Danio rerio

25 known processes

slc4a4a

solute carrier family 4, member 4a

(Aliases: nbce1,si:dkey-256m11.1,id:ibd2520,slc4a4)

slc4a4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
monovalent inorganic cation transportGO:0015672420.790
sodium ion transmembrane transportGO:0035725210.732
anion transportGO:0006820380.727
cation transmembrane transportGO:0098655650.602
kidney developmentGO:0001822920.600
inorganic cation transmembrane transportGO:0098662500.586
regulation of apoptotic processGO:0042981980.581
digestive tract morphogenesisGO:00485462310.472
pronephros developmentGO:0048793690.443
single organism localizationGO:19025782250.442
transmembrane transportGO:00550851200.411
agingGO:000756820.383
inorganic ion transmembrane transportGO:0098660570.371
ion transmembrane transportGO:0034220910.354
regulation of biological qualityGO:00650082630.312
Zebrafish
renal system developmentGO:0072001940.303
single organism transportGO:00447652060.298
urogenital system developmentGO:0001655970.297
organic anion transportGO:0015711150.295
regulation of protein transportGO:005122330.284
nephron developmentGO:0072006310.277
pigmentationGO:0043473850.268
digestive system developmentGO:00551232890.260
organic substance transportGO:0071702580.248
photoreceptor cell developmentGO:0042461400.246
establishment of localizationGO:00512342440.244
sensory organ developmentGO:00074233930.212
sulfate transmembrane transportGO:190235820.205
regulation of cell deathGO:00109411030.202
transportGO:00068102200.200
protein localizationGO:0008104400.183
homophilic cell adhesion via plasma membrane adhesion moleculesGO:000715640.182
sensory organ morphogenesisGO:00905962000.176
regulation of intracellular protein transportGO:003315730.168
embryonic organ developmentGO:00485683810.167
Zebrafish
chemical homeostasisGO:0048878490.159
oligopeptide transportGO:000685710.153
chordate embryonic developmentGO:00430092710.145
ion transportGO:00068111140.144
protein localization to plasma membraneGO:007265910.141
regulation of nitrogen compound metabolic processGO:00511712510.141
nephron tubule morphogenesisGO:007207810.140
digestive tract developmentGO:00485652650.139
regulation of establishment of protein localizationGO:007020140.133
extrinsic apoptotic signaling pathwayGO:009719130.130
developmental pigmentationGO:0048066480.129
heart developmentGO:00075073130.126
nephron morphogenesisGO:007202820.124
cellular component assemblyGO:00226071700.120
regulation of peptidyl tyrosine phosphorylationGO:005073010.119
tube morphogenesisGO:00352393490.118
kidney morphogenesisGO:0060993150.117
positive regulation of transportGO:005105020.116
renal tubule morphogenesisGO:006133310.114
inorganic anion transportGO:0015698250.113
establishment of protein localization to plasma membraneGO:009000210.113
cellular response to estrogen stimulusGO:0071391240.111
sulfur compound transportGO:007234830.110
peptide transportGO:001583310.109
brain developmentGO:00074202930.108
regulation of cellular amino acid metabolic processGO:000652100.107
cellular amine metabolic processGO:004410620.107
cilium organizationGO:0044782710.103
cation transportGO:0006812810.102
cellular component movementGO:00069283350.102
regulation of programmed cell deathGO:00430671010.099
central nervous system developmentGO:00074173870.097
single organism nuclear importGO:190259330.097
nitrogen compound metabolic processGO:00068073190.096
larval developmentGO:000216420.094
response to drugGO:004249330.092
Zebrafish
cellular ketone metabolic processGO:0042180110.091
negative regulation of biological processGO:00485193040.091
cellular nitrogen compound metabolic processGO:00346412900.090
lipid storageGO:001991510.089
peripheral nervous system developmentGO:0007422550.088
system processGO:00030081850.087
mesenchyme developmentGO:00604851270.085
positive regulation of response to stimulusGO:0048584800.085
amine metabolic processGO:000930820.083
regulation of metal ion transportGO:001095940.080
embryonic organ morphogenesisGO:00485622740.079
regulation of cellular macromolecule biosynthetic processGO:20001122220.079
nephron epithelium morphogenesisGO:007208810.078
nuclear transportGO:005116940.078
programmed cell deathGO:00125011190.077
regulation of multicellular organismal processGO:00512392770.076
Worm
apoptotic processGO:00069151160.076
carboxylic acid metabolic processGO:0019752220.075
hindbrain developmentGO:0030902910.074
mesenchymal cell differentiationGO:0048762870.073
regulation of metabolic processGO:00192223590.071
negative regulation of cell communicationGO:0010648960.071
regulation of protein targetingGO:190353320.071
response to carbohydrateGO:000974330.070
locomotionGO:00400113130.069
regionalizationGO:00030022740.069
epithelial cell differentiationGO:00308551160.069
neuron migrationGO:0001764220.069
regulation of signal transductionGO:00099662250.068
positive regulation of nucleobase containing compound metabolic processGO:0045935690.067
regulation of ion transportGO:0043269220.067
negative regulation of programmed cell deathGO:0043069580.067
metal ion transportGO:0030001580.066
single organism cell adhesionGO:0098602290.066
bicarbonate transportGO:001570140.065
epiboly involved in gastrulation with mouth forming secondGO:0055113350.065
epibolyGO:0090504410.065
cellular amino acid metabolic processGO:000652070.064
nucleic acid metabolic processGO:00903042440.063
positive regulation of macromolecule metabolic processGO:0010604930.062
carboxylic acid transportGO:004694280.062
negative regulation of signalingGO:0023057960.062
protein importGO:001703830.061
head developmentGO:00603223030.061
nucleocytoplasmic transportGO:000691340.060
developmental programmed cell deathGO:001062340.060
generation of neuronsGO:00486993850.059
retina morphogenesis in camera type eyeGO:0060042790.059
developmental growth involved in morphogenesisGO:0060560860.059
cellular component biogenesisGO:00440851780.059
positive regulation of nitrogen compound metabolic processGO:0051173690.058
cell deathGO:00082191210.058
homeostatic processGO:00425921420.058
Zebrafish
regulation of signalingGO:00230512350.058
Worm
eye photoreceptor cell differentiationGO:0001754450.056
regulation of cell communicationGO:00106462320.056
Worm
regulation of cellular ketone metabolic processGO:001056570.056
positive regulation of transcription dna templatedGO:0045893570.056
regulation of calcium ion transportGO:005192420.055
neuron differentiationGO:00301823530.055
response to hexoseGO:000974630.055
signal transductionGO:00071654550.054
establishment of protein localization to organelleGO:007259440.054
hematopoietic or lymphoid organ developmentGO:00485341910.054
Zebrafish
establishment of localization in cellGO:0051649770.054
establishment or maintenance of cell polarityGO:0007163290.053
regulation of multicellular organismal developmentGO:20000262230.053
organonitrogen compound metabolic processGO:1901564740.053
organic cyclic compound biosynthetic processGO:19013622230.053
regulation of cellular metabolic processGO:00313233200.052
protein targeting to nucleusGO:004474430.052
positive regulation of map kinase activityGO:004340630.052
pigment cell differentiationGO:0050931380.052
gastrulationGO:00073692080.052
organic acid metabolic processGO:0006082310.051
regulation of cellular amine metabolic processGO:003323800.051
eye morphogenesisGO:00485921440.051
response to glucoseGO:000974930.051
deathGO:00162651210.051
ion homeostasisGO:0050801410.050
maintenance of locationGO:005123540.050
photoreceptor cell differentiationGO:0046530550.050
transcription dna templatedGO:00063511810.050
kidney vasculature developmentGO:006144020.049
ear morphogenesisGO:0042471640.048
renal absorptionGO:007029310.048
positive regulation of biological processGO:00485182530.048
Worm
sulfate transportGO:000827220.048
morphogenesis of an epithelial sheetGO:0002011490.048
negative regulation of signal transductionGO:0009968940.048
epithelial cell developmentGO:0002064420.047
biological adhesionGO:0022610400.046
positive regulation of cellular amino acid metabolic processGO:004576400.045
negative regulation of cell deathGO:0060548600.044
retina development in camera type eyeGO:00600411460.044
homeostasis of number of cellsGO:0048872620.043
Zebrafish
heterophilic cell cell adhesion via plasma membrane cell adhesion moleculesGO:000715720.043
neural tube developmentGO:0021915620.042
columnar cuboidal epithelial cell differentiationGO:0002065380.042
oxoacid metabolic processGO:0043436310.042
renal system vasculature developmentGO:006143720.042
embryo development ending in birth or egg hatchingGO:00097922710.041
hindbrain morphogenesisGO:0021575220.041
protein localization to nucleusGO:003450430.041
sodium ion transportGO:0006814240.040
establishment or maintenance of epithelial cell apical basal polarityGO:0045197110.040
negative regulation of cellular processGO:00485232830.040
regulation of intracellular signal transductionGO:1902531570.039
nuclear importGO:005117030.039
chloride transmembrane transportGO:190247640.039
Worm
positive regulation of cellular amine metabolic processGO:003324000.039
embryonic retina morphogenesis in camera type eyeGO:0060059220.038
morphogenesis of embryonic epitheliumGO:0016331300.038
pronephric nephron developmentGO:0039019140.038
proton transportGO:001599270.038
chloride transportGO:000682180.036
Worm
macromolecule biosynthetic processGO:00090592270.036
cellular biosynthetic processGO:00442492860.036
negative regulation of protein phosphorylationGO:000193340.036
intracellular signal transductionGO:0035556850.035
positive regulation of rna biosynthetic processGO:1902680570.035
single organism metabolic processGO:00447102170.035
cellular component morphogenesisGO:00329893360.034
epithelial tube morphogenesisGO:00605621480.034
gastrulation with mouth forming secondGO:0001702440.034
single organism cellular localizationGO:1902580460.034
stem cell developmentGO:0048864820.034
adherens junction maintenanceGO:003433420.034
negative regulation of kinase activityGO:003367340.034
cell part morphogenesisGO:00329902460.034
protein secretionGO:000930610.034
glucose homeostasisGO:004259310.034
regulation of transportGO:0051049450.034
adherens junction organizationGO:003433240.033
positive regulation of cellular processGO:00485222010.033
neural crest cell differentiationGO:0014033720.033
negative regulation of apoptotic processGO:0043066550.033
hydrogen transportGO:000681870.033
transcription from rna polymerase ii promoterGO:0006366800.033
regulation of fatty acid metabolic processGO:001921710.033
peptidyl tyrosine modificationGO:001821250.033
endomembrane system organizationGO:0010256130.033
positive regulation of gene expressionGO:0010628710.032
camera type eye morphogenesisGO:00485931080.032
regulation of circadian rhythmGO:004275240.032
carbohydrate transportGO:0008643130.032
ras protein signal transductionGO:000726570.031
amide transportGO:0042886120.031
nephric duct developmentGO:0072176130.030
cell fate commitmentGO:0045165990.030
organic substance biosynthetic processGO:19015762890.030
regulation of cytokine productionGO:000181730.030
lateral line system developmentGO:0048925760.029
protein import into nucleusGO:000660630.029
regulation of primary metabolic processGO:00800903110.029
multicellular organism growthGO:003526440.029
Worm
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.029
cell motilityGO:00488702440.029
regulation of gtp catabolic processGO:003312420.028
negative regulation of response to stimulusGO:00485851040.028
regulation of cell substrate adhesionGO:001081010.028
embryonic skeletal system developmentGO:0048706970.028
regulation of nucleic acid templated transcriptionGO:19035062130.028
cell projection assemblyGO:0030031640.028
establishment of endothelial barrierGO:006102830.028
neuronal action potentialGO:0019228180.028
negative regulation of cellular metabolic processGO:0031324770.028
mechanoreceptor differentiationGO:0042490370.027
mesenchymal cell developmentGO:0014031780.027
axon ensheathment in central nervous systemGO:003229120.027
cilium morphogenesisGO:0060271850.026
negative regulation of nitrogen compound metabolic processGO:0051172590.026
anion transmembrane transportGO:0098656120.026
Worm
inositol lipid mediated signalingGO:004801720.026
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.026
biosynthetic processGO:00090582940.026
mitotic cell cycleGO:0000278640.026
camera type eye developmentGO:00430102220.026
regulation of cytoplasmic transportGO:190364940.025
alpha amino acid metabolic processGO:190160530.025
regulation of photoreceptor cell differentiationGO:004653220.025
cellular macromolecule metabolic processGO:00442603910.025
regulation of macromolecule metabolic processGO:00602553170.025
organelle assemblyGO:00709251100.025
endoderm developmentGO:0007492490.025
pancreas developmentGO:0031016840.025
cellular protein metabolic processGO:00442671290.024
guanosine containing compound catabolic processGO:190106920.024
rhombomere morphogenesisGO:0021593170.024
establishment of cell polarityGO:0030010180.024
guanosine containing compound metabolic processGO:190106840.024
pronephros morphogenesisGO:0072114140.024
macromolecule localizationGO:0033036540.023
heterocycle metabolic processGO:00464832900.023
organic acid transportGO:001584990.023
positive regulation of cell adhesionGO:004578510.023
intrahepatic bile duct developmentGO:0035622110.023
response to monosaccharideGO:003428430.023
nucleobase containing compound metabolic processGO:00061392740.023
response to abiotic stimulusGO:00096281220.023
cellular component maintenanceGO:004395430.023
regulation of heart growthGO:006042020.023
small molecule metabolic processGO:0044281770.023
regulation of reproductive processGO:200024140.023
cation homeostasisGO:0055080330.022
regulation of developmental processGO:00507932470.022
Worm
organelle organizationGO:00069962270.022
regulation of protein import into nucleusGO:004230620.022
regulation of nucleoside metabolic processGO:000911820.022
negative regulation of protein kinase activityGO:000646940.022
regulation of rna biosynthetic processGO:20011412130.022
digestive system processGO:002260090.021
response to amino acidGO:004320020.021
regulation of rna metabolic processGO:00512522240.021
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.021
apoptotic process involved in morphogenesisGO:006056120.021
regulation of transmembrane transporter activityGO:002289820.021
response to oxygen containing compoundGO:1901700550.021
neural crest cell migrationGO:0001755420.021
response to radiationGO:0009314510.020
cellular localizationGO:0051641970.020
response to chemicalGO:00422213200.020
Zebrafish Worm
regulation of membrane potentialGO:0042391230.020
positive regulation of reproductive processGO:200024320.020
growthGO:00400071740.020
Worm
cellular response to nutrient levelsGO:003166920.020
regulation of protein complex assemblyGO:004325430.020
eye developmentGO:00016542770.020
glomerular epithelial cell fate commitmentGO:007231440.020
single organism intracellular transportGO:1902582250.020
positive regulation of cellular biosynthetic processGO:0031328680.020
cell projection organizationGO:00300302840.019
nucleobase containing compound biosynthetic processGO:00346542050.019
protein metabolic processGO:00195381830.019
cell migrationGO:00164772370.019
positive regulation of signal transductionGO:0009967560.019
regulation of organ morphogenesisGO:2000027350.019
neuron developmentGO:00486662620.019
negative regulation of protein transportGO:005122430.019
regulation of protein localization to nucleusGO:190018020.019
small gtpase mediated signal transductionGO:000726480.019
cell substrate adhesionGO:003158940.019
xenobiotic metabolic processGO:000680540.019
apoptotic process involved in developmentGO:190274220.019
nucleic acid templated transcriptionGO:00976591810.018
morphogenesis of an epitheliumGO:00020093330.018
multicellular organismal signalingGO:0035637220.018
nitrogen compound transportGO:0071705230.018
regulation of stem cell differentiationGO:200073640.018
positive regulation of small gtpase mediated signal transductionGO:005105710.018
cell morphogenesis involved in neuron differentiationGO:00486671630.018
renal filtrationGO:0097205100.018
endosomal transportGO:001619720.018
monovalent inorganic cation homeostasisGO:005506790.018
wnt signaling pathwayGO:0016055800.018
regulation of nucleobase containing compound metabolic processGO:00192192500.018
heterocycle biosynthetic processGO:00181302150.017
cell cell adhesion involved in gastrulationGO:007058640.017
cellular protein localizationGO:0034613200.017
cellular aromatic compound metabolic processGO:00067252950.017
positive regulation of embryonic developmentGO:004001930.017
long chain fatty acid biosynthetic processGO:004275910.017
sodium ion homeostasisGO:005507830.017
regulation of cell differentiationGO:00455951420.017
carbohydrate homeostasisGO:003350010.017
negative regulation of cell differentiationGO:0045596460.017
hemopoiesisGO:00300971830.017
Zebrafish
forebrain cell migrationGO:002188510.017
positive regulation of rna metabolic processGO:0051254590.017
cell adhesionGO:0007155400.016
leukocyte proliferationGO:007066110.016
response to external stimulusGO:00096052640.016
fertilizationGO:000956630.016
cell surface receptor signaling pathwayGO:00071663250.016
positive regulation of macromolecule biosynthetic processGO:0010557590.016
hormone secretionGO:004687920.016
regulation of dna replicationGO:000627530.016
ameboidal type cell migrationGO:00016671430.016
cellular response to external stimulusGO:007149620.016
regulation of ion transmembrane transporter activityGO:003241220.016
regulation of i kappab kinase nf kappab signalingGO:004312240.016
auditory receptor cell morphogenesisGO:000209340.016
pronephric nephron tubule developmentGO:003902020.016
single organism membrane fusionGO:004480120.016
sensory system developmentGO:0048880760.016
cellular nitrogen compound biosynthetic processGO:00442712180.016
protein targeting to membraneGO:000661210.016
glomerulus vasculature developmentGO:007201220.016
catabolic processGO:0009056320.016
intracellular transportGO:0046907320.015
cellular protein catabolic processGO:004425740.015
macromolecular complex assemblyGO:0065003350.015
purine nucleotide metabolic processGO:0006163270.015
kidney epithelium developmentGO:0072073230.015
lipid oxidationGO:003444010.015
regulation of transcription dna templatedGO:00063552130.015
hepaticobiliary system developmentGO:0061008980.015
inner ear receptor cell differentiationGO:0060113290.015
regulation of nucleocytoplasmic transportGO:004682220.015
response to nutrientGO:000758430.015
phagocytosisGO:000690930.015
nephron epithelium developmentGO:0072009160.015
neuron projection extensionGO:1990138450.015
positive regulation of leukocyte differentiationGO:190210710.015
negative regulation of metabolic processGO:0009892860.014
apoptotic signaling pathwayGO:0097190230.014
regulation of dendrite developmentGO:005077330.014
action potentialGO:0001508190.014
determination of bilateral symmetryGO:00098552040.014
nephric duct morphogenesisGO:007217870.014
negative regulation of cytoplasmic transportGO:190365020.014
positive regulation of nucleic acid templated transcriptionGO:1903508570.014
establishment or maintenance of apical basal cell polarityGO:0035088120.014
protein localization to membraneGO:007265790.014
fatty acid elongation unsaturated fatty acidGO:001936810.014
intestinal absorptionGO:005089220.014
negative regulation of intracellular signal transductionGO:1902532220.014
triglyceride homeostasisGO:007032820.014
regulation of jak stat cascadeGO:004642530.014
cell growthGO:0016049570.014
peptide metabolic processGO:000651810.014
cellular response to starvationGO:000926710.014
regulation of striated muscle contractionGO:000694220.014
axis elongationGO:0003401310.014
inner ear morphogenesisGO:0042472630.014
positive regulation of blood circulationGO:190352420.014
regulation of purine nucleotide catabolic processGO:003312120.014
cell matrix adhesionGO:000716040.014
negative regulation of multicellular organismal processGO:0051241690.013
regulation of wnt signaling pathwayGO:0030111530.013
negative regulation of rna metabolic processGO:0051253480.013
regulation of transporter activityGO:003240920.013
membrane fusionGO:006102520.013
chemosensory behaviorGO:000763510.013
response to organic cyclic compoundGO:0014070510.013
organonitrogen compound biosynthetic processGO:1901566470.013
regulation of protein ubiquitinationGO:003139630.013
regulation of localizationGO:00328791040.013
gtp metabolic processGO:004603940.013
fatty acid elongationGO:003049710.013
cellular component assembly involved in morphogenesisGO:00109271070.013
adult behaviorGO:003053420.013
immune system developmentGO:00025201910.013
Zebrafish
cardiac muscle tissue developmentGO:0048738480.013
neural tube patterningGO:0021532330.013
positive regulation of protein complex assemblyGO:003133420.013
proteolysis involved in cellular protein catabolic processGO:005160330.013
amino acid transportGO:000686520.013
blood vessel developmentGO:00015682460.013
axon extensionGO:0048675450.012
dicarboxylic acid transportGO:000683510.012
rhombomere 6 developmentGO:002157240.012
positive regulation of nucleoside metabolic processGO:004597910.012
cell morphogenesisGO:00009022890.012
cytoskeleton organizationGO:0007010960.012
positive regulation of catabolic processGO:000989640.012
skeletal system morphogenesisGO:00487051020.012
developmental cell growthGO:0048588520.012
aromatic compound biosynthetic processGO:00194382170.012
regulation of transcription from rna polymerase ii promoterGO:00063571140.012
stem cell differentiationGO:00488631170.012
negative regulation of rna biosynthetic processGO:1902679450.012
regulation of biosynthetic processGO:00098892500.012
epidermis developmentGO:0008544480.012
regulation of sodium ion transmembrane transporter activityGO:200064910.012
anterior posterior pattern specificationGO:00099521520.012
positive regulation of programmed cell deathGO:0043068290.012
proteasomal protein catabolic processGO:001049820.012
sensory perceptionGO:0007600390.012
anatomical structure arrangementGO:004853220.012
circulatory system processGO:0003013870.012
tyrosine phosphorylation of stat proteinGO:000726010.012
axon developmentGO:00615641660.012
positive regulation of biosynthetic processGO:0009891680.012
regulation of nucleotide catabolic processGO:003081120.012
calcium ion importGO:007050940.012
neural precursor cell proliferationGO:0061351200.012
positive regulation of epithelial cell differentiationGO:003085820.012
renal tubule developmentGO:006132650.012
receptor internalizationGO:003162320.012
regulation of gene expressionGO:00104682650.011
rhombomere 5 developmentGO:002157140.011
positive regulation of cellular metabolic processGO:0031325940.011
intrinsic apoptotic signaling pathwayGO:0097193200.011
glucose transportGO:001575860.011
phosphatidylinositol mediated signalingGO:004801520.011
common bile duct developmentGO:0061009130.011
response to ketoneGO:190165410.011
rna metabolic processGO:00160702190.011
protein modification processGO:00362111000.011
cell cell adhesion via plasma membrane adhesion moleculesGO:009874260.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
establishment or maintenance of monopolar cell polarityGO:006133920.011
inner ear receptor stereocilium organizationGO:006012280.011
monocarboxylic acid transportGO:001571850.011
metal ion homeostasisGO:0055065260.011
positive regulation of cell communicationGO:0010647560.011
striated muscle tissue developmentGO:00147061100.011
regulation of anatomical structure morphogenesisGO:00226031300.011
embryonic hemopoiesisGO:0035162530.011
Zebrafish
negative regulation of gene expressionGO:0010629650.011
establishment of organelle localizationGO:0051656450.011
negative regulation of dna metabolic processGO:005105340.011
pronephric duct developmentGO:0039022130.011
regulation of multicellular organism growthGO:004001440.011
Worm
embryonic skeletal joint developmentGO:007249830.011
ubiquitin dependent protein catabolic processGO:000651130.011
gene expressionGO:00104672520.011
rho protein signal transductionGO:000726650.011
cellular modified amino acid metabolic processGO:000657530.011
regenerationGO:0031099910.011

slc4a4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.073
disease of cellular proliferationDOID:1456600.073
disease of anatomical entityDOID:700.053
urinary system diseaseDOID:1800.053
urinary system cancerDOID:399600.048
organ system cancerDOID:005068600.048
maturity onset diabetes of the youngDOID:005052400.036
diabetes mellitusDOID:935100.022
disease of metabolismDOID:001466700.022
carbohydrate metabolism diseaseDOID:005001300.022
type 2 diabetes mellitusDOID:935200.022
acquired metabolic diseaseDOID:006015800.022
glucose metabolism diseaseDOID:419400.022
kidney cancerDOID:26300.015