Danio rerio

0 known processes

tm9sf2

transmembrane 9 superfamily member 2

(Aliases: wu:fi43d12,wu:fi20b05)

tm9sf2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
single organism transportGO:00447652060.776
establishment of localizationGO:00512342440.715
signal transductionGO:00071654550.672
larval developmentGO:000216420.475
cellular response to external stimulusGO:007149620.468
single organism localizationGO:19025782250.432
gene expressionGO:00104672520.388
cellular aromatic compound metabolic processGO:00067252950.347
muscle cell differentiationGO:00426921390.314
regulation of primary metabolic processGO:00800903110.311
transportGO:00068102200.303
cellular nitrogen compound metabolic processGO:00346412900.301
heterocycle metabolic processGO:00464832900.300
positive regulation of cellular processGO:00485222010.289
embryonic skeletal system morphogenesisGO:0048704930.288
defense responseGO:0006952470.267
chordate embryonic developmentGO:00430092710.267
cellular biosynthetic processGO:00442492860.264
multi organism processGO:00517041340.259
regulation of response to stimulusGO:00485832690.255
embryo development ending in birth or egg hatchingGO:00097922710.253
tube morphogenesisGO:00352393490.244
head developmentGO:00603223030.228
regulation of cellular metabolic processGO:00313233200.228
regulation of gene expressionGO:00104682650.213
nitrogen compound metabolic processGO:00068073190.211
regulation of multicellular organismal developmentGO:20000262230.211
immune system processGO:00023762410.210
small molecule metabolic processGO:0044281770.206
guanosine containing compound catabolic processGO:190106920.204
cellular response to nutrient levelsGO:003166920.201
negative regulation of tor signalingGO:003200720.198
gtp catabolic processGO:000618420.197
negative regulation of autophagyGO:001050710.194
regulation of cell communicationGO:00106462320.193
nucleobase containing small molecule metabolic processGO:0055086320.191
macroautophagyGO:001623610.191
positive regulation of gtp catabolic processGO:003312610.188
regulation of cellular response to oxidative stressGO:190040720.188
symbiosis encompassing mutualism through parasitismGO:004440340.186
phagocytosisGO:000690930.185
cellular response to starvationGO:000926710.182
heart developmentGO:00075073130.179
regulation of nitrogen compound metabolic processGO:00511712510.177
endosomal transportGO:001619720.177
gtp metabolic processGO:004603940.176
organophosphate metabolic processGO:0019637370.174
response to stressGO:00069502630.174
aromatic compound biosynthetic processGO:00194382170.168
cellular response to extracellular stimulusGO:003166820.165
nucleotide metabolic processGO:0009117280.162
regulation of nucleobase containing compound metabolic processGO:00192192500.159
embryonic organ developmentGO:00485683810.159
cell surface receptor signaling pathwayGO:00071663250.156
response to chemicalGO:00422213200.155
modification dependent macromolecule catabolic processGO:004363230.151
organic cyclic compound metabolic processGO:19013603010.149
regulation of metabolic processGO:00192223590.149
single organism metabolic processGO:00447102170.149
regulation of photoreceptor cell differentiationGO:004653220.149
rna metabolic processGO:00160702190.147
positive regulation of biological processGO:00485182530.147
positive regulation of gtpase activityGO:004354710.147
sensory organ developmentGO:00074233930.143
guanosine containing compound metabolic processGO:190106840.141
cellular macromolecule metabolic processGO:00442603910.141
nucleobase containing compound metabolic processGO:00061392740.140
hindbrain developmentGO:0030902910.140
generation of neuronsGO:00486993850.133
embryonic organ morphogenesisGO:00485622740.127
nucleic acid templated transcriptionGO:00976591810.126
cell migrationGO:00164772370.122
purine nucleotide metabolic processGO:0006163270.122
regulation of macromolecule metabolic processGO:00602553170.121
neuron neuron synaptic transmissionGO:000727010.121
muscle structure developmentGO:00610611960.119
cellular response to chemical stimulusGO:00708871570.118
transcription dna templatedGO:00063511810.118
regulation of transcription from rna polymerase ii promoter in response to oxidative stressGO:004361900.116
autophagyGO:000691440.115
regulation of signal transductionGO:00099662250.115
interspecies interaction between organismsGO:004441940.114
organic substance biosynthetic processGO:19015762890.112
striated muscle cell developmentGO:00550021080.110
agingGO:000756820.110
lipid storageGO:001991510.110
organelle fusionGO:004828430.108
establishment of localization in cellGO:0051649770.105
cellular macromolecule biosynthetic processGO:00346452240.104
hemopoiesisGO:00300971830.102
regulation of synaptic plasticityGO:004816710.101
regulation of purine nucleotide catabolic processGO:003312120.101
positive regulation of transportGO:005105020.101
regulation of gtp catabolic processGO:003312420.100
response to salt stressGO:0009651100.098
regulation of response to oxidative stressGO:190288220.098
organonitrogen compound metabolic processGO:1901564740.097
positive regulation of response to stimulusGO:0048584800.096
carbohydrate derivative metabolic processGO:1901135610.095
nucleocytoplasmic transportGO:000691340.094
positive regulation of cellular metabolic processGO:0031325940.094
morphogenesis of an epitheliumGO:00020093330.093
regulation of nucleotide catabolic processGO:003081120.092
stem cell fate commitmentGO:004886510.091
ubiquitin dependent protein catabolic processGO:000651130.091
negative regulation of metabolic processGO:0009892860.091
regulation of biological qualityGO:00650082630.090
specification of symmetryGO:00097992040.090
regulation of protein ubiquitinationGO:003139630.090
nucleoside phosphate metabolic processGO:0006753280.090
regulation of nucleoside metabolic processGO:000911820.089
negative regulation of response to stimulusGO:00485851040.089
regulation of alternative mrna splicing via spliceosomeGO:000038110.089
heterocycle catabolic processGO:0046700150.088
embryonic limb morphogenesisGO:003032620.088
deathGO:00162651210.087
striated muscle cell differentiationGO:00511461290.087
cellular amide metabolic processGO:004360340.085
blood vessel developmentGO:00015682460.084
regulation of cellular macromolecule biosynthetic processGO:20001122220.084
locomotionGO:00400113130.084
cellular component morphogenesisGO:00329893360.083
organic substance transportGO:0071702580.082
negative regulation of signalingGO:0023057960.081
heterocycle biosynthetic processGO:00181302150.080
nuclear transportGO:005116940.080
cell substrate adhesionGO:003158940.078
homeostatic processGO:00425921420.077
programmed cell deathGO:00125011190.076
response to biotic stimulusGO:0009607970.075
positive regulation of neuron apoptotic processGO:004352510.075
negative regulation of catabolic processGO:000989530.074
negative regulation of cell deathGO:0060548600.073
positive regulation of nitrogen compound metabolic processGO:0051173690.073
regulation of cellular biosynthetic processGO:00313262450.072
negative regulation of biological processGO:00485193040.072
embryonic cranial skeleton morphogenesisGO:0048701900.072
neurotransmitter secretionGO:000726920.071
photoreceptor cell morphogenesisGO:000859410.071
positive regulation of nucleobase containing compound metabolic processGO:0045935690.071
cell morphogenesisGO:00009022890.071
protein secretionGO:000930610.071
intracellular signal transductionGO:0035556850.070
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217620.070
extrinsic apoptotic signaling pathwayGO:009719130.070
cellular response to organic substanceGO:00713101050.069
gastrulation with mouth forming secondGO:0001702440.069
cell projection organizationGO:00300302840.068
notch signaling pathwayGO:0007219350.067
regulation of signalingGO:00230512350.066
ribose phosphate metabolic processGO:0019693270.065
positive regulation of secretion by cellGO:190353210.065
establishment of protein localization to organelleGO:007259440.065
regulation of cytokine productionGO:000181730.065
regulation of establishment of protein localizationGO:007020140.065
purine containing compound metabolic processGO:0072521290.064
regulation of programmed cell deathGO:00430671010.064
transcription from rna polymerase ii promoterGO:0006366800.063
response to endogenous stimulusGO:0009719830.063
cell projection morphogenesisGO:00488582440.062
single organism organelle organizationGO:19025891990.062
exocytosisGO:000688710.061
cell death in response to oxidative stressGO:003647320.061
regulation of biosynthetic processGO:00098892500.060
regulation of purine nucleotide metabolic processGO:1900542170.060
response to bacteriumGO:0009617580.060
regulation of cell deathGO:00109411030.059
digestive tract morphogenesisGO:00485462310.059
morphogenesis of an epithelial sheetGO:0002011490.059
cellular response to stressGO:0033554620.059
heart morphogenesisGO:00030071560.058
regulation of transportGO:0051049450.058
neuron projection developmentGO:00311751800.058
positive regulation of ras protein signal transductionGO:004657910.058
immune effector processGO:0002252230.057
protein metabolic processGO:00195381830.056
cellular nitrogen compound biosynthetic processGO:00442712180.056
apoptotic processGO:00069151160.056
muscle cell developmentGO:00550011150.056
regionalizationGO:00030022740.056
apoptotic signaling pathwayGO:0097190230.056
epiboly involved in gastrulation with mouth forming secondGO:0055113350.056
response to external stimulusGO:00096052640.055
regulation of multicellular organismal processGO:00512392770.055
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.055
cognitionGO:005089010.055
regulation of macromolecule biosynthetic processGO:00105562250.053
rna transportGO:005065820.053
response to light stimulusGO:0009416460.053
regulation of nucleotide metabolic processGO:0006140170.053
response to other organismGO:0051707970.053
purine ribonucleotide metabolic processGO:0009150270.053
viral processGO:001603210.053
regulation of response to stressGO:0080134360.052
skeletal system morphogenesisGO:00487051020.052
intracellular transportGO:0046907320.052
regulation of gtpase activityGO:004308720.052
striated muscle tissue developmentGO:00147061100.051
cell morphogenesis involved in differentiationGO:00009041950.050
muscle cell migrationGO:001481240.050
regulation of tube sizeGO:003515020.049
biosynthetic processGO:00090582940.049
brain developmentGO:00074202930.049
regulation of rna biosynthetic processGO:20011412130.049
regulation of mrna splicing via spliceosomeGO:004802430.048
embryonic skeletal system developmentGO:0048706970.048
regulation of autophagyGO:001050630.048
immune system developmentGO:00025201910.048
regulation of anatomical structure sizeGO:0090066330.047
regulation of developmental processGO:00507932470.047
gastrulationGO:00073692080.047
positive regulation of purine nucleotide catabolic processGO:003312310.047
positive regulation of catabolic processGO:000989640.046
regulation of oxidative stress induced cell deathGO:190320120.046
cellular response to organic cyclic compoundGO:0071407380.046
protein localization to nucleusGO:003450430.045
cellular carbohydrate metabolic processGO:004426240.045
neuron developmentGO:00486662620.045
peptide metabolic processGO:000651810.045
blood vessel morphogenesisGO:00485142160.044
response to uvGO:000941130.044
organelle assemblyGO:00709251100.044
cell motilityGO:00488702440.044
phosphorus metabolic processGO:00067931090.044
modification dependent protein catabolic processGO:001994130.043
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.043
negative regulation of gene expressionGO:0010629650.043
establishment or maintenance of cell polarityGO:0007163290.043
cellular response to topologically incorrect proteinGO:003596720.043
positive regulation of cellular biosynthetic processGO:0031328680.042
positive regulation of macromolecule metabolic processGO:0010604930.042
regulation of extrinsic apoptotic signaling pathwayGO:200123630.042
epibolyGO:0090504410.042
positive regulation of secretionGO:005104710.042
regulation of metal ion transportGO:001095940.041
glycosyl compound metabolic processGO:1901657110.041
stem cell proliferationGO:007208940.041
cell morphogenesis involved in neuron differentiationGO:00486671630.041
positive regulation of nucleotide catabolic processGO:003081310.041
nucleic acid metabolic processGO:00903042440.041
eye developmentGO:00016542770.040
positive regulation of metabolic processGO:00098931080.040
protein importGO:001703830.040
cellular response to unfolded proteinGO:003462020.040
intestinal epithelial cell differentiationGO:006057530.040
response to external biotic stimulusGO:0043207970.039
maintenance of locationGO:005123540.039
myosin filament organizationGO:003103360.039
membrane organizationGO:0061024210.039
cellular process involved in reproduction in multicellular organismGO:0022412280.039
neuron differentiationGO:00301823530.038
biological adhesionGO:0022610400.038
central nervous system developmentGO:00074173870.038
endocytosisGO:0006897160.038
regulation of nucleic acid templated transcriptionGO:19035062130.038
digestive system developmentGO:00551232890.038
regulation of protein modification by small protein conjugation or removalGO:190332030.038
response to xenobiotic stimulusGO:0009410450.038
reproductive processGO:0022414400.037
branching morphogenesis of an epithelial tubeGO:0048754150.037
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.037
odontogenesis of dentin containing toothGO:004247510.037
cellular response to endogenous stimulusGO:0071495680.037
regulation of epidermis developmentGO:004568220.037
regulation of transcription dna templatedGO:00063552130.036
nuclear importGO:005117030.036
alternative mrna splicing via spliceosomeGO:000038010.036
photoreceptor cell developmentGO:0042461400.036
regulation of protein metabolic processGO:0051246560.036
embryonic heart tube developmentGO:00350501330.036
neurotransmitter transportGO:000683620.036
compound eye developmentGO:004874920.035
hematopoietic or lymphoid organ developmentGO:00485341910.035
multi organism cellular processGO:004476420.034
single organism nuclear importGO:190259330.034
negative regulation of cell communicationGO:0010648960.034
response to organic substanceGO:00100331530.034
determination of heart left right asymmetryGO:00613711170.033
growthGO:00400071740.033
phosphate containing compound metabolic processGO:00067961080.033
determination of bilateral symmetryGO:00098552040.033
regulation of cytoplasmic transportGO:190364940.033
regulation of mrna processingGO:005068430.033
positive regulation of myeloid cell differentiationGO:004563920.033
vesicle mediated transportGO:0016192220.033
ribonucleotide metabolic processGO:0009259270.033
regulation of apoptotic processGO:0042981980.033
muscle organ developmentGO:00075171010.033
negative regulation of oxidative stress induced cell deathGO:190320220.033
signal transduction in absence of ligandGO:003803410.032
endoplasmic reticulum unfolded protein responseGO:003096820.032
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.032
positive regulation of gene expressionGO:0010628710.032
protein targeting to nucleusGO:004474430.032
regulation of rna metabolic processGO:00512522240.032
response to extracellular stimulusGO:0009991100.032
regulation of phosphorus metabolic processGO:0051174430.032
negative regulation of cellular catabolic processGO:003133030.032
rna localizationGO:000640340.031
cartilage developmentGO:0051216960.031
organic cyclic compound biosynthetic processGO:19013622230.031
regulation of cell shapeGO:000836010.030
multicellular organismal homeostasisGO:0048871290.030
response to abiotic stimulusGO:00096281220.030
regulation of nucleocytoplasmic transportGO:004682220.030
nucleobase containing compound transportGO:001593120.030
tissue remodelingGO:004877140.030
morphogenesis of an epithelial foldGO:006057110.030
organic acid metabolic processGO:0006082310.030
vesicle organizationGO:001605060.030
cellular nitrogen compound catabolic processGO:0044270150.029
response to starvationGO:004259450.029
regulation of reactive oxygen species metabolic processGO:200037720.029
regulation of response to extracellular stimulusGO:003210410.029
cellular response to light stimulusGO:007148240.029
primary neural tube formationGO:001402010.029
cellular localizationGO:0051641970.029
response to nutrientGO:000758430.029
oocyte developmentGO:0048599140.028
multicellular organism growthGO:003526440.028
cellular protein modification processGO:00064641000.028
response to topologically incorrect proteinGO:003596620.028
regulation of wound healingGO:006104120.028
regulation of hormone secretionGO:004688320.028
positive regulation of nucleic acid templated transcriptionGO:1903508570.027
pigmentationGO:0043473850.027
proteasomal protein catabolic processGO:001049820.027
cellular response to radiationGO:007147840.027
protein localizationGO:0008104400.027
mrna metabolic processGO:0016071200.027
negative regulation of programmed cell deathGO:0043069580.027
developmental maturationGO:0021700340.027
positive regulation of cellular catabolic processGO:003133130.027
skin developmentGO:0043588540.027
regulation of protein targetingGO:190353320.027
negative regulation of apoptotic processGO:0043066550.027
synaptic vesicle transportGO:004848910.026
vasculature developmentGO:00019442780.026
regulation of intracellular signal transductionGO:1902531570.026
skeletal muscle organ developmentGO:0060538780.026
ras protein signal transductionGO:000726570.026
establishment of synaptic vesicle localizationGO:009748010.026
regulation of protein transportGO:005122330.026
ion transportGO:00068111140.026
neuron projection morphogenesisGO:00488121610.026
cellular component movementGO:00069283350.026
thioester metabolic processGO:003538310.026
negative regulation of signal transductionGO:0009968940.025
response to metal ionGO:0010038340.025
single organism intracellular transportGO:1902582250.025
defense response to bacteriumGO:0042742220.025
nucleobase containing compound biosynthetic processGO:00346542050.025
nucleic acid transportGO:005065720.025
oocyte differentiationGO:0009994140.025
rna biosynthetic processGO:00327741810.025
cell deathGO:00082191210.024
negative regulation of cellular metabolic processGO:0031324770.024
apoptotic process involved in developmentGO:190274220.024
synaptic transmissionGO:0007268350.024
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.024
establishment or maintenance of bipolar cell polarityGO:0061245120.024
er nucleus signaling pathwayGO:000698420.024
establishment of cell polarityGO:0030010180.024
specification of organ identityGO:001009220.024
cellular response to molecule of bacterial originGO:007121930.024
intracellular mrna localizationGO:000829810.024
cellular protein metabolic processGO:00442671290.024
ear developmentGO:00435831270.024
regulation of endocytosisGO:003010070.024
positive regulation of signalingGO:0023056560.024
g protein coupled receptor signaling pathwayGO:0007186740.024
negative regulation of nitrogen compound metabolic processGO:0051172590.024
positive regulation of macromolecule biosynthetic processGO:0010557590.023
proteolysis involved in cellular protein catabolic processGO:005160330.023
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.023
epithelial tube morphogenesisGO:00605621480.023
hormone transportGO:000991420.023
ribonucleoside metabolic processGO:0009119110.023
regulation of protein catabolic processGO:004217610.023
cortical cytoskeleton organizationGO:003086510.023
tissue homeostasisGO:0001894250.023
macromolecule localizationGO:0033036540.023
oxoacid metabolic processGO:0043436310.023
hormone secretionGO:004687920.022
muscle tissue developmentGO:00605371100.022
establishment or maintenance of epithelial cell apical basal polarityGO:0045197110.022
regulation of growthGO:0040008420.022
response to unfolded proteinGO:000698620.022
negative regulation of macromolecule metabolic processGO:0010605760.022
regulation of multicellular organism growthGO:004001440.022
regulation of response to external stimulusGO:0032101310.022
i kappab kinase nf kappab signalingGO:000724940.022
circadian sleep wake cycle sleepGO:005080210.022
connective tissue developmentGO:0061448990.022
embryonic appendage morphogenesisGO:0035113300.021
regulation of erk1 and erk2 cascadeGO:007037240.021
regulation of neurotransmitter secretionGO:004692810.021
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377100.021
regulation of vesicle mediated transportGO:006062790.021
regulation of transcription from rna polymerase ii promoterGO:00063571140.021
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.021
skeletal system developmentGO:00015011810.021
collagen metabolic processGO:003296320.021
iron ion homeostasisGO:005507240.021
positive regulation of nucleoside metabolic processGO:004597910.021
retina development in camera type eyeGO:00600411460.020
defense response to other organismGO:0098542330.020
regulation of locomotionGO:0040012550.020
regulation of blood vessel sizeGO:005088020.020
determination of left right symmetryGO:00073681790.020
gamete generationGO:0007276330.020
oocyte anterior posterior axis specificationGO:000731440.020
peripheral nervous system developmentGO:0007422550.020
enzyme linked receptor protein signaling pathwayGO:00071671060.020
cellular response to xenobiotic stimulusGO:0071466350.020
aromatic compound catabolic processGO:0019439150.020
production of molecular mediator of immune responseGO:000244020.020
system processGO:00030081850.020
protein targeting to vacuoleGO:000662310.020
actin filament based movementGO:003004810.020
establishment of rna localizationGO:005123630.019
cell cell signalingGO:0007267520.019
organelle organizationGO:00069962270.019
angiogenesisGO:00015251580.019
regulation of cellular component organizationGO:0051128860.019
female gamete generationGO:0007292140.019
mesenchymal cell differentiationGO:0048762870.019
muscle fiber developmentGO:0048747520.019
regulation of organ growthGO:004662030.018
vacuolar transportGO:000703420.018
purine nucleoside triphosphate metabolic processGO:000914490.018
synaptic vesicle localizationGO:009747910.018
positive regulation of neuron deathGO:190121610.018
inner ear developmentGO:00488391260.018
phosphorylationGO:0016310690.018
peptidyl serine phosphorylationGO:001810510.018
protein import into nucleusGO:000660630.018
regulation of cell sizeGO:0008361290.018
cellular response to hypoxiaGO:007145610.018
osteoclast differentiationGO:003031610.018
positive regulation of multicellular organismal processGO:0051240520.018
regulation of cardiac muscle cell contractionGO:008600410.018
positive regulation of lymphocyte mediated immunityGO:000270810.018
glial cell migrationGO:000834730.018
localization of cellGO:00516742440.018
single organism membrane fusionGO:004480120.018
mitotic dna damage checkpointGO:004477340.018
regulation of bindingGO:005109830.017
positive regulation of immune system processGO:0002684170.017
purine containing compound biosynthetic processGO:0072522200.017
regulation of cellular response to stressGO:0080135200.017
regulation of intracellular protein transportGO:003315730.017
peptide transportGO:001583310.017
regulation of ras gtpase activityGO:003231820.017
camera type eye developmentGO:00430102220.017
positive regulation of multi organism processGO:004390230.017
negative regulation of protein phosphorylationGO:000193340.017
atp synthesis coupled electron transportGO:004277310.017
golgi vesicle transportGO:004819330.017
cellular protein catabolic processGO:004425740.017
positive regulation of immune responseGO:0050778110.017
positive regulation of biosynthetic processGO:0009891680.017
response to vitaminGO:003327330.017
positive regulation of ras gtpase activityGO:003232010.017
neural crest cell developmentGO:0014032620.017
positive regulation of dna metabolic processGO:005105410.017
regulation of cell projection organizationGO:0031344440.017
macromolecular complex subunit organizationGO:0043933740.017
phagocytosis engulfmentGO:000691110.016
single organism membrane organizationGO:0044802200.016
positive regulation of i kappab kinase nf kappab signalingGO:004312330.016
cellular lipid metabolic processGO:0044255360.016
response to radiationGO:0009314510.016
axon cargo transportGO:000808820.016
cellular response to lipidGO:0071396390.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.016
rhombomere 5 developmentGO:002157140.015
nucleobase containing compound catabolic processGO:0034655150.015
cytoplasm organizationGO:000702840.015
developmental cell growthGO:0048588520.015
cellular component assemblyGO:00226071700.015
protein modification processGO:00362111000.015
regulation of exocytosisGO:001715710.015
positive regulation of exocytosisGO:004592110.015
cell growthGO:0016049570.015
membrane fusionGO:006102520.015

tm9sf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.044
cancerDOID:16200.028
disease of cellular proliferationDOID:1456600.028
organ system cancerDOID:005068600.023
gastrointestinal system cancerDOID:311900.023
endocrine gland cancerDOID:17000.016
respiratory system cancerDOID:005061500.016
lung cancerDOID:132400.016
thoracic cancerDOID:509300.016