IMP: Integrative Multi-species Prediction

Drosophila melanogaster

23 genes annotated in fly

response to metal ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to metal ion"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to metal ion" (in gray)

Name	Description	Probability	Func Analog Organism
Rac1	CG2248 gene product from transcript CG2248-RA	0.924
Cdc42	CG12530 gene product from transcript CG12530-RA	0.447
Sod	Superoxide dismutase	0.439	Zebrafish Rat
Tpi	Triose phosphate isomerase	0.386
ci	cubitus interruptus	0.328
Fer1HCH	Ferritin 1 heavy chain homologue	0.284
ptc	patched	0.265
Stat92E	Signal-transducer and activator of transcription protein at 92E	0.252
PHGPx	CG12013 gene product from transcript CG12013-RC	0.242
Gapdh2	Glyceraldehyde 3 phosphate dehydrogenase 2	0.231
Nlp	Nucleoplasmin	0.206
Cyp12a4	CG6042 gene product from transcript CG6042-RA	0.199
Gapdh1	Glyceraldehyde 3 phosphate dehydrogenase 1	0.199
trio	CG18214 gene product from transcript CG18214-RA	0.192
Dcr-2	Dicer-2	0.189
Src42A	Src oncogene at 42A	0.189
Ugt35a	UDP-glycosyltransferase 35a	0.168
Pink1	PTEN-induced putative kinase 1	0.146
Aldh	Aldehyde dehydrogenase	0.144
N	Notch	0.135
Eno	Enolase	0.131
mys	myospheroid	0.125
LamC	Lamin C	0.109
CG2107	CG2107 gene product from transcript CG2107-RA	0.102
Trx-2	thioredoxin-2	0.102
Jafrac1	thioredoxin peroxidase 1	0.095
Adh	Alcohol dehydrogenase	0.093
CG1927	CG1927 gene product from transcript CG1927-RA	0.091
Tequila	CG4821 gene product from transcript CG4821-RE	0.090
Cat	Catalase	0.090	Zebrafish
if	inflated	0.088
NPFR1	neuropeptide F receptor	0.084
Ork1	Open rectifier K[+] channel 1	0.083
bsk	basket	0.082
Cyp6a21	CG10247 gene product from transcript CG10247-RA	0.077	Rat Fly
JhI-26	Juvenile hormone-inducible protein 26	0.074
mth	methuselah	0.073
par-1	CG8201 gene product from transcript CG8201-RA	0.073
CG12171	CG12171 gene product from transcript CG12171-RA	0.072
Mpk2	CG5475 gene product from transcript CG5475-RB	0.071
smt3	CG4494 gene product from transcript CG4494-RA	0.071
Jheh2	Juvenile hormone epoxide hydrolase 2	0.070
Rya-r44F	Ryanodine receptor 44F	0.070	Human
Cyp6a2	Cytochrome P450-6a2	0.069	Rat Fly
CG6834	CG6834 gene product from transcript CG6834-RA	0.066
slo	slowpoke	0.066	Human
kay	kayak	0.066	Mouse
l(2)05510	lethal (2) 05510	0.064
Got2	Glutamate oxaloacetate transaminase 2	0.063
CG10863	CG10863 gene product from transcript CG10863-RA	0.062	Human
S6k	RPS6-p70-protein kinase	0.061
Tsp29Fb	Tetraspanin 29Fb	0.060
Osi6	Osiris 6	0.059
milt	milton	0.059
CG17325	CG17325 gene product from transcript CG17325-RA	0.058
Vha16	Vacuolar H[+] ATPase 16kD subunit	0.056
TotA	Turandot A	0.055
slow	slowdown	0.054
drk	downstream of receptor kinase	0.052
pan	pangolin	0.052
blow	blown fuse	0.050
CG10638	CG10638 gene product from transcript CG10638-RA	0.049	Human
Rala	Ras-related protein	0.049
rols	rolling pebbles	0.048
kst	karst	0.048
Dsor1	Downstream of raf1	0.047
MTF-1	Metal response element-binding Transcription Factor-1	0.046
ImpL3	Ecdysone-inducible gene L3	0.045
CG4860	CG4860 gene product from transcript CG4860-RA	0.044
Cyp6a9	Cytochrome P450-6a9	0.044	Rat Fly
Mekk1	CG7717 gene product from transcript CG7717-RB	0.043
Chd64	CG14996 gene product from transcript CG14996-RB	0.042
Cyp6g1	CG8453 gene product from transcript CG8453-RA	0.042
lola	longitudinals lacking	0.042
CG15611	CG15611 gene product from transcript CG15611-RB	0.041
Cyp6a23	CG10242 gene product from transcript CG10242-RA	0.041	Rat Fly
alpha-Est7	alpha-Esterase-7	0.040
NLaz	Neural Lazarillo	0.039
Fer2LCH	Ferritin 2 light chain homologue	0.038
CG5362	CG5362 gene product from transcript CG5362-RA	0.036
Abl	Abl tyrosine kinase	0.036
ple	pale	0.035
Tak1	TGF-beta activated kinase 1	0.034
EcR	Ecdysone receptor	0.034
Cg25C	Collagen type IV	0.033
Rab11	Rab-protein 11	0.033
spi	spitz	0.033
CG11897	CG11897 gene product from transcript CG11897-RA	0.033
Rel	Relish	0.033	Rat
clt	cricklet	0.033
blw	bellwether	0.033
eIF4G	eukaryotic translation initiation factor 4G	0.032
Argk	Arginine kinase	0.031
Clk	Clock	0.031
CG2233	CG2233 gene product from transcript CG2233-RA	0.031
sina	seven in absentia	0.031
CG2852	CG2852 gene product from transcript CG2852-RA	0.030
CG11674	CG11674 gene product from transcript CG11674-RA	0.029
PGRP-LE	Peptidoglycan recognition protein LE	0.029
Yp3	Yolk protein 3	0.029
inaD	inactivation no afterpotential D	0.029
cathD	CG1548 gene product from transcript CG1548-RA	0.028
LanA	Laminin A	0.028
ush	u-shaped	0.028
Rab5	Rab-protein 5	0.028
neb	nebbish	0.027
hth	homothorax	0.027
CG3759	CG3759 gene product from transcript CG3759-RB	0.027	Yeast
Pkc98E	Protein C kinase 98E	0.027
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.026	Worm
Shaw	Shaker cognate w	0.026
Tsp42Ed	Tetraspanin 42Ed	0.026
ref(2)P	refractory to sigma P	0.026
l(3)82Fd	CG32464 gene product from transcript CG32464-RR	0.026
dib	disembodied	0.026
Cyp12d1-d	CG33503 gene product from transcript CG33503-RA	0.026
CG6283	CG6283 gene product from transcript CG6283-RA	0.025	Rat
mtt	mangetout	0.025
drpr	draper	0.025
HspB8	CG14207 gene product from transcript CG14207-RB	0.025
aop	anterior open	0.025
CG6543	CG6543 gene product from transcript CG6543-RA	0.025
Arp8	Actin-related protein 8	0.024
Pros26.4	Proteasome 26S subunit subunit 4 ATPase	0.024
Cyp12e1	CG14680 gene product from transcript CG14680-RC	0.024
Lar	Leukocyte-antigen-related-like	0.024
Sap47	Synapse-associated protein 47kD	0.024
pst	pastrel	0.024
Ih	I[[h]] channel	0.024
porin	CG6647 gene product from transcript CG6647-RA	0.024
Crc	Calreticulin	0.023	Rat
Ilp5	Insulin-like peptide 5	0.023
wupA	wings up A	0.023
yip2	yippee interacting protein 2	0.023
CG3371	CG3371 gene product from transcript CG3371-RA	0.022
chico	CG5686 gene product from transcript CG5686-RB	0.022
SK	small conductance calcium-activated potassium channel	0.022
cindr	CIN85 and CD2AP orthologue	0.022
Epac	CG34392 gene product from transcript CG34392-RC	0.022
CG3270	CG3270 gene product from transcript CG3270-RA	0.021
CG14196	CG14196 gene product from transcript CG14196-RA	0.021
foxo	forkhead box, sub-group O	0.021
Tsp42Eg	Tetraspanin 42Eg	0.021
Brca2	Breast cancer 2, early onset homolog	0.021
CG14837	CG14837 gene product from transcript CG14837-RC	0.020
Cyp12a5	CG11821 gene product from transcript CG11821-RA	0.020
CG9512	CG9512 gene product from transcript CG9512-RA	0.020
LvpD	Larval visceral protein D	0.020
NTPase	CG3059 gene product from transcript CG3059-RD	0.020
Ipp	Inositol polyphosphate 1-phosphatase	0.020
plu	plutonium	0.019
Traf6	TNF-receptor-associated factor 6	0.019
norpA	no receptor potential A	0.019
Idh	Isocitrate dehydrogenase	0.019
CG12370	CG12370 gene product from transcript CG12370-RB	0.019
CG16718	CG16718 gene product from transcript CG16718-RA	0.018
rig	rigor mortis	0.018
Hmu	Hemomucin	0.018
Rh50	CG7499 gene product from transcript CG7499-RA	0.018
MRP	Multidrug-Resistance like Protein 1	0.018	Yeast
Ace	Acetylcholine esterase	0.018
ERR	estrogen-related receptor	0.018
CG5639	CG5639 gene product from transcript CG5639-RA	0.018
CG4585	CG4585 gene product from transcript CG4585-RA	0.018
CG7530	CG7530 gene product from transcript CG7530-RB	0.018
InR	Insulin-like receptor	0.018	Rat
Cyp4ac1	CG14032 gene product from transcript CG14032-RA	0.018
CG5741	CG5741 gene product from transcript CG5741-RC	0.018
CG4752	CG4752 gene product from transcript CG4752-RA	0.018
CG5010	CG5010 gene product from transcript CG5010-RA	0.017
Pfrx	6-phosphofructo-2-kinase	0.017
CG33080	CG33080 gene product from transcript CG33080-RA	0.017
Scp1	Sarcoplasmic calcium-binding protein 1	0.017
CG10750	CG10750 gene product from transcript CG10750-RA	0.017
Alk	CG8250 gene product from transcript CG8250-RA	0.017
cora	coracle	0.016
CG12672	CG12672 gene product from transcript CG12672-RA	0.016
CG4365	CG4365 gene product from transcript CG4365-RB	0.016
CG10560	CG10560 gene product from transcript CG10560-RA	0.016
dap	dacapo	0.016
CG8907	CG8907 gene product from transcript CG8907-RA	0.016
alphaTry	alphaTrypsin	0.016
garz	gartenzwerg	0.016
Grip	Glutamate receptor binding protein	0.016
pum	pumilio	0.016
Jra	Jun-related antigen	0.016	Zebrafish Mouse
Lip3	CG8823 gene product from transcript CG8823-RA	0.016
slif	slimfast	0.015
Pkn	Protein kinase related to protein kinase N	0.015
betaTry	betaTrypsin	0.015
Eip63F-1	Ecdysone-induced protein 63F 1	0.015
CG2076	CG2076 gene product from transcript CG2076-RA	0.015
sinah	sina homologue	0.015
Cyp4p1	Cytochrome P450-4p1	0.015
RhoGAP68F	CG6811 gene product from transcript CG6811-RA	0.015
CG10562	CG10562 gene product from transcript CG10562-RA	0.015
CG7272	CG7272 gene product from transcript CG7272-RA	0.015
Akt1	CG4006 gene product from transcript CG4006-RA	0.015
Hnf4	Hepatocyte nuclear factor 4	0.015
atl	atlastin	0.015
trp	transient receptor potential	0.015	Human
Cbl	CG7037 gene product from transcript CG7037-RB	0.015
Cyp28d1	CG10833 gene product from transcript CG10833-RA	0.015	Rat Fly
sr	stripe	0.014
CG34350	CG34350 gene product from transcript CG34350-RA	0.014
CG9510	CG9510 gene product from transcript CG9510-RC	0.014
CG10237	CG10237 gene product from transcript CG10237-RA	0.014
CG6277	CG6277 gene product from transcript CG6277-RA	0.014	Rat
beta4GalNAcTA	CG8536 gene product from transcript CG8536-RA	0.014
Sply	Sphingosine-1-phosphate lyase	0.014
CG14931	CG14931 gene product from transcript CG14931-RB	0.014
emc	extra macrochaetae	0.014	Mouse
CG6045	CG6045 gene product from transcript CG6045-RA	0.014
CG9360	CG9360 gene product from transcript CG9360-RA	0.014
Picot	CG8098 gene product from transcript CG8098-RA	0.014
Cyp6a13	CG2397 gene product from transcript CG2397-RA	0.014	Rat Fly
loco	locomotion defects	0.014
Thor	CG8846 gene product from transcript CG8846-RA	0.014
spas	spastin	0.014
CG5541	CG5541 gene product from transcript CG5541-RA	0.014
CG14715	CG14715 gene product from transcript CG14715-RA	0.014
Galpha49B	G protein alpha49B	0.014
Amy-d	Amylase distal	0.014
fd59A	forkhead domain 59A	0.014
Cyp12b2	CG15077 gene product from transcript CG15077-RA	0.013
Cyp28a5	CG8864 gene product from transcript CG8864-RA	0.013	Rat Fly
CG15408	CG15408 gene product from transcript CG15408-RA	0.013
CG13117	CG13117 gene product from transcript CG13117-RA	0.013
ninaB	neither inactivation nor afterpotential B	0.013
tum	tumbleweed	0.013
Cyp9f2	CG11466 gene product from transcript CG11466-RB	0.013	Rat Fly
mol	moladietz	0.013
CG11055	CG11055 gene product from transcript CG11055-RB	0.013
Ilp6	Insulin-like peptide 6	0.013
JhI-21	CG12317 gene product from transcript CG12317-RB	0.013
CG31326	CG31326 gene product from transcript CG31326-RA	0.013
CG10550	CG10550 gene product from transcript CG10550-RB	0.013
CG14820	CG14820 gene product from transcript CG14820-RA	0.013
Mf	Myofilin	0.013
CG10694	CG10694 gene product from transcript CG10694-RA	0.013
insc	inscuteable	0.013
CG8790	CG8790 gene product from transcript CG8790-RB	0.013
CG3714	CG3714 gene product from transcript CG3714-RC	0.013
Pxd	Peroxidase	0.013
LanB1	CG7123 gene product from transcript CG7123-RA	0.013
CG17189	CG17189 gene product from transcript CG17189-RA	0.013
CG7044	CG7044 gene product from transcript CG7044-RA	0.013
trpml	transient receptor potential mucolipin	0.013
CG30069	CG30069 gene product from transcript CG30069-RA	0.013
Ssadh	Succinic semialdehyde dehydrogenase	0.013
Cyp6t3	CG8457 gene product from transcript CG8457-RA	0.013	Rat Fly
eEF1delta	CG4912 gene product from transcript CG4912-RB	0.012
CG3679	CG3679 gene product from transcript CG3679-RA	0.012
Cdk4	Cyclin-dependent kinase 4	0.012
CG6830	CG6830 gene product from transcript CG6830-RA	0.012
Atg2	Autophagy-specific gene 2	0.012
p130CAS	CG1212 gene product from transcript CG1212-RA	0.012
msn	misshapen	0.012
CG11891	CG11891 gene product from transcript CG11891-RD	0.012
eve	even skipped	0.012
CG34330	CG34330 gene product from transcript CG34330-RA	0.012
Msp-300	Muscle-specific protein 300	0.012
Eaat1	Excitatory amino acid transporter 1	0.012
Gr28b	Gustatory receptor 28b	0.012
pdfr	PDF receptor	0.012
CG30377	CG30377 gene product from transcript CG30377-RA	0.012
WASp	CG1520 gene product from transcript CG1520-RA	0.012
CG10361	CG10361 gene product from transcript CG10361-RA	0.012
Atg7	Autophagy-specific gene 7	0.012
png	pan gu	0.012
Scsalpha	Succinyl coenzyme A synthetase alpha subunit	0.012
cnc	cap-n-collar	0.012
CG8449	CG8449 gene product from transcript CG8449-RA	0.012
Tm2	Tropomyosin 2	0.012
l(1)dd4	lethal (1) discs degenerate 4	0.012
CG5287	CG5287 gene product from transcript CG5287-RA	0.011
Acon	Aconitase	0.011
Zasp66	Z band alternatively spliced PDZ-motif protein 66	0.011
CG11889	CG11889 gene product from transcript CG11889-RA	0.011
Sp7	Serine protease 7	0.011
CG15549	CG15549 gene product from transcript CG15549-RA	0.011
CG10514	CG10514 gene product from transcript CG10514-RA	0.011
CG10979	CG10979 gene product from transcript CG10979-RA	0.011
sls	sallimus	0.011
CG31103	CG31103 gene product from transcript CG31103-RB	0.011
ZIP1	Zinc/iron regulated transporter-related protein 1	0.011
DmsR-2	Dromyosuppressin receptor 2	0.011
CG6225	CG6225 gene product from transcript CG6225-RB	0.011
CG11899	CG11899 gene product from transcript CG11899-RA	0.011
CG4623	CG4623 gene product from transcript CG4623-RA	0.011
PEK	pancreatic eIF-2alpha kinase	0.011
VhaM8.9	CG8444 gene product from transcript CG8444-RA	0.011
rap	retina aberrant in pattern	0.011
Mmp1	Matrix metalloproteinase 1	0.011
Tbh	Tyramine beta hydroxylase	0.011	Rat
Myd88	CG2078 gene product from transcript CG2078-RA	0.011
CG10226	CG10226 gene product from transcript CG10226-RA	0.011	Rat
CG7627	CG7627 gene product from transcript CG7627-RA	0.011	Fly
CG5381	CG5381 gene product from transcript CG5381-RA	0.011
Corp	Companion of reaper	0.011
Cpr73D	Cuticular protein 73D	0.011
obst-A	obstructor-A	0.011
Hop	Hsp70/Hsp90 organizing protein homolog	0.011
Spn77Bc	Serpin 77Bc	0.011
mal	maroon-like	0.011
Cyp6a8	Cytochrome P450-6a8	0.011	Rat Fly
CG3523	CG3523 gene product from transcript CG3523-RA	0.011
CG5568	CG5568 gene product from transcript CG5568-RA	0.010
CG14410	CG14410 gene product from transcript CG14410-RA	0.010
NAAT1	Nutrient Amino Acid Transporter 1	0.010	Fly
Pvr	PDGF- and VEGF-receptor related	0.010
CG3860	CG3860 gene product from transcript CG3860-RA	0.010
CG10208	CG10208 gene product from transcript CG10208-RA	0.010
Lk6	CG17342 gene product from transcript CG17342-RA	0.010
Ugt36Bc	CG17932 gene product from transcript CG17932-RB	0.010
Hmgcr	HMG Coenzyme A reductase	0.010
mus201	mutagen-sensitive 201	0.010
CG4991	CG4991 gene product from transcript CG4991-RB	0.010
CG30160	CG30160 gene product from transcript CG30160-RA	0.010
Ilp4	Insulin-like peptide 4	0.010
Cyp12d1-p	CG30489 gene product from transcript CG30489-RA	0.010
CG10824	CG10824 gene product from transcript CG10824-RA	0.010
CG16771	CG16771 gene product from transcript CG16771-RC	0.010