Danio rerio

21 known processes

tie1

endothelium-specific receptor tyrosine kinase 1

(Aliases: tie-1)

tie1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
osteoclast developmentGO:003603510.933
immune system developmentGO:00025201910.872
immune system processGO:00023762410.870
regulation of multicellular organismal processGO:00512392770.820
Mouse
regulation of signal transductionGO:00099662250.812
regulation of mononuclear cell migrationGO:007167510.811
regulation of cell shapeGO:000836010.796
central nervous system developmentGO:00074173870.757
microglia differentiationGO:001400410.741
heart developmentGO:00075073130.736
positive regulation of macrophage chemotaxisGO:001075910.719
xanthophore differentiationGO:005093630.717
regulation of cell adhesionGO:0030155150.713
melanocyte apoptotic processGO:190236220.681
hematopoietic or lymphoid organ developmentGO:00485341910.632
signal transductionGO:00071654550.629
cell motilityGO:00488702440.606
Mouse
regulation of developmental processGO:00507932470.597
Mouse
venous blood vessel developmentGO:006084190.593
cell substrate adhesionGO:003158940.585
positive regulation of retina development in camera type eyeGO:190286810.568
tube morphogenesisGO:00352393490.542
embryonic organ developmentGO:00485683810.540
cellular component morphogenesisGO:00329893360.536
phosphate containing compound metabolic processGO:00067961080.536
hemopoiesisGO:00300971830.516
cell projection organizationGO:00300302840.516
enzyme linked receptor protein signaling pathwayGO:00071671060.511
system processGO:00030081850.502
regulation of cell communicationGO:00106462320.500
lymph vessel developmentGO:0001945270.482
macrophage chemotaxisGO:004824630.465
leukocyte differentiationGO:0002521250.464
positive regulation of neural retina developmentGO:006107510.412
negative regulation of biological processGO:00485193040.401
Mouse
cell adhesionGO:0007155400.382
negative regulation of heart contractionGO:004582220.378
patterning of blood vesselsGO:0001569150.371
regulation of response to stimulusGO:00485832690.355
biological adhesionGO:0022610400.340
cardiac cell fate commitmentGO:006091110.329
response to chemicalGO:00422213200.321
Mouse
regulation of cell motilityGO:2000145460.320
Mouse
regulation of locomotionGO:0040012550.320
Mouse
melanocyte migrationGO:009732440.317
single organismal cell cell adhesionGO:0016337290.307
cell morphogenesisGO:00009022890.303
protein targeting to nucleusGO:004474430.301
cellular component assemblyGO:00226071700.299
muscle contractionGO:0006936180.294
locomotionGO:00400113130.293
Mouse
cellular component movementGO:00069283350.291
Mouse
negative regulation of angiogenesisGO:001652570.287
Mouse
cellular component biogenesisGO:00440851780.286
positive regulation of cell adhesionGO:004578510.277
vascular endothelial growth factor receptor signaling pathwayGO:0048010130.258
positive regulation of leukocyte migrationGO:000268720.255
mononuclear cell migrationGO:007167410.254
intracellular signal transductionGO:0035556850.251
regulation of cell morphogenesisGO:0022604420.248
phosphorus metabolic processGO:00067931090.241
response to organic substanceGO:00100331530.240
Mouse
development of primary female sexual characteristicsGO:004654540.239
cellular response to chemical stimulusGO:00708871570.236
embryonic heart tube developmentGO:00350501330.233
positive regulation of cell motilityGO:2000147110.226
blood vessel morphogenesisGO:00485142160.222
Mouse
stem cell differentiationGO:00488631170.218
negative regulation of blood circulationGO:190352320.214
positive regulation of cellular component movementGO:0051272110.214
blood circulationGO:0008015870.214
response to oxygen containing compoundGO:1901700550.209
Mouse
response to mechanical stimulusGO:0009612240.207
regulation of retina development in camera type eyeGO:190286620.203
single organism metabolic processGO:00447102170.193
localization of cellGO:00516742440.193
Mouse
selective angioblast sproutingGO:003547450.188
organonitrogen compound metabolic processGO:1901564740.186
myeloid cell differentiationGO:0030099860.185
response to external stimulusGO:00096052640.185
positive regulation of locomotionGO:0040017140.185
vasculature developmentGO:00019442780.183
heart processGO:0003015710.181
positive regulation of endothelial cell proliferationGO:000193810.180
peptidyl tyrosine modificationGO:001821250.178
apoptotic processGO:00069151160.176
positive regulation of cell migrationGO:0030335110.174
morphogenesis of an epitheliumGO:00020093330.171
myeloid leukocyte differentiationGO:0002573150.169
regulation of anatomical structure morphogenesisGO:00226031300.169
Mouse
positive regulation of stress activated mapk cascadeGO:003287430.169
venous endothelial cell migration involved in lymph vessel developmentGO:006085540.168
positive regulation of developmental processGO:0051094500.166
regulation of signalingGO:00230512350.162
regulation of heart contractionGO:0008016320.161
cellular response to external stimulusGO:007149620.161
behaviorGO:0007610740.159
positive regulation of cellular component biogenesisGO:004408930.159
response to lipidGO:0033993600.157
Mouse
carbohydrate derivative metabolic processGO:1901135610.156
response to endogenous stimulusGO:0009719830.155
regulation of vasculature developmentGO:1901342330.154
Mouse
negative regulation of cellular processGO:00485232830.149
Mouse
positive regulation of cellular processGO:00485222010.146
negative regulation of multicellular organismal processGO:0051241690.146
Mouse
regulation of cellular metabolic processGO:00313233200.146
positive regulation of biological processGO:00485182530.143
larval developmentGO:000216420.141
cellular response to hormone stimulusGO:0032870390.139
glomerulus vasculature developmentGO:007201220.138
regulation of intracellular protein transportGO:003315730.137
regulation of immune system processGO:0002682340.136
lymph vessel morphogenesisGO:0036303250.134
positive regulation of erk1 and erk2 cascadeGO:007037420.130
heart contractionGO:0060047710.129
cellular nitrogen compound metabolic processGO:00346412900.128
cellular biosynthetic processGO:00442492860.128
protein metabolic processGO:00195381830.127
cell part morphogenesisGO:00329902460.127
cell surface receptor signaling pathwayGO:00071663250.126
angiogenesisGO:00015251580.125
Mouse
sprouting angiogenesisGO:0002040530.120
camp biosynthetic processGO:0006171110.120
response to biotic stimulusGO:0009607970.116
regulation of growthGO:0040008420.114
neuron developmentGO:00486662620.112
actin filament based processGO:0030029640.111
heterocycle metabolic processGO:00464832900.110
ameboidal type cell migrationGO:00016671430.108
regulation of multicellular organismal developmentGO:20000262230.105
Mouse
protein secretionGO:000930610.104
organic substance biosynthetic processGO:19015762890.100
positive regulation of cell proliferationGO:0008284150.099
regulation of apoptotic processGO:0042981980.099
response to hormoneGO:0009725480.099
protein localization to nucleusGO:003450430.099
smooth muscle contractionGO:000693920.099
regulation of cellular component organizationGO:0051128860.098
regulation of dna templated transcription elongationGO:003278430.098
cellular response to endogenous stimulusGO:0071495680.097
protein complex biogenesisGO:0070271300.096
macromolecular complex subunit organizationGO:0043933740.096
regulation of purine nucleotide catabolic processGO:003312120.095
lymphatic endothelial cell differentiationGO:006083610.094
cell growthGO:0016049570.094
regulation of vasculogenesisGO:200121210.094
response to organic cyclic compoundGO:0014070510.092
establishment of protein localization to organelleGO:007259440.092
nucleobase containing compound metabolic processGO:00061392740.092
stem cell developmentGO:0048864820.092
positive regulation of map kinase activityGO:004340630.091
regulation of metabolic processGO:00192223590.091
regulation of phosphate metabolic processGO:0019220430.091
regulation of endothelial cell proliferationGO:000193610.091
nitrogen compound metabolic processGO:00068073190.089
small molecule metabolic processGO:0044281770.088
regulation of chemotaxisGO:0050920180.088
developmental growthGO:00485891660.086
nuclear transportGO:005116940.086
cell migration to the midline involved in heart developmentGO:0003318120.086
guanosine containing compound catabolic processGO:190106920.085
agingGO:000756820.085
pericardium developmentGO:006003910.084
regulation of jun kinase activityGO:004350630.083
positive regulation of leukocyte chemotaxisGO:000269010.083
growthGO:00400071740.082
organic cyclic compound metabolic processGO:19013603010.081
negative regulation of apoptotic processGO:0043066550.081
regulation of cellular component movementGO:0051270550.081
Mouse
epithelium migrationGO:0090132250.080
leukocyte migrationGO:0050900150.079
single organism organelle organizationGO:19025891990.079
cardiac atrium morphogenesisGO:000320920.079
nucleocytoplasmic transportGO:000691340.079
protein import into nucleusGO:000660630.079
regulation of protein import into nucleusGO:004230620.079
tissue remodelingGO:004877140.077
ovulation cycle processGO:002260220.077
single organism cell adhesionGO:0098602290.077
regulation of cytoplasmic transportGO:190364940.076
protein importGO:001703830.076
antimicrobial humoral responseGO:001973020.076
heart morphogenesisGO:00030071560.075
vasculogenesisGO:0001570410.075
cell migrationGO:00164772370.074
Mouse
positive regulation of response to stimulusGO:0048584800.073
embryonic heart tube morphogenesisGO:00031431080.073
cell migration involved in heart formationGO:0060974100.073
determination of heart left right asymmetryGO:00613711170.073
regulation of cell cell adhesionGO:0022407130.072
phosphatidylinositol 3 kinase signalingGO:001406520.071
cell projection morphogenesisGO:00488582440.071
cellular response to growth factor stimulusGO:0071363390.071
regulation of erk1 and erk2 cascadeGO:007037240.070
regulation of blood circulationGO:1903522320.069
neuron projection morphogenesisGO:00488121610.068
actin filament organizationGO:0007015150.068
establishment of localizationGO:00512342440.068
regulation of synapse organizationGO:005080730.067
regulation of behaviorGO:0050795240.067
cellular response to organic substanceGO:00713101050.067
regulation of macrophage chemotaxisGO:001075810.066
response to abiotic stimulusGO:00096281220.066
osteoclast differentiationGO:003031610.066
response to stressGO:00069502630.066
endothelial cell differentiationGO:0045446200.065
regulation of nucleotide catabolic processGO:003081120.065
determination of left right symmetryGO:00073681790.064
cell chemotaxisGO:0060326170.064
cellular amine metabolic processGO:004410620.064
deathGO:00162651210.063
positive regulation of cell communicationGO:0010647560.062
cell migration involved in heart developmentGO:0060973220.062
negative regulation of metabolic processGO:0009892860.062
regulation of heart growthGO:006042020.062
lymphangiogenesisGO:0001946250.062
bmp signaling pathwayGO:0030509520.062
actin cytoskeleton organizationGO:0030036630.061
regulation of cell substrate adhesionGO:001081010.061
fin regenerationGO:0031101510.060
macromolecule modificationGO:00434121110.059
regulation of biological qualityGO:00650082630.058
regulation of primary metabolic processGO:00800903110.058
circulatory system processGO:0003013870.058
positive regulation of cellular metabolic processGO:0031325940.058
regulation of mesenchymal cell proliferationGO:001046410.058
regulation of tube sizeGO:003515020.058
digestive tract developmentGO:00485652650.057
regulation of cell migrationGO:0030334400.057
Mouse
cardiac atrium developmentGO:000323040.057
cell proliferationGO:0008283800.057
regulation of cytokine productionGO:000181730.057
cell deathGO:00082191210.056
protein phosphorylationGO:0006468470.056
trabecula morphogenesisGO:006138320.055
organelle organizationGO:00069962270.055
cell morphogenesis involved in differentiationGO:00009041950.055
negative regulation of axon guidanceGO:190266810.055
protein complex subunit organizationGO:0071822460.054
tissue migrationGO:0090130370.053
regulation of molecular functionGO:0065009700.053
homeostatic processGO:00425921420.053
peptidyl tyrosine phosphorylationGO:001810850.052
cellular protein modification processGO:00064641000.052
regulation of metal ion transportGO:001095940.052
regulation of system processGO:0044057400.051
b cell activationGO:004211320.051
regulation of nucleoside metabolic processGO:000911820.050
neuron projection developmentGO:00311751800.050
glial cell migrationGO:000834730.050
regulation of phosphorus metabolic processGO:0051174430.050
venous blood vessel morphogenesisGO:004884530.050
striated muscle tissue developmentGO:00147061100.050
positive regulation of chemotaxisGO:005092150.049
cellular response to organic cyclic compoundGO:0071407380.048
response to steroid hormoneGO:0048545350.048
cell projection assemblyGO:0030031640.048
regulation of neural retina developmentGO:006107420.048
multicellular organism growthGO:003526440.048
response to estrogenGO:0043627270.047
synaptic growth at neuromuscular junctionGO:005112420.046
negative regulation of protein complex assemblyGO:003133310.046
septum transversum developmentGO:000334340.046
regulation of synaptic growth at neuromuscular junctionGO:000858210.046
regulation of cell proliferationGO:0042127370.046
programmed cell deathGO:00125011190.046
reactive nitrogen species metabolic processGO:200105700.046
multicellular organismal homeostasisGO:0048871290.046
nucleic acid templated transcriptionGO:00976591810.046
organic acid metabolic processGO:0006082310.045
organophosphate metabolic processGO:0019637370.045
regulation of synapse assemblyGO:005196330.045
ribonucleotide metabolic processGO:0009259270.045
endocardial cushion formationGO:000327220.045
blood vessel developmentGO:00015682460.045
aromatic compound biosynthetic processGO:00194382170.045
innate immune responseGO:0045087130.044
regulation of cellular amino acid metabolic processGO:000652100.044
determination of bilateral symmetryGO:00098552040.044
gastrulationGO:00073692080.044
nuclear importGO:005117030.043
muscle system processGO:0003012200.043
carboxylic acid metabolic processGO:0019752220.043
regulation of nucleic acid templated transcriptionGO:19035062130.043
phagocytosis engulfmentGO:000691110.043
regulation of phosphorylationGO:0042325260.043
phosphorylationGO:0016310690.043
macrophage differentiationGO:003022570.043
maintenance of locationGO:005123540.043
ion homeostasisGO:0050801410.043
cardiac ventricle formationGO:000321110.043
regulation of mapk cascadeGO:0043408140.043
endothelial cell migrationGO:0043542190.042
nik nf kappab signalingGO:003806110.042
dna templated transcription elongationGO:000635430.042
granulocyte chemotaxisGO:0071621110.042
positive regulation of transportGO:005105020.042
ovulation cycleGO:004269820.042
lymphocyte proliferationGO:004665110.042
transcription from rna polymerase ii promoterGO:0006366800.041
cardiac conduction system developmentGO:000316110.041
regulation of developmental growthGO:0048638380.041
amine metabolic processGO:000930820.041
regulation of cell projection assemblyGO:006049140.041
cellular protein metabolic processGO:00442671290.041
positive regulation of cytokine productionGO:000181920.040
purine containing compound metabolic processGO:0072521290.040
regulation of cardiac muscle tissue developmentGO:005502410.040
epithelial tube morphogenesisGO:00605621480.040
epithelial cell migrationGO:0010631250.040
guanosine containing compound metabolic processGO:190106840.040
collagen metabolic processGO:003296320.039
regulation of nitrogen compound metabolic processGO:00511712510.039
germ line stem cell maintenanceGO:003071820.039
ubiquitin dependent protein catabolic processGO:000651130.039
pathway restricted smad protein phosphorylationGO:006038910.038
regulation of programmed cell deathGO:00430671010.038
regulation of establishment of protein localizationGO:007020140.038
retina development in camera type eyeGO:00600411460.038
response to other organismGO:0051707970.038
gtp catabolic processGO:000618420.038
regulation of tyrosine phosphorylation of stat proteinGO:004250910.038
negative regulation of cellular component organizationGO:0051129160.037
cellular aromatic compound metabolic processGO:00067252950.037
myeloid leukocyte migrationGO:0097529120.037
artery developmentGO:0060840220.037
regulation of blood pressureGO:000821710.036
aorta developmentGO:003590440.036
g protein coupled receptor signaling pathwayGO:0007186740.036
ribose phosphate metabolic processGO:0019693270.036
single organism biosynthetic processGO:0044711710.036
neurological system processGO:0050877620.036
positive regulation of cell substrate adhesionGO:001081110.036
pigmentationGO:0043473850.036
female gonad developmentGO:000858540.035
heterocycle biosynthetic processGO:00181302150.035
cellular macromolecule metabolic processGO:00442603910.035
activation of jun kinase activityGO:000725720.035
epithelial cell cell adhesionGO:009013610.034
megakaryocyte developmentGO:003585510.034
single organism transportGO:00447652060.034
biosynthetic processGO:00090582940.034
small gtpase mediated signal transductionGO:000726480.034
ras protein signal transductionGO:000726570.033
leukocyte chemotaxisGO:0030595120.033
positive regulation of jak stat cascadeGO:004642720.033
reactive oxygen species biosynthetic processGO:190340910.033
regulation of protein targetingGO:190353320.033
nucleobase containing small molecule metabolic processGO:0055086320.033
macromolecular complex assemblyGO:0065003350.033
regulation of protein localization to nucleusGO:190018020.033
positive regulation of signal transductionGO:0009967560.033
response to antibioticGO:004667710.033
positive regulation of nitrogen compound metabolic processGO:0051173690.033
taxisGO:00423301090.033
gtp metabolic processGO:004603940.032
cation homeostasisGO:0055080330.032
negative regulation of cell deathGO:0060548600.032
positive regulation of cellular catabolic processGO:003133130.032
positive regulation of gtp catabolic processGO:003312610.032
metal ion homeostasisGO:0055065260.032
phagocytosisGO:000690930.032
blood vessel endothelial cell migrationGO:0043534180.032
regulation of organ growthGO:004662030.032
negative regulation of secretionGO:005104820.031
myeloid cell developmentGO:0061515320.031
receptor recyclingGO:000188140.031
dorsal aorta morphogenesisGO:003591230.031
energy reserve metabolic processGO:000611220.031
positive regulation of purine nucleotide catabolic processGO:003312310.030
single organism localizationGO:19025782250.030
cell matrix adhesionGO:000716040.030
stem cell maintenanceGO:001982740.030
transportGO:00068102200.030
female sex differentiationGO:004666040.029
regulation of neuron migrationGO:200122220.029
innervationGO:006038430.029
cellular response to vascular endothelial growth factor stimulusGO:003592430.029
positive regulation of multicellular organismal processGO:0051240520.029
regulation of transcription dna templatedGO:00063552130.029
regulation of angiogenesisGO:0045765260.029
Mouse
regulation of neutrophil differentiationGO:004565830.029
activation of mapk activityGO:000018730.028
axonal defasciculationGO:000741420.028
regulation of bindingGO:005109830.028
cellular amino acid metabolic processGO:000652070.028
mitochondrion organizationGO:000700540.028
embryonic hemopoiesisGO:0035162530.027
regulation of receptor recyclingGO:000191930.027
response to hypoxiaGO:0001666250.027
anatomical structure homeostasisGO:0060249360.027
granulocyte migrationGO:0097530110.027
regulation of peptidyl tyrosine phosphorylationGO:005073010.027
response to external biotic stimulusGO:0043207970.027
carbohydrate derivative biosynthetic processGO:1901137430.027
blood vessel endothelial cell proliferation involved in sprouting angiogenesisGO:000204340.027
heart loopingGO:0001947940.027
negative regulation of cell adhesionGO:000716260.027
negative regulation of programmed cell deathGO:0043069580.026
regulation of calcium ion transportGO:005192420.026
trabecula formationGO:006034320.026
regulation of intracellular signal transductionGO:1902531570.026
nitric oxide biosynthetic processGO:000680920.026
lipid storageGO:001991510.026
organophosphate biosynthetic processGO:0090407230.026
organelle assemblyGO:00709251100.026
negative regulation of feeding behaviorGO:200025220.026
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.026
positive regulation of molecular functionGO:0044093330.026
gas transportGO:001566930.026
positive regulation of secretionGO:005104710.025
regulation of gtp catabolic processGO:003312420.025
positive regulation of endothelial cell migrationGO:001059520.025
lymphatic endothelial cell fate commitmentGO:006083810.025
artery morphogenesisGO:0048844140.025
cellular catabolic processGO:0044248270.025
neuron differentiationGO:00301823530.025
cognitionGO:005089010.025
negative regulation of signal transductionGO:0009968940.025
kidney vasculature developmentGO:006144020.025
negative regulation of protein phosphorylationGO:000193340.025
cell migration involved in gastrulationGO:0042074790.025
cell cycleGO:0007049930.025
smad protein complex assemblyGO:000718310.025
regulation of nucleocytoplasmic transportGO:004682220.025
vascular endothelial growth factor signaling pathwayGO:003808430.025
ovarian follicle developmentGO:000154120.024
regulation of cellular amine metabolic processGO:003323800.024
gland developmentGO:00487321430.024
response to decreased oxygen levelsGO:0036293250.024
lamellipodium organizationGO:009758110.024
mitotic cell cycle processGO:1903047480.024
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.024
release of sequestered calcium ion into cytosolGO:005120930.024
positive regulation of epithelial cell migrationGO:001063420.024
oxoacid metabolic processGO:0043436310.023
catecholamine metabolic processGO:000658420.023
hypothalamus cell differentiationGO:002197940.023
regulation of jak stat cascadeGO:004642530.023
dorsal aorta developmentGO:003590740.023
regulation of blood vessel sizeGO:005088020.023
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.023
positive regulation of phosphate metabolic processGO:0045937210.023
regulation of cell differentiationGO:00455951420.023
cell migration involved in sprouting angiogenesisGO:000204280.023
positive regulation of phosphorus metabolic processGO:0010562210.023
regulation of cellular component biogenesisGO:0044087120.022
cellular lipid metabolic processGO:0044255360.022
regulation of bmp signaling pathwayGO:0030510390.022
microtubule cytoskeleton organizationGO:0000226330.022
atrioventricular valve formationGO:000319030.022
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296810.022
endodermal cell fate determinationGO:000749320.022
response to growth factorGO:0070848390.022
proteolysis involved in cellular protein catabolic processGO:005160330.022
b cell differentiationGO:003018310.022
g1 s transition of mitotic cell cycleGO:000008210.022
heart field specificationGO:000312810.022
negative regulation of protein kinase activityGO:000646940.021
regulation of cell deathGO:00109411030.021
positive regulation of jun kinase activityGO:004350720.021
positive regulation of secretion by cellGO:190353210.021
negative regulation of response to stimulusGO:00485851040.021
purine ribonucleotide metabolic processGO:0009150270.021
mononuclear cell proliferationGO:003294310.021
extrinsic apoptotic signaling pathwayGO:009719130.021
cardioblast migration to the midline involved in heart rudiment formationGO:000331950.021
forebrain developmentGO:0030900960.021
sensory perceptionGO:0007600390.021
endocardial cushion developmentGO:000319760.021
inositol lipid mediated signalingGO:004801720.021
regulation of receptor mediated endocytosisGO:004825940.021
otic vesicle morphogenesisGO:0071600340.021
regulation of response to external stimulusGO:0032101310.021
specification of symmetryGO:00097992040.021
positive regulation of cell activationGO:005086710.020
embryonic organ morphogenesisGO:00485622740.020
transcription elongation from rna polymerase ii promoterGO:000636830.020
positive regulation of macromolecule metabolic processGO:0010604930.020
hematopoietic stem cell differentiationGO:0060218200.020
regulation of gtpase activityGO:004308720.019
positive regulation of metabolic processGO:00098931080.019
regulation of cell developmentGO:00602841000.019
cellular response to nitrogen compoundGO:190169960.019
regulation of cell activationGO:005086510.019

tie1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.237
cardiovascular system diseaseDOID:128700.112
muscle tissue diseaseDOID:6600.111
muscular diseaseDOID:008000000.111
heart diseaseDOID:11400.111
cardiomyopathyDOID:005070000.111
musculoskeletal system diseaseDOID:1700.111
myopathyDOID:42300.111
intrinsic cardiomyopathyDOID:006003600.078
immune system diseaseDOID:291400.020