO:0044765	206	0.263
phagocytosis	GO:0006909	3	0.259
muscle structure development	GO:0061061	196	0.259
organic substance biosynthetic process	GO:1901576	289	0.257
amine metabolic process	GO:0009308	2	0.251
positive regulation of metabolic process	GO:0009893	108	0.251	Zebrafish Fly
single organism localization	GO:1902578	225	0.247
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.242
positive regulation of cellular component biogenesis	GO:0044089	3	0.242	Fly
heterocycle biosynthetic process	GO:0018130	215	0.238
regulation of protein binding	GO:0043393	3	0.236
single organismal cell cell adhesion	GO:0016337	29	0.234
protein metabolic process	GO:0019538	183	0.232	Mouse
regulation of cell differentiation	GO:0045595	142	0.232	Zebrafish Fly
cell surface receptor signaling pathway	GO:0007166	325	0.232	Zebrafish Mouse Fly
bmp signaling pathway involved in heart development	GO:0061312	15	0.230	Zebrafish
neuron projection development	GO:0031175	180	0.230
cytoskeleton organization	GO:0007010	96	0.228
developmental growth involved in morphogenesis	GO:0060560	86	0.226
establishment of mitotic spindle orientation	GO:0000132	10	0.224
determination of dorsal ventral asymmetry	GO:0048262	34	0.224	Zebrafish
regulation of protein import into nucleus	GO:0042306	2	0.224
cellular component movement	GO:0006928	335	0.219	Zebrafish Fly
protein import	GO:0017038	3	0.218
organic cyclic compound metabolic process	GO:1901360	301	0.214
negative regulation of canonical wnt signaling pathway	GO:0090090	21	0.213
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.213
cellular modified amino acid metabolic process	GO:0006575	3	0.213
cellular component assembly	GO:0022607	170	0.208	Fly
single organism nuclear import	GO:1902593	3	0.207
nucleobase containing compound biosynthetic process	GO:0034654	205	0.206
positive regulation of cellular metabolic process	GO:0031325	94	0.204	Zebrafish Fly
positive regulation of protein metabolic process	GO:0051247	23	0.203
regulation of mitotic cell cycle	GO:0007346	25	0.201	Worm Fly
mitotic cell cycle	GO:0000278	64	0.199	Worm Fly
dorsal convergence	GO:0060030	14	0.193	Zebrafish
notochord development	GO:0030903	54	0.191
regulation of embryonic development	GO:0045995	47	0.188	Zebrafish
nitrogen compound metabolic process	GO:0006807	319	0.188
oxoacid metabolic process	GO:0043436	31	0.183
cellular amino acid metabolic process	GO:0006520	7	0.180
regulation of cellular amine metabolic process	GO:0033238	0	0.179
establishment of protein localization to organelle	GO:0072594	4	0.178
muscle cell development	GO:0055001	115	0.177
cellular macromolecule metabolic process	GO:0044260	391	0.177
response to fluid shear stress	GO:0034405	2	0.175
g1 s transition of mitotic cell cycle	GO:0000082	1	0.172	Fly
fin regeneration	GO:0031101	51	0.170
cellular aromatic compound metabolic process	GO:0006725	295	0.170
striated muscle tissue development	GO:0014706	110	0.170
regulation of axonogenesis	GO:0050770	32	0.168
response to growth factor	GO:0070848	39	0.168	Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.166
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.166	Zebrafish Mouse Fly
single organism cell adhesion	GO:0098602	29	0.162
cell morphogenesis	GO:0000902	289	0.161
cellular protein catabolic process	GO:0044257	4	0.161
axis elongation	GO:0003401	31	0.160
regulation of cell migration	GO:0030334	40	0.160
skeletal muscle tissue development	GO:0007519	67	0.160
response to external stimulus	GO:0009605	264	0.159	Fly
embryonic eye morphogenesis	GO:0048048	30	0.158
organic cyclic compound biosynthetic process	GO:1901362	223	0.157
regulation of cellular component organization	GO:0051128	86	0.157	Fly
defense response	GO:0006952	47	0.156
regulation of metabolic process	GO:0019222	359	0.156
positive regulation of cell cycle	GO:0045787	3	0.154	Worm
negative regulation of biological process	GO:0048519	304	0.153
regulation of intracellular protein transport	GO:0033157	3	0.153
aromatic compound biosynthetic process	GO:0019438	217	0.147
positive regulation of nervous system development	GO:0051962	25	0.146	Fly
generation of neurons	GO:0048699	385	0.146
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.146	Zebrafish
regulation of cellular amino acid metabolic process	GO:0006521	0	0.145
protein complex disassembly	GO:0043241	1	0.145
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.145
organelle organization	GO:0006996	227	0.143
response to nutrient	GO:0007584	3	0.142
sensory organ development	GO:0007423	393	0.142	Zebrafish Fly
blood circulation	GO:0008015	87	0.139
regulation of cardiac muscle tissue development	GO:0055024	1	0.138
chemotaxis	GO:0006935	104	0.134	Fly
locomotion	GO:0040011	313	0.134	Zebrafish Fly
sensory organ morphogenesis	GO:0090596	200	0.133	Zebrafish Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.133
regulation of phosphorus metabolic process	GO:0051174	43	0.131
gene expression	GO:0010467	252	0.129
actin polymerization or depolymerization	GO:0008154	2	0.129
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.129
cellular protein modification process	GO:0006464	100	0.129	Mouse
regulation of signal transduction	GO:0009966	225	0.128	Zebrafish
neuron projection morphogenesis	GO:0048812	161	0.128
positive regulation of catabolic process	GO:0009896	4	0.127
regulation of locomotion	GO:0040012	55	0.127
negative regulation of nuclear division	GO:0051784	3	0.127
nuclear division	GO:0000280	23	0.127
erk1 and erk2 cascade	GO:0070371	4	0.126
protein modification process	GO:0036211	100	0.123	Mouse
synapse organization	GO:0050808	21	0.123	Fly
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway	GO:0022002	1	0.122
response to chemical	GO:0042221	320	0.121	Mouse Fly
striated muscle cell development	GO:0055002	108	0.119
stem cell differentiation	GO:0048863	117	0.119	Fly
positive regulation of cellular protein metabolic process	GO:0032270	22	0.118
axonogenesis	GO:0007409	152	0.118
regulation of cell cycle	GO:0051726	52	0.117	Worm Fly
regulation of dendrite development	GO:0050773	3	0.116
regulation of rna biosynthetic process	GO:2001141	213	0.116
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	9	0.116
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.116
cellular component morphogenesis	GO:0032989	336	0.116
system process	GO:0003008	185	0.115
transport	GO:0006810	220	0.115
cellular macromolecule biosynthetic process	GO:0034645	224	0.115
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.114	Zebrafish
regulation of neuron differentiation	GO:0045664	56	0.114
negative chemotaxis	GO:0050919	1	0.114
optic placode formation	GO:0001743	4	0.114
embryonic skeletal system morphogenesis	GO:0048704	93	0.113
response to stress	GO:0006950	263	0.112
regulation of anatomical structure morphogenesis	GO:0022603	130	0.111	Zebrafish
protein polymerization	GO:0051258	4	0.111
protein complex biogenesis	GO:0070271	30	0.110
regulation of cellular metabolic process	GO:0031323	320	0.110
spindle localization	GO:0051653	12	0.110
establishment of mitotic spindle localization	GO:0040001	12	0.110
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.110	Zebrafish
regulation of cell motility	GO:2000145	46	0.109
regulation of biological quality	GO:0065008	263	0.108	Fly
tissue regeneration	GO:0042246	74	0.107
blood vessel endothelial cell migration	GO:0043534	18	0.106
nucleic acid templated transcription	GO:0097659	181	0.106
regulation of multicellular organismal process	GO:0051239	277	0.105	Zebrafish Worm Fly
notochord morphogenesis	GO:0048570	17	0.105
cell migration involved in heart development	GO:0060973	22	0.104
neural plate pattern specification	GO:0060896	12	0.103
positive regulation of cellular amine metabolic process	GO:0033240	0	0.103
morphogenesis of an epithelial fold	GO:0060571	1	0.102
regulation of protein catabolic process	GO:0042176	1	0.102
regulation of localization	GO:0032879	104	0.100
regulation of axon extension	GO:0030516	24	0.100
single organism cellular localization	GO:1902580	46	0.098
mesenchyme development	GO:0060485	127	0.097
microtubule based process	GO:0007017	60	0.097
ventricular system development	GO:0021591	12	0.096
cell death	GO:0008219	121	0.096
organelle localization	GO:0051640	49	0.096
regeneration	GO:0031099	91	0.095
cell migration	GO:0016477	237	0.095	Zebrafish Fly
positive regulation of oocyte development	GO:0060282	1	0.095	Zebrafish
regulation of apoptotic process	GO:0042981	98	0.094
regulation of biosynthetic process	GO:0009889	250	0.092
negative regulation of mitotic cell cycle	GO:0045930	11	0.092	Worm Fly
modification dependent protein catabolic process	GO:0019941	3	0.091
gland development	GO:0048732	143	0.091
positive regulation of striated muscle tissue development	GO:0045844	1	0.090
positive regulation of small gtpase mediated signal transduction	GO:0051057	1	0.088
cell projection morphogenesis	GO:0048858	244	0.088
response to abiotic stimulus	GO:0009628	122	0.088
response to organic substance	GO:0010033	153	0.087	Mouse Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.086	Fly
regulation of binding	GO:0051098	3	0.086
regulation of cytoplasmic transport	GO:1903649	4	0.084
regulation of protein metabolic process	GO:0051246	56	0.084
mesenchymal cell differentiation	GO:0048762	87	0.084
single organism metabolic process	GO:0044710	217	0.083
gall bladder development	GO:0061010	1	0.083
phosphate containing compound metabolic process	GO:0006796	108	0.083	Mouse
cytokinesis	GO:0000910	3	0.082
negative regulation of cellular process	GO:0048523	283	0.081
response to endogenous stimulus	GO:0009719	83	0.081	Fly
stem cell maintenance	GO:0019827	4	0.081	Fly
positive regulation of cell proliferation	GO:0008284	15	0.080
mesenchymal cell proliferation	GO:0010463	1	0.079
determination of ventral identity	GO:0048264	21	0.079	Zebrafish
negative regulation of mitosis	GO:0045839	3	0.078
cellular response to growth factor stimulus	GO:0071363	39	0.077	Fly
camera type eye morphogenesis	GO:0048593	108	0.077
nucleic acid metabolic process	GO:0090304	244	0.077
protein phosphorylation	GO:0006468	47	0.077	Mouse
regulation of neuron projection development	GO:0010975	40	0.076
establishment of cell polarity	GO:0030010	18	0.076
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.075
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.075
neuron projection extension	GO:1990138	45	0.075
regulation of nervous system development	GO:0051960	90	0.075	Fly
embryonic neurocranium morphogenesis	GO:0048702	15	0.074
muscle tissue development	GO:0060537	110	0.074
peptidyl serine modification	GO:0018209	2	0.074
cellular component disassembly	GO:0022411	1	0.073
embryonic organ development	GO:0048568	381	0.073	Zebrafish
regulation of canonical wnt signaling pathway	GO:0060828	34	0.073
microtubule cytoskeleton organization	GO:0000226	33	0.072
positive regulation of gene expression	GO:0010628	71	0.072	Zebrafish Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.071
regulation of heart contraction	GO:0008016	32	0.071
negative regulation of protein localization to nucleus	GO:1900181	2	0.071
regulation of chromosome segregation	GO:0051983	1	0.071
transcription from rna polymerase ii promoter	GO:0006366	80	0.071	Zebrafish Mouse Fly
regionalization	GO:0003002	274	0.070
positive regulation of synapse assembly	GO:0051965	1	0.070	Fly
striated muscle cell differentiation	GO:0051146	129	0.069
skeletal system morphogenesis	GO:0048705	102	0.069
epithelial cell proliferation involved in liver morphogenesis	GO:0072575	2	0.069
brain development	GO:0007420	293	0.069	Mouse
axon extension	GO:0048675	45	0.069
cellular protein metabolic process	GO:0044267	129	0.068	Mouse
regulation of cell projection organization	GO:0031344	44	0.068
regulation of establishment of protein localization	GO:0070201	4	0.068
endoderm development	GO:0007492	49	0.067	Fly
cell division	GO:0051301	20	0.067	Fly
convergent extension involved in axis elongation	GO:0060028	26	0.067
phagocytosis engulfment	GO:0006911	1	0.066
mesenchymal cell development	GO:0014031	78	0.066
ear development	GO:0043583	127	0.064	Zebrafish
regulation of anterior head development	GO:2000742	2	0.064
stem cell division	GO:0017145	1	0.063	Fly
eye morphogenesis	GO:0048592	144	0.063	Fly
cortical actin cytoskeleton organization	GO:0030866	1	0.063
actin filament polymerization	GO:0030041	2	0.063
mapk cascade	GO:0000165	18	0.063
regulation of protein targeting	GO:1903533	2	0.062
neurological system process	GO:0050877	62	0.062
epithelial cell migration	GO:0010631	25	0.061
formation of primary germ layer	GO:0001704	62	0.059	Fly
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.059
regulation of erk1 and erk2 cascade	GO:0070372	4	0.059
mitotic cell cycle process	GO:1903047	48	0.059	Fly
spemann organizer formation	GO:0060061	10	0.059
regulation of cellular protein metabolic process	GO:0032268	52	0.058
transcription dna templated	GO:0006351	181	0.058
regulation of neurogenesis	GO:0050767	87	0.058
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.057	Zebrafish
pathway restricted smad protein phosphorylation	GO:0060389	1	0.057
developmental cell growth	GO:0048588	52	0.056
circulatory system process	GO:0003013	87	0.056
regulation of phosphorylation	GO:0042325	26	0.056
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.056
eye development	GO:0001654	277	0.056	Fly
cell proliferation	GO:0008283	80	0.055
stem cell development	GO:0048864	82	0.055	Fly
chondrocyte development	GO:0002063	4	0.055
positive regulation of muscle tissue development	GO:1901863	1	0.055
regulation of cellular component movement	GO:0051270	55	0.054
wnt signaling pathway	GO:0016055	80	0.054
small molecule metabolic process	GO:0044281	77	0.054
aging	GO:0007568	2	0.054
regulation of protein transport	GO:0051223	3	0.054
programmed cell death	GO:0012501	119	0.053
negative regulation of intracellular protein transport	GO:0090317	3	0.053
growth	GO:0040007	174	0.052	Worm Fly
cell cycle g1 s phase transition	GO:0044843	1	0.052	Fly
skeletal muscle organ development	GO:0060538	78	0.052
protein complex assembly	GO:0006461	30	0.052
cardiac muscle cell differentiation	GO:0055007	30	0.051
regulation of cell development	GO:0060284	100	0.051	Zebrafish
regulation of fibroblast growth factor receptor signaling pathway	GO:0040036	20	0.050
larval development	GO:0002164	2	0.050
cellular response to chemical stimulus	GO:0070887	157	0.050	Mouse Fly
phosphorus metabolic process	GO:0006793	109	0.050	Mouse
camera type eye development	GO:0043010	222	0.050
positive regulation of ras protein signal transduction	GO:0046579	1	0.050
wound healing	GO:0042060	90	0.049
regulation of kinase activity	GO:0043549	15	0.049
cellular ketone metabolic process	GO:0042180	11	0.049
establishment of spindle localization	GO:0051293	12	0.048
single organism behavior	GO:0044708	24	0.048
ubiquitin dependent protein catabolic process	GO:0006511	3	0.048
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.048
regulation of phosphate metabolic process	GO:0019220	43	0.048
tissue migration	GO:0090130	37	0.048
positive regulation of transport	GO:0051050	2	0.047
cell cycle process	GO:0022402	53	0.047	Worm Fly
heterocycle metabolic process	GO:0046483	290	0.047
mesoderm morphogenesis	GO:0048332	51	0.046
negative regulation of signaling	GO:0023057	96	0.046
cell substrate adhesion	GO:0031589	4	0.046
protein localization	GO:0008104	40	0.045
negative regulation of protein complex assembly	GO:0031333	1	0.045
organelle assembly	GO:0070925	110	0.045
cellular component biogenesis	GO:0044085	178	0.045	Fly
immune system process	GO:0002376	241	0.045
central nervous system neuron differentiation	GO:0021953	74	0.045
lymph vessel development	GO:0001945	27	0.045
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.044
macromolecule biosynthetic process	GO:0009059	227	0.044
axon guidance	GO:0007411	86	0.044
embryonic skeletal joint development	GO:0072498	3	0.044
regulation of rna metabolic process	GO:0051252	224	0.044
negative regulation of cell differentiation	GO:0045596	46	0.043	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.043	Zebrafish Fly
modification dependent macromolecule catabolic process	GO:0043632	3	0.043
positive regulation of immune system process	GO:0002684	17	0.043
positive regulation of cellular extravasation	GO:0002693	1	0.043
regulation of cellular ketone metabolic process	GO:0010565	7	0.042
nucleobase containing compound metabolic process	GO:0006139	274	0.042
positive regulation of rna biosynthetic process	GO:1902680	57	0.042	Zebrafish Fly
small gtpase mediated signal transduction	GO:0007264	8	0.042
establishment of localization	GO:0051234	244	0.042
macromolecule modification	GO:0043412	111	0.042	Mouse
ossification	GO:0001503	23	0.042
mitotic nuclear division	GO:0007067	18	0.042
positive regulation of muscle organ development	GO:0048636	1	0.042
hindbrain development	GO:0030902	91	0.041	Mouse
positive regulation of cellular catabolic process	GO:0031331	3	0.041
thrombocyte differentiation	GO:0002574	4	0.040
positive regulation of developmental process	GO:0051094	50	0.040	Zebrafish Worm Fly
positive regulation of phosphate metabolic process	GO:0045937	21	0.040
actomyosin structure organization	GO:0031032	53	0.040
positive regulation of signaling	GO:0023056	56	0.040
maintenance of location	GO:0051235	4	0.039
germ line stem cell division	GO:0042078	1	0.039	Fly
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation	GO:0060823	4	0.039
cell growth	GO:0016049	57	0.039
regulation of meiotic cell cycle	GO:0051445	1	0.039	Worm
neural tube patterning	GO:0021532	33	0.038
embryonic heart tube left right pattern formation	GO:0060971	5	0.038
regulation of protein localization to nucleus	GO:1900180	2	0.038
cartilage development	GO:0051216	96	0.038	Mouse
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.037
positive regulation of signal transduction	GO:0009967	56	0.037
response to external biotic stimulus	GO:0043207	97	0.037
response to wounding	GO:0009611	116	0.037
epithelium migration	GO:0090132	25	0.037
post anal tail morphogenesis	GO:0036342	19	0.037	Zebrafish
negative regulation of nucleocytoplasmic transport	GO:0046823	2	0.037
endothelial cell migration	GO:0043542	19	0.037
regulation of cell size	GO:0008361	29	0.037
axis specification	GO:0009798	43	0.037
myeloid cell development	GO:0061515	32	0.036
activation of mapk activity	GO:0000187	3	0.036
response to radiation	GO:0009314	51	0.036
stem cell proliferation	GO:0072089	4	0.036
regulation of nucleocytoplasmic transport	GO:0046822	2	0.036
fin development	GO:0033333	77	0.036
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.036
gland morphogenesis	GO:0022612	13	0.035
muscle organ development	GO:0007517	101	0.035
synaptic growth at neuromuscular junction	GO:0051124	2	0.035	Fly
positive regulation of wound healing	GO:0090303	1	0.035
liver development	GO:0001889	96	0.035
heart field specification	GO:0003128	1	0.035
atrial ventricular junction remodeling	GO:0003294	2	0.035
regulation of bmp signaling pathway	GO:0030510	39	0.034	Zebrafish
cell adhesion	GO:0007155	40	0.034
regulation of muscle organ development	GO:0048634	9	0.034
angiogenesis	GO:0001525	158	0.034
mesoderm formation	GO:0001707	43	0.034
immune system development	GO:0002520	191	0.034
regulation of nucleoside metabolic process	GO:0009118	2	0.034
cardiac muscle tissue development	GO:0048738	48	0.034
cellular response to stress	GO:0033554	62	0.034
regulation of organ morphogenesis	GO:2000027	35	0.034	Zebrafish
regulation of cardiac muscle cell differentiation	GO:2000725	1	0.033
regulation of sequestering of calcium ion	GO:0051282	4	0.033
regulation of molecular function	GO:0065009	70	0.033
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.033	Zebrafish Fly
lymph vessel morphogenesis	GO:0036303	25	0.033
positive regulation of cellular component organization	GO:0051130	13	0.033	Fly
organic acid metabolic process	GO:0006082	31	0.032
cell cell signaling involved in cell fate commitment	GO:0045168	12	0.032
regulation of biomineral tissue development	GO:0070167	2	0.032
regulation of developmental growth	GO:0048638	38	0.032	Worm Fly
biosynthetic process	GO:0009058	294	0.032
cellular protein complex assembly	GO:0043623	19	0.032
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	1	0.032
hepatocyte proliferation	GO:0072574	2	0.032
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.032	Fly
muscle cell differentiation	GO:0042692	139	0.032
positive regulation of biosynthetic process	GO:0009891	68	0.032	Zebrafish Fly
protein complex subunit organization	GO:0071822	46	0.031
membrane invagination	GO:0010324	1	0.031
regulation of cell activation	GO:0050865	1	0.031
neural crest cell development	GO:0014032	62	0.031
positive regulation of response to stimulus	GO:0048584	80	0.030
regulation of growth	GO:0040008	42	0.030	Worm Fly
heart contraction	GO:0060047	71	0.030
embryonic camera type eye morphogenesis	GO:0048596	19	0.030
response to fibroblast growth factor	GO:0071774	22	0.030
biological adhesion	GO:0022610	40	0.030
positive regulation of dna metabolic process	GO:0051054	1	0.029
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.029
neural tube development	GO:0021915	62	0.029
regulation of protein ubiquitination	GO:0031396	3	0.029
regulation of establishment of planar polarity	GO:0090175	4	0.029
apical junction assembly	GO:0043297	1	0.028
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.028	Zebrafish Fly
peptidyl serine phosphorylation	GO:0018105	1	0.028
regulation of gastrulation	GO:0010470	24	0.028
death	GO:0016265	121	0.028
cellular component assembly involved in morphogenesis	GO:0010927	107	0.028
exocytosis	GO:0006887	1	0.028
blood vessel development	GO:0001568	246	0.028	Zebrafish
regulation of endocytosis	GO:0030100	7	0.028
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.028
cellular protein localization	GO:0034613	20	0.027
eye photoreceptor cell differentiation	GO:0001754	45	0.027
macromolecule localization	GO:0033036	54	0.027
cell matrix adhesion	GO:0007160	4	0.027
embryonic camera type eye development	GO:0031076	29	0.026
regulation of cellular protein catabolic process	GO:1903362	1	0.026
cellular response to endogenous stimulus	GO:0071495	68	0.026	Fly
taxis	GO:0042330	109	0.026	Fly
positive regulation of cell adhesion	GO:0045785	1	0.026
carboxylic acid metabolic process	GO:0019752	22	0.026
macromolecular complex subunit organization	GO:0043933	74	0.026
regulation of cell death	GO:0010941	103	0.026
regulation of extent of cell growth	GO:0061387	29	0.026
positive regulation of cell activation	GO:0050867	1	0.026
cellular response to biotic stimulus	GO:0071216	3	0.026
regulation of smoothened signaling pathway	GO:0008589	18	0.026
protein depolymerization	GO:0051261	1	0.026
anterior posterior axon guidance	GO:0033564	5	0.025
somatic muscle development	GO:0007525	4	0.025
response to hypoxia	GO:0001666	25	0.025
regulation of wnt signaling pathway involved in digestive tract morphogenesis	GO:2000056	2	0.025
regulation of protein modification process	GO:0031399	29	0.025
neural plate anterior posterior regionalization	GO:0021999	8	0.025
photoreceptor cell differentiation	GO:0046530	55	0.025
specification of axis polarity	GO:0065001	4	0.024
behavior	GO:0007610	74	0.024
negative regulation of synapse assembly	GO:0051964	2	0.024
hepaticobiliary system development	GO:0061008	98	0.024
spinal cord development	GO:0021510	46	0.024
regulation of protein phosphorylation	GO:0001932	18	0.024
morphogenesis of a branching epithelium	GO:0061138	16	0.024
regulation of mitosis	GO:0007088	9	0.023

smad9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.058
cancer	DOID:162	0.024
organ system cancer	DOID:0050686	0.024
disease of cellular proliferation	DOID:14566	0.024

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