IMP: Integrative Multi-species Prediction

Drosophila melanogaster

21 genes annotated in fly

receptor mediated endocytosis

An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "receptor mediated endocytosis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "receptor mediated endocytosis" (in gray)

Name	Description	Probability	Func Analog Organism
Moe	Moesin	0.271	Mouse Worm
arm	armadillo	0.243	Worm
Gp150	CG5820 gene product from transcript CG5820-RA	0.222
mop	myopic	0.150
put	punt	0.149
Atpalpha	Na pump alpha subunit	0.148
cpa	capping protein alpha	0.141
tsr	twinstar	0.133
Mer	Merlin	0.130
ebi	CG4063 gene product from transcript CG4063-RA	0.113
Arp14D	Actin-related protein 14D	0.108	Worm
cpb	capping protein beta	0.106
Chc	Clathrin heavy chain	0.099	Worm
Xbp1	X box binding protein-1	0.097
srp	serpent	0.095
dom	domino	0.088
Rab5	Rab-protein 5	0.086	Human Worm
Arc-p34	CG10954 gene product from transcript CG10954-RA	0.084	Yeast
CkIIalpha	Casein kinase II alpha subunit	0.084
Rho1	CG8416 gene product from transcript CG8416-RB	0.083
mbc	myoblast city	0.080
SF2	CG6987 gene product from transcript CG6987-RA	0.077	Worm
CG8258	CG8258 gene product from transcript CG8258-RA	0.076	Worm
Itp-r83A	Inositol 1,4,5,-tris-phosphate receptor	0.075	Worm
zip	zipper	0.074	Worm
Rab11	Rab-protein 11	0.071	Worm
scra	scraps	0.070
lace	CG4162 gene product from transcript CG4162-RA	0.063
Spt5	CG7626 gene product from transcript CG7626-RA	0.058
ik2	IkappaB kinase-like 2	0.053
Rala	Ras-related protein	0.053
par-6	CG5884 gene product from transcript CG5884-RA	0.052	Worm
capt	capulet	0.050
rhea	CG6831 gene product from transcript CG6831-RA	0.049
Khc	Kinesin heavy chain	0.049
LanA	Laminin A	0.047	Worm
Cdc37	CG12019 gene product from transcript CG12019-RA	0.042	Worm
Actn	alpha actinin	0.041
polo	CG12306 gene product from transcript CG12306-RA	0.041
usp	ultraspiracle	0.040
Nmt	N-myristoyl transferase	0.040	Worm
osa	CG7467 gene product from transcript CG7467-RD	0.039
Amph	Amphiphysin	0.039
gish	gilgamesh	0.038
klar	klarsicht	0.037
Pvr	PDGF- and VEGF-receptor related	0.037
numb	CG3779 gene product from transcript CG3779-RB	0.037
Hem	HEM-protein	0.035	Worm
sesB	stress-sensitive B	0.035	Worm
beta-Spec	beta Spectrin	0.034
cora	coracle	0.034
CG10754	CG10754 gene product from transcript CG10754-RA	0.033
Rab7	Rab-protein 7	0.033
gammaCop	gamma-coatomer protein	0.033	Worm
skpA	CG16983 gene product from transcript CG16983-RD	0.033	Worm
G-oalpha47A	G protein oalpha 47A	0.033
sti	sticky	0.033
ecd	ecdysoneless	0.032
Prp8	pre-mRNA processing factor 8	0.032	Worm
Acf1	ATP-dependent chromatin assembly factor large subunit	0.031
Aos1	CG12276 gene product from transcript CG12276-RA	0.031
Klp61F	Kinesin-like protein at 61F	0.030
eIF3-S8	CG4954 gene product from transcript CG4954-RA	0.030
alphaTub67C	alpha-Tubulin at 67C	0.030
T-cp1	Tcp1-like	0.029	Worm
Vha100-1	CG1709 gene product from transcript CG1709-RF	0.028
alpha-Adaptin	CG4260 gene product from transcript CG4260-RA	0.028	Worm
Trxr-1	Thioredoxin reductase-1	0.027
pit	pitchoune	0.027
Kap-alpha3	karyopherin alpha3	0.027
Tab2	TAK1-associated binding protein 2	0.027
mbo	members only	0.027
EndoGI	Endonuclease G inhibitor	0.027
Sra-1	specifically Rac1-associated protein 1	0.027
smo	smoothened	0.027
Pp1-87B	Protein phosphatase 1 at 87B	0.027
lwr	lesswright	0.026
Tcp-1zeta	T-cp1zeta	0.026
BRWD3	CG31132 gene product from transcript CG31132-RA	0.026
egl	egalitarian	0.026
Gnf1	Germ line transcription factor 1	0.026	Worm
Rab6	Rab-protein 6	0.025
eff	effete	0.024	Worm
eya	eyes absent	0.024
Tak1	TGF-beta activated kinase 1	0.024
CG4699	CG4699 gene product from transcript CG4699-RJ	0.024
CG12301	CG12301 gene product from transcript CG12301-RA	0.024
cact	cactus	0.024
Nrg	Neuroglian	0.024
hiw	highwire	0.024
CG13096	CG13096 gene product from transcript CG13096-RA	0.024
Tcp-1eta	CG8351 gene product from transcript CG8351-RA	0.023	Worm
Bap	Beta Adaptin	0.023
dsh	dishevelled	0.023
CG32344	CG32344 gene product from transcript CG32344-RA	0.023
da	daughterless	0.023
Dap160	Dynamin associated protein 160	0.023
Hrs	Hepatocyte growth factor regulated tyrosine kinase substrate	0.023
SdhA	Succinate dehydrogenase A	0.023
mys	myospheroid	0.022
CG6724	CG6724 gene product from transcript CG6724-RA	0.022
VhaM8.9	CG8444 gene product from transcript CG8444-RA	0.022
baz	bazooka	0.022	Worm
asp	abnormal spindle	0.022
sqh	spaghetti squash	0.021
betaTub56D	beta-Tubulin at 56D	0.021
tgo	tango	0.021
BicD	Bicaudal D	0.020
Cbp80	cap binding protein 80	0.020	Worm
CG7033	CG7033 gene product from transcript CG7033-RC	0.020	Worm
jar	jaguar	0.020
brm	brahma	0.020
Snap	Soluble NSF attachment protein	0.020
RhoGAP92B	CG4755 gene product from transcript CG4755-RA	0.020
twi	twist	0.020
Galpha49B	G protein alpha49B	0.020
WASp	CG1520 gene product from transcript CG1520-RA	0.019
eIF-3p40	Eukaryotic initiation factor 3 p40 subunit	0.019
Lsd-2	Lipid storage droplet-2	0.019
Elp3	Elongator complex protein 3	0.019
CG18178	CG18178 gene product from transcript CG18178-RA	0.019
sec6	CG5341 gene product from transcript CG5341-RA	0.019	Worm
NP15.6	CG6008 gene product from transcript CG6008-RA	0.019
Arf102F	ADP ribosylation factor 102F	0.019
aux	auxillin	0.019	Mouse
l(2)09851	lethal (2) 09851	0.019
mmy	mummy	0.019
wupA	wings up A	0.019
Rac1	CG2248 gene product from transcript CG2248-RA	0.019
Uba1	Ubiquitin activating enzyme 1	0.018	Worm
ras	raspberry	0.018
sec15	CG7034 gene product from transcript CG7034-RA	0.018
Cctgamma	CG8977 gene product from transcript CG8977-RC	0.018
Ras85D	Ras oncogene at 85D	0.018	Worm
CG3683	CG3683 gene product from transcript CG3683-RC	0.018
flr	flare	0.018
l(2)03709	lethal (2) 03709	0.018
Mfap1	Microfibril-associated protein 1	0.018
ttv	tout-velu	0.018
Rpb5	CG11979 gene product from transcript CG11979-RA	0.018
Ars2	CG7843 gene product from transcript CG7843-RA	0.018
Dcr-2	Dicer-2	0.018
sktl	skittles	0.018
Dad	Daughters against dpp	0.017
Zn72D	CG5215 gene product from transcript CG5215-RB	0.017
drd	drop dead	0.017
eIF5	CG9177 gene product from transcript CG9177-RE	0.017
ci	cubitus interruptus	0.017	Worm
Cct5	T-complex Chaperonin 5	0.017	Worm
Hsp83	Heat shock protein 83	0.017
mod	modulo	0.017
chb	chromosome bows	0.017
Art3	Arginine methyltransferase 3	0.017
levy	CG17280 gene product from transcript CG17280-RA	0.017
porin	CG6647 gene product from transcript CG6647-RA	0.017
Dlic	Dynein light intermediate chain	0.017	Worm
pont	pontin	0.017
l(3)01239	lethal (3) 01239	0.017
CG8636	CG8636 gene product from transcript CG8636-RA	0.017
comt	comatose	0.016	Worm
CG5728	CG5728 gene product from transcript CG5728-RA	0.016
mib1	mind bomb 1	0.016
geminin	CG3183 gene product from transcript CG3183-RA	0.016
hyd	hyperplastic discs	0.016
dre4	CG1828 gene product from transcript CG1828-RB	0.016
Dhc64C	Dynein heavy chain 64C	0.016
caz	cabeza	0.016
Fib	Fibrillarin	0.015
mRpL12	mitochondrial ribosomal protein L12	0.015
RpL36	Ribosomal protein L36	0.015
shg	shotgun	0.015
Cam	Calmodulin	0.015	Worm
Mrtf	Myocardin-related transcription factor	0.015
Nrx-IV	Neurexin IV	0.015
CG7845	CG7845 gene product from transcript CG7845-RB	0.015
Mo25	CG4083 gene product from transcript CG4083-RA	0.015
CG11583	CG11583 gene product from transcript CG11583-RA	0.015
Dsp1	Dorsal switch protein 1	0.015	Worm
CG11076	CG11076 gene product from transcript CG11076-RB	0.015
CG7028	CG7028 gene product from transcript CG7028-RA	0.015
Ced-12	CG5336 gene product from transcript CG5336-RA	0.015
RpL13	Ribosomal protein L13	0.015
CG7728	CG7728 gene product from transcript CG7728-RA	0.015
Nsf2	NEM-sensitive fusion protein 2	0.015	Worm
CG7993	CG7993 gene product from transcript CG7993-RA	0.015
puc	puckered	0.015
trc	tricornered	0.015
RnpS1	RNA-binding protein S1	0.015
Pp2A-29B	Protein phosphatase 2A at 29B	0.015
didum	dilute class unconventional myosin	0.015
alphaCop	alpha-coatomer protein	0.015
cindr	CIN85 and CD2AP orthologue	0.015
Rab1	Rab-protein 1	0.014	Worm
CG2469	CG2469 gene product from transcript CG2469-RB	0.014	Worm
bsk	basket	0.014
scny	scrawny	0.014
Ank2	Ankyrin 2	0.014
betaCop	beta-coatomer protein	0.014
eIF-4a	Eukaryotic initiation factor 4a	0.014
Pkn	Protein kinase related to protein kinase N	0.014
shn	schnurri	0.014
CTCF	CG8591 gene product from transcript CG8591-RA	0.014
Rm62	CG10279 gene product from transcript CG10279-RD	0.014
eIF4AIII	CG7483 gene product from transcript CG7483-RA	0.014
Ca-P60A	Calcium ATPase at 60A	0.014	Worm
gek	genghis khan	0.013
CG8939	CG8939 gene product from transcript CG8939-RA	0.013	Worm
spas	spastin	0.013
gammaTub23C	gamma-Tubulin at 23C	0.013
rok	Rho-kinase	0.013
Mlf	Myelodysplasia/myeloid leukemia factor	0.013
cp309	CG33957 gene product from transcript CG33957-RB	0.013
CG10722	CG10722 gene product from transcript CG10722-RA	0.013
TfIIB	Transcription factor IIB	0.013
CG12259	CG12259 gene product from transcript CG12259-RA	0.013
CG30122	CG30122 gene product from transcript CG30122-RB	0.013
CG6712	CG6712 gene product from transcript CG6712-RA	0.013	Worm
CG16903	CG16903 gene product from transcript CG16903-RA	0.013
defl	deflated	0.013	Worm
mats	mob as tumor suppressor	0.013
Bap55	Brahma associated protein 55kD	0.013
betaTub60D	beta-Tubulin at 60D	0.013
Jra	Jun-related antigen	0.013
CG2260	CG2260 gene product from transcript CG2260-RA	0.013
Vps35	Vacuolar protein sorting 35	0.013	Worm
CG3573	CG3573 gene product from transcript CG3573-RA	0.013
Pp4-19C	Protein phosphatase 19C	0.013
CG6015	CG6015 gene product from transcript CG6015-RA	0.013
Chrac-14	CG13399 gene product from transcript CG13399-RA	0.013
Vps16A	Vacuolar protein sorting 16A	0.013
lig	lingerer	0.013
scb	scab	0.012
Rac2	CG8556 gene product from transcript CG8556-RA	0.012
Srp54	CG4602 gene product from transcript CG4602-RA	0.012	Worm
Eps-15	Epidermal growth factor receptor pathway substrate clone 15	0.012
Dmn	Dynamitin	0.012
wcd	wicked	0.012
blot	bloated tubules	0.012
CG5114	CG5114 gene product from transcript CG5114-RA	0.012
Ggamma1	G protein gamma 1	0.012
CG2199	CG2199 gene product from transcript CG2199-RB	0.012
Top2	Topoisomerase 2	0.012
Ef1gamma	CG11901 gene product from transcript CG11901-RC	0.012
ash2	absent, small, or homeotic discs 2	0.012
Pli	Pellino	0.012
tra	transformer	0.012
par-1	CG8201 gene product from transcript CG8201-RA	0.012
CG16941	CG16941 gene product from transcript CG16941-RA	0.012	Worm
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.012
sl	small wing	0.012
bif	bifocal	0.012
Ilk	Integrin linked kinase	0.012
Act42A	Actin 42A	0.012
enok	enoki mushroom	0.012
GluRIIA	Glutamate receptor IIA	0.012
MED27	Mediator complex subunit 27	0.012
fz2	frizzled 2	0.012
Abl	Abl tyrosine kinase	0.012
Nnp-1	CG12396 gene product from transcript CG12396-RA	0.012
spdo	sanpodo	0.012
Pi3K68D	Phosphotidylinositol 3 kinase 68D	0.012
Su(var)205	Suppressor of variegation 205	0.012
Arp66B	Actin-related protein 66B	0.012
CG9548	CG9548 gene product from transcript CG9548-RA	0.012
crn	crooked neck	0.011
Lis-1	Lissencephaly-1	0.011
Pak	PAK-kinase	0.011
Nup107	Nucleoporin 107	0.011
Chmp1	CG4108 gene product from transcript CG4108-RA	0.011
sda	slamdance	0.011
RpLP0	Ribosomal protein LP0	0.011
pcm	pacman	0.011
Egfr	Epidermal growth factor receptor	0.011
nwk	nervous wreck	0.011
Unc-76	CG3981 gene product from transcript CG3981-RB	0.011
Taf4	TBP-associated factor 4	0.011
Adam	CG12131 gene product from transcript CG12131-RA	0.011
pUf68	poly U binding factor 68kD	0.011	Worm
Nat1	CG12202 gene product from transcript CG12202-RA	0.011
ATPsyn-b	ATP synthase, subunit b	0.011
MED11	Mediator complex subunit 11	0.011
CG11660	CG11660 gene product from transcript CG11660-RA	0.011
trio	CG18214 gene product from transcript CG18214-RA	0.011
CG6610	CG6610 gene product from transcript CG6610-RA	0.011
Nup50	Nucleoporin 50	0.011
fzy	fizzy	0.011	Worm
Fip1	CG1078 gene product from transcript CG1078-RA	0.011
Mys45A	Mystery 45A	0.011
hpo	hippo	0.011
Ppat-Dpck	Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase	0.011
kuz	kuzbanian	0.011
Nop60B	Nucleolar protein at 60B	0.011
neb	nebbish	0.011
HLH106	Helix loop helix protein 106	0.011
mago	mago nashi	0.011
CG7006	CG7006 gene product from transcript CG7006-RA	0.011	Worm
CG2807	CG2807 gene product from transcript CG2807-RA	0.011	Worm
Vha68-2	CG3762 gene product from transcript CG3762-RA	0.011	Worm
CG12499	CG12499 gene product from transcript CG12499-RA	0.011
desat1	CG5887 gene product from transcript CG5887-RA	0.011	Worm
CG4751	CG4751 gene product from transcript CG4751-RA	0.011
Elf	Ef1alpha-like factor	0.010
Sema-1a	CG18405 gene product from transcript CG18405-RD	0.010
Cip4	CG15015 gene product from transcript CG15015-RA	0.010	Human
LanB2	Laminin B2	0.010
sno	strawberry notch	0.010
Vha36	CG8186 gene product from transcript CG8186-RA	0.010
lds	lodestar	0.010
dia	diaphanous	0.010	Worm
Letm1	CG4589 gene product from transcript CG4589-RB	0.010
SMC1	CG6057 gene product from transcript CG6057-RA	0.010	Worm
CG11920	CG11920 gene product from transcript CG11920-RA	0.010
Suv4-20	CG13363 gene product from transcript CG13363-RA	0.010
Arf51F	ADP ribosylation factor 51F	0.010
mRpS26	mitochondrial ribosomal protein S26	0.010
pod1	CG4532 gene product from transcript CG4532-RF	0.010
Sulf1	Sulfated	0.010
CG11523	CG11523 gene product from transcript CG11523-RA	0.010
G-salpha60A	G protein salpha 60A	0.010	Worm
TBPH	CG10327 gene product from transcript CG10327-RC	0.010
NHP2	CG5258 gene product from transcript CG5258-RA	0.010
CG9306	CG9306 gene product from transcript CG9306-RA	0.010	Worm
Sas10	CG4202 gene product from transcript CG4202-RA	0.010
rut	rutabaga	0.010
Glt	Glutactin	0.010
wb	wing blister	0.010
RpL7-like	Ribosomal protein L7-like	0.010