IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

mylz2

myosin, light polypeptide 2, skeletal muscle

(Aliases: sb:cb46,cb46,mlc2f)

Entrez: 30429
ZFIN: ZDB-GENE-990712-15
Ensembl: ENSDARG00000053254
UniProtKB: O93409

Process Predictions
Disease Predictions

mylz2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
actin filament based process	GO:0030029	64	0.970	Zebrafish
muscle system process	GO:0003012	20	0.948	Worm
myofibril assembly	GO:0030239	48	0.924	Zebrafish
skeletal muscle thin filament assembly	GO:0030240	4	0.915
ventricular cardiac myofibril assembly	GO:0055005	4	0.905	Zebrafish
muscle cell development	GO:0055001	115	0.894	Zebrafish
skeletal myofibril assembly	GO:0014866	7	0.875
embryo development ending in birth or egg hatching	GO:0009792	271	0.871
single organism organelle organization	GO:1902589	199	0.863	Zebrafish
striated muscle cell differentiation	GO:0051146	129	0.852	Zebrafish
cardiac muscle cell differentiation	GO:0055007	30	0.852	Zebrafish
muscle contraction	GO:0006936	18	0.811	Worm
myotube differentiation	GO:0014902	45	0.788
cellular component assembly	GO:0022607	170	0.770	Zebrafish
cytokinesis	GO:0000910	3	0.769
cellular component biogenesis	GO:0044085	178	0.711	Zebrafish
system process	GO:0003008	185	0.697	Zebrafish Worm
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.684
muscle cell differentiation	GO:0042692	139	0.652	Zebrafish
cellular component morphogenesis	GO:0032989	336	0.635	Zebrafish
cellular amino acid biosynthetic process	GO:0008652	2	0.623
organelle organization	GO:0006996	227	0.600	Zebrafish
biosynthetic process	GO:0009058	294	0.583
skeletal muscle contraction	GO:0003009	5	0.582
nitrogen compound metabolic process	GO:0006807	319	0.581
actomyosin structure organization	GO:0031032	53	0.568	Zebrafish
organelle assembly	GO:0070925	110	0.551	Zebrafish
nucleobase containing compound metabolic process	GO:0006139	274	0.537
generation of neurons	GO:0048699	385	0.465
muscle tissue development	GO:0060537	110	0.465	Zebrafish Mouse Rat
voluntary skeletal muscle contraction	GO:0003010	4	0.464
embryonic heart tube development	GO:0035050	133	0.459
musculoskeletal movement	GO:0050881	8	0.415
muscle structure development	GO:0061061	196	0.408	Zebrafish Mouse Rat Worm
skeletal muscle organ development	GO:0060538	78	0.405	Mouse Rat
striated muscle contraction	GO:0006941	12	0.399
striated muscle cell development	GO:0055002	108	0.396	Zebrafish
ventricular cardiac muscle tissue morphogenesis	GO:0055010	2	0.395
atp catabolic process	GO:0006200	4	0.371
myosin filament organization	GO:0031033	6	0.364
twitch skeletal muscle contraction	GO:0014721	4	0.342
ventricular cardiac muscle cell differentiation	GO:0055012	6	0.336	Zebrafish
heart development	GO:0007507	313	0.328	Zebrafish
multi organism process	GO:0051704	134	0.324	Worm
locomotion	GO:0040011	313	0.323	Worm
sarcomere organization	GO:0045214	26	0.322	Zebrafish
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.317
larval development	GO:0002164	2	0.312	Worm
neuron development	GO:0048666	262	0.308
nucleoside monophosphate catabolic process	GO:0009125	4	0.304
striated muscle tissue development	GO:0014706	110	0.301	Zebrafish Mouse Rat
actin cytoskeleton organization	GO:0030036	63	0.298	Zebrafish
actin filament based movement	GO:0030048	1	0.294
heterocycle biosynthetic process	GO:0018130	215	0.289
skeletal muscle tissue development	GO:0007519	67	0.285	Mouse Rat
macromolecular complex subunit organization	GO:0043933	74	0.258
cytoskeleton dependent cytokinesis	GO:0061640	3	0.256
sequestering of calcium ion	GO:0051208	3	0.230
chordate embryonic development	GO:0043009	271	0.225
multicellular organismal movement	GO:0050879	8	0.223
behavior	GO:0007610	74	0.222	Worm
cardiac myofibril assembly	GO:0055003	9	0.222	Zebrafish
positive regulation of biological process	GO:0048518	253	0.221	Zebrafish
neuron differentiation	GO:0030182	353	0.217
regulation of macromolecule biosynthetic process	GO:0010556	225	0.216
reproduction	GO:0000003	40	0.207	Worm
signal transduction	GO:0007165	455	0.200
regulation of metabolic process	GO:0019222	359	0.193
anatomical structure homeostasis	GO:0060249	36	0.190
myotube cell development	GO:0014904	35	0.184
cellular aromatic compound metabolic process	GO:0006725	295	0.167
organonitrogen compound metabolic process	GO:1901564	74	0.166
regulation of sarcomere organization	GO:0060297	2	0.163
organic substance biosynthetic process	GO:1901576	289	0.163
regulation of cellular metabolic process	GO:0031323	320	0.162
regulation of muscle contraction	GO:0006937	3	0.158	Worm
lymphoid lineage cell migration	GO:0097534	4	0.157
heart process	GO:0003015	71	0.155	Zebrafish
organic cyclic compound metabolic process	GO:1901360	301	0.152
somite development	GO:0061053	96	0.151
regulation of primary metabolic process	GO:0080090	311	0.149
gene expression	GO:0010467	252	0.148
cell division	GO:0051301	20	0.146
cell part morphogenesis	GO:0032990	246	0.145
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.140
response to stress	GO:0006950	263	0.138
somitogenesis	GO:0001756	87	0.132
reactive nitrogen species metabolic process	GO:2001057	0	0.130
cellular component assembly involved in morphogenesis	GO:0010927	107	0.130	Zebrafish
cell projection organization	GO:0030030	284	0.130
cell motility	GO:0048870	244	0.123
establishment of localization	GO:0051234	244	0.122
cellular nitrogen compound metabolic process	GO:0034641	290	0.117
axon development	GO:0061564	166	0.115
cytoskeleton organization	GO:0007010	96	0.112	Zebrafish
cellular protein complex assembly	GO:0043623	19	0.111
calcium ion homeostasis	GO:0055074	19	0.109
cell projection morphogenesis	GO:0048858	244	0.108
neuron projection development	GO:0031175	180	0.107
somite specification	GO:0001757	12	0.106
lymphoid lineage cell migration into thymus	GO:0097535	4	0.106
heterocycle metabolic process	GO:0046483	290	0.104
multicellular organismal reproductive process	GO:0048609	35	0.103	Worm
anterior posterior pattern specification	GO:0009952	152	0.103
blood circulation	GO:0008015	87	0.103	Zebrafish
multi organism reproductive process	GO:0044703	36	0.101	Worm
regulation of transcription dna templated	GO:0006355	213	0.099
growth plate cartilage morphogenesis	GO:0003422	1	0.098
adult behavior	GO:0030534	2	0.094
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.093
regulation of macromolecule metabolic process	GO:0060255	317	0.093
muscle fiber development	GO:0048747	52	0.093
cation homeostasis	GO:0055080	33	0.092
myosin filament assembly	GO:0031034	6	0.091
cell migration	GO:0016477	237	0.091
heart morphogenesis	GO:0003007	156	0.091
cell morphogenesis	GO:0000902	289	0.089
positive regulation of nucleoside metabolic process	GO:0045979	1	0.089
protein complex subunit organization	GO:0071822	46	0.088
nucleic acid metabolic process	GO:0090304	244	0.085
skeletal muscle fiber development	GO:0048741	35	0.083
regulation of nitrogen compound metabolic process	GO:0051171	251	0.082
cardiac cell development	GO:0055006	21	0.082	Zebrafish
mitotic cell cycle	GO:0000278	64	0.081
cellular component movement	GO:0006928	335	0.080
nucleic acid templated transcription	GO:0097659	181	0.080
regulation of purine nucleotide catabolic process	GO:0033121	2	0.078
single organism metabolic process	GO:0044710	217	0.078
cardiac muscle fiber development	GO:0048739	3	0.077
slow twitch skeletal muscle fiber contraction	GO:0031444	3	0.077
somatic muscle development	GO:0007525	4	0.076
endocardial cushion formation	GO:0003272	2	0.076
neuron projection morphogenesis	GO:0048812	161	0.075
membrane repolarization	GO:0086009	2	0.074
taxis	GO:0042330	109	0.073
aging	GO:0007568	2	0.073
protein complex assembly	GO:0006461	30	0.073
cardiocyte differentiation	GO:0035051	44	0.072	Zebrafish
regulation of response to stimulus	GO:0048583	269	0.071	Worm
regulation of cellular component organization	GO:0051128	86	0.067
regulation of metal ion transport	GO:0010959	4	0.065
axonogenesis	GO:0007409	152	0.064
positive regulation of cellular metabolic process	GO:0031325	94	0.063
regulation of cell communication	GO:0010646	232	0.063
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.062
ribonucleotide metabolic process	GO:0009259	27	0.062
muscle organ development	GO:0007517	101	0.061	Mouse Rat Worm
purine nucleotide metabolic process	GO:0006163	27	0.060
response to organic substance	GO:0010033	153	0.060
positive regulation of transcription dna templated	GO:0045893	57	0.060
small molecule metabolic process	GO:0044281	77	0.060
response to other organism	GO:0051707	97	0.060
mitotic cell cycle process	GO:1903047	48	0.058
embryonic organ development	GO:0048568	381	0.054
rna biosynthetic process	GO:0032774	181	0.054
purine containing compound metabolic process	GO:0072521	29	0.050
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.050
regulation of skeletal muscle fiber development	GO:0048742	2	0.050
positive regulation of metabolic process	GO:0009893	108	0.050
regulation of heart growth	GO:0060420	2	0.050
regionalization	GO:0003002	274	0.050
post embryonic organ development	GO:0048569	4	0.049
regulation of rna biosynthetic process	GO:2001141	213	0.049
cell cycle process	GO:0022402	53	0.048
heart looping	GO:0001947	94	0.048
maintenance of location	GO:0051235	4	0.048
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.047
carbohydrate derivative metabolic process	GO:1901135	61	0.046
single organism biosynthetic process	GO:0044711	71	0.046
regulation of developmental process	GO:0050793	247	0.045
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.045
cellular biosynthetic process	GO:0044249	286	0.044
regulation of anatomical structure morphogenesis	GO:0022603	130	0.044
oxoacid metabolic process	GO:0043436	31	0.043
cellular macromolecule metabolic process	GO:0044260	391	0.043
regulation of nitric oxide mediated signal transduction	GO:0010749	1	0.042
lipid storage	GO:0019915	1	0.041
negative regulation of cellular process	GO:0048523	283	0.041
atp metabolic process	GO:0046034	5	0.040
cardiac muscle contraction	GO:0060048	6	0.039
cardiac muscle tissue development	GO:0048738	48	0.039	Zebrafish
reactive oxygen species metabolic process	GO:0072593	6	0.039
cellular macromolecule biosynthetic process	GO:0034645	224	0.039
phosphate containing compound metabolic process	GO:0006796	108	0.039
heterocycle catabolic process	GO:0046700	15	0.038
oogenesis	GO:0048477	14	0.038
aromatic compound biosynthetic process	GO:0019438	217	0.038
ventricular cardiac muscle tissue development	GO:0003229	3	0.038
response to external stimulus	GO:0009605	264	0.037
striated muscle myosin thick filament assembly	GO:0071688	6	0.037
ribose phosphate metabolic process	GO:0019693	27	0.037
macromolecular complex assembly	GO:0065003	35	0.037
mitochondrion organization	GO:0007005	4	0.037
purine ribonucleotide metabolic process	GO:0009150	27	0.036
connective tissue development	GO:0061448	99	0.036
protein complex disassembly	GO:0043241	1	0.036
organic acid metabolic process	GO:0006082	31	0.036
regulation of multicellular organismal process	GO:0051239	277	0.036	Zebrafish Worm
digestive system development	GO:0055123	289	0.035
reactive oxygen species biosynthetic process	GO:1903409	1	0.035
blood vessel development	GO:0001568	246	0.035
cell cycle	GO:0007049	93	0.035
embryonic heart tube morphogenesis	GO:0003143	108	0.035
regulation of protein complex assembly	GO:0043254	3	0.035
cellular modified amino acid metabolic process	GO:0006575	3	0.033
purine ribonucleoside monophosphate metabolic process	GO:0009167	5	0.033
transport	GO:0006810	220	0.033
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.033
regulation of catalytic activity	GO:0050790	55	0.032
rna metabolic process	GO:0016070	219	0.032
cellular macromolecular complex assembly	GO:0034622	24	0.031
oocyte anterior posterior axis specification	GO:0007314	4	0.031
muscle organ morphogenesis	GO:0048644	8	0.031
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.031
adherens junction organization	GO:0034332	4	0.031
actin filament organization	GO:0007015	15	0.031
cardiac muscle cell development	GO:0055013	20	0.029	Zebrafish
tube morphogenesis	GO:0035239	349	0.029
response to drug	GO:0042493	3	0.029
regulation of protein polymerization	GO:0032271	2	0.029
phosphorus metabolic process	GO:0006793	109	0.029
regulation of signal transduction	GO:0009966	225	0.029
positive regulation of rna biosynthetic process	GO:1902680	57	0.028
cell matrix adhesion	GO:0007160	4	0.028
positive regulation of cellular process	GO:0048522	201	0.028
regulation of rna metabolic process	GO:0051252	224	0.027
organic cyclic compound biosynthetic process	GO:1901362	223	0.027
carboxylic acid metabolic process	GO:0019752	22	0.027
regulation of cellular biosynthetic process	GO:0031326	245	0.027
catabolic process	GO:0009056	32	0.027
regulation of anatomical structure size	GO:0090066	33	0.026
body morphogenesis	GO:0010171	16	0.026
protein metabolic process	GO:0019538	183	0.026
intracellular signal transduction	GO:0035556	85	0.025
germ cell development	GO:0007281	22	0.025
digestive tract development	GO:0048565	265	0.025
regulation of ion transmembrane transporter activity	GO:0032412	2	0.025
multicellular organism reproduction	GO:0032504	35	0.025	Worm
defense response	GO:0006952	47	0.025
regulation of nucleoside metabolic process	GO:0009118	2	0.025
regulation of cytoskeleton organization	GO:0051493	11	0.025
purine nucleoside monophosphate metabolic process	GO:0009126	5	0.025
regulation of nucleic acid templated transcription	GO:1903506	213	0.025
transcription dna templated	GO:0006351	181	0.025
mitotic cytokinesis	GO:0000281	3	0.025
regulation of actin filament based process	GO:0032970	9	0.024
positive regulation of macromolecule metabolic process	GO:0010604	93	0.024
muscle tissue morphogenesis	GO:0060415	7	0.024
regulation of nucleotide catabolic process	GO:0030811	2	0.024
organophosphate metabolic process	GO:0019637	37	0.024
pole plasm assembly	GO:0007315	4	0.023
regulation of transmembrane transporter activity	GO:0022898	2	0.023
angiogenesis	GO:0001525	158	0.023
regulation of actin cytoskeleton organization	GO:0032956	8	0.022
epithelial tube morphogenesis	GO:0060562	148	0.022
positive regulation of gene expression	GO:0010628	71	0.022
heart contraction	GO:0060047	71	0.022	Zebrafish
regulation of myotube differentiation	GO:0010830	2	0.022
protein polymerization	GO:0051258	4	0.022
macromolecule catabolic process	GO:0009057	15	0.022
single organism localization	GO:1902578	225	0.022
skeletal muscle myosin thick filament assembly	GO:0030241	5	0.021
protein complex biogenesis	GO:0070271	30	0.021
reproductive process	GO:0022414	40	0.021	Worm
regulation of striated muscle contraction	GO:0006942	2	0.021
nucleoside phosphate metabolic process	GO:0006753	28	0.021
regulation of transporter activity	GO:0032409	2	0.021
localization of cell	GO:0051674	244	0.021
rna localization	GO:0006403	4	0.021
response to nutrient	GO:0007584	3	0.020
regulation of transmembrane transport	GO:0034762	18	0.020
regulation of reproductive process	GO:2000241	4	0.020
defense response to other organism	GO:0098542	33	0.020
cellular response to chemical stimulus	GO:0070887	157	0.020
er nucleus signaling pathway	GO:0006984	2	0.020
regulation of gene expression	GO:0010468	265	0.020
axonal fasciculation	GO:0007413	11	0.019
renal system development	GO:0072001	94	0.019
protein stabilization	GO:0050821	2	0.019
inositol lipid mediated signaling	GO:0048017	2	0.019
morphogenesis of an epithelium	GO:0002009	333	0.019
endocardial cushion morphogenesis	GO:0003203	3	0.019
actin filament polymerization	GO:0030041	2	0.018
tissue remodeling	GO:0048771	4	0.018
protein acylation	GO:0043543	3	0.018
cardiac muscle tissue morphogenesis	GO:0055008	7	0.018
regulation of biological quality	GO:0065008	263	0.018
response to external biotic stimulus	GO:0043207	97	0.018
negative regulation of biological process	GO:0048519	304	0.018
cellular localization	GO:0051641	97	0.018
regulation of cellular amine metabolic process	GO:0033238	0	0.018
divalent inorganic cation homeostasis	GO:0072507	22	0.017
regulation of sequestering of calcium ion	GO:0051282	4	0.017
protein import into nucleus	GO:0006606	3	0.017
response to wounding	GO:0009611	116	0.017
nitric oxide biosynthetic process	GO:0006809	2	0.017
segmentation	GO:0035282	97	0.017
regulation of protein complex disassembly	GO:0043244	1	0.017
post embryonic morphogenesis	GO:0009886	4	0.017
response to chemical	GO:0042221	320	0.017
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.017
amine metabolic process	GO:0009308	2	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	9	0.016
programmed cell death	GO:0012501	119	0.016
protein localization to nucleus	GO:0034504	3	0.016
negative regulation of protein phosphorylation	GO:0001933	4	0.016
regulation of signaling	GO:0023051	235	0.016
organonitrogen compound biosynthetic process	GO:1901566	47	0.016
nitric oxide metabolic process	GO:0046209	2	0.016
regulation of cytokine mediated signaling pathway	GO:0001959	3	0.015
gastrulation	GO:0007369	208	0.015
cell substrate adhesion	GO:0031589	4	0.015
organic substance catabolic process	GO:1901575	28	0.015
regulation of calcium ion transport	GO:0051924	2	0.015
positive regulation of catabolic process	GO:0009896	4	0.015
aromatic compound catabolic process	GO:0019439	15	0.015
negative regulation of kinase activity	GO:0033673	4	0.015
regulation of organelle organization	GO:0033043	29	0.015
glycosyl compound metabolic process	GO:1901657	11	0.015
regulation of cell development	GO:0060284	100	0.015
calcium ion import	GO:0070509	4	0.015
regulation of i kappab kinase nf kappab signaling	GO:0043122	4	0.014
cellular amino acid metabolic process	GO:0006520	7	0.014
nucleoside metabolic process	GO:0009116	11	0.014
regulation of blood pressure	GO:0008217	1	0.014
directional locomotion	GO:0033058	1	0.014
oocyte development	GO:0048599	14	0.014
regulation of circadian rhythm	GO:0042752	4	0.014
chemotaxis	GO:0006935	104	0.014
p38mapk cascade	GO:0038066	1	0.014
positive regulation of cellular biosynthetic process	GO:0031328	68	0.014
positive regulation of transport	GO:0051050	2	0.014
nucleotide metabolic process	GO:0009117	28	0.013
i kappab kinase nf kappab signaling	GO:0007249	4	0.013
positive regulation of striated muscle cell differentiation	GO:0051155	1	0.013
regulation of membrane potential	GO:0042391	23	0.013
nucleoside biosynthetic process	GO:0009163	2	0.013
intestinal epithelial cell differentiation	GO:0060575	3	0.013
cellular component disassembly	GO:0022411	1	0.013
regulation of cellular component size	GO:0032535	30	0.013
regulation of cell shape	GO:0008360	1	0.013
cellular response to organic substance	GO:0071310	105	0.012
extrinsic apoptotic signaling pathway	GO:0097191	3	0.012
regulation of mrna processing	GO:0050684	3	0.012
venous blood vessel morphogenesis	GO:0048845	3	0.012
small molecule catabolic process	GO:0044282	3	0.012
eye development	GO:0001654	277	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	13	0.012
regulation of protein binding	GO:0043393	3	0.012
female gamete generation	GO:0007292	14	0.012
response to activity	GO:0014823	14	0.012
cell morphogenesis involved in differentiation	GO:0000904	195	0.012
vasculature development	GO:0001944	278	0.012
myoblast fusion	GO:0007520	10	0.012
macromolecule biosynthetic process	GO:0009059	227	0.012
nucleobase containing small molecule metabolic process	GO:0055086	32	0.012
positive regulation of muscle cell differentiation	GO:0051149	1	0.012
positive regulation of muscle organ development	GO:0048636	1	0.012
stem cell differentiation	GO:0048863	117	0.011
protein depolymerization	GO:0051261	1	0.011
pharyngeal muscle development	GO:0043282	4	0.011
nucleobase containing compound biosynthetic process	GO:0034654	205	0.011
regulation of multicellular organismal development	GO:2000026	223	0.011
regulation of wnt signaling pathway planar cell polarity pathway	GO:2000095	2	0.011
post embryonic development	GO:0009791	7	0.011	Worm
positive regulation of cellular catabolic process	GO:0031331	3	0.011
positive regulation of hydrolase activity	GO:0051345	13	0.011
cellular amine metabolic process	GO:0044106	2	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.011
vesicle mediated transport	GO:0016192	22	0.011
nucleoside triphosphate biosynthetic process	GO:0009142	2	0.011
skeletal system development	GO:0001501	181	0.010
homeostatic process	GO:0042592	142	0.010
nuclear division	GO:0000280	23	0.010
regulation of locomotion	GO:0040012	55	0.010
cellular metal ion homeostasis	GO:0006875	16	0.010

mylz2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.282
musculoskeletal system disease	DOID:17	0.121
cardiomyopathy	DOID:0050700	0.025
heart disease	DOID:114	0.025
muscular disease	DOID:0080000	0.025
myopathy	DOID:423	0.025
intrinsic cardiomyopathy	DOID:0060036	0.025
muscle tissue disease	DOID:66	0.025
cardiovascular system disease	DOID:1287	0.025
cancer	DOID:162	0.020
disease of cellular proliferation	DOID:14566	0.020
organ system cancer	DOID:0050686	0.019
osteogenesis imperfecta	DOID:12347	0.018
bone disease	DOID:0080001	0.018
osteochondrodysplasia	DOID:2256	0.018
bone development disease	DOID:0080006	0.018
connective tissue disease	DOID:65	0.018
distal arthrogryposis	DOID:0050646	0.014
gastrointestinal system cancer	DOID:3119	0.013

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