IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

zgc:64133

(Aliases: wu:fj48c08,wu:fj55d06)

ZFIN: ZDB-GENE-040426-2143
Entrez: 406405
Ensembl: ENSDARG00000043371
UniProtKB: Q7T334

Process Predictions
Disease Predictions

zgc:64133 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dicarboxylic acid metabolic process	GO:0043648	1	0.582	Human
hydrogen peroxide metabolic process	GO:0042743	2	0.496
oxidative phosphorylation	GO:0006119	1	0.435
carboxylic acid catabolic process	GO:0046395	3	0.434
removal of superoxide radicals	GO:0019430	2	0.325
small molecule catabolic process	GO:0044282	3	0.307
embryo development ending in birth or egg hatching	GO:0009792	271	0.297	Worm
cellular respiration	GO:0045333	3	0.293	Fly
electron transport chain	GO:0022900	2	0.282
aging	GO:0007568	2	0.276	Worm
organic acid catabolic process	GO:0016054	3	0.275
cellular response to oxygen radical	GO:0071450	2	0.266
lipid storage	GO:0019915	1	0.258
oxidation reduction process	GO:0055114	41	0.256	Human Fly
mitochondrial electron transport nadh to ubiquinone	GO:0006120	1	0.245
small molecule metabolic process	GO:0044281	77	0.205	Human
single organism biosynthetic process	GO:0044711	71	0.195
phosphorus metabolic process	GO:0006793	109	0.195
atp synthesis coupled electron transport	GO:0042773	1	0.191
larval development	GO:0002164	2	0.185	Worm
transport	GO:0006810	220	0.175	Worm
apoptotic process	GO:0006915	116	0.172	Fly
cellular amino acid biosynthetic process	GO:0008652	2	0.158
response to abiotic stimulus	GO:0009628	122	0.150
mitochondrion organization	GO:0007005	4	0.149
regulation of multicellular organism growth	GO:0040014	4	0.133
carbohydrate biosynthetic process	GO:0016051	1	0.130
somatic muscle development	GO:0007525	4	0.123
purine nucleotide metabolic process	GO:0006163	27	0.118
nitrogen compound metabolic process	GO:0006807	319	0.117
response to chemical	GO:0042221	320	0.115
cellular response to superoxide	GO:0071451	2	0.107
carbohydrate derivative metabolic process	GO:1901135	61	0.104
spermatid development	GO:0007286	2	0.102
pyruvate metabolic process	GO:0006090	1	0.093
maintenance of location	GO:0051235	4	0.092
alpha amino acid metabolic process	GO:1901605	3	0.092
branched chain amino acid metabolic process	GO:0009081	1	0.092
negative regulation of kinase activity	GO:0033673	4	0.091
purine containing compound metabolic process	GO:0072521	29	0.090
digestive tract development	GO:0048565	265	0.090
nucleobase containing compound metabolic process	GO:0006139	274	0.087
spermatid differentiation	GO:0048515	2	0.086
regulation of reactive oxygen species metabolic process	GO:2000377	2	0.084
regulation of biological quality	GO:0065008	263	0.082
reactive oxygen species biosynthetic process	GO:1903409	1	0.081
organic acid metabolic process	GO:0006082	31	0.081	Human
regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902175	2	0.078
oxoacid metabolic process	GO:0043436	31	0.074	Human
response to oxygen radical	GO:0000305	2	0.073
regulation of oxidative stress induced cell death	GO:1903201	2	0.070
protein localization to nucleus	GO:0034504	3	0.070
multi organism process	GO:0051704	134	0.070
alcohol biosynthetic process	GO:0046165	2	0.069
reactive oxygen species metabolic process	GO:0072593	6	0.069
response to drug	GO:0042493	3	0.066
catechol containing compound metabolic process	GO:0009712	2	0.063
cellular component morphogenesis	GO:0032989	336	0.061	Worm
neuron neuron synaptic transmission	GO:0007270	1	0.061
energy reserve metabolic process	GO:0006112	2	0.056
establishment of localization	GO:0051234	244	0.056	Worm
lateral inhibition	GO:0046331	1	0.055
response to superoxide	GO:0000303	2	0.055
response to stress	GO:0006950	263	0.055
nucleoside monophosphate catabolic process	GO:0009125	4	0.055
cellular aromatic compound metabolic process	GO:0006725	295	0.055
ubiquitin dependent protein catabolic process	GO:0006511	3	0.054
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.054
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.052
neurotransmitter transport	GO:0006836	2	0.050
cellular nitrogen compound metabolic process	GO:0034641	290	0.049
regulation of jun kinase activity	GO:0043506	3	0.048
developmental growth	GO:0048589	166	0.048
regulation of multicellular organismal process	GO:0051239	277	0.048
digestive system development	GO:0055123	289	0.047
mitochondrial atp synthesis coupled electron transport	GO:0042775	1	0.046
organic substance biosynthetic process	GO:1901576	289	0.046
phototransduction	GO:0007602	2	0.045
negative regulation of protein kinase activity	GO:0006469	4	0.045
phosphate containing compound metabolic process	GO:0006796	108	0.044
monoamine transport	GO:0015844	1	0.044
signal transduction	GO:0007165	455	0.043
response to oxygen levels	GO:0070482	25	0.042
response to oxidative stress	GO:0006979	11	0.042
locomotion	GO:0040011	313	0.041
system process	GO:0003008	185	0.039
organonitrogen compound metabolic process	GO:1901564	74	0.039
response to radiation	GO:0009314	51	0.038
heart development	GO:0007507	313	0.038
organelle organization	GO:0006996	227	0.038	Worm
response to light stimulus	GO:0009416	46	0.038
single organism metabolic process	GO:0044710	217	0.038	Human Fly
protein stabilization	GO:0050821	2	0.038
response to external stimulus	GO:0009605	264	0.038
cellular modified amino acid metabolic process	GO:0006575	3	0.037
respiratory electron transport chain	GO:0022904	2	0.037
modification dependent protein catabolic process	GO:0019941	3	0.037
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.036
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	2	0.035
multicellular organismal signaling	GO:0035637	22	0.035
cellular amine metabolic process	GO:0044106	2	0.035
multicellular organism growth	GO:0035264	4	0.034
gtp metabolic process	GO:0046039	4	0.034
neurological system process	GO:0050877	62	0.034
regulation of tube size	GO:0035150	2	0.034
response to organic substance	GO:0010033	153	0.034
nucleotide metabolic process	GO:0009117	28	0.034
carboxylic acid metabolic process	GO:0019752	22	0.034	Human
regulation of blood vessel size	GO:0050880	2	0.033
superoxide metabolic process	GO:0006801	2	0.033
positive regulation of biological process	GO:0048518	253	0.032	Fly
regulation of membrane potential	GO:0042391	23	0.032
response to hydrogen peroxide	GO:0042542	3	0.032
zymogen activation	GO:0031638	3	0.032	Fly
organic cyclic compound metabolic process	GO:1901360	301	0.031
regulation of gene expression	GO:0010468	265	0.031
regulation of cellular ketone metabolic process	GO:0010565	7	0.031
stem cell proliferation	GO:0072089	4	0.031
regulation of metabolic process	GO:0019222	359	0.030	Fly
digestive tract morphogenesis	GO:0048546	231	0.030
regulation of cellular amine metabolic process	GO:0033238	0	0.030
amine metabolic process	GO:0009308	2	0.030
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.029
programmed cell death	GO:0012501	119	0.029	Fly
nucleocytoplasmic transport	GO:0006913	4	0.029
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.029
regulation of nucleoside metabolic process	GO:0009118	2	0.029
cellular macromolecule metabolic process	GO:0044260	391	0.029	Human Fly
adult behavior	GO:0030534	2	0.029
positive regulation of programmed cell death	GO:0043068	29	0.029	Fly
cell death	GO:0008219	121	0.028	Fly
phagocytosis	GO:0006909	3	0.028
regulation of response to oxidative stress	GO:1902882	2	0.028
amino acid transport	GO:0006865	2	0.028
growth	GO:0040007	174	0.028
generation of neurons	GO:0048699	385	0.027
negative regulation of protein phosphorylation	GO:0001933	4	0.027
detection of external stimulus	GO:0009581	24	0.027
cellular catabolic process	GO:0044248	27	0.027
leukocyte proliferation	GO:0070661	1	0.027
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.027
phosphorylation	GO:0016310	69	0.026
cellular protein metabolic process	GO:0044267	129	0.026	Human Fly
protein modification process	GO:0036211	100	0.026	Human
regulation of developmental process	GO:0050793	247	0.025
cellular protein modification process	GO:0006464	100	0.025	Human
regulation of endothelial cell proliferation	GO:0001936	1	0.025
macromolecule modification	GO:0043412	111	0.024	Human
gtp catabolic process	GO:0006184	2	0.024
nitric oxide biosynthetic process	GO:0006809	2	0.024
regulation of endopeptidase activity	GO:0052548	23	0.024	Fly
neuroblast proliferation	GO:0007405	2	0.023
guanosine containing compound catabolic process	GO:1901069	2	0.023
regulation of cellular response to oxidative stress	GO:1900407	2	0.023
cell death in response to oxidative stress	GO:0036473	2	0.023
single organism localization	GO:1902578	225	0.023
regulation of blood pressure	GO:0008217	1	0.023
nuclear transport	GO:0051169	4	0.023
tube morphogenesis	GO:0035239	349	0.022
cellular macromolecular complex assembly	GO:0034622	24	0.022	Worm
regulation of protein transport	GO:0051223	3	0.022
gastrulation	GO:0007369	208	0.022
positive regulation of map kinase activity	GO:0043406	3	0.022
regulation of protein localization to nucleus	GO:1900180	2	0.022
catabolic process	GO:0009056	32	0.021
phagocytosis engulfment	GO:0006911	1	0.021
cellular component biogenesis	GO:0044085	178	0.021	Worm
detection of light stimulus	GO:0009583	12	0.021
organophosphate biosynthetic process	GO:0090407	23	0.021
cellular ketone metabolic process	GO:0042180	11	0.021
regulation of programmed cell death	GO:0043067	101	0.021	Fly
cellular biosynthetic process	GO:0044249	286	0.021
regulation of response to stress	GO:0080134	36	0.021
brain development	GO:0007420	293	0.020
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	2	0.020
regulation of protein catabolic process	GO:0042176	1	0.020
purine nucleoside triphosphate biosynthetic process	GO:0009145	2	0.020
extrinsic apoptotic signaling pathway	GO:0097191	3	0.020
gene expression	GO:0010467	252	0.020	Fly
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	2	0.020
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.020
small molecule biosynthetic process	GO:0044283	16	0.020
sexual reproduction	GO:0019953	36	0.020
death	GO:0016265	121	0.020	Fly
regulation of cell activation	GO:0050865	1	0.020
behavior	GO:0007610	74	0.020
response to wounding	GO:0009611	116	0.020
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	2	0.020
regulation of cell communication	GO:0010646	232	0.019
heterocycle metabolic process	GO:0046483	290	0.019
response to hypoxia	GO:0001666	25	0.019
regulation of cytokine production	GO:0001817	3	0.019
embryonic organ morphogenesis	GO:0048562	274	0.019
positive regulation of wound healing	GO:0090303	1	0.019
monocarboxylic acid metabolic process	GO:0032787	17	0.019
atp catabolic process	GO:0006200	4	0.019
negative regulation of protein serine threonine kinase activity	GO:0071901	2	0.019
regulation of response to stimulus	GO:0048583	269	0.019
fatty acid oxidation	GO:0019395	1	0.019
detection of stimulus	GO:0051606	29	0.019
proteasomal protein catabolic process	GO:0010498	2	0.019
guanosine containing compound metabolic process	GO:1901068	4	0.018
regulation of inflammatory response	GO:0050727	2	0.018
camera type eye development	GO:0043010	222	0.018
centrosome organization	GO:0051297	1	0.018
neuron development	GO:0048666	262	0.018
cellular response to reactive oxygen species	GO:0034614	2	0.018
cell cell signaling	GO:0007267	52	0.018
negative regulation of cytoplasmic transport	GO:1903650	2	0.018
regulation of developmental growth	GO:0048638	38	0.018
positive regulation of cellular amine metabolic process	GO:0033240	0	0.018
ion transport	GO:0006811	114	0.017
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
organophosphate metabolic process	GO:0019637	37	0.017
negative regulation of catabolic process	GO:0009895	3	0.017
regulation of apoptotic process	GO:0042981	98	0.017	Fly
cellular component movement	GO:0006928	335	0.017
cell part morphogenesis	GO:0032990	246	0.017
cellular amino acid metabolic process	GO:0006520	7	0.017
regulation of signal transduction	GO:0009966	225	0.017
startle response	GO:0001964	4	0.017
carboxylic acid biosynthetic process	GO:0046394	12	0.017
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.017
protein modification by small protein removal	GO:0070646	1	0.017
multicellular organismal reproductive process	GO:0048609	35	0.017
myotube differentiation	GO:0014902	45	0.017
positive regulation of secretion	GO:0051047	1	0.016
membrane invagination	GO:0010324	1	0.016
single organism nuclear import	GO:1902593	3	0.016
regulation of catalytic activity	GO:0050790	55	0.016	Fly
regeneration	GO:0031099	91	0.016
regulation of signaling	GO:0023051	235	0.016
cellular aldehyde metabolic process	GO:0006081	4	0.016
nuclear export	GO:0051168	1	0.016
regulation of systemic arterial blood pressure	GO:0003073	1	0.016
actin mediated cell contraction	GO:0070252	1	0.016
regulation of establishment of protein localization	GO:0070201	4	0.015
regulation of transmembrane transporter activity	GO:0022898	2	0.015
glycosyl compound metabolic process	GO:1901657	11	0.015
response to amphetamine	GO:0001975	1	0.015
adherens junction organization	GO:0034332	4	0.015
cell aging	GO:0007569	2	0.015
organic acid biosynthetic process	GO:0016053	12	0.015
response to other organism	GO:0051707	97	0.015
negative regulation of cysteine type endopeptidase activity	GO:2000117	8	0.015
cellular component assembly	GO:0022607	170	0.015	Worm
cellular lipid catabolic process	GO:0044242	3	0.015
ribose phosphate metabolic process	GO:0019693	27	0.015
regulation of binding	GO:0051098	3	0.015
protein phosphorylation	GO:0006468	47	0.015
response to reactive oxygen species	GO:0000302	5	0.015
xenobiotic metabolic process	GO:0006805	4	0.015
cognition	GO:0050890	1	0.015
protein complex subunit organization	GO:0071822	46	0.015	Worm
purine ribonucleoside metabolic process	GO:0046128	10	0.014
autophagy	GO:0006914	4	0.014
response to amine	GO:0014075	1	0.014
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.014
nucleobase containing compound biosynthetic process	GO:0034654	205	0.014
organonitrogen compound biosynthetic process	GO:1901566	47	0.014
regulation of cytoplasmic transport	GO:1903649	4	0.014
neurotransmitter secretion	GO:0007269	2	0.014
negative regulation of epithelial cell proliferation	GO:0050680	1	0.014
organic substance catabolic process	GO:1901575	28	0.014
activation of mapk activity	GO:0000187	3	0.014
cellular response to external stimulus	GO:0071496	2	0.014
ribonucleoside metabolic process	GO:0009119	11	0.014
negative regulation of intracellular transport	GO:0032387	3	0.014
positive regulation of transport	GO:0051050	2	0.014
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	1	0.014
regulation of cell death	GO:0010941	103	0.014	Fly
regulation of protein ubiquitination	GO:0031396	3	0.013
sequestering of metal ion	GO:0051238	3	0.013
sensory organ morphogenesis	GO:0090596	200	0.013
morphogenesis of an epithelium	GO:0002009	333	0.013
energy derivation by oxidation of organic compounds	GO:0015980	5	0.013	Fly
immune system process	GO:0002376	241	0.013
central nervous system development	GO:0007417	387	0.013
sensory organ development	GO:0007423	393	0.013
regulation of transporter activity	GO:0032409	2	0.013
centrosome cycle	GO:0007098	1	0.013
fin development	GO:0033333	77	0.013
single organism catabolic process	GO:0044712	13	0.013
nucleoside phosphate metabolic process	GO:0006753	28	0.013
protein homooligomerization	GO:0051260	3	0.013
cellular protein complex assembly	GO:0043623	19	0.012	Worm
embryonic organ development	GO:0048568	381	0.012
reactive nitrogen species metabolic process	GO:2001057	0	0.012
smooth muscle contraction	GO:0006939	2	0.012
regulation of cell differentiation	GO:0045595	142	0.012
astral microtubule organization	GO:0030953	1	0.012
eye development	GO:0001654	277	0.012
response to nutrient	GO:0007584	3	0.012
regulation of cysteine type endopeptidase activity	GO:2000116	21	0.012	Fly
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	1	0.012
single organism reproductive process	GO:0044702	40	0.012
regulation of intracellular protein transport	GO:0033157	3	0.012
negative regulation of cellular catabolic process	GO:0031330	3	0.012
nitric oxide metabolic process	GO:0046209	2	0.012
cellular carbohydrate metabolic process	GO:0044262	4	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
synaptic transmission	GO:0007268	35	0.011
catecholamine metabolic process	GO:0006584	2	0.011
cellular macromolecule biosynthetic process	GO:0034645	224	0.011
negative regulation of signaling	GO:0023057	96	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	9	0.011
cell migration	GO:0016477	237	0.011
mononuclear cell proliferation	GO:0032943	1	0.011
purine ribonucleoside biosynthetic process	GO:0046129	2	0.011
regulation of protein metabolic process	GO:0051246	56	0.011	Fly
negative regulation of response to stimulus	GO:0048585	104	0.011
cellular protein catabolic process	GO:0044257	4	0.011
regulation of carbohydrate metabolic process	GO:0006109	4	0.011
striated muscle cell differentiation	GO:0051146	129	0.011	Worm
macromolecule localization	GO:0033036	54	0.011
multicellular organismal response to stress	GO:0033555	2	0.011
pectoral fin development	GO:0033339	50	0.011
regulation of reproductive process	GO:2000241	4	0.011
inner ear morphogenesis	GO:0042472	63	0.011
biosynthetic process	GO:0009058	294	0.011
small gtpase mediated signal transduction	GO:0007264	8	0.011
regulation of molecular function	GO:0065009	70	0.011	Fly
multicellular organismal macromolecule metabolic process	GO:0044259	2	0.011
lipid catabolic process	GO:0016042	4	0.011
tissue homeostasis	GO:0001894	25	0.011
microtubule organizing center organization	GO:0031023	1	0.011
regulation of gtpase activity	GO:0043087	2	0.011
protein import into nucleus	GO:0006606	3	0.011
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.010
transmission of nerve impulse	GO:0019226	19	0.010
detection of abiotic stimulus	GO:0009582	24	0.010
generation of precursor metabolites and energy	GO:0006091	5	0.010	Fly
cellular component disassembly	GO:0022411	1	0.010
neuron differentiation	GO:0030182	353	0.010
response to copper ion	GO:0046688	13	0.010
catecholamine biosynthetic process	GO:0042423	2	0.010
positive regulation of multicellular organismal process	GO:0051240	52	0.010
negative regulation of cellular process	GO:0048523	283	0.010
regulation of mrna processing	GO:0050684	3	0.010
positive regulation of cellular catabolic process	GO:0031331	3	0.010
nucleobase containing small molecule metabolic process	GO:0055086	32	0.010
protein polyubiquitination	GO:0000209	4	0.010
establishment of localization in cell	GO:0051649	77	0.010
nucleic acid templated transcription	GO:0097659	181	0.010

zgc:64133 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
mitochondrial metabolism disease	DOID:700	0.164
disease of metabolism	DOID:0014667	0.164
inherited metabolic disorder	DOID:655	0.164
disease of anatomical entity	DOID:7	0.084
nervous system disease	DOID:863	0.060
neurodegenerative disease	DOID:1289	0.051
central nervous system disease	DOID:331	0.051
synucleinopathy	DOID:0050890	0.051
parkinson s disease	DOID:14330	0.051
cancer	DOID:162	0.033
organ system cancer	DOID:0050686	0.033
disease of cellular proliferation	DOID:14566	0.033
leigh disease	DOID:3652	0.028
acquired metabolic disease	DOID:0060158	0.012
carbohydrate metabolism disease	DOID:0050013	0.012

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