IMP: Integrative Multi-species Prediction

Danio rerio

100 known processes

smad1

MAD homolog 1 (Drosophila)

(Aliases: wu:fb39h09,madh1,fb39h09,MGC92101,wu:fb97e04)

Entrez: 30628
Ensembl: ENSDARG00000027199
ZFIN: ZDB-GENE-991119-8
UniProtKB: Q5PQZ2
UniProtKB: Q9I8V2

Process Predictions
Disease Predictions

smad1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
digestive tract morphogenesis	GO:0048546	231	0.981	Zebrafish Mouse Fly
digestive tract development	GO:0048565	265	0.948	Zebrafish Mouse Fly
digestive system development	GO:0055123	289	0.932	Zebrafish Mouse Fly
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.903	Mouse Fly
cell surface receptor signaling pathway	GO:0007166	325	0.864
embryonic organ morphogenesis	GO:0048562	274	0.765	Zebrafish
gastrulation	GO:0007369	208	0.740	Zebrafish Mouse Fly
sensory neuron axon guidance	GO:0097374	3	0.719
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.689	Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.687	Fly
oocyte maturation	GO:0001556	4	0.672
negative regulation of biological process	GO:0048519	304	0.644
signal transduction	GO:0007165	455	0.640
chordate embryonic development	GO:0043009	271	0.636
positive regulation of cellular component biogenesis	GO:0044089	3	0.629	Fly
axon regeneration	GO:0031103	14	0.626
locomotion	GO:0040011	313	0.599	Zebrafish Fly
response to stress	GO:0006950	263	0.598	Mouse
endoderm development	GO:0007492	49	0.583	Fly
gamete generation	GO:0007276	33	0.575	Zebrafish Mouse Fly
skeletal system development	GO:0001501	181	0.565	Mouse
oocyte development	GO:0048599	14	0.551	Zebrafish
neuron projection guidance	GO:0097485	86	0.540
positive regulation of cell cycle	GO:0045787	3	0.531	Worm
embryonic skeletal system morphogenesis	GO:0048704	93	0.521
mesenchyme development	GO:0060485	127	0.517
developmental growth	GO:0048589	166	0.514	Worm Fly
immune system development	GO:0002520	191	0.496
axon guidance	GO:0007411	86	0.486
cell migration	GO:0016477	237	0.484	Zebrafish Fly
otic vesicle morphogenesis	GO:0071600	34	0.481	Zebrafish
regulation of metabolic process	GO:0019222	359	0.480
nitrogen compound metabolic process	GO:0006807	319	0.466
cellular component morphogenesis	GO:0032989	336	0.465
embryonic organ development	GO:0048568	381	0.459	Zebrafish
regulation of synapse organization	GO:0050807	3	0.458	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.455	Zebrafish Mouse Fly
localization of cell	GO:0051674	244	0.453	Zebrafish Fly
macromolecule biosynthetic process	GO:0009059	227	0.441
tube morphogenesis	GO:0035239	349	0.433	Zebrafish Mouse Fly
sexual reproduction	GO:0019953	36	0.411	Zebrafish Mouse Fly
reproductive process	GO:0022414	40	0.405	Zebrafish Mouse Worm Fly
mesoderm morphogenesis	GO:0048332	51	0.403	Mouse
neuron projection regeneration	GO:0031102	16	0.392
response to chemical	GO:0042221	320	0.390	Mouse Fly
regulation of synapse assembly	GO:0051963	3	0.381	Fly
regulation of developmental growth	GO:0048638	38	0.375	Worm Fly
mesenchymal cell development	GO:0014031	78	0.371
ear morphogenesis	GO:0042471	64	0.369	Zebrafish
skeletal system morphogenesis	GO:0048705	102	0.367
peptidyl serine phosphorylation	GO:0018105	1	0.365
ear development	GO:0043583	127	0.364	Zebrafish
axon development	GO:0061564	166	0.360
blood vessel development	GO:0001568	246	0.358	Zebrafish
protein localization to nucleus	GO:0034504	3	0.358
ameboidal type cell migration	GO:0001667	143	0.355	Zebrafish
cranial nerve development	GO:0021545	42	0.354
cellular ketone metabolic process	GO:0042180	11	0.349
cell substrate adhesion	GO:0031589	4	0.348
single organism organelle organization	GO:1902589	199	0.343
ion transport	GO:0006811	114	0.336
negative regulation of cellular process	GO:0048523	283	0.330
oligodendrocyte differentiation	GO:0048709	23	0.329
somite development	GO:0061053	96	0.329
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.328
developmental process involved in reproduction	GO:0003006	27	0.325	Zebrafish Worm Fly
embryo development ending in birth or egg hatching	GO:0009792	271	0.323
biological adhesion	GO:0022610	40	0.318
larval development	GO:0002164	2	0.318
protein modification process	GO:0036211	100	0.313	Mouse
single organism nuclear import	GO:1902593	3	0.296
heart development	GO:0007507	313	0.293	Zebrafish Mouse
growth	GO:0040007	174	0.288	Mouse Worm Fly
phosphorus metabolic process	GO:0006793	109	0.287	Mouse
stem cell differentiation	GO:0048863	117	0.287	Fly
synaptic transmission	GO:0007268	35	0.281	Fly
peripheral nervous system neuron differentiation	GO:0048934	28	0.280
cellular macromolecule biosynthetic process	GO:0034645	224	0.277
regulation of peptidase activity	GO:0052547	23	0.274
regulation of axonogenesis	GO:0050770	32	0.273
sensory organ development	GO:0007423	393	0.273	Zebrafish Fly
muscle cell migration	GO:0014812	4	0.272
post embryonic organ development	GO:0048569	4	0.269	Fly
regulation of gene expression	GO:0010468	265	0.269
positive regulation of cellular amine metabolic process	GO:0033240	0	0.256
embryonic skeletal system development	GO:0048706	97	0.256
liver development	GO:0001889	96	0.254
cellular component assembly	GO:0022607	170	0.253	Human Fly
regulation of cellular component organization	GO:0051128	86	0.253	Fly
regulation of macromolecule metabolic process	GO:0060255	317	0.251
membrane organization	GO:0061024	21	0.251
inner ear development	GO:0048839	126	0.248	Zebrafish
neuron development	GO:0048666	262	0.245
regulation of cellular amino acid metabolic process	GO:0006521	0	0.242
synaptic growth at neuromuscular junction	GO:0051124	2	0.240	Fly
determination of heart left right asymmetry	GO:0061371	117	0.238	Zebrafish
convergent extension involved in gastrulation	GO:0060027	71	0.234	Zebrafish
cellular protein metabolic process	GO:0044267	129	0.234	Mouse
regulation of reproductive process	GO:2000241	4	0.233	Zebrafish
segmentation	GO:0035282	97	0.233	Fly
sensory system development	GO:0048880	76	0.231
regulation of multicellular organismal development	GO:2000026	223	0.230	Zebrafish Mouse Fly
oxoacid metabolic process	GO:0043436	31	0.230
head development	GO:0060322	303	0.229	Mouse
response to external stimulus	GO:0009605	264	0.228	Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.222
response to wounding	GO:0009611	116	0.218
cell cell signaling	GO:0007267	52	0.215	Fly
negative regulation of collateral sprouting	GO:0048671	2	0.214
regulation of cellular amine metabolic process	GO:0033238	0	0.213
retina development in camera type eye	GO:0060041	146	0.212
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.209
gland development	GO:0048732	143	0.206
gene expression	GO:0010467	252	0.203
regulation of cellular ketone metabolic process	GO:0010565	7	0.203
eye morphogenesis	GO:0048592	144	0.203	Fly
neural crest cell differentiation	GO:0014033	72	0.199
positive regulation of neuron apoptotic process	GO:0043525	1	0.199
amine metabolic process	GO:0009308	2	0.195
meiotic nuclear division	GO:0007126	4	0.194
posterior lateral line neuromast hair cell differentiation	GO:0048923	8	0.192
cellular amine metabolic process	GO:0044106	2	0.191
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.190
transcription dna templated	GO:0006351	181	0.185
positive regulation of transport	GO:0051050	2	0.183
central nervous system neuron differentiation	GO:0021953	74	0.181
cellular aromatic compound metabolic process	GO:0006725	295	0.180
heterocycle biosynthetic process	GO:0018130	215	0.180
positive regulation of nervous system development	GO:0051962	25	0.180	Fly
positive regulation of gene expression	GO:0010628	71	0.179	Human Zebrafish Mouse Fly
forebrain cell migration	GO:0021885	1	0.179
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.178
anterior posterior pattern specification	GO:0009952	152	0.177	Fly
metal ion transport	GO:0030001	58	0.175
regulation of cell development	GO:0060284	100	0.174	Zebrafish
inner ear morphogenesis	GO:0042472	63	0.172	Zebrafish
cellular component maintenance	GO:0043954	3	0.171
rhombomere boundary formation	GO:0021654	10	0.168
nerve development	GO:0021675	45	0.168
forebrain development	GO:0030900	96	0.167
synapse assembly	GO:0007416	9	0.167	Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.167	Zebrafish
central nervous system development	GO:0007417	387	0.166	Mouse
nuclear transport	GO:0051169	4	0.163
multicellular organism reproduction	GO:0032504	35	0.161	Zebrafish Mouse Fly
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.161	Zebrafish Mouse Fly
cellular component movement	GO:0006928	335	0.160	Zebrafish Fly
organelle organization	GO:0006996	227	0.160
positive regulation of developmental process	GO:0051094	50	0.158	Zebrafish Mouse Worm Fly
myotube differentiation	GO:0014902	45	0.156
nucleocytoplasmic transport	GO:0006913	4	0.155
cellular response to external stimulus	GO:0071496	2	0.154
positive regulation of synapse assembly	GO:0051965	1	0.154	Fly
phosphate containing compound metabolic process	GO:0006796	108	0.152	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.152
negative regulation of apoptotic process	GO:0043066	55	0.151
cellular nitrogen compound metabolic process	GO:0034641	290	0.151
immune system process	GO:0002376	241	0.150
cytoskeleton organization	GO:0007010	96	0.149
posterior lateral line neuromast development	GO:0048919	20	0.149
cellular macromolecule localization	GO:0070727	21	0.148
branching morphogenesis of a nerve	GO:0048755	4	0.148
macromolecular complex subunit organization	GO:0043933	74	0.146	Human
lateral line system development	GO:0048925	76	0.145
positive regulation of cellular metabolic process	GO:0031325	94	0.144	Zebrafish Mouse Fly
muscle organ development	GO:0007517	101	0.144
negative regulation of cellular metabolic process	GO:0031324	77	0.143
lateral line development	GO:0048882	66	0.143
wnt signaling pathway	GO:0016055	80	0.141
regulation of multicellular organismal process	GO:0051239	277	0.140	Zebrafish Mouse Worm Fly
stem cell development	GO:0048864	82	0.139	Fly
dna metabolic process	GO:0006259	27	0.138
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.138
cellular component biogenesis	GO:0044085	178	0.136	Human Fly
mitotic cell cycle	GO:0000278	64	0.136	Worm Fly
chondrocyte development	GO:0002063	4	0.136
small molecule metabolic process	GO:0044281	77	0.135
regulation of photoreceptor cell differentiation	GO:0046532	2	0.134
neural crest cell migration	GO:0001755	42	0.133
organonitrogen compound metabolic process	GO:1901564	74	0.132
cellular component assembly involved in morphogenesis	GO:0010927	107	0.132
forebrain neuron differentiation	GO:0021879	14	0.131
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.130
branchiomotor neuron axon guidance	GO:0021785	1	0.130
system process	GO:0003008	185	0.129
protein metabolic process	GO:0019538	183	0.128	Mouse
microtubule based process	GO:0007017	60	0.128
establishment of mitotic spindle localization	GO:0040001	12	0.128
negative regulation of cell communication	GO:0010648	96	0.128
convergent extension	GO:0060026	118	0.127	Zebrafish
positive regulation of mesenchymal cell proliferation	GO:0002053	1	0.127
tissue regeneration	GO:0042246	74	0.124
immune response	GO:0006955	28	0.124
regulation of proteolysis	GO:0030162	24	0.124
adherens junction organization	GO:0034332	4	0.123
oocyte differentiation	GO:0009994	14	0.122	Zebrafish
embryonic viscerocranium morphogenesis	GO:0048703	52	0.120
peptidyl serine modification	GO:0018209	2	0.120
protein localization	GO:0008104	40	0.120
stem cell maintenance	GO:0019827	4	0.118	Fly
regulation of cellular biosynthetic process	GO:0031326	245	0.118
negative regulation of collateral sprouting of intact axon in response to injury	GO:0048685	2	0.117
regeneration	GO:0031099	91	0.116
aromatic compound biosynthetic process	GO:0019438	217	0.115
extracellular structure organization	GO:0043062	27	0.115
positive regulation of rna biosynthetic process	GO:1902680	57	0.113	Zebrafish Mouse Fly
positive regulation of oocyte development	GO:0060282	1	0.112	Zebrafish
cellular protein modification process	GO:0006464	100	0.111	Mouse
regulation of axon extension	GO:0030516	24	0.110
neural crest cell development	GO:0014032	62	0.109
eye development	GO:0001654	277	0.108	Fly
regulation of intracellular protein transport	GO:0033157	3	0.107
regulation of signaling	GO:0023051	235	0.107	Zebrafish
mesenchymal cell differentiation	GO:0048762	87	0.106
somitogenesis	GO:0001756	87	0.106
nucleic acid metabolic process	GO:0090304	244	0.106
brain development	GO:0007420	293	0.106	Mouse
connective tissue development	GO:0061448	99	0.105	Mouse
protein import	GO:0017038	3	0.105
cell motility	GO:0048870	244	0.105	Zebrafish Fly
single organism reproductive process	GO:0044702	40	0.104	Zebrafish Mouse Fly
camera type eye development	GO:0043010	222	0.103
positive regulation of muscle organ development	GO:0048636	1	0.101
cell morphogenesis	GO:0000902	289	0.100
regulation of neuron projection regeneration	GO:0070570	7	0.100
transport	GO:0006810	220	0.099
regulation of protein transport	GO:0051223	3	0.099
cellular protein catabolic process	GO:0044257	4	0.096
notochord development	GO:0030903	54	0.096
rhombomere formation	GO:0021594	12	0.095
regulation of transcription dna templated	GO:0006355	213	0.095
neuromast development	GO:0048884	46	0.095
regulation of hydrolase activity	GO:0051336	28	0.095
germ cell development	GO:0007281	22	0.095	Zebrafish Fly
cellular biosynthetic process	GO:0044249	286	0.094
appendage morphogenesis	GO:0035107	56	0.094	Fly
apoptotic process	GO:0006915	116	0.091
heart morphogenesis	GO:0003007	156	0.090	Zebrafish
negative regulation of signaling	GO:0023057	96	0.090
hard palate development	GO:0060022	4	0.090	Zebrafish
skeletal muscle tissue development	GO:0007519	67	0.090
chemotaxis	GO:0006935	104	0.088	Fly
organelle localization	GO:0051640	49	0.088
developmental growth involved in morphogenesis	GO:0060560	86	0.088
neuromuscular synaptic transmission	GO:0007274	2	0.087
negative regulation of neuron projection regeneration	GO:0070571	4	0.087
camera type eye morphogenesis	GO:0048593	108	0.086
regulation of biosynthetic process	GO:0009889	250	0.086
wound healing	GO:0042060	90	0.086
post anal tail morphogenesis	GO:0036342	19	0.085	Zebrafish
regulation of cell differentiation	GO:0045595	142	0.085	Zebrafish Mouse Fly
regulation of embryonic development	GO:0045995	47	0.084	Zebrafish
epithelial cell morphogenesis	GO:0003382	2	0.084
taxis	GO:0042330	109	0.084	Fly
ossification	GO:0001503	23	0.083	Mouse
negative regulation of catalytic activity	GO:0043086	21	0.083
multicellular organism growth	GO:0035264	4	0.082	Worm
cytokine mediated signaling pathway	GO:0019221	7	0.082
mesoderm development	GO:0007498	88	0.079	Mouse
biosynthetic process	GO:0009058	294	0.078
regulation of macromolecule biosynthetic process	GO:0010556	225	0.078
regionalization	GO:0003002	274	0.078
regulation of biological quality	GO:0065008	263	0.077	Mouse Fly
negative regulation of protein phosphorylation	GO:0001933	4	0.077
transcription from rna polymerase ii promoter	GO:0006366	80	0.076
negative regulation of metabolic process	GO:0009892	86	0.075
primary neural tube formation	GO:0014020	1	0.075
angioblast cell migration involved in selective angioblast sprouting	GO:0035475	4	0.075
axonogenesis	GO:0007409	152	0.075
rhombomere morphogenesis	GO:0021593	17	0.075
somatic muscle development	GO:0007525	4	0.075
regulation of collateral sprouting of intact axon in response to injury	GO:0048683	2	0.074
nucleobase containing compound metabolic process	GO:0006139	274	0.074
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.074
female sex differentiation	GO:0046660	4	0.074
collateral sprouting	GO:0048668	9	0.073
skin development	GO:0043588	54	0.073
negative regulation of phosphate metabolic process	GO:0045936	13	0.073
response to growth factor	GO:0070848	39	0.072	Mouse Fly
single organism transport	GO:0044765	206	0.072
negative regulation of signal transduction	GO:0009968	94	0.072
phosphorylation	GO:0016310	69	0.072	Mouse
regulation of nucleic acid templated transcription	GO:1903506	213	0.071
negative regulation of map kinase activity	GO:0043407	2	0.071
blood vessel morphogenesis	GO:0048514	216	0.071	Zebrafish
cellular macromolecule metabolic process	GO:0044260	391	0.071
regulation of wnt signaling pathway	GO:0030111	53	0.070
blood circulation	GO:0008015	87	0.070
regulation of multicellular organism growth	GO:0040014	4	0.070	Worm
regulation of metal ion transport	GO:0010959	4	0.070
oogenesis	GO:0048477	14	0.070	Zebrafish Fly
formation of primary germ layer	GO:0001704	62	0.070	Mouse Fly
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	22	0.070
protein import into nucleus	GO:0006606	3	0.069
regulation of response to stimulus	GO:0048583	269	0.069	Zebrafish
cell part morphogenesis	GO:0032990	246	0.069
negative regulation of mapk cascade	GO:0043409	4	0.068
regulation of cytoplasmic transport	GO:1903649	4	0.068
establishment of protein localization to organelle	GO:0072594	4	0.068
regulation of cell communication	GO:0010646	232	0.068	Zebrafish
positive regulation of macromolecule metabolic process	GO:0010604	93	0.068	Human Zebrafish Mouse Fly
specification of axis polarity	GO:0065001	4	0.068
rna metabolic process	GO:0016070	219	0.067
adenohypophysis development	GO:0021984	15	0.067
angiogenesis	GO:0001525	158	0.067
cellular response to growth factor stimulus	GO:0071363	39	0.067	Mouse Fly
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.067
positive regulation of neuron death	GO:1901216	1	0.066
ectodermal placode development	GO:0071696	37	0.066	Zebrafish
regulation of programmed cell death	GO:0043067	101	0.065
neuron projection morphogenesis	GO:0048812	161	0.065
negative regulation of response to stimulus	GO:0048585	104	0.065
hindbrain development	GO:0030902	91	0.063	Mouse
facial nerve development	GO:0021561	3	0.062
regulation of mitotic cell cycle	GO:0007346	25	0.062	Worm Fly
muscle cell development	GO:0055001	115	0.062
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.061
regulation of rna metabolic process	GO:0051252	224	0.060
single organism cellular localization	GO:1902580	46	0.060
mitotic cell cycle process	GO:1903047	48	0.060	Fly
cellular amino acid metabolic process	GO:0006520	7	0.059
positive regulation of metabolic process	GO:0009893	108	0.059	Human Zebrafish Mouse Fly
positive regulation of biological process	GO:0048518	253	0.059	Human Zebrafish Mouse Worm Fly
regulation of synaptic plasticity	GO:0048167	1	0.058
organic cyclic compound biosynthetic process	GO:1901362	223	0.058
phagocytosis	GO:0006909	3	0.058
positive regulation of transcription dna templated	GO:0045893	57	0.058	Zebrafish Mouse Fly
positive regulation of cellular biosynthetic process	GO:0031328	68	0.058	Zebrafish Mouse Fly
regulation of cell cycle process	GO:0010564	20	0.058	Fly
cell migration involved in gastrulation	GO:0042074	79	0.058	Zebrafish
response to drug	GO:0042493	3	0.057
negative regulation of catabolic process	GO:0009895	3	0.057
regulation of binding	GO:0051098	3	0.057
multicellular organismal homeostasis	GO:0048871	29	0.056
cellular protein localization	GO:0034613	20	0.056
positive regulation of biosynthetic process	GO:0009891	68	0.056	Zebrafish Mouse Fly
generation of neurons	GO:0048699	385	0.055
microtubule cytoskeleton organization	GO:0000226	33	0.055
negative regulation of protein kinase activity	GO:0006469	4	0.055
mapk cascade	GO:0000165	18	0.054	Mouse
regulation of axon regeneration	GO:0048679	7	0.054
mechanoreceptor differentiation	GO:0042490	37	0.054
neurotransmitter transport	GO:0006836	2	0.053
multicellular organismal reproductive process	GO:0048609	35	0.052	Zebrafish Mouse Fly
negative regulation of axon regeneration	GO:0048681	4	0.052
nucleoside monophosphate catabolic process	GO:0009125	4	0.052
positive regulation of striated muscle tissue development	GO:0045844	1	0.052
cell projection organization	GO:0030030	284	0.051
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.051
semicircular canal morphogenesis	GO:0048752	18	0.051
phagocytosis engulfment	GO:0006911	1	0.050
pronephros development	GO:0048793	69	0.050
phenol containing compound metabolic process	GO:0018958	5	0.050
cellular response to stress	GO:0033554	62	0.049
extracellular matrix organization	GO:0030198	27	0.049
cardiogenic plate morphogenesis	GO:0003142	1	0.049
divalent metal ion transport	GO:0070838	20	0.048
macromolecule modification	GO:0043412	111	0.048	Mouse
erk1 and erk2 cascade	GO:0070371	4	0.048
dorsal convergence	GO:0060030	14	0.048	Zebrafish
mechanosensory lateral line system development	GO:0048881	49	0.048
motor neuron axon guidance	GO:0008045	23	0.048
heart jogging	GO:0003146	40	0.048	Zebrafish
neuromuscular junction development	GO:0007528	9	0.047	Fly
glial cell differentiation	GO:0010001	42	0.047
muscle tissue development	GO:0060537	110	0.047	Mouse
regulation of skeletal muscle tissue development	GO:0048641	4	0.047
mesoderm formation	GO:0001707	43	0.047	Mouse
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.047	Zebrafish Fly
retinal ganglion cell axon guidance	GO:0031290	35	0.046
synapse organization	GO:0050808	21	0.046	Fly
cell cell recognition	GO:0009988	1	0.046
nuclear migration	GO:0007097	3	0.046
hepaticobiliary system development	GO:0061008	98	0.046
embryonic digestive tract morphogenesis	GO:0048557	3	0.046
embryonic heart tube development	GO:0035050	133	0.046	Zebrafish
establishment of localization	GO:0051234	244	0.046
muscle fiber development	GO:0048747	52	0.045
regulation of rna biosynthetic process	GO:2001141	213	0.045
ectodermal placode formation	GO:0060788	26	0.045	Zebrafish
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.045	Zebrafish Mouse Fly
regulation of nervous system development	GO:0051960	90	0.044	Fly
organic cyclic compound metabolic process	GO:1901360	301	0.044
negative regulation of reproductive process	GO:2000242	3	0.044
epidermis development	GO:0008544	48	0.044
innate immune response	GO:0045087	13	0.044
embryonic skeletal joint morphogenesis	GO:0060272	3	0.044
blood vessel endothelial cell migration	GO:0043534	18	0.044
negative regulation of programmed cell death	GO:0043069	58	0.044
positive regulation of cell proliferation	GO:0008284	15	0.043
regulation of protein ubiquitination	GO:0031396	3	0.043
epithelial tube morphogenesis	GO:0060562	148	0.043	Zebrafish Fly
aging	GO:0007568	2	0.043
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.043
regulation of collateral sprouting in absence of injury	GO:0048696	4	0.042
myeloid cell development	GO:0061515	32	0.042
energy reserve metabolic process	GO:0006112	2	0.042
response to xenobiotic stimulus	GO:0009410	45	0.042
regulation of dna replication	GO:0006275	3	0.042
regulation of dna templated transcription in response to stress	GO:0043620	0	0.042
anatomical structure arrangement	GO:0048532	2	0.042
lateral mesoderm development	GO:0048368	23	0.042
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.041
cell death	GO:0008219	121	0.041
neuron differentiation	GO:0030182	353	0.041
regulation of meiotic cell cycle	GO:0051445	1	0.041	Worm
neurological system process	GO:0050877	62	0.041
membrane fusion	GO:0061025	2	0.040
fin development	GO:0033333	77	0.040
regulation of nucleocytoplasmic transport	GO:0046822	2	0.040
axonogenesis involved in innervation	GO:0060385	1	0.040
centrosome organization	GO:0051297	1	0.040
muscle structure development	GO:0061061	196	0.040
regulation of membrane potential	GO:0042391	23	0.040
regulation of striated muscle tissue development	GO:0016202	6	0.039
regulation of protein localization to nucleus	GO:1900180	2	0.039
purine ribonucleotide metabolic process	GO:0009150	27	0.038
regulation of heart morphogenesis	GO:2000826	17	0.038	Zebrafish
diencephalon development	GO:0021536	58	0.038
establishment of organelle localization	GO:0051656	45	0.038
cell projection morphogenesis	GO:0048858	244	0.038
regulation of collateral sprouting	GO:0048670	7	0.038
sensory organ morphogenesis	GO:0090596	200	0.038	Zebrafish Fly
organelle assembly	GO:0070925	110	0.038
hair cell differentiation	GO:0035315	32	0.037
establishment of localization in cell	GO:0051649	77	0.037
nuclear import	GO:0051170	3	0.037
negative regulation of cell death	GO:0060548	60	0.037
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.037	Zebrafish Mouse Fly
tissue migration	GO:0090130	37	0.037
protein targeting to nucleus	GO:0044744	3	0.036
regulation of heart growth	GO:0060420	2	0.036
regulation of phosphorus metabolic process	GO:0051174	43	0.036
skeletal muscle organ development	GO:0060538	78	0.036
ectodermal placode morphogenesis	GO:0071697	32	0.035	Zebrafish
regulation of epithelial cell proliferation	GO:0050678	3	0.035
ion homeostasis	GO:0050801	41	0.035
cellular response to chemical stimulus	GO:0070887	157	0.035	Mouse Fly
innervation	GO:0060384	3	0.035
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.035
female gonad development	GO:0008585	4	0.035
peripheral nervous system development	GO:0007422	55	0.035
positive regulation of cellular component organization	GO:0051130	13	0.035	Fly
positive regulation of reproductive process	GO:2000243	2	0.035	Zebrafish
regulation of transmembrane transport	GO:0034762	18	0.035
mitotic g2 dna damage checkpoint	GO:0007095	3	0.035
response to mechanical stimulus	GO:0009612	24	0.035
female gamete generation	GO:0007292	14	0.034	Zebrafish Fly
negative regulation of axon extension	GO:0030517	7	0.034
endocardial cushion formation	GO:0003272	2	0.034
regulation of localization	GO:0032879	104	0.034
positive regulation of cellular process	GO:0048522	201	0.034	Zebrafish Mouse Worm Fly
body morphogenesis	GO:0010171	16	0.034
calcium ion transport	GO:0006816	18	0.034
embryonic digestive tract development	GO:0048566	4	0.034
spindle localization	GO:0051653	12	0.034
neuron recognition	GO:0008038	18	0.034
meiotic chromosome segregation	GO:0045132	3	0.034
positive regulation of apoptotic process	GO:0043065	29	0.034
regulation of cellular metabolic process	GO:0031323	320	0.034
response to abiotic stimulus	GO:0009628	122	0.034
endodermal cell differentiation	GO:0035987	19	0.034	Fly
secondary metabolic process	GO:0019748	3	0.034
lymph vessel development	GO:0001945	27	0.033
programmed cell death	GO:0012501	119	0.033
regulation of response to cytokine stimulus	GO:0060759	3	0.033
single organism biosynthetic process	GO:0044711	71	0.033
negative regulation of phosphorus metabolic process	GO:0010563	13	0.033
establishment of cell polarity	GO:0030010	18	0.033
regulation of stem cell differentiation	GO:2000736	4	0.033
septum transversum development	GO:0003343	4	0.033
organic substance biosynthetic process	GO:1901576	289	0.033
homeostatic process	GO:0042592	142	0.033	Mouse
protein phosphorylation	GO:0006468	47	0.032	Mouse
collateral sprouting of intact axon in response to injury	GO:0048673	2	0.032
negative regulation of gene expression	GO:0010629	65	0.032
response to alkaloid	GO:0043279	2	0.032
mesodermal cell fate specification	GO:0007501	12	0.032
membrane invagination	GO:0010324	1	0.032
neural retina development	GO:0003407	49	0.032
cellular localization	GO:0051641	97	0.032
extrinsic apoptotic signaling pathway	GO:0097191	3	0.032
digestive tract mesoderm development	GO:0007502	1	0.032
regulation of cardiac muscle tissue development	GO:0055024	1	0.031
regulation of apoptotic process	GO:0042981	98	0.031
cell proliferation	GO:0008283	80	0.031	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.031
regulation of establishment of protein localization	GO:0070201	4	0.031
positive regulation of catabolic process	GO:0009896	4	0.031
regulation of oocyte development	GO:0060281	3	0.031	Zebrafish
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	1	0.031
embryonic heart tube morphogenesis	GO:0003143	108	0.031	Zebrafish

smad1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.710
disease of cellular proliferation	DOID:14566	0.105
organ system cancer	DOID:0050686	0.105
cancer	DOID:162	0.105
nervous system disease	DOID:863	0.036

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