IMP: Integrative Multi-species Prediction

Danio rerio

77 known processes

esr2a

estrogen receptor 2a

(Aliases: ER[b]2,ER[b]a,zfER-beta2,zfER[b]2)

ZFIN: ZDB-GENE-030116-2
Entrez: 317734
Ensembl: ENSDARG00000016454
UniProtKB: Q7ZU32

Process Predictions
Disease Predictions

esr2a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
steroid hormone mediated signaling pathway	GO:0043401	9	1.000
hormone mediated signaling pathway	GO:0009755	9	0.997
heterocycle biosynthetic process	GO:0018130	215	0.864
organic cyclic compound biosynthetic process	GO:1901362	223	0.857
camera type eye development	GO:0043010	222	0.804
negative regulation of cellular process	GO:0048523	283	0.795	Human Mouse Rat
regulation of macromolecule biosynthetic process	GO:0010556	225	0.772
locomotion	GO:0040011	313	0.732	Zebrafish Mouse
cellular response to hormone stimulus	GO:0032870	39	0.708
cell surface receptor signaling pathway	GO:0007166	325	0.703	Rat
cellular response to estrogen stimulus	GO:0071391	24	0.653	Zebrafish Rat
multicellular organism growth	GO:0035264	4	0.625
regulation of cell communication	GO:0010646	232	0.625	Mouse Rat
intracellular receptor signaling pathway	GO:0030522	30	0.618
otolith formation	GO:0032475	2	0.612	Zebrafish
response to dexamethasone	GO:0071548	1	0.581	Rat
regulation of signal transduction	GO:0009966	225	0.556	Mouse Rat
nucleobase containing compound biosynthetic process	GO:0034654	205	0.548
response to organic substance	GO:0010033	153	0.546
signal transduction	GO:0007165	455	0.519
organic substance biosynthetic process	GO:1901576	289	0.513
biosynthetic process	GO:0009058	294	0.510
cellular macromolecule metabolic process	GO:0044260	391	0.497
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.494
regulation of cellular metabolic process	GO:0031323	320	0.483
intracellular estrogen receptor signaling pathway	GO:0030520	3	0.471
aromatic compound biosynthetic process	GO:0019438	217	0.470
cellular response to chemical stimulus	GO:0070887	157	0.453
regulation of biosynthetic process	GO:0009889	250	0.448
rna metabolic process	GO:0016070	219	0.437
regulation of nucleic acid templated transcription	GO:1903506	213	0.429
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.423	Human Rat
cellular response to steroid hormone stimulus	GO:0071383	31	0.421
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.392	Human Rat
regulation of gene expression	GO:0010468	265	0.389
carbohydrate metabolic process	GO:0005975	12	0.376	Fly
nucleic acid templated transcription	GO:0097659	181	0.376
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.373	Rat
g protein coupled receptor signaling pathway	GO:0007186	74	0.371
regulation of developmental process	GO:0050793	247	0.362
sensory organ development	GO:0007423	393	0.358	Zebrafish
regulation of signaling	GO:0023051	235	0.355	Mouse Rat
regulation of multicellular organismal process	GO:0051239	277	0.338
determination of left right symmetry	GO:0007368	179	0.337
purine nucleotide biosynthetic process	GO:0006164	20	0.324
gland development	GO:0048732	143	0.321	Mouse Rat
positive regulation of gene expression	GO:0010628	71	0.320	Rat
cell cell signaling	GO:0007267	52	0.318
regulation of primary metabolic process	GO:0080090	311	0.313
growth	GO:0040007	174	0.311
transcription from rna polymerase ii promoter	GO:0006366	80	0.306
determination of heart left right asymmetry	GO:0061371	117	0.303
negative regulation of biological process	GO:0048519	304	0.292	Human Mouse Rat
homeostatic process	GO:0042592	142	0.281
programmed cell death	GO:0012501	119	0.277	Mouse Rat
chemical homeostasis	GO:0048878	49	0.276
regulation of macromolecule metabolic process	GO:0060255	317	0.274
response to stress	GO:0006950	263	0.274	Rat
embryonic organ development	GO:0048568	381	0.249	Zebrafish
regulation of cell death	GO:0010941	103	0.243	Rat
heart development	GO:0007507	313	0.239
regulation of rna metabolic process	GO:0051252	224	0.233
organic cyclic compound metabolic process	GO:1901360	301	0.232
cellular biosynthetic process	GO:0044249	286	0.230
apoptotic process	GO:0006915	116	0.228	Mouse Rat
maintenance of location	GO:0051235	4	0.228
glucose homeostasis	GO:0042593	1	0.224
positive regulation of cellular biosynthetic process	GO:0031328	68	0.222	Rat
positive regulation of signal transduction	GO:0009967	56	0.216	Rat
regulation of transcription dna templated	GO:0006355	213	0.210
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.208	Rat
positive regulation of rna metabolic process	GO:0051254	59	0.205	Rat
cellular macromolecule biosynthetic process	GO:0034645	224	0.201
establishment of localization in cell	GO:0051649	77	0.201
sensory organ morphogenesis	GO:0090596	200	0.195	Zebrafish
gastrulation	GO:0007369	208	0.190	Zebrafish
regulation of multicellular organism growth	GO:0040014	4	0.187
macromolecule biosynthetic process	GO:0009059	227	0.186
negative regulation of biosynthetic process	GO:0009890	55	0.182	Human Rat
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.180
regulation of cardiac muscle tissue development	GO:0055024	1	0.178
positive regulation of response to stimulus	GO:0048584	80	0.176	Rat
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.172	Human Rat
response to hormone	GO:0009725	48	0.171
embryonic organ morphogenesis	GO:0048562	274	0.169	Zebrafish
rna biosynthetic process	GO:0032774	181	0.165
lipid metabolic process	GO:0006629	52	0.164
negative regulation of cellular biosynthetic process	GO:0031327	55	0.162	Human Rat
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.150
eye morphogenesis	GO:0048592	144	0.149
protein metabolic process	GO:0019538	183	0.147
regulation of phosphorus metabolic process	GO:0051174	43	0.147	Rat
regulation of nervous system development	GO:0051960	90	0.146
negative regulation of innate immune response	GO:0045824	2	0.145
specification of symmetry	GO:0009799	204	0.145
response to lipid	GO:0033993	60	0.141
gene expression	GO:0010467	252	0.138
regulation of cellular biosynthetic process	GO:0031326	245	0.138
response to oxygen containing compound	GO:1901700	55	0.136	Zebrafish Rat
developmental growth	GO:0048589	166	0.133
positive regulation of metabolic process	GO:0009893	108	0.130	Rat
cellular component movement	GO:0006928	335	0.125	Zebrafish Mouse
nitrogen compound metabolic process	GO:0006807	319	0.122
regulation of response to oxidative stress	GO:1902882	2	0.119
light adaption	GO:0036367	1	0.118
response to alkaloid	GO:0043279	2	0.116
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.116	Human Rat
positive regulation of transcription dna templated	GO:0045893	57	0.112	Rat
regulation of rna biosynthetic process	GO:2001141	213	0.111
hormone secretion	GO:0046879	2	0.110
transcription dna templated	GO:0006351	181	0.110
response to chemical	GO:0042221	320	0.108
cation homeostasis	GO:0055080	33	0.107
ovulation cycle	GO:0042698	2	0.105	Mouse Rat
cell projection morphogenesis	GO:0048858	244	0.102
single organism transport	GO:0044765	206	0.101
cellular response to estradiol stimulus	GO:0071392	1	0.101	Rat
rhythmic process	GO:0048511	21	0.100	Mouse Rat
response to external stimulus	GO:0009605	264	0.099	Rat
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.098	Rat
establishment of localization	GO:0051234	244	0.097
striated muscle cell differentiation	GO:0051146	129	0.095
hormone transport	GO:0009914	2	0.094
negative regulation of signal transduction	GO:0009968	94	0.094	Mouse
regulation of cellular protein metabolic process	GO:0032268	52	0.094
tube morphogenesis	GO:0035239	349	0.092	Zebrafish
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.091	Rat
dicarboxylic acid transport	GO:0006835	1	0.090
negative regulation of feeding behavior	GO:2000252	2	0.089	Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.088	Rat
negative regulation of response to stimulus	GO:0048585	104	0.087	Mouse Rat
positive regulation of rna biosynthetic process	GO:1902680	57	0.085	Rat
cellular localization	GO:0051641	97	0.084
single organism localization	GO:1902578	225	0.083
regulation of multicellular organismal development	GO:2000026	223	0.080
positive regulation of signaling	GO:0023056	56	0.079	Rat
larval development	GO:0002164	2	0.078
cell motility	GO:0048870	244	0.077	Zebrafish Mouse
organelle organization	GO:0006996	227	0.077
negative regulation of cell communication	GO:0010648	96	0.075	Mouse
carbohydrate homeostasis	GO:0033500	1	0.075
posterior lateral line neuromast primordium migration	GO:0048920	12	0.075	Zebrafish
macromolecule localization	GO:0033036	54	0.074
digestive tract morphogenesis	GO:0048546	231	0.074	Zebrafish
hepaticobiliary system development	GO:0061008	98	0.073
cellular protein metabolic process	GO:0044267	129	0.072
regulation of apoptotic process	GO:0042981	98	0.072	Rat
negative regulation of macromolecule metabolic process	GO:0010605	76	0.071	Human Rat
camera type eye morphogenesis	GO:0048593	108	0.070
localization of cell	GO:0051674	244	0.070	Zebrafish Mouse
phosphate containing compound metabolic process	GO:0006796	108	0.069	Rat
cellular response to organic substance	GO:0071310	105	0.069
macromolecule modification	GO:0043412	111	0.068
negative regulation of cellular metabolic process	GO:0031324	77	0.067	Human Rat
odontogenesis of dentin containing tooth	GO:0042475	1	0.066
regulation of response to stimulus	GO:0048583	269	0.066	Mouse Rat
negative regulation of gene expression	GO:0010629	65	0.066	Human Rat
ion homeostasis	GO:0050801	41	0.066
regulation of heart growth	GO:0060420	2	0.065
death	GO:0016265	121	0.065	Mouse Rat
stem cell division	GO:0017145	1	0.064
single organism metabolic process	GO:0044710	217	0.063	Rat
positive regulation of phosphate metabolic process	GO:0045937	21	0.063	Rat
embryonic heart tube morphogenesis	GO:0003143	108	0.063
positive regulation of macromolecule metabolic process	GO:0010604	93	0.063	Rat
liver development	GO:0001889	96	0.059
regionalization	GO:0003002	274	0.058
response to endogenous stimulus	GO:0009719	83	0.058
determination of bilateral symmetry	GO:0009855	204	0.057
intracellular signal transduction	GO:0035556	85	0.057	Rat
single organism biosynthetic process	GO:0044711	71	0.056
organic acid transport	GO:0015849	9	0.055
regulation of nitrogen compound metabolic process	GO:0051171	251	0.055
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.054
carboxylic acid transport	GO:0046942	8	0.053
regulation of localization	GO:0032879	104	0.053
regulation of intracellular signal transduction	GO:1902531	57	0.052	Rat
camp metabolic process	GO:0046058	11	0.051
cellular lipid metabolic process	GO:0044255	36	0.049
transport	GO:0006810	220	0.049
regulation of protein metabolic process	GO:0051246	56	0.049
positive regulation of cell communication	GO:0010647	56	0.048	Rat
system process	GO:0003008	185	0.048	Rat
negative regulation of apoptotic process	GO:0043066	55	0.047
regulation of blood vessel size	GO:0050880	2	0.045
regulation of phosphate metabolic process	GO:0019220	43	0.045	Rat
regulation of cellular component organization	GO:0051128	86	0.045
positive regulation of cellular metabolic process	GO:0031325	94	0.045	Rat
response to fibroblast growth factor	GO:0071774	22	0.045
nitrogen compound transport	GO:0071705	23	0.045
reflex	GO:0060004	2	0.044
negative regulation of cell death	GO:0060548	60	0.044	Rat
behavior	GO:0007610	74	0.043	Rat
triglyceride homeostasis	GO:0070328	2	0.043
anion transport	GO:0006820	38	0.042
regulation of cell development	GO:0060284	100	0.041
aging	GO:0007568	2	0.041
response to estradiol	GO:0032355	6	0.040	Zebrafish Rat
mesenchyme development	GO:0060485	127	0.040
kupffer s vesicle development	GO:0070121	50	0.039
organ growth	GO:0035265	12	0.039
lateral line system development	GO:0048925	76	0.038	Zebrafish
fin development	GO:0033333	77	0.038
mitochondrion organization	GO:0007005	4	0.037
cognition	GO:0050890	1	0.037	Rat
pancreas development	GO:0031016	84	0.037
lateral line development	GO:0048882	66	0.037	Zebrafish
cell death	GO:0008219	121	0.037	Mouse Rat
cellular response to oxygen containing compound	GO:1901701	20	0.036	Rat
response to cortisol	GO:0051414	1	0.036
regulation of carbohydrate metabolic process	GO:0006109	4	0.036
response to wounding	GO:0009611	116	0.036
heterocycle metabolic process	GO:0046483	290	0.035
cell projection organization	GO:0030030	284	0.035
cellular response to nitrogen compound	GO:1901699	6	0.035
primary amino compound biosynthetic process	GO:1901162	1	0.035
response to organic cyclic compound	GO:0014070	51	0.034
regulation of biological quality	GO:0065008	263	0.034
regulation of growth	GO:0040008	42	0.034
divalent inorganic cation homeostasis	GO:0072507	22	0.034
regulation of organ growth	GO:0046620	3	0.034
neuromast primordium migration	GO:0048883	12	0.034	Zebrafish
androgen metabolic process	GO:0008209	2	0.033
small molecule metabolic process	GO:0044281	77	0.033
organic hydroxy compound biosynthetic process	GO:1901617	6	0.033
posterior lateral line development	GO:0048916	38	0.033	Zebrafish
female gonad development	GO:0008585	4	0.033	Mouse Rat
hard palate development	GO:0060022	4	0.033
catechol containing compound biosynthetic process	GO:0009713	2	0.032
negative regulation of rna metabolic process	GO:0051253	48	0.032	Human Rat
positive regulation of biological process	GO:0048518	253	0.032	Human Rat
regulation of reactive oxygen species metabolic process	GO:2000377	2	0.032	Rat
nucleic acid metabolic process	GO:0090304	244	0.031
gamma aminobutyric acid signaling pathway	GO:0007214	1	0.031
cellular response to lipid	GO:0071396	39	0.031
reproductive process	GO:0022414	40	0.031	Mouse Rat
negative regulation of rna biosynthetic process	GO:1902679	45	0.031	Human Rat
retina development in camera type eye	GO:0060041	146	0.030
regulation of hormone secretion	GO:0046883	2	0.030
meiotic nuclear division	GO:0007126	4	0.030
organic substance transport	GO:0071702	58	0.030
skin development	GO:0043588	54	0.029
regulation of neural retina development	GO:0061074	2	0.029
positive regulation of developmental process	GO:0051094	50	0.029
mechanosensory lateral line system development	GO:0048881	49	0.029	Zebrafish
lipid storage	GO:0019915	1	0.028
organic anion transport	GO:0015711	15	0.027
neuron differentiation	GO:0030182	353	0.027
regulation of molecular function	GO:0065009	70	0.027	Human
regulation of developmental growth	GO:0048638	38	0.027
regulation of programmed cell death	GO:0043067	101	0.027	Rat
digestive system development	GO:0055123	289	0.027	Zebrafish
determination of dorsal ventral asymmetry	GO:0048262	34	0.027
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.027
ovarian follicle development	GO:0001541	2	0.026	Mouse Rat
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.026
bmp signaling pathway	GO:0030509	52	0.026
negative regulation of programmed cell death	GO:0043069	58	0.026
negative regulation of signaling	GO:0023057	96	0.025	Mouse
single organism organelle organization	GO:1902589	199	0.024
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.024	Rat
muscle cell development	GO:0055001	115	0.024
negative regulation of catalytic activity	GO:0043086	21	0.024
response to xenobiotic stimulus	GO:0009410	45	0.024	Zebrafish
negative regulation of protein kinase activity	GO:0006469	4	0.023
regulation of catalytic activity	GO:0050790	55	0.023
pigmentation	GO:0043473	85	0.023
wound healing	GO:0042060	90	0.023
somitogenesis	GO:0001756	87	0.022
cellular nitrogen compound metabolic process	GO:0034641	290	0.022
response to steroid hormone	GO:0048545	35	0.022
neural retina development	GO:0003407	49	0.021
digestive tract development	GO:0048565	265	0.021	Zebrafish
organic acid metabolic process	GO:0006082	31	0.021
positive regulation of phosphorus metabolic process	GO:0010562	21	0.021	Rat
response to ketone	GO:1901654	1	0.021	Rat
negative regulation of metabolic process	GO:0009892	86	0.021	Human Rat
regulation of reproductive process	GO:2000241	4	0.021
positive regulation of protein metabolic process	GO:0051247	23	0.021
negative regulation of response to cytokine stimulus	GO:0060761	2	0.021
hormone metabolic process	GO:0042445	19	0.020
oligodendrocyte differentiation	GO:0048709	23	0.020
response to inorganic substance	GO:0010035	38	0.020	Rat
cellular response to endogenous stimulus	GO:0071495	68	0.020
cell proliferation	GO:0008283	80	0.020	Mouse Rat
positive regulation of secretion by cell	GO:1903532	1	0.019
phosphorylation	GO:0016310	69	0.019	Rat
cellular hormone metabolic process	GO:0034754	19	0.019
positive regulation of cellular catabolic process	GO:0031331	3	0.019
neurological system process	GO:0050877	62	0.019	Rat
cell migration	GO:0016477	237	0.019	Zebrafish Mouse
positive regulation of secretion	GO:0051047	1	0.019
regulation of neurogenesis	GO:0050767	87	0.018
negative regulation of developmental process	GO:0051093	65	0.018
ear development	GO:0043583	127	0.018	Zebrafish
cellular response to peptide hormone stimulus	GO:0071375	5	0.018
cellular response to organic cyclic compound	GO:0071407	38	0.018
single organism carbohydrate metabolic process	GO:0044723	12	0.018
activation of mapk activity	GO:0000187	3	0.018
regulation of lipid catabolic process	GO:0050994	2	0.017
calcium ion homeostasis	GO:0055074	19	0.017
vesicle localization	GO:0051648	27	0.017
terpenoid catabolic process	GO:0016115	2	0.017
vitamin catabolic process	GO:0009111	2	0.017
organonitrogen compound metabolic process	GO:1901564	74	0.017
axis elongation	GO:0003401	31	0.017
ovulation cycle process	GO:0022602	2	0.016	Mouse Rat
regulation of cell proliferation	GO:0042127	37	0.016	Mouse Rat
response to acid chemical	GO:0001101	17	0.016	Rat
neuron projection development	GO:0031175	180	0.016
cellular response to growth factor stimulus	GO:0071363	39	0.016
striated muscle cell development	GO:0055002	108	0.015
positive regulation of muscle organ development	GO:0048636	1	0.015
cellular biogenic amine metabolic process	GO:0006576	2	0.015
fin regeneration	GO:0031101	51	0.015
phosphorus metabolic process	GO:0006793	109	0.015	Rat
cellular aromatic compound metabolic process	GO:0006725	295	0.015
negative regulation of transcription dna templated	GO:0045892	45	0.015	Human Rat
regulation of neurological system process	GO:0031644	2	0.015
regulation of metabolic process	GO:0019222	359	0.015
metal ion homeostasis	GO:0055065	26	0.015
fatty acid oxidation	GO:0019395	1	0.014
primary amino compound metabolic process	GO:1901160	1	0.014
amino acid transport	GO:0006865	2	0.014
positive regulation of transport	GO:0051050	2	0.014
development of primary female sexual characteristics	GO:0046545	4	0.014	Mouse Rat
blood vessel morphogenesis	GO:0048514	216	0.014
regulation of protein complex assembly	GO:0043254	3	0.014
ear morphogenesis	GO:0042471	64	0.014	Zebrafish
hindbrain development	GO:0030902	91	0.014	Rat
positive regulation of cell cycle	GO:0045787	3	0.014
response to abiotic stimulus	GO:0009628	122	0.014	Rat
defense response	GO:0006952	47	0.014	Rat
neuron development	GO:0048666	262	0.014
neurotransmitter transport	GO:0006836	2	0.013
regulation of cell cycle	GO:0051726	52	0.013
positive regulation of lipid metabolic process	GO:0045834	1	0.013
cellular carbohydrate metabolic process	GO:0044262	4	0.013
inner ear morphogenesis	GO:0042472	63	0.013	Zebrafish
circadian sleep wake cycle sleep	GO:0050802	1	0.013
determination of pancreatic left right asymmetry	GO:0035469	11	0.013
posterior commissure morphogenesis	GO:0021961	1	0.013
response to growth factor	GO:0070848	39	0.013
sensory perception of smell	GO:0007608	2	0.013
regulation of cellular component movement	GO:0051270	55	0.013
cellular component biogenesis	GO:0044085	178	0.013
cell morphogenesis	GO:0000902	289	0.013
regulation of establishment of protein localization	GO:0070201	4	0.013
cellular response to fibroblast growth factor stimulus	GO:0044344	22	0.013
heart looping	GO:0001947	94	0.013
circulatory system process	GO:0003013	87	0.013
multicellular organismal reproductive process	GO:0048609	35	0.013	Mouse Rat
intracellular steroid hormone receptor signaling pathway	GO:0030518	5	0.012
regulation of hormone levels	GO:0010817	21	0.012
positive regulation of cellular process	GO:0048522	201	0.012	Rat
diterpenoid catabolic process	GO:0016103	2	0.012
protein modification process	GO:0036211	100	0.012
urogenital system development	GO:0001655	97	0.012	Mouse Rat
axon extension	GO:0048675	45	0.012
positive regulation of biosynthetic process	GO:0009891	68	0.012	Rat
embryonic heart tube development	GO:0035050	133	0.012
female sex differentiation	GO:0046660	4	0.012	Mouse Rat
protein complex disassembly	GO:0043241	1	0.012
diencephalon development	GO:0021536	58	0.012	Rat
tissue regeneration	GO:0042246	74	0.012
cellular component assembly	GO:0022607	170	0.012
cellular response to retinoic acid	GO:0071300	1	0.012
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway	GO:0022002	1	0.012
specification of organ identity	GO:0010092	2	0.011
regulation of calcium ion transport into cytosol	GO:0010522	1	0.011
germ line stem cell maintenance	GO:0030718	2	0.011
cellular response to vitamin a	GO:0071299	1	0.011
regulation of phosphorylation	GO:0042325	26	0.011	Rat
regulation of alcohol biosynthetic process	GO:1902930	1	0.011
multi organism process	GO:0051704	134	0.011
response to peptide hormone	GO:0043434	6	0.011
response to hexose	GO:0009746	3	0.011
lipid biosynthetic process	GO:0008610	22	0.011
aromatic amino acid family metabolic process	GO:0009072	1	0.011
fat soluble vitamin catabolic process	GO:0042363	2	0.011
peptide transport	GO:0015833	1	0.011
positive regulation of molecular function	GO:0044093	33	0.011	Human
regulation of protein complex disassembly	GO:0043244	1	0.011
stem cell maintenance	GO:0019827	4	0.011
cell migration involved in gastrulation	GO:0042074	79	0.011	Zebrafish
organelle localization	GO:0051640	49	0.010
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.010
muscle organ development	GO:0007517	101	0.010
response to monosaccharide	GO:0034284	3	0.010
eye development	GO:0001654	277	0.010
response to peptide	GO:1901652	6	0.010
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.010
positive regulation of multicellular organismal process	GO:0051240	52	0.010
regulation of protein phosphorylation	GO:0001932	18	0.010
long chain fatty acid transport	GO:0015909	1	0.010
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.010	Human Rat

esr2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.109
musculoskeletal system disease	DOID:17	0.024
acrocephalosyndactylia	DOID:12960	0.024
connective tissue disease	DOID:65	0.024
synostosis	DOID:11971	0.024
bone development disease	DOID:0080006	0.024
bone disease	DOID:0080001	0.024
dysostosis	DOID:1934	0.024
osteochondrodysplasia	DOID:2256	0.023
cleidocranial dysplasia	DOID:13994	0.023
pfeiffer syndrome	DOID:14705	0.020
heart disease	DOID:114	0.015
congenital heart disease	DOID:1682	0.015
heart septal defect	DOID:1681	0.015
cardiovascular system disease	DOID:1287	0.015
atrioventricular septal defect	DOID:0050651	0.015
disease of mental health	DOID:150	0.014
developmental disorder of mental health	DOID:0060037	0.014
cancer	DOID:162	0.014
disease of cellular proliferation	DOID:14566	0.014
tooth and nail syndrome	DOID:6678	0.013
syndrome	DOID:225	0.013
organ system cancer	DOID:0050686	0.013
kidney cancer	DOID:263	0.013
urinary system cancer	DOID:3996	0.013
nephroblastoma	DOID:2154	0.013
visual pathway disease	DOID:1393	0.012
nervous system disease	DOID:863	0.012
eye disease	DOID:5614	0.012
eye and adnexa disease	DOID:1492	0.012
sensory system disease	DOID:0050155	0.012
iris disease	DOID:240	0.010
aniridia	DOID:12271	0.010
uveal disease	DOID:3480	0.010

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