IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

tpm2

tropomyosin 2 (beta)

(Aliases: wu:fb68h02,fb68h02,tpm4l,zgc:86810,wu:fj63f03,cb836)

ZFIN: ZDB-GENE-040625-114
Ensembl: ENSDARG00000068385
Entrez: 415209
UniProtKB: Q6IQD7

Process Predictions
Disease Predictions

tpm2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
myofibril assembly	GO:0030239	48	0.432	Zebrafish
actin filament based process	GO:0030029	64	0.342	Zebrafish Worm
organelle assembly	GO:0070925	110	0.311	Zebrafish
larval development	GO:0002164	2	0.284	Worm
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.259
axon development	GO:0061564	166	0.254
cardiac muscle cell development	GO:0055013	20	0.245	Zebrafish
muscle tissue development	GO:0060537	110	0.243	Zebrafish
cell morphogenesis involved in differentiation	GO:0000904	195	0.243
muscle cell development	GO:0055001	115	0.224	Zebrafish
striated muscle cell development	GO:0055002	108	0.213	Zebrafish
cell morphogenesis	GO:0000902	289	0.209
heart development	GO:0007507	313	0.185	Zebrafish Fly
cytokinesis	GO:0000910	3	0.175	Worm
neuron projection morphogenesis	GO:0048812	161	0.172
cell projection organization	GO:0030030	284	0.139
neuron development	GO:0048666	262	0.138
cardiac muscle tissue development	GO:0048738	48	0.133	Zebrafish
nucleoside monophosphate catabolic process	GO:0009125	4	0.128	Human
cellular component morphogenesis	GO:0032989	336	0.128	Zebrafish
circulatory system process	GO:0003013	87	0.127	Zebrafish
muscle structure development	GO:0061061	196	0.126	Zebrafish
cellular component assembly involved in morphogenesis	GO:0010927	107	0.119	Zebrafish
neuron projection development	GO:0031175	180	0.119
regulation of gene expression	GO:0010468	265	0.112
cytoskeleton dependent cytokinesis	GO:0061640	3	0.106
generation of neurons	GO:0048699	385	0.105
sarcomere organization	GO:0045214	26	0.100
blood circulation	GO:0008015	87	0.098	Zebrafish
muscle contraction	GO:0006936	18	0.096	Zebrafish
muscle organ development	GO:0007517	101	0.095
skeletal muscle organ development	GO:0060538	78	0.091
neuron differentiation	GO:0030182	353	0.089
regulation of metal ion transport	GO:0010959	4	0.086
actomyosin structure organization	GO:0031032	53	0.084	Zebrafish
cytoskeleton organization	GO:0007010	96	0.081	Zebrafish Worm
embryo development ending in birth or egg hatching	GO:0009792	271	0.078	Worm
multi organism process	GO:0051704	134	0.077	Worm
skeletal muscle tissue development	GO:0007519	67	0.073
system process	GO:0003008	185	0.073	Zebrafish
directional locomotion	GO:0033058	1	0.073
regulation of nucleoside metabolic process	GO:0009118	2	0.072	Human
cardiac myofibril assembly	GO:0055003	9	0.067	Zebrafish
cellular component assembly	GO:0022607	170	0.067	Zebrafish Worm
regulation of mrna splicing via spliceosome	GO:0048024	3	0.066
axonogenesis	GO:0007409	152	0.065
regulation of macromolecule biosynthetic process	GO:0010556	225	0.064
cell cycle process	GO:0022402	53	0.061	Worm
cell projection morphogenesis	GO:0048858	244	0.060
aging	GO:0007568	2	0.059
regionalization	GO:0003002	274	0.057
cell part morphogenesis	GO:0032990	246	0.056
regulation of muscle contraction	GO:0006937	3	0.055
somatic muscle development	GO:0007525	4	0.053
maintenance of location	GO:0051235	4	0.053
regulation of primary metabolic process	GO:0080090	311	0.051	Human
positive regulation of transport	GO:0051050	2	0.051
locomotion	GO:0040011	313	0.050	Worm
mitochondrion organization	GO:0007005	4	0.049
cell migration	GO:0016477	237	0.048
muscle cell differentiation	GO:0042692	139	0.048	Zebrafish
alternative mrna splicing via spliceosome	GO:0000380	1	0.047
cellular component biogenesis	GO:0044085	178	0.047	Zebrafish Worm
regulation of biological quality	GO:0065008	263	0.046	Worm
spermatid differentiation	GO:0048515	2	0.046
neurotransmitter transport	GO:0006836	2	0.045
positive regulation of cytokine production	GO:0001819	2	0.045
cellular component movement	GO:0006928	335	0.045
regulation of cellular metabolic process	GO:0031323	320	0.045	Human
regulation of system process	GO:0044057	40	0.045
ameboidal type cell migration	GO:0001667	143	0.044
cellular macromolecule metabolic process	GO:0044260	391	0.044
regulation of developmental process	GO:0050793	247	0.044
positive regulation of cell cycle	GO:0045787	3	0.043
protein stabilization	GO:0050821	2	0.042
neuron recognition	GO:0008038	18	0.041
cardiac muscle fiber development	GO:0048739	3	0.041
regulation of cell projection assembly	GO:0060491	4	0.040
response to biotic stimulus	GO:0009607	97	0.039
spermatid development	GO:0007286	2	0.039
cognition	GO:0050890	1	0.038
striated muscle cell differentiation	GO:0051146	129	0.038	Zebrafish
regulation of synapse assembly	GO:0051963	3	0.038
regulation of mrna processing	GO:0050684	3	0.036
nucleobase containing compound metabolic process	GO:0006139	274	0.036	Human
single organism membrane fusion	GO:0044801	2	0.035
response to external stimulus	GO:0009605	264	0.035
ventricular cardiac muscle tissue morphogenesis	GO:0055010	2	0.034
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.034	Human
heart process	GO:0003015	71	0.034	Zebrafish
multicellular organism reproduction	GO:0032504	35	0.034	Worm
regulation of dendrite development	GO:0050773	3	0.034
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.034
transport	GO:0006810	220	0.034
synaptic growth at neuromuscular junction	GO:0051124	2	0.034
cytokinetic process	GO:0032506	2	0.033
cardiac muscle contraction	GO:0060048	6	0.033	Zebrafish
cellular nitrogen compound metabolic process	GO:0034641	290	0.032	Human
glial cell migration	GO:0008347	3	0.032
growth	GO:0040007	174	0.032
chordate embryonic development	GO:0043009	271	0.032
cytoplasm organization	GO:0007028	4	0.032
taxis	GO:0042330	109	0.031
anterior posterior pattern specification	GO:0009952	152	0.031
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.031	Human
stem cell development	GO:0048864	82	0.031
regulation of cellular ketone metabolic process	GO:0010565	7	0.031
muscle attachment	GO:0016203	9	0.030
regulation of binding	GO:0051098	3	0.030	Worm
biosynthetic process	GO:0009058	294	0.030
maintenance of epithelial cell apical basal polarity	GO:0045199	5	0.030
regulation of cellular component organization	GO:0051128	86	0.030	Worm
muscle system process	GO:0003012	20	0.030	Zebrafish
cell recognition	GO:0008037	19	0.029
inositol lipid mediated signaling	GO:0048017	2	0.029
lipid homeostasis	GO:0055088	3	0.029
nucleic acid templated transcription	GO:0097659	181	0.029
post embryonic morphogenesis	GO:0009886	4	0.029
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.029	Human
intracellular mrna localization	GO:0008298	1	0.029
aromatic compound biosynthetic process	GO:0019438	217	0.029
lamellipodium assembly	GO:0030032	1	0.028
actin cytoskeleton organization	GO:0030036	63	0.028	Zebrafish Worm
ventricular cardiac muscle tissue development	GO:0003229	3	0.028
cellular biosynthetic process	GO:0044249	286	0.027
somitogenesis	GO:0001756	87	0.027
regulation of cell differentiation	GO:0045595	142	0.027
negative regulation of macromolecule metabolic process	GO:0010605	76	0.027
neuroblast proliferation	GO:0007405	2	0.027
regulation of ion transmembrane transporter activity	GO:0032412	2	0.027
rna localization	GO:0006403	4	0.027
regulation of alternative mrna splicing via spliceosome	GO:0000381	1	0.026
circadian sleep wake cycle sleep	GO:0050802	1	0.026
regulation of nucleotide catabolic process	GO:0030811	2	0.026	Human
heterocycle metabolic process	GO:0046483	290	0.026	Human
collagen metabolic process	GO:0032963	2	0.025
sequestering of metal ion	GO:0051238	3	0.025
single organism organelle organization	GO:1902589	199	0.025	Zebrafish Worm
regulation of nitrogen compound metabolic process	GO:0051171	251	0.025	Human
mesodermal cell migration	GO:0008078	12	0.025
positive regulation of cellular component biogenesis	GO:0044089	3	0.025
behavior	GO:0007610	74	0.025	Worm
regulation of purine nucleotide catabolic process	GO:0033121	2	0.024	Human
long chain fatty acid biosynthetic process	GO:0042759	1	0.024
carboxylic acid metabolic process	GO:0019752	22	0.024
voluntary skeletal muscle contraction	GO:0003010	4	0.024
actin polymerization or depolymerization	GO:0008154	2	0.024	Worm
ventricular cardiac myofibril assembly	GO:0055005	4	0.024
regulation of biosynthetic process	GO:0009889	250	0.023
regulation of cell shape	GO:0008360	1	0.023
maternal determination of anterior posterior axis embryo	GO:0008358	4	0.023
axonal fasciculation	GO:0007413	11	0.023
cardiac muscle cell differentiation	GO:0055007	30	0.023	Zebrafish
regulation of localization	GO:0032879	104	0.023
gene expression	GO:0010467	252	0.023
lipid storage	GO:0019915	1	0.023
signal transduction	GO:0007165	455	0.023
negative regulation of cellular process	GO:0048523	283	0.022	Worm
ventricular cardiac muscle cell differentiation	GO:0055012	6	0.022
reproductive process	GO:0022414	40	0.022	Worm
nitrogen compound metabolic process	GO:0006807	319	0.022	Human
oxoacid metabolic process	GO:0043436	31	0.022
regulation of organelle organization	GO:0033043	29	0.022	Worm
organic substance biosynthetic process	GO:1901576	289	0.022
ion transport	GO:0006811	114	0.021
regulation of rna metabolic process	GO:0051252	224	0.021
nucleic acid metabolic process	GO:0090304	244	0.021
convergent extension involved in gastrulation	GO:0060027	71	0.021
fatty acid transport	GO:0015908	1	0.021
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.021
organic cyclic compound metabolic process	GO:1901360	301	0.021	Human
regulation of blood circulation	GO:1903522	32	0.020
segmentation	GO:0035282	97	0.020
regulation of synapse organization	GO:0050807	3	0.020
multi organism reproductive process	GO:0044703	36	0.020	Worm
pole plasm assembly	GO:0007315	4	0.020
regulation of macromolecule metabolic process	GO:0060255	317	0.020
sequestering of calcium ion	GO:0051208	3	0.020
oocyte anterior posterior axis specification	GO:0007314	4	0.019
mrna metabolic process	GO:0016071	20	0.019
fatty acid biosynthetic process	GO:0006633	4	0.019
regulation of dendrite morphogenesis	GO:0048814	3	0.019
mitotic cell cycle	GO:0000278	64	0.019
cellular amine metabolic process	GO:0044106	2	0.019
neurotransmitter secretion	GO:0007269	2	0.019
regulation of meiotic cell cycle	GO:0051445	1	0.018
regulation of transmembrane transporter activity	GO:0022898	2	0.018
localization of cell	GO:0051674	244	0.018
regulation of cell cycle	GO:0051726	52	0.018
organonitrogen compound metabolic process	GO:1901564	74	0.018	Human
regulation of circadian rhythm	GO:0042752	4	0.018
small molecule metabolic process	GO:0044281	77	0.018	Human
multicellular organism growth	GO:0035264	4	0.018
membrane fusion	GO:0061025	2	0.018
single organism metabolic process	GO:0044710	217	0.018	Human
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.018
axis specification	GO:0009798	43	0.017
regulation of response to stimulus	GO:0048583	269	0.017
cell division	GO:0051301	20	0.017	Worm
neuron projection guidance	GO:0097485	86	0.017
g1 s transition of mitotic cell cycle	GO:0000082	1	0.017
protein metabolic process	GO:0019538	183	0.017
circadian sleep wake cycle process	GO:0022410	2	0.017
striated muscle contraction	GO:0006941	12	0.017	Zebrafish
heart morphogenesis	GO:0003007	156	0.017
actin filament based movement	GO:0030048	1	0.017
regulation of blood pressure	GO:0008217	1	0.017
regulation of heart contraction	GO:0008016	32	0.017
long chain fatty acid metabolic process	GO:0001676	1	0.017
single organism reproductive process	GO:0044702	40	0.017	Worm
long chain fatty acid transport	GO:0015909	1	0.017
anatomical structure homeostasis	GO:0060249	36	0.017
dorsal ventral pattern formation	GO:0009953	125	0.017
amine metabolic process	GO:0009308	2	0.017
regulation of striated muscle contraction	GO:0006942	2	0.017
rna metabolic process	GO:0016070	219	0.017
cellular ketone metabolic process	GO:0042180	11	0.016
twitch skeletal muscle contraction	GO:0014721	4	0.016
cardiac atrium development	GO:0003230	4	0.016
regulation of multicellular organismal process	GO:0051239	277	0.016
establishment of protein localization to organelle	GO:0072594	4	0.016
macromolecular complex disassembly	GO:0032984	1	0.016	Worm
striated muscle tissue development	GO:0014706	110	0.016	Zebrafish
anatomical structure arrangement	GO:0048532	2	0.016
slow twitch skeletal muscle fiber contraction	GO:0031444	3	0.015
cell cycle	GO:0007049	93	0.015	Worm
regulation of sequestering of calcium ion	GO:0051282	4	0.015
negative regulation of developmental process	GO:0051093	65	0.015
cellular component disassembly	GO:0022411	1	0.015	Worm
macromolecule modification	GO:0043412	111	0.015
regulation of rho protein signal transduction	GO:0035023	2	0.015
modification dependent protein catabolic process	GO:0019941	3	0.015
protein depolymerization	GO:0051261	1	0.015	Worm
nitric oxide biosynthetic process	GO:0006809	2	0.015
membrane invagination	GO:0010324	1	0.015
rna splicing	GO:0008380	16	0.015
negative regulation of biological process	GO:0048519	304	0.015	Worm
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.015
reactive oxygen species biosynthetic process	GO:1903409	1	0.015
nitric oxide metabolic process	GO:0046209	2	0.015
calcium ion transport into cytosol	GO:0060402	3	0.015
ubiquitin dependent protein catabolic process	GO:0006511	3	0.014
lipid oxidation	GO:0034440	1	0.014
regulation of cytokine production	GO:0001817	3	0.014
muscle cell cellular homeostasis	GO:0046716	5	0.014
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.014	Human
regulation of cell activation	GO:0050865	1	0.014
regulation of protein complex assembly	GO:0043254	3	0.014	Worm
symbiosis encompassing mutualism through parasitism	GO:0044403	4	0.014
somite development	GO:0061053	96	0.014
meiotic nuclear division	GO:0007126	4	0.014
protein localization to plasma membrane	GO:0072659	1	0.014
cellular response to starvation	GO:0009267	1	0.014
cardiac atrium morphogenesis	GO:0003209	2	0.014
cell cycle g1 s phase transition	GO:0044843	1	0.014
midbrain development	GO:0030901	28	0.014
adult behavior	GO:0030534	2	0.014
phagocytosis engulfment	GO:0006911	1	0.014
nuclear division	GO:0000280	23	0.014
cellular aromatic compound metabolic process	GO:0006725	295	0.014	Human
cardiac cell development	GO:0055006	21	0.014	Zebrafish
cell surface receptor signaling pathway	GO:0007166	325	0.013
negative regulation of protein kinase activity	GO:0006469	4	0.013
intracellular signal transduction	GO:0035556	85	0.013
negative regulation of protein phosphorylation	GO:0001933	4	0.013
locomotor rhythm	GO:0045475	3	0.013
oocyte development	GO:0048599	14	0.013
establishment of localization	GO:0051234	244	0.013
regulation of cytoplasmic transport	GO:1903649	4	0.013
developmental programmed cell death	GO:0010623	4	0.013
cellular amino acid metabolic process	GO:0006520	7	0.013
negative regulation of translation	GO:0017148	1	0.013
regulation of calcium ion transport	GO:0051924	2	0.013
heterocycle biosynthetic process	GO:0018130	215	0.013
multicellular organismal reproductive process	GO:0048609	35	0.013	Worm
regulation of cell communication	GO:0010646	232	0.013
cell fate commitment	GO:0045165	99	0.013
heart contraction	GO:0060047	71	0.013	Zebrafish
regulation of multicellular organism growth	GO:0040014	4	0.013
catabolic process	GO:0009056	32	0.013	Human
regulation of intracellular protein transport	GO:0033157	3	0.013
homeostatic process	GO:0042592	142	0.013
regulation of signaling	GO:0023051	235	0.012
modification dependent macromolecule catabolic process	GO:0043632	3	0.012
positive regulation of catabolic process	GO:0009896	4	0.012
positive regulation of cellular catabolic process	GO:0031331	3	0.012
regulation of organ growth	GO:0046620	3	0.012
regulation of synaptic plasticity	GO:0048167	1	0.012
germ line stem cell maintenance	GO:0030718	2	0.012
protein import	GO:0017038	3	0.012
nuclear import	GO:0051170	3	0.012
apoptotic process involved in development	GO:1902742	2	0.012
response to external biotic stimulus	GO:0043207	97	0.012
neurological system process	GO:0050877	62	0.012
organic acid metabolic process	GO:0006082	31	0.012
monocarboxylic acid metabolic process	GO:0032787	17	0.012
phosphorus metabolic process	GO:0006793	109	0.012	Human
mitotic cytokinesis	GO:0000281	3	0.012
cellular response to extracellular stimulus	GO:0031668	2	0.011
3 utr mediated mrna stabilization	GO:0070935	3	0.011
mrna stabilization	GO:0048255	4	0.011
positive regulation of cytoskeleton organization	GO:0051495	3	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.011
regulation of cellular amine metabolic process	GO:0033238	0	0.011
skeletal muscle myosin thick filament assembly	GO:0030241	5	0.011
neuroblast fate determination	GO:0007400	1	0.011
regulation of metabolic process	GO:0019222	359	0.011	Human
regulation of protein binding	GO:0043393	3	0.011	Worm
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
nucleoside phosphate metabolic process	GO:0006753	28	0.011	Human
neuroblast differentiation	GO:0014016	1	0.011
blood vessel morphogenesis	GO:0048514	216	0.011
chemosensory behavior	GO:0007635	1	0.011
lipid catabolic process	GO:0016042	4	0.011
regulation of nervous system development	GO:0051960	90	0.011
regulation of response to biotic stimulus	GO:0002831	2	0.011
regulation of cellular biosynthetic process	GO:0031326	245	0.011
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.011
phagocytosis	GO:0006909	3	0.011
adherens junction organization	GO:0034332	4	0.011
proteasomal protein catabolic process	GO:0010498	2	0.011
rna biosynthetic process	GO:0032774	181	0.011
carbohydrate derivative biosynthetic process	GO:1901137	43	0.011
proximal distal pattern formation	GO:0009954	1	0.011
regulation of heart growth	GO:0060420	2	0.011
epithelial cell morphogenesis	GO:0003382	2	0.011
chemotaxis	GO:0006935	104	0.011
multi organism cellular process	GO:0044764	2	0.011
dna templated transcription elongation	GO:0006354	3	0.011
cytosolic calcium ion transport	GO:0060401	3	0.011
feeding behavior	GO:0007631	5	0.011
sensory organ development	GO:0007423	393	0.011
angiogenesis	GO:0001525	158	0.011
cell death	GO:0008219	121	0.011
cellular macromolecule biosynthetic process	GO:0034645	224	0.011
death	GO:0016265	121	0.011
nucleocytoplasmic transport	GO:0006913	4	0.010
blood vessel development	GO:0001568	246	0.010
regulation of immune system process	GO:0002682	34	0.010
negative regulation of sequestering of calcium ion	GO:0051283	4	0.010
actin filament polymerization	GO:0030041	2	0.010	Worm
inorganic cation transmembrane transport	GO:0098662	50	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
complement activation	GO:0006956	3	0.010
cellular protein metabolic process	GO:0044267	129	0.010
cell motility	GO:0048870	244	0.010
small molecule catabolic process	GO:0044282	3	0.010
positive regulation of cellular amine metabolic process	GO:0033240	0	0.010
regulation of locomotion	GO:0040012	55	0.010
regulation of organelle assembly	GO:1902115	4	0.010
pigmentation	GO:0043473	85	0.010
protein complex disassembly	GO:0043241	1	0.010	Worm

tpm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.136	Human
myopathy	DOID:423	0.090
musculoskeletal system disease	DOID:17	0.090	Human
muscle tissue disease	DOID:66	0.090	Human
muscular disease	DOID:0080000	0.090	Human
cardiovascular system disease	DOID:1287	0.039
heart disease	DOID:114	0.022
cardiomyopathy	DOID:0050700	0.022
intrinsic cardiomyopathy	DOID:0060036	0.022
hypertrophic cardiomyopathy	DOID:11984	0.015

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