Danio rerio

6 known processes

plk1

polo-like kinase 1 (Drosophila)

(Aliases: ik:tdsubc_2d1,MGC110073,wu:fb37g11,wu:fb76g03,cb636,xx:tdsubc_2d1,cb525,plk)

plk1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo development ending in birth or egg hatchingGO:00097922710.905
Worm
spindle assembly involved in mitosisGO:009030710.806
positive regulation of cell cycleGO:004578730.797
Human Yeast
mitotic nuclear divisionGO:0007067180.764
Human Worm Fly
microtubule depolymerizationGO:000701910.704
centrosome cycleGO:000709810.694
Worm
microtubule organizing center organizationGO:003102310.677
Human Yeast Worm Fly
centrosome organizationGO:005129710.643
Human Worm Fly
regulation of cell cycleGO:0051726520.640
Human Yeast Worm
single organism nuclear importGO:190259330.634
protein targeting to nucleusGO:004474430.624
protein import into nucleusGO:000660630.589
negative regulation of nuclear divisionGO:005178430.555
Human
meiosis iGO:000712710.547
Yeast Worm
proteolysis involved in cellular protein catabolic processGO:005160330.544
Human
protein localization to nucleusGO:003450430.535
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.527
Human
cellular macromolecule metabolic processGO:00442603910.525
Human Yeast Mouse Rat Fly
meiotic nuclear divisionGO:000712640.524
Yeast Rat Worm Fly
regulation of intracellular protein transportGO:003315730.508
regulation of protein import into nucleusGO:004230620.502
nucleocytoplasmic transportGO:000691340.499
cleavage furrow formationGO:003608920.498
negative regulation of protein localization to nucleusGO:190018120.489
nuclear transportGO:005116940.468
nuclear importGO:005117030.465
regulation of mitotic cell cycle phase transitionGO:190199080.455
Human
establishment of protein localization to organelleGO:007259440.442
spindle assemblyGO:005122520.438
Yeast Fly
spindle assembly involved in meiosisGO:009030610.431
Yeast Fly
positive regulation of chromosome segregationGO:005198410.428
Human
protein importGO:001703830.417
negative regulation of cell cycleGO:0045786140.414
Human
regulation of meiotic cell cycleGO:005144510.389
Worm
histone phosphorylationGO:001657220.388
regulation of nucleocytoplasmic transportGO:004682220.387
regulation of protein transportGO:005122330.386
meiotic spindle organizationGO:000021210.379
Yeast Fly
single organism transportGO:00447652060.373
Fly
digestive system developmentGO:00551232890.373
modification dependent protein catabolic processGO:001994130.372
Human
ubiquitin dependent protein catabolic processGO:000651130.362
Human
regulation of protein targetingGO:190353320.356
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.354
Human
mitotic dna integrity checkpointGO:004477440.346
regulation of establishment of protein localizationGO:007020140.346
embryonic cleavageGO:004001630.337
mitotic cell cycle embryonicGO:004544820.335
regulation of protein localization to nucleusGO:190018020.328
negative regulation of nucleocytoplasmic transportGO:004682320.327
single organism organelle organizationGO:19025891990.312
Human Yeast Worm Fly
larval developmentGO:000216420.308
Worm
regulation of chromosome segregationGO:005198310.306
Human
cytokinesisGO:000091030.302
Human Rat Worm Fly
modification dependent macromolecule catabolic processGO:004363230.297
Human
peptidyl serine phosphorylationGO:001810510.296
Human
cellular protein catabolic processGO:004425740.294
Human
regulation of cytoplasmic transportGO:190364940.293
centrosome duplicationGO:005129810.286
negative regulation of cell cycle phase transitionGO:190198850.284
Human
negative regulation of cellular catabolic processGO:003133030.281
Human
chromosome segregationGO:0007059120.275
Human Yeast Worm
protein metabolic processGO:00195381830.274
Human Yeast Mouse Rat Fly
mitotic cell cycle processGO:1903047480.272
Human Worm Fly
mitotic metaphase plate congressionGO:000708010.265
single organism localizationGO:19025782250.264
Fly
cellular protein metabolic processGO:00442671290.254
Human Yeast Mouse Rat Fly
negative regulation of protein transportGO:005122430.235
cell cycleGO:0007049930.235
gene expressionGO:00104672520.222
Human
cellular localizationGO:0051641970.219
Human Fly
microtubule polymerization or depolymerizationGO:003110930.218
Fly
negative regulation of mitosisGO:004583930.214
Human
oocyte maturationGO:000155640.203
maintenance of locationGO:005123540.195
establishment of localizationGO:00512342440.195
Human Fly
organelle organizationGO:00069962270.187
Human Yeast Rat Worm Fly
regulation of microtubule cytoskeleton organizationGO:007050730.187
Yeast
regulation of cell communicationGO:00106462320.185
response to organic substanceGO:00100331530.181
positive regulation of cellular processGO:00485222010.173
Human Yeast
agingGO:000756820.171
negative regulation of cell cycle processGO:001094890.163
Human
regulation of protein catabolic processGO:004217610.160
Human
negative regulation of mitotic cell cycleGO:0045930110.159
Human
single organism metabolic processGO:00447102170.159
Human Yeast
regulation of organelle organizationGO:0033043290.158
Human Yeast Worm
homologous chromosome segregationGO:004514310.157
female meiotic divisionGO:000714320.156
Rat Worm Fly
locomotionGO:00400113130.155
negative regulation of chromosome organizationGO:200125110.154
Human
microtubule based processGO:0007017600.153
Human Yeast Worm Fly
negative regulation of mitotic cell cycle phase transitionGO:190199150.147
Human
chordate embryonic developmentGO:00430092710.146
sister chromatid segregationGO:000081960.144
Human
regulation of protein depolymerizationGO:190187910.138
regulation of cellular protein catabolic processGO:190336210.136
Human
meiotic chromosome segregationGO:004513230.134
Yeast Worm
regulation of protein modification by small protein conjugation or removalGO:190332030.134
Human
negative regulation of biological processGO:00485193040.134
Human Fly
negative regulation of catabolic processGO:000989530.126
Human
positive regulation of cellular catabolic processGO:003133130.126
Human
negative regulation of response to stimulusGO:00485851040.125
digestive tract developmentGO:00485652650.121
meiosis iiGO:000713510.120
Worm Fly
regulation of nuclear divisionGO:005178390.118
Human Worm
heterocycle metabolic processGO:00464832900.115
Human Yeast
cytoskeleton dependent cytokinesisGO:006164030.115
Human Rat Worm Fly
mitotic spindle organizationGO:000705250.112
Worm Fly
regulation of localizationGO:00328791040.110
regulation of cellular metabolic processGO:00313233200.107
Human
peptidyl serine modificationGO:001820920.107
Human
negative regulation of protein import into nucleusGO:004230820.107
heterocycle biosynthetic processGO:00181302150.107
Human
single organism intracellular transportGO:1902582250.107
regulation of cellular protein metabolic processGO:0032268520.103
Human
signal transductionGO:00071654550.100
mitotic cytokinesisGO:000028130.098
Human
proteasomal protein catabolic processGO:001049820.096
Human
mitotic sister chromatid segregationGO:000007060.095
Human
regulation of biological qualityGO:00650082630.094
Human
dna metabolic processGO:0006259270.094
Yeast
protein modification processGO:00362111000.093
Human Yeast Mouse Rat Fly
cell cycle processGO:0022402530.092
Human Yeast Rat Worm Fly
macromolecular complex assemblyGO:0065003350.092
Yeast Fly
response to chemicalGO:00422213200.092
Rat
cell divisionGO:0051301200.087
Human Rat Worm Fly
microtubule cytoskeleton organizationGO:0000226330.086
Human Yeast Worm Fly
single organism cellular localizationGO:1902580460.086
cell surface receptor signaling pathwayGO:00071663250.085
meiotic cell cycle processGO:190304630.084
Yeast Rat Worm Fly
phosphate containing compound metabolic processGO:00067961080.083
Human Yeast Mouse Rat Fly
protein complex disassemblyGO:004324110.082
g2 m transition of mitotic cell cycleGO:000008640.081
Human
positive regulation of transportGO:005105020.081
cell cycle checkpointGO:000007570.080
Human
regulation of cytoskeleton organizationGO:0051493110.080
Yeast
reproductionGO:0000003400.079
Yeast Rat Worm Fly
microtubule based movementGO:0007018330.079
regulation of protein ubiquitinationGO:003139630.078
Human
intracellular transportGO:0046907320.077
hematopoietic or lymphoid organ developmentGO:00485341910.076
protein localization to microtubule cytoskeletonGO:007269810.075
nuclear divisionGO:0000280230.075
Human Yeast Rat Worm Fly
mitotic cell cycleGO:0000278640.075
protein complex subunit organizationGO:0071822460.075
Yeast Worm Fly
regulation of heart growthGO:006042020.073
biosynthetic processGO:00090582940.071
Human
negative regulation of intracellular transportGO:003238730.071
cellular nitrogen compound metabolic processGO:00346412900.070
Human Yeast
proteolysisGO:0006508380.070
Human
nitrogen compound metabolic processGO:00068073190.065
Human Yeast
cellular response to biotic stimulusGO:007121630.065
negative regulation of cytoplasmic transportGO:190365020.064
mitotic cell cycle checkpointGO:000709350.063
Human
positive regulation of cytoskeleton organizationGO:005149530.063
Yeast
regulation of bindingGO:005109830.063
Human
cellular protein localizationGO:0034613200.062
Human Fly
regulation of microtubule polymerization or depolymerizationGO:003111030.061
negative regulation of cell communicationGO:0010648960.061
microtubule cytoskeleton organization involved in mitosisGO:190285010.061
guanosine containing compound metabolic processGO:190106840.060
regulation of mitotic cell cycleGO:0007346250.060
Human
organic substance transportGO:0071702580.059
regulation of proteolysisGO:0030162240.059
Human
cell projection organizationGO:00300302840.059
cytokinetic processGO:003250620.057
Fly
protein depolymerizationGO:005126110.056
organic cyclic compound metabolic processGO:19013603010.056
Human Yeast
negative regulation of intracellular protein transportGO:009031730.055
macromolecular complex subunit organizationGO:0043933740.055
Yeast Worm Fly
aromatic compound biosynthetic processGO:00194382170.055
Human
positive regulation of biological processGO:00485182530.055
Human Yeast
protein phosphorylationGO:0006468470.055
Human Yeast Mouse Rat Fly
rna metabolic processGO:00160702190.054
Human
cellular biosynthetic processGO:00442492860.054
Human
regulation of multicellular organism growthGO:004001440.054
transportGO:00068102200.053
Fly
regulation of transferase activityGO:0051338160.052
Human
cellular component disassemblyGO:002241110.052
Yeast Worm
macromolecule modificationGO:00434121110.051
Human Yeast Mouse Rat Fly
regulation of cell divisionGO:0051302120.049
Human Worm
regulation of multicellular organismal processGO:00512392770.049
Fly
regulation of gene expressionGO:00104682650.049
Human
chromosome organizationGO:0051276310.049
Human Yeast
phosphorus metabolic processGO:00067931090.048
Human Yeast Mouse Rat Fly
organelle transport along microtubuleGO:007238410.047
protein localizationGO:0008104400.047
Human Yeast Fly
deathGO:00162651210.047
Human Worm
regulation of cell cycle phase transitionGO:190198780.046
Human
regulation of macromolecule metabolic processGO:00602553170.046
Human
neuron projection developmentGO:00311751800.046
determination of heart left right asymmetryGO:00613711170.045
negative regulation of cell divisionGO:005178240.044
Human
cell proliferationGO:0008283800.044
Fly
male meiosisGO:000714020.044
Fly
mitotic cell cycle phase transitionGO:004477290.044
Human
response to abiotic stimulusGO:00096281220.044
response to decreased oxygen levelsGO:0036293250.043
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.043
Human
nucleobase containing compound metabolic processGO:00061392740.042
Human Yeast
response to biotic stimulusGO:0009607970.042
cellular aromatic compound metabolic processGO:00067252950.042
Human Yeast
heart developmentGO:00075073130.041
Fly
negative regulation of cellular processGO:00485232830.041
Human Fly
cell migrationGO:00164772370.041
tube morphogenesisGO:00352393490.041
immune system processGO:00023762410.041
regulation of rna biosynthetic processGO:20011412130.040
Human
organelle assemblyGO:00709251100.040
Yeast Fly
negative regulation of metabolic processGO:0009892860.040
Human
nucleobase containing compound biosynthetic processGO:00346542050.039
Human
macromolecular complex disassemblyGO:003298410.039
regulation of mitosisGO:000708890.039
Human
regulation of organelle assemblyGO:190211540.039
phosphorylationGO:0016310690.038
Human Yeast Mouse Rat Fly
regulation of cellular biosynthetic processGO:00313262450.038
Human
cell cycle g2 m phase transitionGO:004483940.038
Human
regulation of cell cycle processGO:0010564200.038
Human Yeast Worm
positive regulation of catabolic processGO:000989640.038
Human
organelle localizationGO:0051640490.038
Fly
regulation of catalytic activityGO:0050790550.037
Human Yeast
cellular component biogenesisGO:00440851780.037
Yeast Fly
cell deathGO:00082191210.037
Human Worm
cellular nitrogen compound biosynthetic processGO:00442712180.037
Human
chromosome localizationGO:005000020.037
cellular response to chemical stimulusGO:00708871570.036
determination of left right symmetryGO:00073681790.036
organelle fissionGO:0048285230.036
Human Yeast Rat Worm Fly
spindle assembly involved in female meiosisGO:000705610.036
Fly
regulation of metabolic processGO:00192223590.034
Human Yeast
cellular protein modification processGO:00064641000.034
Human Yeast Mouse Rat Fly
regulation of primary metabolic processGO:00800903110.034
Human
regulation of organ growthGO:004662030.034
cytoskeleton organizationGO:0007010960.034
Human Yeast Worm Fly
positive regulation of muscle organ developmentGO:004863610.033
vesicle transport along microtubuleGO:004749610.033
organic cyclic compound biosynthetic processGO:19013622230.033
Human
negative regulation of cellular component organizationGO:0051129160.032
Human
regulation of dna replicationGO:000627530.032
dna integrity checkpointGO:003157060.032
Human
regulation of molecular functionGO:0065009700.032
Human Yeast
response to drugGO:004249330.032
positive regulation of cellular metabolic processGO:0031325940.032
Human
sister chromatid cohesionGO:000706220.031
multicellular organism growthGO:003526440.031
negative regulation of cellular metabolic processGO:0031324770.030
Human
cell cycle g1 s phase transitionGO:004484310.030
regulation of signalingGO:00230512350.030
establishment of localization in cellGO:0051649770.030
Fly
cell part morphogenesisGO:00329902460.029
regulation of protein complex assemblyGO:004325430.029
chromatin modificationGO:0016568210.028
g1 s transition of mitotic cell cycleGO:000008210.028
cellular macromolecule localizationGO:0070727210.028
Human Fly
muscle structure developmentGO:00610611960.027
multi organism processGO:00517041340.027
Worm Fly
chromosome organization involved in meiosisGO:007019210.027
response to endogenous stimulusGO:0009719830.027
positive regulation of oocyte developmentGO:006028210.027
mitotic g2 m transition checkpointGO:004481830.027
response to external stimulusGO:00096052640.026
neuron developmentGO:00486662620.026
positive regulation of chromosome organizationGO:200125210.026
Human
peptidyl threonine phosphorylationGO:001810710.026
Human
regulation of cellular component organizationGO:0051128860.025
Human Yeast Worm
head developmentGO:00603223030.025
growthGO:00400071740.025
intracellular signal transductionGO:0035556850.025
regulation of rna metabolic processGO:00512522240.025
Human
positive regulation of purine nucleotide catabolic processGO:003312310.025
positive regulation of nitrogen compound metabolic processGO:0051173690.025
regulation of cardiac muscle tissue developmentGO:005502410.024
negative regulation of organelle organizationGO:001063940.024
Human
pancreas developmentGO:0031016840.024
mitotic dna damage checkpointGO:004477340.024
female meiosis chromosome segregationGO:001632110.024
organic substance biosynthetic processGO:19015762890.024
Human
regulation of transportGO:0051049450.023
regulation of signal transductionGO:00099662250.023
positive regulation of macromolecule metabolic processGO:0010604930.023
Human
regulation of chromosome organizationGO:003304450.022
Human
guanosine containing compound catabolic processGO:190106920.022
mitotic g2 dna damage checkpointGO:000709530.022
nucleic acid metabolic processGO:00903042440.021
Human Yeast
negative regulation of gene expressionGO:0010629650.021
Human
regulation of programmed cell deathGO:00430671010.021
Human
nucleic acid templated transcriptionGO:00976591810.021
Human
regulation of embryonic developmentGO:0045995470.020
carboxylic acid metabolic processGO:0019752220.020
cellular response to decreased oxygen levelsGO:003629410.020
neuron differentiationGO:00301823530.020
cellular protein complex disassemblyGO:004362410.020
regulation of apoptotic processGO:0042981980.020
Human
negative regulation of signalingGO:0023057960.020
positive regulation of chromatin modificationGO:190331010.020
vesicle mediated transportGO:0016192220.020
Fly
regulation of dendrite developmentGO:005077330.020
cellular component assemblyGO:00226071700.020
Yeast Fly
regulation of nervous system developmentGO:0051960900.020
Fly
regulation of protein modification processGO:0031399290.019
Human
cell projection morphogenesisGO:00488582440.019
regulation of intracellular signal transductionGO:1902531570.019
programmed cell deathGO:00125011190.019
Human Worm
ras protein signal transductionGO:000726570.019
eye developmentGO:00016542770.019
regulation of nucleic acid templated transcriptionGO:19035062130.019
Human
intracellular estrogen receptor signaling pathwayGO:003052030.019
regulation of cell developmentGO:00602841000.018
Fly
regulation of purine nucleotide catabolic processGO:003312120.018
regulation of transcription dna templatedGO:00063552130.018
Human
regenerationGO:0031099910.018
response to oxygen containing compoundGO:1901700550.018
covalent chromatin modificationGO:0016569200.018
negative regulation of signal transductionGO:0009968940.018
regulation of cellular localizationGO:0060341120.017
regulation of response to stimulusGO:00485832690.017
hemopoiesisGO:00300971830.017
positive regulation of striated muscle tissue developmentGO:004584410.017
regulation of protein bindingGO:004339330.017
Human
peptidyl threonine modificationGO:001821010.016
Human
regulation of developmental processGO:00507932470.016
Fly
cellular component movementGO:00069283350.016
regulation of microtubule based processGO:003288660.016
Yeast
cellular macromolecular complex assemblyGO:0034622240.015
Fly
cellular response to hypoxiaGO:007145610.015
g2 dna damage checkpointGO:003157230.015
Human
regulation of multicellular organismal developmentGO:20000262230.015
Fly
positive regulation of cell divisionGO:005178120.015
Human
cellular response to organic substanceGO:00713101050.015
positive regulation of rna metabolic processGO:0051254590.015
developmental growthGO:00485891660.015
cellular macromolecule catabolic processGO:0044265120.015
Human
regulation of phosphate metabolic processGO:0019220430.014
Human
proximal distal pattern formationGO:000995410.014
regulation of cell differentiationGO:00455951420.014
Fly
embryonic skeletal system developmentGO:0048706970.014
regulation of dna metabolic processGO:0051052110.014
enzyme linked receptor protein signaling pathwayGO:00071671060.014
response to stressGO:00069502630.014
Human
negative regulation of molecular functionGO:0044092230.014
Human
establishment of protein localizationGO:0045184140.014
Human
positive regulation of metabolic processGO:00098931080.014
Human Yeast
protein polymerizationGO:005125840.014
Fly
establishment of organelle localizationGO:0051656450.013
Fly
cell morphogenesis involved in differentiationGO:00009041950.013
negative regulation of protein phosphorylationGO:000193340.013
Human
response to external biotic stimulusGO:0043207970.013
protein localization to centrosomeGO:007153910.013
regulation of reproductive processGO:200024140.013
regionalizationGO:00030022740.013
convergent extensionGO:00600261180.013
response to oxygen levelsGO:0070482250.013
homeostatic processGO:00425921420.013
cellular protein complex assemblyGO:0043623190.013
Fly
epithelial cell morphogenesisGO:000338220.012
positive regulation of histone modificationGO:003105810.012
regulation of nucleobase containing compound metabolic processGO:00192192500.012
Human
establishment of chromosome localizationGO:005130320.012
protein dephosphorylationGO:000647030.012
regulation of synapse organizationGO:005080730.012
negative regulation of ras protein signal transductionGO:004658010.012
cellular response to stressGO:0033554620.012
Human
regulation of neurogenesisGO:0050767870.012
Fly
positive regulation of multi organism processGO:004390230.012
cellular response to endogenous stimulusGO:0071495680.012
regulation of protein phosphorylationGO:0001932180.012
Human
cytoplasmic transportGO:0016482110.012
primary neural tube formationGO:001402010.012
cell motilityGO:00488702440.012
macromolecule localizationGO:0033036540.012
Human Yeast Fly
positive regulation of cell communicationGO:0010647560.012
apoptotic processGO:00069151160.012
Human Worm
response to hypoxiaGO:0001666250.012
regulation of nitrogen compound metabolic processGO:00511712510.012
Human
transcription dna templatedGO:00063511810.011
Human
protein complex biogenesisGO:0070271300.011
Yeast Fly
small gtpase mediated signal transductionGO:000726480.011
neural retina developmentGO:0003407490.011
immune system developmentGO:00025201910.011
protein complex assemblyGO:0006461300.011
Yeast Fly
gastrulationGO:00073692080.011
central nervous system developmentGO:00074173870.011
peptidyl tyrosine dephosphorylationGO:003533510.011
dna biosynthetic processGO:007189730.011
embryonic organ morphogenesisGO:00485622740.011
developmental maturationGO:0021700340.011
cell proliferation in forebrainGO:002184630.010
macromolecule biosynthetic processGO:00090592270.010
Human
response to lipidGO:0033993600.010
camera type eye developmentGO:00430102220.010
regulation of anatomical structure morphogenesisGO:00226031300.010
wnt signaling pathwayGO:0016055800.010
cell maturationGO:0048469230.010
stem cell maintenanceGO:001982740.010
phagocytosisGO:000690930.010
Fly

plk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
gastrointestinal system cancerDOID:311900.029
organ system cancerDOID:005068600.029
cancerDOID:16200.029
disease of cellular proliferationDOID:1456600.029
colorectal cancerDOID:925600.028
intestinal cancerDOID:1015500.028
large intestine cancerDOID:567200.028
physical disorderDOID:008001500.021
colon cancerDOID:21900.019
colon carcinomaDOID:152000.019