IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

runx2a

runt-related transcription factor 2a

Entrez: 405784
Ensembl: ENSDARG00000040261
ZFIN: ZDB-GENE-040629-3
UniProtKB: B3DKD9
UniProtKB: Q6U1J2

Process Predictions
Disease Predictions

runx2a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular macromolecule metabolic process	GO:0044260	391	0.951	Human Zebrafish Mouse Fly
nitrogen compound metabolic process	GO:0006807	319	0.949	Human Zebrafish Mouse Fly
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.910	Human Zebrafish Mouse Fly
embryonic organ morphogenesis	GO:0048562	274	0.873	Zebrafish Mouse
positive regulation of cellular process	GO:0048522	201	0.858	Human Zebrafish Mouse Fly
central nervous system development	GO:0007417	387	0.857
regulation of rna metabolic process	GO:0051252	224	0.794	Human Zebrafish Mouse Fly
positive regulation of macromolecule metabolic process	GO:0010604	93	0.791	Human Zebrafish Mouse Fly
odontogenesis of dentin containing tooth	GO:0042475	1	0.771	Mouse
regulation of primary metabolic process	GO:0080090	311	0.760	Human Zebrafish Mouse Fly
regulation of metabolic process	GO:0019222	359	0.751	Human Zebrafish Mouse Fly
heterocycle biosynthetic process	GO:0018130	215	0.747	Human Zebrafish Mouse Fly
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.743	Human Zebrafish Mouse Fly
chordate embryonic development	GO:0043009	271	0.724	Zebrafish Mouse
heterocycle metabolic process	GO:0046483	290	0.702	Human Zebrafish Mouse Fly
immune system process	GO:0002376	241	0.681	Zebrafish Mouse Fly
nucleobase containing compound biosynthetic process	GO:0034654	205	0.676	Human Zebrafish Mouse Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.664	Human Zebrafish Mouse Fly
regulation of multicellular organismal process	GO:0051239	277	0.650	Mouse Worm Fly
embryonic skeletal system development	GO:0048706	97	0.646	Zebrafish Mouse
signal transduction	GO:0007165	455	0.645	Mouse
positive regulation of biological process	GO:0048518	253	0.645	Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic process	GO:1901362	223	0.639	Human Zebrafish Mouse Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.630	Human Zebrafish Mouse Fly
aromatic compound biosynthetic process	GO:0019438	217	0.624	Human Zebrafish Mouse Fly
embryonic skeletal system morphogenesis	GO:0048704	93	0.615	Zebrafish Mouse
tube morphogenesis	GO:0035239	349	0.602	Fly
regulation of gene expression	GO:0010468	265	0.579	Human Zebrafish Mouse Fly
regulation of rna biosynthetic process	GO:2001141	213	0.579	Human Zebrafish Mouse Fly
positive regulation of rna metabolic process	GO:0051254	59	0.573	Human Zebrafish Mouse Fly
response to external stimulus	GO:0009605	264	0.562	Fly
t cell differentiation	GO:0030217	6	0.555	Mouse
cellular nitrogen compound metabolic process	GO:0034641	290	0.549	Human Zebrafish Mouse Fly
transport	GO:0006810	220	0.539
positive regulation of metabolic process	GO:0009893	108	0.535	Human Zebrafish Mouse Fly
biosynthetic process	GO:0009058	294	0.532	Human Zebrafish Mouse Fly
t cell activation	GO:0042110	6	0.531	Mouse
macromolecule biosynthetic process	GO:0009059	227	0.528	Human Zebrafish Mouse Fly
regulation of transcription dna templated	GO:0006355	213	0.525	Human Zebrafish Mouse Fly
organic cyclic compound metabolic process	GO:1901360	301	0.516	Human Zebrafish Mouse Fly
nucleic acid templated transcription	GO:0097659	181	0.511	Human Zebrafish Mouse Fly
sensory organ development	GO:0007423	393	0.508	Fly
growth	GO:0040007	174	0.506	Worm
cellular aromatic compound metabolic process	GO:0006725	295	0.499	Human Zebrafish Mouse Fly
glial cell migration	GO:0008347	3	0.488
response to other organism	GO:0051707	97	0.488
skeletal system development	GO:0001501	181	0.483	Zebrafish Mouse
digestive system development	GO:0055123	289	0.481	Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.472	Human Zebrafish Mouse Fly
inner ear development	GO:0048839	126	0.470
regulation of nucleic acid templated transcription	GO:1903506	213	0.467	Human Zebrafish Mouse Fly
hemopoiesis	GO:0030097	183	0.466	Zebrafish Mouse Fly
ameboidal type cell migration	GO:0001667	143	0.465
regulation of biosynthetic process	GO:0009889	250	0.451	Human Zebrafish Mouse Fly
sensory organ morphogenesis	GO:0090596	200	0.437	Fly
multi organism process	GO:0051704	134	0.431
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.428	Zebrafish Mouse
embryonic organ development	GO:0048568	381	0.422	Zebrafish Mouse Fly
phosphorus metabolic process	GO:0006793	109	0.417
ossification	GO:0001503	23	0.408	Human Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.404	Human Zebrafish Mouse Fly
negative regulation of biological process	GO:0048519	304	0.393	Human Mouse Fly
regulation of cellular metabolic process	GO:0031323	320	0.383	Human Zebrafish Mouse Fly
mechanoreceptor differentiation	GO:0042490	37	0.365
chondrocyte development	GO:0002063	4	0.361	Mouse
cell morphogenesis	GO:0000902	289	0.361	Fly
transcription dna templated	GO:0006351	181	0.357	Human Zebrafish Mouse Fly
endocrine system development	GO:0035270	65	0.354
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.354	Human Zebrafish Mouse Fly
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.353
transcription from rna polymerase ii promoter	GO:0006366	80	0.349	Mouse Fly
rna biosynthetic process	GO:0032774	181	0.344	Human Zebrafish Mouse Fly
appendage development	GO:0048736	80	0.344	Mouse
hematopoietic or lymphoid organ development	GO:0048534	191	0.342	Zebrafish Mouse Fly
regulation of developmental process	GO:0050793	247	0.326	Mouse Worm Fly
protein localization to nucleus	GO:0034504	3	0.326
nucleic acid metabolic process	GO:0090304	244	0.325	Human Zebrafish Mouse Fly
neuron projection morphogenesis	GO:0048812	161	0.322	Fly
cellular component biogenesis	GO:0044085	178	0.320
response to stress	GO:0006950	263	0.313	Fly
positive regulation of cellular biosynthetic process	GO:0031328	68	0.312	Human Zebrafish Mouse Fly
digestive tract development	GO:0048565	265	0.311	Fly
leukocyte differentiation	GO:0002521	25	0.309	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.305	Human Zebrafish Mouse Fly
response to external biotic stimulus	GO:0043207	97	0.303
ear development	GO:0043583	127	0.298
cell surface receptor signaling pathway	GO:0007166	325	0.295	Mouse
immune system development	GO:0002520	191	0.294	Zebrafish Mouse Fly
generation of neurons	GO:0048699	385	0.294	Fly
cellular response to chemical stimulus	GO:0070887	157	0.294	Mouse
positive regulation of cellular metabolic process	GO:0031325	94	0.293	Human Zebrafish Mouse Fly
organic substance biosynthetic process	GO:1901576	289	0.290	Human Zebrafish Mouse Fly
myotube cell development	GO:0014904	35	0.287
protein modification process	GO:0036211	100	0.287
neuromuscular synaptic transmission	GO:0007274	2	0.286
aging	GO:0007568	2	0.286
leukocyte proliferation	GO:0070661	1	0.283
appendage morphogenesis	GO:0035107	56	0.281	Mouse
positive regulation of transcription dna templated	GO:0045893	57	0.281	Human Zebrafish Mouse Fly
locomotion	GO:0040011	313	0.280	Fly
positive regulation of developmental process	GO:0051094	50	0.277	Mouse Worm Fly
regulation of macromolecule metabolic process	GO:0060255	317	0.277	Human Zebrafish Mouse Fly
stem cell differentiation	GO:0048863	117	0.271	Mouse
rna metabolic process	GO:0016070	219	0.261	Human Zebrafish Mouse Fly
kidney development	GO:0001822	92	0.260
neuron differentiation	GO:0030182	353	0.260	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.253	Mouse
cell part morphogenesis	GO:0032990	246	0.249	Fly
eye morphogenesis	GO:0048592	144	0.249	Fly
defense response	GO:0006952	47	0.247
neuron development	GO:0048666	262	0.246	Fly
positive regulation of cell differentiation	GO:0045597	30	0.245	Mouse Fly
response to wounding	GO:0009611	116	0.244	Fly
regulation of nervous system development	GO:0051960	90	0.237
regulation of cell differentiation	GO:0045595	142	0.236	Mouse Fly
gastrulation	GO:0007369	208	0.234	Fly
negative regulation of cellular process	GO:0048523	283	0.232	Human Mouse Fly
urogenital system development	GO:0001655	97	0.230
regulation of signal transduction	GO:0009966	225	0.228	Mouse
muscle cell differentiation	GO:0042692	139	0.227
muscle structure development	GO:0061061	196	0.223
muscle cell development	GO:0055001	115	0.222
developmental growth	GO:0048589	166	0.217	Worm
eye development	GO:0001654	277	0.216	Fly
cell fate specification	GO:0001708	68	0.212
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.212	Human Mouse Fly
positive regulation of rna biosynthetic process	GO:1902680	57	0.211	Human Zebrafish Mouse Fly
regulation of multicellular organismal development	GO:2000026	223	0.208	Mouse Fly
axon guidance	GO:0007411	86	0.205	Fly
positive regulation of transport	GO:0051050	2	0.203
cellular component movement	GO:0006928	335	0.196	Fly
nephron epithelium morphogenesis	GO:0072088	1	0.192
cellular response to organic substance	GO:0071310	105	0.190	Mouse
regulation of cell cycle	GO:0051726	52	0.186
muscle tissue development	GO:0060537	110	0.185
establishment of localization	GO:0051234	244	0.184
peptide transport	GO:0015833	1	0.180
homeostatic process	GO:0042592	142	0.180
gene expression	GO:0010467	252	0.180	Human Zebrafish Mouse Fly
protein targeting to nucleus	GO:0044744	3	0.179
regulation of endodermal cell fate specification	GO:0042663	15	0.178
skeletal muscle fiber development	GO:0048741	35	0.177
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.176	Mouse Fly
single organism localization	GO:1902578	225	0.174
hepaticobiliary system development	GO:0061008	98	0.173
nucleobase containing compound metabolic process	GO:0006139	274	0.172	Human Zebrafish Mouse Fly
response to endogenous stimulus	GO:0009719	83	0.171	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.170	Mouse Fly
amide transport	GO:0042886	12	0.169
cellular component assembly	GO:0022607	170	0.168
regulation of cellular component organization	GO:0051128	86	0.168
dorsal ventral pattern formation	GO:0009953	125	0.165	Zebrafish
regulation of anatomical structure morphogenesis	GO:0022603	130	0.165	Mouse Fly
regulation of stem cell differentiation	GO:2000736	4	0.163
positive regulation of biosynthetic process	GO:0009891	68	0.161	Human Zebrafish Mouse Fly
regulation of immune system process	GO:0002682	34	0.161
organelle localization	GO:0051640	49	0.161
small molecule metabolic process	GO:0044281	77	0.159
heart development	GO:0007507	313	0.155
regulation of neurogenesis	GO:0050767	87	0.155
regulation of localization	GO:0032879	104	0.154
brain development	GO:0007420	293	0.153
skeletal system morphogenesis	GO:0048705	102	0.151	Zebrafish Mouse
bmp signaling pathway	GO:0030509	52	0.150	Mouse
negative regulation of response to stimulus	GO:0048585	104	0.149	Mouse
lymphocyte differentiation	GO:0030098	9	0.149	Mouse
larval development	GO:0002164	2	0.147
cellular response to growth factor stimulus	GO:0071363	39	0.147	Mouse
type b pancreatic cell development	GO:0003323	4	0.146
cell projection assembly	GO:0030031	64	0.145
inner ear receptor cell differentiation	GO:0060113	29	0.145
modification dependent protein catabolic process	GO:0019941	3	0.145
positive regulation of gene expression	GO:0010628	71	0.143	Human Zebrafish Mouse Fly
mononuclear cell proliferation	GO:0032943	1	0.141
establishment of localization in cell	GO:0051649	77	0.140
cell migration	GO:0016477	237	0.139
renal system development	GO:0072001	94	0.139
regulation of cartilage development	GO:0061035	7	0.135	Mouse
positive regulation of cell communication	GO:0010647	56	0.134
regulation of signaling	GO:0023051	235	0.133	Mouse
regulation of cellular biosynthetic process	GO:0031326	245	0.131	Human Zebrafish Mouse Fly
embryonic viscerocranium morphogenesis	GO:0048703	52	0.131	Zebrafish
multicellular organismal homeostasis	GO:0048871	29	0.131
microtubule cytoskeleton organization	GO:0000226	33	0.130
otic vesicle development	GO:0071599	42	0.127
response to chemical	GO:0042221	320	0.127	Mouse Fly
mesoderm development	GO:0007498	88	0.126
protein complex subunit organization	GO:0071822	46	0.125
cellular protein catabolic process	GO:0044257	4	0.124
lymphocyte activation	GO:0046649	10	0.124	Mouse
cell fate commitment	GO:0045165	99	0.123	Mouse
tissue regeneration	GO:0042246	74	0.123
cartilage condensation	GO:0001502	3	0.122
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.122	Human Zebrafish Mouse Fly
regulation of cell communication	GO:0010646	232	0.120	Mouse
neuron projection guidance	GO:0097485	86	0.118	Fly
response to biotic stimulus	GO:0009607	97	0.116
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.113	Human Mouse Fly
regulation of establishment of protein localization	GO:0070201	4	0.111
response to alkaloid	GO:0043279	2	0.111
response to bacterium	GO:0009617	58	0.111
protein secretion	GO:0009306	1	0.110
wound healing	GO:0042060	90	0.110	Fly
cellular component morphogenesis	GO:0032989	336	0.110	Fly
peripheral nervous system neuron differentiation	GO:0048934	28	0.107
negative regulation of transcription dna templated	GO:0045892	45	0.107	Human Mouse Fly
auditory receptor cell fate commitment	GO:0009912	4	0.106
regulation of cell activation	GO:0050865	1	0.106
cellular protein modification process	GO:0006464	100	0.106
regulation of multicellular organism growth	GO:0040014	4	0.104	Worm
cell projection organization	GO:0030030	284	0.104	Fly
cellular localization	GO:0051641	97	0.103
nephron morphogenesis	GO:0072028	2	0.103
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.103
specification of symmetry	GO:0009799	204	0.102
gliogenesis	GO:0042063	45	0.101
negative regulation of gene expression	GO:0010629	65	0.099	Human Mouse Fly
single organism nuclear import	GO:1902593	3	0.098
lipid catabolic process	GO:0016042	4	0.098
regulation of protein metabolic process	GO:0051246	56	0.098
lymphocyte proliferation	GO:0046651	1	0.097
renal system vasculature development	GO:0061437	2	0.097
developmental maturation	GO:0021700	34	0.097	Mouse
response to organic cyclic compound	GO:0014070	51	0.097
cellular biosynthetic process	GO:0044249	286	0.096	Human Zebrafish Mouse Fly
positive regulation of multicellular organismal process	GO:0051240	52	0.095	Mouse Worm Fly
otic vesicle morphogenesis	GO:0071600	34	0.093
modification dependent macromolecule catabolic process	GO:0043632	3	0.093
nephron tubule morphogenesis	GO:0072078	1	0.090
collagen metabolic process	GO:0032963	2	0.090
positive regulation of immune system process	GO:0002684	17	0.089
protein localization	GO:0008104	40	0.089
skeletal muscle tissue development	GO:0007519	67	0.089
er nucleus signaling pathway	GO:0006984	2	0.088
cell morphogenesis involved in differentiation	GO:0000904	195	0.088	Fly
stem cell proliferation	GO:0072089	4	0.088
caudal fin morphogenesis	GO:0035143	7	0.087
maintenance of location	GO:0051235	4	0.087
camera type eye development	GO:0043010	222	0.086
regulation of transport	GO:0051049	45	0.083
fin development	GO:0033333	77	0.083
mesenchyme development	GO:0060485	127	0.083
head development	GO:0060322	303	0.082
convergent extension	GO:0060026	118	0.082
regulation of response to stimulus	GO:0048583	269	0.082	Mouse
myotube differentiation	GO:0014902	45	0.081
regulation of cell development	GO:0060284	100	0.081	Fly
protein import into nucleus	GO:0006606	3	0.081
positive regulation of cell proliferation	GO:0008284	15	0.081	Mouse
defense response to other organism	GO:0098542	33	0.081
forebrain development	GO:0030900	96	0.080
positive regulation of cell cycle	GO:0045787	3	0.080
fin regeneration	GO:0031101	51	0.080
organelle organization	GO:0006996	227	0.080
regulation of cell morphogenesis	GO:0022604	42	0.079
cellular response to external stimulus	GO:0071496	2	0.079
negative regulation of biosynthetic process	GO:0009890	55	0.079	Human Mouse Fly
reproduction	GO:0000003	40	0.079	Worm
nephron development	GO:0072006	31	0.078
gland development	GO:0048732	143	0.078
morphogenesis of a branching structure	GO:0001763	21	0.078
muscle fiber development	GO:0048747	52	0.077
neuron projection development	GO:0031175	180	0.077	Fly
regulation of ossification	GO:0030278	5	0.077	Mouse
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.075
positive regulation of muscle organ development	GO:0048636	1	0.075
medial fin development	GO:0033338	16	0.075
ubiquitin dependent protein catabolic process	GO:0006511	3	0.074
osteoblast differentiation	GO:0001649	5	0.074	Human Mouse
cell motility	GO:0048870	244	0.073
otic vesicle formation	GO:0030916	27	0.072
epithelial cell development	GO:0002064	42	0.072
regulation of cytokine production	GO:0001817	3	0.072
establishment of protein localization to organelle	GO:0072594	4	0.071
taxis	GO:0042330	109	0.071	Fly
hair cell differentiation	GO:0035315	32	0.071
wnt signaling pathway	GO:0016055	80	0.070
convergent extension involved in organogenesis	GO:0060029	10	0.070
intracellular signal transduction	GO:0035556	85	0.070
response to abiotic stimulus	GO:0009628	122	0.069
single organism cellular localization	GO:1902580	46	0.069
multicellular organismal reproductive process	GO:0048609	35	0.069
skeletal muscle organ development	GO:0060538	78	0.068
cell proliferation	GO:0008283	80	0.068	Mouse
positive regulation of apoptotic process	GO:0043065	29	0.067
embryonic skeletal joint development	GO:0072498	3	0.067
camera type eye morphogenesis	GO:0048593	108	0.067
signal transduction in absence of ligand	GO:0038034	1	0.066
phosphorylation	GO:0016310	69	0.066
glucose homeostasis	GO:0042593	1	0.066
bone morphogenesis	GO:0060349	11	0.065	Mouse
connective tissue development	GO:0061448	99	0.065	Zebrafish Mouse
regulation of protein transport	GO:0051223	3	0.064
vasculature development	GO:0001944	278	0.064
nuclear transport	GO:0051169	4	0.063
cellular protein localization	GO:0034613	20	0.063
negative regulation of macromolecule metabolic process	GO:0010605	76	0.063	Human Mouse Fly
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.063	Human Zebrafish Mouse Fly
renal tubule morphogenesis	GO:0061333	1	0.062
single organism metabolic process	GO:0044710	217	0.062
localization of cell	GO:0051674	244	0.061
regulation of hormone secretion	GO:0046883	2	0.061
foregut morphogenesis	GO:0007440	4	0.061
positive regulation of signaling	GO:0023056	56	0.061
regulation of biological quality	GO:0065008	263	0.060
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.060	Fly
cellular response to endogenous stimulus	GO:0071495	68	0.060	Mouse
positive regulation of signal transduction	GO:0009967	56	0.060
regulation of protein catabolic process	GO:0042176	1	0.060
bone development	GO:0060348	14	0.060	Mouse
regulation of mitotic cell cycle	GO:0007346	25	0.059
response to carbohydrate	GO:0009743	3	0.059
cellular response to retinoic acid	GO:0071300	1	0.058
morphogenesis of an epithelium	GO:0002009	333	0.057
epidermal cell differentiation	GO:0009913	36	0.057
single organism behavior	GO:0044708	24	0.056
regulation of cell motility	GO:2000145	46	0.056
determination of left right symmetry	GO:0007368	179	0.055
positive regulation of cell activation	GO:0050867	1	0.055
multicellular organism growth	GO:0035264	4	0.055	Worm
embryonic heart tube development	GO:0035050	133	0.055
regulation of cytoplasmic transport	GO:1903649	4	0.054
endodermal cell fate determination	GO:0007493	2	0.053
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.053	Fly
cranial suture morphogenesis	GO:0060363	1	0.053
extracellular structure organization	GO:0043062	27	0.052
secondary metabolic process	GO:0019748	3	0.052
system process	GO:0003008	185	0.052
negative regulation of metabolic process	GO:0009892	86	0.052	Human Mouse Fly
single organism transport	GO:0044765	206	0.051
regulation of cellular protein metabolic process	GO:0032268	52	0.051
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.051
regulation of reproductive process	GO:2000241	4	0.050
regulation of nucleocytoplasmic transport	GO:0046822	2	0.050
glomerulus vasculature development	GO:0072012	2	0.050
intracellular transport	GO:0046907	32	0.050
nitrogen compound transport	GO:0071705	23	0.050
immune effector process	GO:0002252	23	0.050
negative regulation of rna biosynthetic process	GO:1902679	45	0.049	Human Mouse Fly
endochondral bone morphogenesis	GO:0060350	8	0.049	Mouse
positive regulation of cell division	GO:0051781	2	0.049
heart looping	GO:0001947	94	0.048
immune response	GO:0006955	28	0.048
negative regulation of developmental process	GO:0051093	65	0.047
embryonic camera type eye development	GO:0031076	29	0.047
protein phosphorylation	GO:0006468	47	0.047
protein heterooligomerization	GO:0051291	1	0.047
smoothened signaling pathway	GO:0007224	30	0.046	Mouse
fin morphogenesis	GO:0033334	53	0.046
ion homeostasis	GO:0050801	41	0.046
positive regulation of epithelial cell differentiation	GO:0030858	2	0.046
glycoprotein metabolic process	GO:0009100	23	0.045
protein import	GO:0017038	3	0.045
regulation of molecular function	GO:0065009	70	0.044
embryonic camera type eye morphogenesis	GO:0048596	19	0.044
pancreas development	GO:0031016	84	0.044
cell cycle	GO:0007049	93	0.044
liver development	GO:0001889	96	0.043
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.043	Mouse
embryonic limb morphogenesis	GO:0030326	2	0.043	Mouse
endothelial cell differentiation	GO:0045446	20	0.043
negative regulation of cellular metabolic process	GO:0031324	77	0.042	Human Mouse Fly
embryonic eye morphogenesis	GO:0048048	30	0.042
positive regulation of molecular function	GO:0044093	33	0.042
nucleocytoplasmic transport	GO:0006913	4	0.042
hindbrain development	GO:0030902	91	0.042
myeloid cell differentiation	GO:0030099	86	0.042
response to drug	GO:0042493	3	0.042
glomerulus development	GO:0032835	27	0.041
determination of bilateral symmetry	GO:0009855	204	0.041
positive regulation of catabolic process	GO:0009896	4	0.041
cell death	GO:0008219	121	0.041	Fly
leukocyte activation	GO:0045321	12	0.041	Mouse
negative regulation of muscle cell differentiation	GO:0051148	1	0.041
negative regulation of cell differentiation	GO:0045596	46	0.040
regulation of programmed cell death	GO:0043067	101	0.040	Fly
single organism organelle organization	GO:1902589	199	0.040
regulation of protein localization to nucleus	GO:1900180	2	0.039
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.039	Human Mouse Fly
specification of organ identity	GO:0010092	2	0.039
regulation of cell migration	GO:0030334	40	0.039
retina development in camera type eye	GO:0060041	146	0.039
response to corticosteroid	GO:0031960	1	0.039
embryonic heart tube morphogenesis	GO:0003143	108	0.039
regulation of cell division	GO:0051302	12	0.039
multicellular organism reproduction	GO:0032504	35	0.038
catabolic process	GO:0009056	32	0.038
regulation of gastrulation	GO:0010470	24	0.038
positive regulation of canonical wnt signaling pathway	GO:0090263	4	0.038
epithelial tube morphogenesis	GO:0060562	148	0.037
cell maturation	GO:0048469	23	0.037	Mouse
striated muscle tissue development	GO:0014706	110	0.037
peripheral nervous system neuron development	GO:0048935	22	0.037
regulation of oligodendrocyte differentiation	GO:0048713	1	0.036
medial fin morphogenesis	GO:0035141	14	0.036
regulation of protein import into nucleus	GO:0042306	2	0.036
embryonic neurocranium morphogenesis	GO:0048702	15	0.036
negative regulation of rna metabolic process	GO:0051253	48	0.036	Human Mouse Fly
adenohypophysis development	GO:0021984	15	0.035
regulation of metal ion transport	GO:0010959	4	0.035
ectodermal placode development	GO:0071696	37	0.035
cellular response to fibroblast growth factor stimulus	GO:0044344	22	0.034	Mouse
determination of heart left right asymmetry	GO:0061371	117	0.034
negative regulation of signal transduction in absence of ligand	GO:1901099	1	0.034
calcium ion transport	GO:0006816	18	0.034
positive regulation of programmed cell death	GO:0043068	29	0.034	Fly
digestive tract morphogenesis	GO:0048546	231	0.034	Fly
regulation of myotube differentiation	GO:0010830	2	0.033
positive regulation of inflammatory response	GO:0050729	1	0.033
negative regulation of cellular biosynthetic process	GO:0031327	55	0.033	Human Mouse Fly
inner ear morphogenesis	GO:0042472	63	0.033
kupffer s vesicle development	GO:0070121	50	0.033
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.033	Human Mouse Fly
swim bladder inflation	GO:0048798	5	0.033
mitotic cell cycle process	GO:1903047	48	0.033
positive regulation of cellular component biogenesis	GO:0044089	3	0.033
regulation of i kappab kinase nf kappab signaling	GO:0043122	4	0.033
lipid biosynthetic process	GO:0008610	22	0.032
striated muscle cell development	GO:0055002	108	0.032
regulation of apoptotic process	GO:0042981	98	0.032	Fly
proteolysis	GO:0006508	38	0.032
branching morphogenesis of an epithelial tube	GO:0048754	15	0.031
protein acetylation	GO:0006473	2	0.031
defense response to bacterium	GO:0042742	22	0.031
locomotor rhythm	GO:0045475	3	0.031
organic acid metabolic process	GO:0006082	31	0.031
pronephros development	GO:0048793	69	0.030
positive regulation of stem cell proliferation	GO:2000648	1	0.030
regulation of inflammatory response	GO:0050727	2	0.030
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.030
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.030
regulation of calcium ion transport	GO:0051924	2	0.030
cellular protein metabolic process	GO:0044267	129	0.030
response to glucocorticoid	GO:0051384	1	0.030
response to nutrient	GO:0007584	3	0.030
embryonic hemopoiesis	GO:0035162	53	0.030	Fly
developmental programmed cell death	GO:0010623	4	0.030	Fly
response to monosaccharide	GO:0034284	3	0.030
regulation of neuron differentiation	GO:0045664	56	0.030
formation of primary germ layer	GO:0001704	62	0.029
response to mechanical stimulus	GO:0009612	24	0.029
hormone biosynthetic process	GO:0042446	3	0.029
determination of ventral identity	GO:0048264	21	0.029
ear morphogenesis	GO:0042471	64	0.029
response to immobilization stress	GO:0035902	1	0.029
cell cell signaling	GO:0007267	52	0.029
negative regulation of feeding behavior	GO:2000252	2	0.029
stem cell division	GO:0017145	1	0.028
positive regulation of cell death	GO:0010942	29	0.028	Fly
response to steroid hormone	GO:0048545	35	0.028
positive regulation of cellular catabolic process	GO:0031331	3	0.028
heart morphogenesis	GO:0003007	156	0.028
cartilage development	GO:0051216	96	0.028	Zebrafish Mouse
multicellular organismal macromolecule metabolic process	GO:0044259	2	0.028
oxoacid metabolic process	GO:0043436	31	0.028
positive regulation of secretion by cell	GO:1903532	1	0.027
epithelial cell morphogenesis	GO:0003382	2	0.027
nuclear import	GO:0051170	3	0.027
striated muscle cell differentiation	GO:0051146	129	0.027
stem cell development	GO:0048864	82	0.027
regeneration	GO:0031099	91	0.027
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.027	Human Mouse Fly
ectodermal placode morphogenesis	GO:0071697	32	0.027
protein complex biogenesis	GO:0070271	30	0.027
regulation of organelle organization	GO:0033043	29	0.027
calcium ion homeostasis	GO:0055074	19	0.026
macromolecule localization	GO:0033036	54	0.026
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.026	Mouse
i kappab kinase nf kappab signaling	GO:0007249	4	0.026
vestibular receptor cell development	GO:0060118	3	0.026
cellular ketone metabolic process	GO:0042180	11	0.026
activation of mapk activity	GO:0000187	3	0.026
alcohol biosynthetic process	GO:0046165	2	0.026
response to light stimulus	GO:0009416	46	0.026
single organism intracellular transport	GO:1902582	25	0.026
pathway restricted smad protein phosphorylation	GO:0060389	1	0.026
embryonic digestive tract development	GO:0048566	4	0.026
embryonic pattern specification	GO:0009880	44	0.026
chemotaxis	GO:0006935	104	0.025	Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.025	Mouse
reproductive process	GO:0022414	40	0.025	Worm Fly
intracellular receptor signaling pathway	GO:0030522	30	0.025
cell activation	GO:0001775	16	0.025	Mouse
cellular response to lipid	GO:0071396	39	0.025
striated muscle cell proliferation	GO:0014855	7	0.025
sequestering of calcium ion	GO:0051208	3	0.025
hard palate development	GO:0060022	4	0.025
phosphate containing compound metabolic process	GO:0006796	108	0.025
regulation of cell cycle process	GO:0010564	20	0.024

runx2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.657	Human
osteochondrodysplasia	DOID:2256	0.287	Human
bone development disease	DOID:0080006	0.287	Human
bone disease	DOID:0080001	0.287	Human
connective tissue disease	DOID:65	0.287	Human
musculoskeletal system disease	DOID:17	0.287	Human
nervous system disease	DOID:863	0.109

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