Danio rerio

60 known processes

spry2

sprouty homolog 2

(Aliases: wu:fk93e11,wu:fk66h11,zgc:110440)

spry2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
hindbrain developmentGO:0030902910.857
eye field cell fate commitment involved in camera type eye formationGO:006089830.852
neuron differentiationGO:00301823530.852
regionalizationGO:00030022740.758
type b pancreatic cell proliferationGO:004434210.748
head developmentGO:00603223030.657
central nervous system developmentGO:00074173870.640
response to external stimulusGO:00096052640.621
digestive tract morphogenesisGO:00485462310.599
mesodermal cell differentiationGO:0048333210.597
chordate embryonic developmentGO:00430092710.585
regulation of metabolic processGO:00192223590.566
cell fate commitment involved in formation of primary germ layerGO:0060795260.564
generation of neuronsGO:00486993850.547
non canonical wnt signaling pathway involved in heart developmentGO:006134120.545
carbohydrate derivative biosynthetic processGO:1901137430.540
stem cell proliferationGO:007208940.519
brain developmentGO:00074202930.516
hematopoietic or lymphoid organ developmentGO:00485341910.513
immune system processGO:00023762410.492
anterior posterior pattern specificationGO:00099521520.492
cellular component morphogenesisGO:00329893360.479
sensory organ morphogenesisGO:00905962000.478
cell projection organizationGO:00300302840.470
collateral sprouting in absence of injuryGO:004866940.461
positive regulation of programmed cell deathGO:0043068290.456
regulation of cell communicationGO:00106462320.452
response to stressGO:00069502630.451
regulation of response to stimulusGO:00485832690.433
convergent extension involved in gastrulationGO:0060027710.432
signal transductionGO:00071654550.429
neuroblast proliferationGO:000740520.428
axon guidanceGO:0007411860.423
retina development in camera type eyeGO:00600411460.421
regulation of signalingGO:00230512350.420
stem cell maintenanceGO:001982740.419
dorsal convergenceGO:0060030140.418
central nervous system neuron differentiationGO:0021953740.416
aromatic compound biosynthetic processGO:00194382170.411
larval developmentGO:000216420.398
embryonic camera type eye developmentGO:0031076290.395
localization of cellGO:00516742440.381
cell cycleGO:0007049930.367
regulation of multicellular organismal developmentGO:20000262230.367
optic placode formation involved in camera type eye formationGO:004661930.361
neural tube developmentGO:0021915620.352
regulation of wnt signaling pathwayGO:0030111530.347
cellular macromolecule metabolic processGO:00442603910.346
spinal cord radial glial cell differentiationGO:002153120.343
nephron morphogenesisGO:007202820.339
ectodermal placode formationGO:0060788260.328
heart developmentGO:00075073130.324
morphogenesis of embryonic epitheliumGO:0016331300.324
nuclear transportGO:005116940.308
camera type eye developmentGO:00430102220.308
cell fate commitmentGO:0045165990.298
camera type eye morphogenesisGO:00485931080.293
fin regenerationGO:0031101510.292
gastrulationGO:00073692080.285
wnt signaling pathwayGO:0016055800.284
mesoderm developmentGO:0007498880.283
gall bladder developmentGO:006101010.277
negative regulation of protein phosphorylationGO:000193340.273
negative regulation of protein kinase activityGO:000646940.272
female gonad developmentGO:000858540.272
pancreas developmentGO:0031016840.272
gastrulation with mouth forming secondGO:0001702440.269
nuclear migrationGO:000709730.267
ear morphogenesisGO:0042471640.266
regulation of gene expressionGO:00104682650.259
rhombomere boundary formationGO:0021654100.253
spinal cord anterior posterior patterningGO:002151210.251
immune system developmentGO:00025201910.251
locomotionGO:00400113130.247
neuron developmentGO:00486662620.240
negative regulation of mapk cascadeGO:004340940.236
macromolecule biosynthetic processGO:00090592270.236
endodermal cell fate commitmentGO:0001711180.230
forebrain regionalizationGO:002187140.229
regulation of nervous system developmentGO:0051960900.228
regenerationGO:0031099910.225
homeostatic processGO:00425921420.225
positive regulation of biological processGO:00485182530.223
negative regulation of signalingGO:0023057960.220
dorsal ventral pattern formationGO:00099531250.216
regulation of canonical wnt signaling pathwayGO:0060828340.215
phosphorylationGO:0016310690.211
regulation of wnt signaling pathway involved in digestive tract morphogenesisGO:200005620.209
glomerular epithelial cell fate commitmentGO:007231440.209
blood vessel developmentGO:00015682460.207
embryo development ending in birth or egg hatchingGO:00097922710.205
response to monosaccharideGO:003428430.205
gland developmentGO:00487321430.202
heterocycle biosynthetic processGO:00181302150.201
metencephalon developmentGO:0022037270.198
regulation of cell cycleGO:0051726520.198
ectodermal placode morphogenesisGO:0071697320.198
rhombomere morphogenesisGO:0021593170.198
response to endogenous stimulusGO:0009719830.196
eye developmentGO:00016542770.192
nephron tubule morphogenesisGO:007207810.191
response to woundingGO:00096111160.190
optic placode formationGO:000174340.188
peptide transportGO:001583310.186
cellular response to growth factor stimulusGO:0071363390.186
regulation of cellular metabolic processGO:00313233200.185
ectodermal placode developmentGO:0071696370.180
heart morphogenesisGO:00030071560.178
medulla oblongata developmentGO:002155040.178
protein metabolic processGO:00195381830.177
positive regulation of oocyte developmentGO:006028210.177
formation of primary germ layerGO:0001704620.175
skin developmentGO:0043588540.175
negative regulation of map kinase activityGO:004340720.174
regulation of catalytic activityGO:0050790550.173
regulation of protein targetingGO:190353320.172
axon developmentGO:00615641660.171
intracellular signal transductionGO:0035556850.169
eye morphogenesisGO:00485921440.168
single organism metabolic processGO:00447102170.168
sensory system developmentGO:0048880760.168
rhombomere developmentGO:0021546190.166
negative regulation of cellular processGO:00485232830.166
positive regulation of jnk cascadeGO:004633030.165
negative regulation of canonical wnt signaling pathwayGO:0090090210.165
organic substance biosynthetic processGO:19015762890.164
response to organic substanceGO:00100331530.164
astrocyte differentiationGO:004870810.162
neural tube formationGO:0001841160.162
epithelium regenerationGO:1990399140.162
ectoderm developmentGO:000739890.158
regulation of cell differentiationGO:00455951420.157
sensory organ developmentGO:00074233930.157
phosphate containing compound metabolic processGO:00067961080.156
response to biotic stimulusGO:0009607970.156
positive regulation of signalingGO:0023056560.155
sequestering of metal ionGO:005123830.155
regulation of macromolecule biosynthetic processGO:00105562250.153
protein import into nucleusGO:000660630.150
biosynthetic processGO:00090582940.149
response to growth factorGO:0070848390.148
tube formationGO:0035148250.147
regulation of programmed cell deathGO:00430671010.147
renal tubule morphogenesisGO:006133310.146
forebrain anterior posterior pattern specificationGO:002179730.146
neuron projection developmentGO:00311751800.145
cellular nitrogen compound biosynthetic processGO:00442712180.142
cell morphogenesisGO:00009022890.142
canonical wnt signaling pathwayGO:0060070480.142
protein localization to nucleusGO:003450430.142
vasculature developmentGO:00019442780.141
cellular lipid catabolic processGO:004424230.141
cellular aromatic compound metabolic processGO:00067252950.140
negative regulation of collateral sprouting of intact axon in response to injuryGO:004868520.139
regulation of signal transductionGO:00099662250.137
cellular amine metabolic processGO:004410620.134
cellular response to nutrient levelsGO:003166920.133
organic cyclic compound biosynthetic processGO:19013622230.132
cell proliferationGO:0008283800.129
negative regulation of phosphate metabolic processGO:0045936130.128
regulation of wnt signaling pathway calcium modulating pathwayGO:000859130.127
negative regulation of kinase activityGO:003367340.126
leukocyte differentiationGO:0002521250.126
regulation of intracellular signal transductionGO:1902531570.124
development of primary female sexual characteristicsGO:004654540.123
cell part morphogenesisGO:00329902460.123
nucleocytoplasmic transportGO:000691340.122
morphogenesis of an epithelial sheetGO:0002011490.120
cellular response to chemical stimulusGO:00708871570.120
taxisGO:00423301090.120
cell projection morphogenesisGO:00488582440.120
epidermis developmentGO:0008544480.119
cell migrationGO:00164772370.119
cellular macromolecule biosynthetic processGO:00346452240.117
endoderm developmentGO:0007492490.117
regulation of primary metabolic processGO:00800903110.116
muscle cell migrationGO:001481240.115
hemopoiesisGO:00300971830.115
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.114
glial cell differentiationGO:0010001420.114
endodermal cell fate determinationGO:000749320.114
somite developmentGO:0061053960.114
tube closureGO:006060610.113
embryonic skeletal system morphogenesisGO:0048704930.111
regulation of sequestering of calcium ionGO:005128240.111
carboxylic acid metabolic processGO:0019752220.110
apoptotic processGO:00069151160.110
wnt signaling pathway involved in somitogenesisGO:009024420.109
female sex differentiationGO:004666040.109
morphogenesis of an epitheliumGO:00020093330.109
epithelial tube morphogenesisGO:00605621480.108
amine metabolic processGO:000930820.108
gene expressionGO:00104672520.108
regulation of cell developmentGO:00602841000.106
single organism reproductive processGO:0044702400.106
regulation of multicellular organismal processGO:00512392770.105
regulation of cytoplasmic transportGO:190364940.105
negative regulation of biological processGO:00485193040.103
cell morphogenesis involved in differentiationGO:00009041950.103
blood vessel morphogenesisGO:00485142160.102
retina morphogenesis in camera type eyeGO:0060042790.101
positive regulation of cellular metabolic processGO:0031325940.100
regulation of cellular amino acid metabolic processGO:000652100.099
mesodermal cell fate commitmentGO:0001710140.099
response to other organismGO:0051707970.099
hepatic duct developmentGO:006101120.098
regulation of transcription dna templatedGO:00063552130.097
axonogenesisGO:00074091520.096
embryonic eye morphogenesisGO:0048048300.096
organonitrogen compound metabolic processGO:1901564740.096
carbohydrate derivative metabolic processGO:1901135610.096
hindbrain morphogenesisGO:0021575220.096
single organism nuclear importGO:190259330.095
regulation of establishment of protein localizationGO:007020140.095
peptidyl threonine phosphorylationGO:001810710.092
positive regulation of metabolic processGO:00098931080.092
rna biosynthetic processGO:00327741810.091
nucleic acid metabolic processGO:00903042440.091
cell surface receptor signaling pathwayGO:00071663250.091
negative regulation of cell communicationGO:0010648960.091
endoderm formationGO:0001706290.090
somatic muscle developmentGO:000752540.090
single organism cell adhesionGO:0098602290.090
regulation of response to stressGO:0080134360.089
positive regulation of cell activationGO:005086710.088
small molecule metabolic processGO:0044281770.087
establishment of localizationGO:00512342440.087
rhombomere formationGO:0021594120.087
regulation of protein metabolic processGO:0051246560.087
organonitrogen compound biosynthetic processGO:1901566470.086
protein modification processGO:00362111000.086
regulation of gastrulationGO:0010470240.084
cellular carbohydrate metabolic processGO:004426240.084
nucleic acid templated transcriptionGO:00976591810.083
chemotaxisGO:00069351040.082
embryonic epithelial tube formationGO:0001838170.082
cellular response to external stimulusGO:007149620.082
behaviorGO:0007610740.081
response to external biotic stimulusGO:0043207970.080
positive regulation of cellular amino acid metabolic processGO:004576400.080
regulation of mesodermal cell fate specificationGO:004266190.080
regulation of developmental processGO:00507932470.080
cell morphogenesis involved in neuron differentiationGO:00486671630.079
regulation of protein polymerizationGO:003227120.079
non canonical wnt signaling pathwayGO:0035567130.079
hard palate developmentGO:006002240.078
cellular response to dna damage stimulusGO:0006974240.078
positive regulation of cellular component biogenesisGO:004408930.078
cellular protein metabolic processGO:00442671290.078
negative regulation of fibroblast growth factor receptor signaling pathwayGO:004003760.078
post anal tail morphogenesisGO:0036342190.077
enzyme linked receptor protein signaling pathwayGO:00071671060.077
regulation of purine nucleotide metabolic processGO:1900542170.077
cilium morphogenesisGO:0060271850.077
positive regulation of stress activated mapk cascadeGO:003287430.076
transportGO:00068102200.076
wnt signaling pathway involved in digestive tract morphogenesisGO:004433340.075
neural plate pattern specificationGO:0060896120.075
lipid storageGO:001991510.074
regulation of extent of cell growthGO:0061387290.074
regulation of cellular response to growth factor stimulusGO:0090287350.074
regulation of cellular ketone metabolic processGO:001056570.073
regulation of endodermal cell differentiationGO:1903224150.073
protein importGO:001703830.073
glucose homeostasisGO:004259310.072
stem cell differentiationGO:00488631170.072
positive regulation of wnt signaling pathwayGO:0030177130.071
organic acid metabolic processGO:0006082310.071
regulation of biological qualityGO:00650082630.070
inorganic anion transportGO:0015698250.070
regulation of purine nucleotide catabolic processGO:003312120.070
epithelial cell differentiationGO:00308551160.069
oxoacid metabolic processGO:0043436310.069
forebrain neuron differentiationGO:0021879140.068
mitotic cell cycle processGO:1903047480.068
regulation of epithelial cell proliferationGO:005067830.068
tube morphogenesisGO:00352393490.068
regulation of collateral sprouting in absence of injuryGO:004869640.068
cellular localizationGO:0051641970.068
protein stabilizationGO:005082120.067
collateral sprouting of intact axon in response to injuryGO:004867320.067
cellular component movementGO:00069283350.066
adherens junction organizationGO:003433240.066
oxidation reduction processGO:0055114410.066
regulation of protein localization to nucleusGO:190018020.066
response to vitaminGO:003327330.066
developmental growthGO:00485891660.065
regulation of wound healingGO:006104120.065
cranial nerve morphogenesisGO:0021602150.065
cellular biosynthetic processGO:00442492860.065
regulation of synapse assemblyGO:005196330.065
hormone biosynthetic processGO:004244630.064
negative regulation of collateral sproutingGO:004867120.063
regulation of production of molecular mediator of immune responseGO:000270010.063
positive regulation of cellular processGO:00485222010.062
negative regulation of cytoplasmic transportGO:190365020.062
positive regulation of apoptotic processGO:0043065290.061
posterior lateral line system developmentGO:0048915460.061
negative regulation of wnt signaling pathwayGO:0030178300.061
diterpenoid metabolic processGO:0016101150.061
regulation of intracellular protein transportGO:003315730.061
peptidyl threonine modificationGO:001821010.061
single organism biosynthetic processGO:0044711710.061
response to chemicalGO:00422213200.061
negative regulation of metabolic processGO:0009892860.059
germ line stem cell divisionGO:004207810.059
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.059
epithelial tube formationGO:0072175190.059
organic cyclic compound metabolic processGO:19013603010.059
positive regulation of map kinase activityGO:004340630.059
mitotic cell cycleGO:0000278640.058
regulation of cell proliferationGO:0042127370.058
actin filament polymerizationGO:003004120.058
positive regulation of biosynthetic processGO:0009891680.058
determination of heart left right asymmetryGO:00613711170.058
positive regulation of neuron apoptotic processGO:004352510.058
nucleobase containing compound biosynthetic processGO:00346542050.058
regulation of apoptotic processGO:0042981980.058
cell differentiation in spinal cordGO:0021515400.057
cellular response to endogenous stimulusGO:0071495680.057
tissue regenerationGO:0042246740.057
regulation of growthGO:0040008420.057
pronuclear migrationGO:003504610.057
positive regulation of nitrogen compound metabolic processGO:0051173690.057
establishment or maintenance of apical basal cell polarityGO:0035088120.057
phosphatidylinositol mediated signalingGO:004801520.057
negative regulation of muscle tissue developmentGO:190186220.056
multi organism reproductive processGO:0044703360.056
multi organism processGO:00517041340.056
phosphorus metabolic processGO:00067931090.056
cellular component biogenesisGO:00440851780.056
posterior lateral line developmentGO:0048916380.056
negative regulation of apoptotic processGO:0043066550.056
establishment of organelle localizationGO:0051656450.056
regulation of bmp signaling pathway involved in heart joggingGO:2000223120.055
programmed cell deathGO:00125011190.055
single organism localizationGO:19025782250.055
response to carbohydrateGO:000974330.055
regulation of organ growthGO:004662030.055
retinoid metabolic processGO:0001523150.055
deathGO:00162651210.055
negative regulation of phosphorylationGO:004232660.054
stem cell divisionGO:001714510.054
negative regulation of cellular catabolic processGO:003133030.054
epibolyGO:0090504410.053
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathwayGO:002200210.052
mesoderm formationGO:0001707430.052
regulation of embryonic developmentGO:0045995470.052
positive regulation of cell cycleGO:004578730.052
negative regulation of cellular metabolic processGO:0031324770.051
transcription dna templatedGO:00063511810.051
response to nutrientGO:000758430.051
regulation of cell deathGO:00109411030.051
liver developmentGO:0001889960.050
oocyte maturationGO:000155640.050
purine ribonucleotide metabolic processGO:0009150270.050
regulation of oocyte developmentGO:006028130.050
positive regulation of molecular functionGO:0044093330.050
regulation of stem cell differentiationGO:200073640.049
swim bladder developmentGO:0048794190.049
glycoprotein metabolic processGO:0009100230.049
angioblast cell migration involved in selective angioblast sproutingGO:003547540.049
lamellipodium assemblyGO:003003210.049
mediolateral intercalationGO:006003130.049
response to organic cyclic compoundGO:0014070510.048
cerebellum morphogenesisGO:0021587100.048
negative regulation of catabolic processGO:000989530.047
regulation of reproductive processGO:200024140.047
glycoprotein biosynthetic processGO:0009101210.047
cellular response to extracellular stimulusGO:003166820.047
hormone secretionGO:004687920.047
regulation of cellular amine metabolic processGO:003323800.047
cilium assemblyGO:0042384580.047
adherens junction maintenanceGO:003433420.047
single organism transportGO:00447652060.047
segmentationGO:0035282970.047
regulation of macromolecule metabolic processGO:00602553170.046
negative regulation of intracellular transportGO:003238730.046
regulation of phosphate metabolic processGO:0019220430.046
regulation of cellular component organizationGO:0051128860.046
neural nucleus developmentGO:0048857150.046
response to glucoseGO:000974930.045
canonical wnt signaling pathway involved in heart developmentGO:006131610.045
heterocycle metabolic processGO:00464832900.045
germ cell developmentGO:0007281220.045
protein targeting to nucleusGO:004474430.045
receptor internalizationGO:003162320.045
nitrogen compound metabolic processGO:00068073190.045
regulation of circadian sleep wake cycle sleepGO:004518710.045
purine nucleotide metabolic processGO:0006163270.045
gliogenesisGO:0042063450.045
establishment of localization in cellGO:0051649770.045
cellular lipid metabolic processGO:0044255360.044
endocrine pancreas developmentGO:0031018270.044
embryonic organ morphogenesisGO:00485622740.044
regulation of cell migrationGO:0030334400.044
sequestering of calcium ionGO:005120830.044
regulation of neuron differentiationGO:0045664560.044
positive regulation of macromolecule metabolic processGO:0010604930.044
spindle localizationGO:0051653120.043
cartilage developmentGO:0051216960.043
ear developmentGO:00435831270.043
angioblast cell migrationGO:003547690.043
sensory neuron axon guidanceGO:009737430.043
lipid catabolic processGO:001604240.043
neural precursor cell proliferationGO:0061351200.042
multicellular organism growthGO:003526440.042
heart rudiment formationGO:000331550.042
mechanosensory lateral line system developmentGO:0048881490.042
regulation of tube sizeGO:003515020.042
nephron epithelium developmentGO:0072009160.042
nitrogen compound transportGO:0071705230.041
negative regulation of phosphorus metabolic processGO:0010563130.041
positive regulation of transportGO:005105020.041
positive regulation of reproductive processGO:200024320.041
regulation of phosphorus metabolic processGO:0051174430.041
fertilizationGO:000956630.041
regulation of nucleotide catabolic processGO:003081120.040
signal transduction by phosphorylationGO:0023014180.040
regulation of erk1 and erk2 cascadeGO:007037240.040
cell motilityGO:00488702440.040
neuron projection morphogenesisGO:00488121610.040
maintenance of locationGO:005123540.040
regulation of nucleoside metabolic processGO:000911820.040
regulation of protein import into nucleusGO:004230620.040
negative regulation of sequestering of calcium ionGO:005128340.040
appendage developmentGO:0048736800.040
single fertilizationGO:000733830.040
muscle structure developmentGO:00610611960.040
positive regulation of nucleic acid templated transcriptionGO:1903508570.039
regulation of anatomical structure sizeGO:0090066330.039
epithelial cell proliferation involved in liver morphogenesisGO:007257520.039
regulation of rna metabolic processGO:00512522240.039
release of sequestered calcium ion into cytosolGO:005120930.039
negative regulation of striated muscle tissue developmentGO:004584320.039
digestive tract developmentGO:00485652650.039
brain morphogenesisGO:0048854180.039
embryonic skeletal joint morphogenesisGO:006027230.038
neuron projection guidanceGO:0097485860.038
artery developmentGO:0060840220.038
otic vesicle developmentGO:0071599420.038
regulation of multicellular organism growthGO:004001440.038
negative regulation of macromolecule metabolic processGO:0010605760.038
regulation of rna biosynthetic processGO:20011412130.038
regulation of nucleocytoplasmic transportGO:004682220.038
regulation of immune system processGO:0002682340.038
female gamete generationGO:0007292140.038
nucleoside phosphate metabolic processGO:0006753280.037
facial nucleus developmentGO:002175470.037
embryonic organ developmentGO:00485683810.037
positive regulation of inflammatory responseGO:005072910.037
regulation of reactive oxygen species metabolic processGO:200037720.037
intracellular transportGO:0046907320.037
positive regulation of striated muscle tissue developmentGO:004584410.037
embryonic limb morphogenesisGO:003032620.037
regulation of mitotic cell cycleGO:0007346250.037
nuclear importGO:005117030.037
cellular protein modification processGO:00064641000.036
locomotory behaviorGO:0007626340.036
rhythmic processGO:0048511210.036
regulation of inflammatory responseGO:005072720.036
negative regulation of protein serine threonine kinase activityGO:007190120.036
system processGO:00030081850.036
regulation of biosynthetic processGO:00098892500.036
cell projection assemblyGO:0030031640.036
cerebellum developmentGO:0021549170.036
positive regulation of epithelial cell proliferationGO:005067910.036
microtubule based processGO:0007017600.036
synaptic growth at neuromuscular junctionGO:005112420.036
dorsal ventral axis specificationGO:0009950140.036
heart loopingGO:0001947940.036
carbohydrate biosynthetic processGO:001605110.036
organophosphate biosynthetic processGO:0090407230.036
nucleotide biosynthetic processGO:0009165210.036
regulation of protein complex assemblyGO:004325430.035
positive regulation of cell deathGO:0010942290.035
extrinsic apoptotic signaling pathwayGO:009719130.035
positive regulation of cellular amine metabolic processGO:003324000.035
multicellular organism reproductionGO:0032504350.035
positive regulation of developmental processGO:0051094500.035
circadian sleep wake cycleGO:004274520.035
regulation of organ morphogenesisGO:2000027350.035
embryonic heart tube developmentGO:00350501330.035
nuclear exportGO:005116810.035
cell proliferation in forebrainGO:002184630.035
negative regulation of intracellular signal transductionGO:1902532220.035
primary neural tube formationGO:001402010.035
urogenital system developmentGO:0001655970.035
renal system developmentGO:0072001940.035
regulation of phosphorylationGO:0042325260.034
cell cycle processGO:0022402530.034
otic vesicle morphogenesisGO:0071600340.034
otic placode formationGO:0043049230.034

spry2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.052
dysostosisDOID:193400.052
bone development diseaseDOID:008000600.052
bone diseaseDOID:008000100.052
connective tissue diseaseDOID:6500.052
disease of anatomical entityDOID:700.052