Danio rerio

0 known processes

pdha1a

pyruvate dehydrogenase (lipoamide) alpha 1a

(Aliases: im:6895726,pdha1,wu:fd18b01,zgc:86692,zgc:73271,wu:fo96f03)

pdha1a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular respirationGO:004533330.663
Human
thioester biosynthetic processGO:003538410.518
Human
coenzyme biosynthetic processGO:000910820.396
Human
pyruvate metabolic processGO:000609010.387
Human
respiratory electron transport chainGO:002290420.374
larval developmentGO:000216420.295
electron transport chainGO:002290020.248
locomotionGO:00400113130.213
Worm
agingGO:000756820.197
Worm
organic substance biosynthetic processGO:19015762890.163
Human
regulation of macromolecule metabolic processGO:00602553170.142
oxidation reduction processGO:0055114410.136
Human Mouse
mitochondrion organizationGO:000700540.129
atp synthesis coupled electron transportGO:004277310.128
cellular biosynthetic processGO:00442492860.123
Human
regulation of gene expressionGO:00104682650.120
nuclear transportGO:005116940.120
organic acid metabolic processGO:0006082310.118
Human
multicellular organism growthGO:003526440.117
dicarboxylic acid metabolic processGO:004364810.099
single organism nuclear importGO:190259330.099
organic cyclic compound biosynthetic processGO:19013622230.097
transmembrane transportGO:00550851200.090
embryo development ending in birth or egg hatchingGO:00097922710.088
Worm
mitochondrial atp synthesis coupled electron transportGO:004277510.087
regulation of cell projection assemblyGO:006049140.086
cellular aromatic compound metabolic processGO:00067252950.085
regulation of multicellular organism growthGO:004001440.084
small molecule metabolic processGO:0044281770.084
Human
regulation of metabolic processGO:00192223590.082
establishment of localizationGO:00512342440.082
Worm
developmental growthGO:00485891660.081
protein localization to nucleusGO:003450430.080
gene expressionGO:00104672520.080
spermatid developmentGO:000728620.078
organic acid catabolic processGO:001605430.077
single organism transportGO:00447652060.077
transportGO:00068102200.076
Worm
system processGO:00030081850.076
nucleocytoplasmic transportGO:000691340.072
carboxylic acid metabolic processGO:0019752220.072
Human
germ cell developmentGO:0007281220.071
Worm
digestive system developmentGO:00551232890.069
protein import into nucleusGO:000660630.069
regulation of biological qualityGO:00650082630.067
digestive tract developmentGO:00485652650.066
maintenance of locationGO:005123540.065
macromolecule biosynthetic processGO:00090592270.065
cellular nitrogen compound metabolic processGO:00346412900.064
organic cyclic compound metabolic processGO:19013603010.063
mitochondrial transportGO:000683920.063
biosynthetic processGO:00090582940.061
Human
spermatid differentiationGO:004851520.060
stem cell proliferationGO:007208940.058
negative regulation of biological processGO:00485193040.057
single organism localizationGO:19025782250.057
response to organic substanceGO:00100331530.056
response to chemicalGO:00422213200.055
positive regulation of cellular processGO:00485222010.055
negative regulation of gene expressionGO:0010629650.054
hydrogen peroxide metabolic processGO:004274320.054
multi organism processGO:00517041340.053
Worm
regulation of establishment of protein localizationGO:007020140.052
cellular nitrogen compound biosynthetic processGO:00442712180.049
cellular localizationGO:0051641970.049
nitrogen compound metabolic processGO:00068073190.049
regulation of neural precursor cell proliferationGO:200017730.048
regulation of multicellular organismal processGO:00512392770.047
oxidative phosphorylationGO:000611910.046
digestive tract morphogenesisGO:00485462310.045
thioester metabolic processGO:003538310.044
Human
central nervous system developmentGO:00074173870.044
cellular process involved in reproduction in multicellular organismGO:0022412280.044
Worm
oxoacid metabolic processGO:0043436310.044
Human
organic substance transportGO:0071702580.043
regulation of multicellular organismal developmentGO:20000262230.043
nucleic acid templated transcriptionGO:00976591810.043
regulation of developmental processGO:00507932470.042
regulation of cellular biosynthetic processGO:00313262450.042
phagocytosisGO:000690930.041
cell substrate adhesionGO:003158940.041
regulation of filopodium assemblyGO:005148920.040
response to biotic stimulusGO:0009607970.040
energy derivation by oxidation of organic compoundsGO:001598050.040
Human
regulation of macromolecule biosynthetic processGO:00105562250.039
reproductionGO:0000003400.039
Worm
growthGO:00400071740.038
cellular component disassemblyGO:002241110.038
cellular macromolecule biosynthetic processGO:00346452240.038
response to external stimulusGO:00096052640.038
response to drugGO:004249330.037
response to stressGO:00069502630.037
regulation of blood pressureGO:000821710.037
carboxylic acid catabolic processGO:004639530.036
nucleobase containing compound metabolic processGO:00061392740.036
endoplasmic reticulum unfolded protein responseGO:003096820.036
organonitrogen compound metabolic processGO:1901564740.036
signal transductionGO:00071654550.035
regulation of rna metabolic processGO:00512522240.035
blood vessel morphogenesisGO:00485142160.035
adult behaviorGO:003053420.035
nucleic acid metabolic processGO:00903042440.034
vasculature developmentGO:00019442780.033
protein importGO:001703830.033
positive regulation of metabolic processGO:00098931080.033
regulation of nucleobase containing compound metabolic processGO:00192192500.033
protein targeting to nucleusGO:004474430.033
positive regulation of transportGO:005105020.032
regulation of primary metabolic processGO:00800903110.032
single organism metabolic processGO:00447102170.032
Human Mouse
tissue regenerationGO:0042246740.032
positive regulation of cellular component biogenesisGO:004408930.031
alpha amino acid metabolic processGO:190160530.031
response to radiationGO:0009314510.031
organelle organizationGO:00069962270.031
proteolysisGO:0006508380.031
neuroblast proliferationGO:000740520.031
macromolecular complex disassemblyGO:003298410.030
rna metabolic processGO:00160702190.030
developmental process involved in reproductionGO:0003006270.030
Worm
actin polymerization or depolymerizationGO:000815420.029
protein complex localizationGO:003150310.029
single organism reproductive processGO:0044702400.029
Worm
coenzyme metabolic processGO:000673250.028
Human
cellular amino acid metabolic processGO:000652070.028
amine metabolic processGO:000930820.028
single organism biosynthetic processGO:0044711710.028
Human
regulation of cytoplasmic transportGO:190364940.028
regulation of intracellular protein transportGO:003315730.027
nuclear migrationGO:000709730.027
positive regulation of cellular amino acid metabolic processGO:004576400.027
regulation of epithelial cell proliferationGO:005067830.027
regulation of membrane potentialGO:0042391230.027
behaviorGO:0007610740.027
i kappab kinase nf kappab signalingGO:000724940.027
lipid storageGO:001991510.026
apoptotic processGO:00069151160.026
cellular amine metabolic processGO:004410620.026
cell motilityGO:00488702440.026
Worm
heterocycle biosynthetic processGO:00181302150.026
protein complex disassemblyGO:004324110.026
heart developmentGO:00075073130.026
establishment of protein localization to organelleGO:007259440.026
regulation of blood vessel sizeGO:005088020.025
regulation of circadian rhythmGO:004275240.025
heterocycle metabolic processGO:00464832900.025
cation transmembrane transportGO:0098655650.025
blood vessel developmentGO:00015682460.025
sequestering of metal ionGO:005123830.025
cellular component assemblyGO:00226071700.025
regulation of protein transportGO:005122330.025
sulfur compound biosynthetic processGO:004427290.025
Human
synaptic growth at neuromuscular junctionGO:005112420.025
nucleobase containing compound biosynthetic processGO:00346542050.025
cell deathGO:00082191210.025
cell migrationGO:00164772370.025
Worm
gamete generationGO:0007276330.024
Worm
neurological system processGO:0050877620.024
acyl coa metabolic processGO:000663710.024
Human
purine containing compound biosynthetic processGO:0072522200.024
zymogen activationGO:003163830.024
regulation of synapse organizationGO:005080730.024
regulation of biosynthetic processGO:00098892500.024
reproductive processGO:0022414400.024
Worm
nuclear importGO:005117030.023
regulation of cellular metabolic processGO:00313233200.023
aromatic compound biosynthetic processGO:00194382170.023
peptide transportGO:001583310.023
regulation of protein complex assemblyGO:004325430.023
phosphorylationGO:0016310690.023
cognitionGO:005089010.023
regulation of cellular macromolecule biosynthetic processGO:20001122220.022
small molecule catabolic processGO:004428230.022
lamellipodium organizationGO:009758110.022
er nucleus signaling pathwayGO:000698420.022
regulation of cellular amine metabolic processGO:003323800.022
ion transmembrane transportGO:0034220910.022
phosphate containing compound metabolic processGO:00067961080.022
head developmentGO:00603223030.022
cellular protein catabolic processGO:004425740.022
localization of cellGO:00516742440.021
Worm
myeloid cell differentiationGO:0030099860.021
negative regulation of kinase activityGO:003367340.021
response to hydrogen peroxideGO:004254230.021
positive regulation of multicellular organismal processGO:0051240520.021
rna biosynthetic processGO:00327741810.021
regulation of endothelial cell proliferationGO:000193610.021
establishment of localization in cellGO:0051649770.021
cellular response to chemical stimulusGO:00708871570.021
wound healingGO:0042060900.021
membrane repolarizationGO:008600920.021
negative regulation of response to stimulusGO:00485851040.021
regulation of cellular amino acid metabolic processGO:000652100.021
deathGO:00162651210.021
neurotransmitter transportGO:000683620.021
fin regenerationGO:0031101510.021
monovalent inorganic cation transportGO:0015672420.021
carbohydrate derivative biosynthetic processGO:1901137430.020
response to topologically incorrect proteinGO:003596620.020
regulation of cellular ketone metabolic processGO:001056570.020
phagocytosis engulfmentGO:000691110.020
regulation of nitrogen compound metabolic processGO:00511712510.020
internal protein amino acid acetylationGO:000647520.020
transcription dna templatedGO:00063511810.020
ion transportGO:00068111140.020
positive regulation of biological processGO:00485182530.020
regulation of signalingGO:00230512350.020
nuclear exportGO:005116810.020
regulation of rna biosynthetic processGO:20011412130.020
peptidyl serine phosphorylationGO:001810510.020
inorganic ion transmembrane transportGO:0098660570.019
determination of bilateral symmetryGO:00098552040.019
angiogenesisGO:00015251580.019
muscle tissue developmentGO:00605371100.019
gastrulationGO:00073692080.019
regulation of tube sizeGO:003515020.019
chemosensory behaviorGO:000763510.019
regulation of nucleocytoplasmic transportGO:004682220.019
organophosphate biosynthetic processGO:0090407230.018
actin filament polymerizationGO:003004120.018
cellular component movementGO:00069283350.018
Worm
purine nucleoside triphosphate biosynthetic processGO:000914520.018
protein polymerizationGO:005125840.018
regulation of nucleoside metabolic processGO:000911820.018
vesicle mediated transportGO:0016192220.018
Worm
negative regulation of cellular processGO:00485232830.018
cellular response to stressGO:0033554620.018
ribonucleotide biosynthetic processGO:0009260200.018
response to unfolded proteinGO:000698620.018
oogenesisGO:0048477140.018
Worm
regulation of sequestering of calcium ionGO:005128240.018
cellular response to decreased oxygen levelsGO:003629410.018
response to abiotic stimulusGO:00096281220.018
regulation of cell shapeGO:000836010.018
regulation of localizationGO:00328791040.018
intracellular estrogen receptor signaling pathwayGO:003052030.017
regulation of stem cell differentiationGO:200073640.017
hemopoiesisGO:00300971830.017
regulation of peptidyl tyrosine phosphorylationGO:005073010.017
tube morphogenesisGO:00352393490.017
regulation of cell communicationGO:00106462320.017
regulation of reproductive processGO:200024140.017
negative regulation of protein phosphorylationGO:000193340.017
negative regulation of metabolic processGO:0009892860.017
regulation of synapse assemblyGO:005196330.017
cation transportGO:0006812810.017
protein stabilizationGO:005082120.017
intracellular signal transductionGO:0035556850.017
protein acetylationGO:000647320.016
positive regulation of secretionGO:005104710.016
regulation of transmembrane transporter activityGO:002289820.016
regulation of protein bindingGO:004339330.016
purine ribonucleoside triphosphate biosynthetic processGO:000920620.016
programmed cell deathGO:00125011190.016
inorganic cation transmembrane transportGO:0098662500.016
monocarboxylic acid metabolic processGO:0032787170.016
Human
macromolecular complex subunit organizationGO:0043933740.016
rna localizationGO:000640340.016
negative regulation of neural precursor cell proliferationGO:200017810.016
intracellular transportGO:0046907320.016
morphogenesis of an epitheliumGO:00020093330.016
protein secretionGO:000930610.016
regulation of stem cell proliferationGO:007209120.016
positive regulation of nitrogen compound metabolic processGO:0051173690.016
negative regulation of macromolecule biosynthetic processGO:0010558480.016
cell agingGO:000756920.015
negative regulation of protein kinase activityGO:000646940.015
dicarboxylic acid transportGO:000683510.015
circulatory system processGO:0003013870.015
cell proliferationGO:0008283800.015
tissue remodelingGO:004877140.015
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.015
intracellular steroid hormone receptor signaling pathwayGO:003051850.015
regulation of striated muscle contractionGO:000694220.015
reactive nitrogen species metabolic processGO:200105700.015
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
regulation of cell proliferationGO:0042127370.015
response to woundingGO:00096111160.015
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.015
regulation of transcription dna templatedGO:00063552130.015
cellular component assembly involved in morphogenesisGO:00109271070.015
cellular response to oxygen levelsGO:007145310.015
regulation of myotube differentiationGO:001083020.015
sequestering of calcium ionGO:005120830.015
response to light stimulusGO:0009416460.015
peptidyl serine modificationGO:001820920.015
regulation of response to stimulusGO:00485832690.015
ion homeostasisGO:0050801410.015
reactive oxygen species metabolic processGO:007259360.014
purine ribonucleoside biosynthetic processGO:004612920.014
regulation of neurotransmitter secretionGO:004692810.014
pole plasm assemblyGO:000731540.014
purine nucleoside biosynthetic processGO:004245120.014
response to other organismGO:0051707970.014
regulation of dna replicationGO:000627530.014
leukocyte proliferationGO:007066110.014
negative regulation of cellular metabolic processGO:0031324770.014
dorsal ventral pattern formationGO:00099531250.014
stem cell maintenanceGO:001982740.014
dna biosynthetic processGO:007189730.014
membrane invaginationGO:001032410.014
positive regulation of developmental processGO:0051094500.014
extrinsic apoptotic signaling pathwayGO:009719130.014
protein metabolic processGO:00195381830.014
protein complex subunit organizationGO:0071822460.014
regulation of signal transductionGO:00099662250.014
regulation of protein import into nucleusGO:004230620.014
lamellipodium assemblyGO:003003210.013
response to external biotic stimulusGO:0043207970.013
regulation of cell substrate adhesionGO:001081010.013
signal transduction in absence of ligandGO:003803410.013
regulation of synaptic growth at neuromuscular junctionGO:000858210.013
oxidoreduction coenzyme metabolic processGO:000673310.013
positive regulation of cytosolic calcium ion concentrationGO:000720440.013
regulation of cytokine productionGO:000181730.013
brain developmentGO:00074202930.013
negative regulation of cell communicationGO:0010648960.013
single organism organelle organizationGO:19025891990.013
nitric oxide biosynthetic processGO:000680920.013
embryonic organ developmentGO:00485683810.013
regulation of programmed cell deathGO:00430671010.013
response to nutrientGO:000758430.013
regulation of bindingGO:005109830.013
centrosome organizationGO:005129710.013
negative regulation of mapk cascadeGO:004340940.013
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280100.013
meiotic cell cycle processGO:190304630.013
regulation of skeletal muscle tissue developmentGO:004864140.013
nucleoside monophosphate catabolic processGO:000912540.013
cellular response to topologically incorrect proteinGO:003596720.013
protein localization to plasma membraneGO:007265910.012
regulation of neurotransmitter transportGO:005158810.012
guanosine containing compound catabolic processGO:190106920.012
muscle structure developmentGO:00610611960.012
carbohydrate biosynthetic processGO:001605110.012
cellular ketone metabolic processGO:0042180110.012
nucleotide biosynthetic processGO:0009165210.012
mononuclear cell proliferationGO:003294310.012
positive regulation of jnk cascadeGO:004633030.012
determination of left right symmetryGO:00073681790.012
positive regulation of muscle cell differentiationGO:005114910.012
mitotic dna damage checkpointGO:004477340.012
cellular component biogenesisGO:00440851780.012
lateral inhibitionGO:004633110.012
negative regulation of cellular biosynthetic processGO:0031327550.012
nucleobase containing small molecule metabolic processGO:0055086320.012
synaptic transmission cholinergicGO:000727140.012
maternal determination of anterior posterior axis embryoGO:000835840.012
immune system developmentGO:00025201910.012
sensory organ developmentGO:00074233930.012
nucleoside triphosphate biosynthetic processGO:000914220.012
cell fate commitmentGO:0045165990.012
regulation of gene expression epigeneticGO:0040029110.012
muscle cell developmentGO:00550011150.012
actin cytoskeleton organizationGO:0030036630.012
blood circulationGO:0008015870.012
regulation of meiotic cell cycleGO:005144510.012
gtp metabolic processGO:004603940.012
cofactor biosynthetic processGO:0051188100.012
Human
regulation of cell activationGO:005086510.011
positive regulation of cell adhesionGO:004578510.011
protein homooligomerizationGO:005126030.011
negative regulation of stem cell differentiationGO:200073720.011
sleepGO:003043110.011
regulation of rho protein signal transductionGO:003502320.011
positive regulation of stress activated mapk cascadeGO:003287430.011
phototransductionGO:000760220.011
neurotransmitter secretionGO:000726920.011
generation of neuronsGO:00486993850.011
positive regulation of molecular functionGO:0044093330.011
fatty acid transportGO:001590810.011
small gtpase mediated signal transductionGO:000726480.011
multicellular organismal response to stressGO:003355520.011
carbohydrate homeostasisGO:003350010.011
positive regulation of catabolic processGO:000989640.011
negative regulation of nitrogen compound metabolic processGO:0051172590.011
mechanosensory behaviorGO:000763820.011
negative regulation of protein transportGO:005122430.011
regulation of protein polymerizationGO:003227120.011
striated muscle cell developmentGO:00550021080.011
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.011
gland developmentGO:00487321430.011
skeletal system developmentGO:00015011810.011
homeostatic processGO:00425921420.011
regulation of transporter activityGO:003240920.011
growth plate cartilage developmentGO:000341720.011
regulation of i kappab kinase nf kappab signalingGO:004312240.011
nucleoside phosphate biosynthetic processGO:1901293210.011
positive regulation of i kappab kinase nf kappab signalingGO:004312330.011
detection of stimulusGO:0051606290.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
lymphocyte proliferationGO:004665110.011
nucleoside biosynthetic processGO:000916320.011
sex differentiationGO:000754850.011
Worm
cytosolic calcium ion transportGO:006040130.011
acetyl coa metabolic processGO:000608410.011
Human
multi organism cellular processGO:004476420.011
regulation of metal ion transportGO:001095940.011
lipid catabolic processGO:001604240.011
regulation of oligodendrocyte differentiationGO:004871310.011
regulation of erk1 and erk2 cascadeGO:007037240.011
proteasomal protein catabolic processGO:001049820.011
response to alkaloidGO:004327920.011
muscle cell differentiationGO:00426921390.011
regulation of protein catabolic processGO:004217610.011
neuron neuron synaptic transmissionGO:000727010.011
positive regulation of cellular amine metabolic processGO:003324000.011
negative regulation of cytokine productionGO:000181810.011
regulation of cellular protein catabolic processGO:190336210.010
regulation of endopeptidase activityGO:0052548230.010
regulation of oocyte developmentGO:006028130.010
protein acylationGO:004354330.010
organonitrogen compound biosynthetic processGO:1901566470.010
regulation of reactive oxygen species metabolic processGO:200037720.010
multicellular organismal metabolic processGO:004423620.010
positive regulation of cytokine productionGO:000181920.010
peptide metabolic processGO:000651810.010
sexual reproductionGO:0019953360.010
Worm
neuromuscular synaptic transmissionGO:000727420.010
cellular protein complex disassemblyGO:004362410.010
macromolecular complex assemblyGO:0065003350.010
calcium ion transport into cytosolGO:006040230.010
regulation of systemic arterial blood pressureGO:000307310.010
negative regulation of multi organism processGO:004390130.010
regulation of locomotionGO:0040012550.010
negative regulation of biosynthetic processGO:0009890550.010
nitric oxide metabolic processGO:004620920.010
detection of light stimulusGO:0009583120.010
ribonucleoside monophosphate catabolic processGO:000915840.010

pdha1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.136
nervous system diseaseDOID:86300.104
disease of metabolismDOID:001466700.056
Human
inherited metabolic disorderDOID:65500.056
Human
mitochondrial metabolism diseaseDOID:70000.031
sensory system diseaseDOID:005015500.028
eye diseaseDOID:561400.028
eye and adnexa diseaseDOID:149200.028
cancerDOID:16200.020
disease of cellular proliferationDOID:1456600.020
organ system cancerDOID:005068600.020
cardiovascular system diseaseDOID:128700.019
musculoskeletal system diseaseDOID:1700.018
muscular diseaseDOID:008000000.018
muscle tissue diseaseDOID:6600.015
leigh diseaseDOID:365200.014
neurodegenerative diseaseDOID:128900.013
central nervous system diseaseDOID:33100.013
amino acid metabolic disorderDOID:925200.013
myopathyDOID:42300.013