IMP: Integrative Multi-species Prediction

Drosophila melanogaster

21 genes annotated in fly

lamellipodium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lamellipodium organization"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "lamellipodium organization" (in gray)

Name	Description	Probability	Func Analog Organism
robo	roundabout	0.938	Zebrafish
da	daughterless	0.819
Sra-1	specifically Rac1-associated protein 1	0.760	Mouse
Rho1	CG8416 gene product from transcript CG8416-RB	0.682
Hem	HEM-protein	0.665	Mouse
cpb	capping protein beta	0.555
Vrp1	Verprolin 1	0.544
ena	enabled	0.465
lea	leak	0.325	Zebrafish
rok	Rho-kinase	0.307
kuz	kuzbanian	0.283
Abi	Abelson interacting protein	0.215
Abl	Abl tyrosine kinase	0.203
trio	CG18214 gene product from transcript CG18214-RA	0.190
sli	slit	0.174	Human
Arp14D	Actin-related protein 14D	0.173
Ephrin	CG1862 gene product from transcript CG1862-RA	0.172
chic	chickadee	0.158
Cdc42	CG12530 gene product from transcript CG12530-RA	0.149
Wnt5	Wnt oncogene analog 5	0.148
Rala	Ras-related protein	0.125
Dscam	Down syndrome cell adhesion molecule	0.110
Rac1	CG2248 gene product from transcript CG2248-RA	0.106
msn	misshapen	0.104
Arc-p34	CG10954 gene product from transcript CG10954-RA	0.094	Human
cta	concertina	0.092
LamC	Lamin C	0.087
Sop2	Suppressor of profilin 2	0.076
S6k	RPS6-p70-protein kinase	0.074
pll	pelle	0.073
RhoGAPp190	CG32555 gene product from transcript CG32555-RB	0.073
l(2)k16918	lethal (2) k16918	0.072
bif	bifocal	0.071
RhoGAP93B	CG3421 gene product from transcript CG3421-RA	0.071
RanBPM	Ran-binding protein M	0.069
mid	midline	0.067
egh	egghead	0.066
otk	off-track	0.066
comm	commissureless	0.065
Dlic	Dynein light intermediate chain	0.064
Mrtf	Myocardin-related transcription factor	0.064
Myo31DF	Myosin 31DF	0.061
twi	twist	0.057
Rac2	CG8556 gene product from transcript CG8556-RA	0.057
cora	coracle	0.056
dock	dreadlocks	0.056	Mouse
RhoGEF2	CG9635 gene product from transcript CG9635-RF	0.055
HSPC300	CG30173 gene product from transcript CG30173-RA	0.054
fra	frazzled	0.054
pod1	CG4532 gene product from transcript CG4532-RF	0.053
zfh1	Zn finger homeodomain 1	0.050
hkb	huckebein	0.045
LIMK1	LIM-kinase1	0.045
fz	frizzled	0.044
par-1	CG8201 gene product from transcript CG8201-RA	0.044
Arp66B	Actin-related protein 66B	0.040
flr	flare	0.038
CG17082	CG17082 gene product from transcript CG17082-RD	0.038
Stim	Stromal interaction molecule	0.036
WASp	CG1520 gene product from transcript CG1520-RA	0.034
mbc	myoblast city	0.034
slp1	sloppy paired 1	0.033
faf	fat facets	0.032
Gef26	CG9491 gene product from transcript CG9491-RB	0.031
Khc	Kinesin heavy chain	0.031
exba	extra bases	0.030
Dap160	Dynamin associated protein 160	0.029
kni	knirps	0.029
caz	cabeza	0.029
ems	empty spiracles	0.029
bin	biniou	0.029
Rab23	CG2108 gene product from transcript CG2108-RA	0.028
Rab2	Rab-protein 2	0.027
not	non-stop	0.027
in	inturned	0.026
Rab6	Rab-protein 6	0.026
Lim3	CG10699 gene product from transcript CG10699-RB	0.026
schlank	CG3576 gene product from transcript CG3576-RB	0.025
stan	starry night	0.025
NetB	Netrin-B	0.025
gcm	glial cells missing	0.023
katanin-60	katanin 60	0.023
drl	derailed	0.022
tll	tailless	0.022
Uba1	Ubiquitin activating enzyme 1	0.022
CG12289	CG12289 gene product from transcript CG12289-RA	0.021
Arf51F	ADP ribosylation factor 51F	0.021
Caps	Calcium activated protein for secretion	0.020
FucT6	alpha1,6-fucosyltransferase	0.020
Pvf1	PDGF- and VEGF-related factor 1	0.020
byn	brachyenteron	0.020
CkIIbeta	Casein kinase II beta subunit	0.020
sn	singed	0.020
Tre1	trapped in endoderm-1	0.019
Rpn6	Proteasome p44.5 subunit	0.019
yki	yorkie	0.019
hipk	homeodomain interacting protein kinase	0.019
beta-Spec	beta Spectrin	0.018
14-3-3zeta	CG17870 gene product from transcript CG17870-RB	0.018
CG11791	CG11791 gene product from transcript CG11791-RB	0.018
twf	twinfilin	0.018
sol	small optic lobes	0.018
Sbf	SET domain binding factor	0.018
tomosyn	CG17762 gene product from transcript CG17762-RB	0.018
SoxN	SoxNeuro	0.018
CG14869	CG14869 gene product from transcript CG14869-RB	0.018
unc-5	CG8166 gene product from transcript CG8166-RA	0.018
Mtl	Mig-2-like	0.017
Nsf2	NEM-sensitive fusion protein 2	0.017
Notum	CG13076 gene product from transcript CG13076-RB	0.017
CG9053	CG9053 gene product from transcript CG9053-RA	0.017
Syb	Synaptobrevin	0.017
lqf	liquid facets	0.017
arr	arrow	0.017
Peb	Protein ejaculatory bulb	0.017
run	runt	0.016
Rbsn-5	Rabenosyn-5	0.016
cindr	CIN85 and CD2AP orthologue	0.016
bnl	branchless	0.016
nvy	nervy	0.016
wg	wingless	0.016
nullo	CG14426 gene product from transcript CG14426-RB	0.015
Pak3	CG14895 gene product from transcript CG14895-RA	0.015
pcx	pecanex	0.015
HLH54F	CG5005 gene product from transcript CG5005-RA	0.015
Nrt	Neurotactin	0.015
CG6234	CG6234 gene product from transcript CG6234-RA	0.015
dsh	dishevelled	0.015
CG11242	CG11242 gene product from transcript CG11242-RA	0.015
Eip63E	Ecdysone-induced protein 63E	0.014
form3	formin 3	0.014
vav	CG7893 gene product from transcript CG7893-RB	0.014	Mouse
dy	dusky	0.014
crp	cropped	0.014
CG12029	CG12029 gene product from transcript CG12029-RB	0.014
Gef64C	Guanine nucleotide exchange factor GEF64C	0.014
erm	earmuff	0.014
Flo-2	flotillin 2	0.014
btl	breathless	0.014
Sema-1a	CG18405 gene product from transcript CG18405-RD	0.014
vfl	vielfaltig	0.013
Fas3	Fasciclin 3	0.013
CG3563	CG3563 gene product from transcript CG3563-RA	0.013
CG31352	CG31352 gene product from transcript CG31352-RA	0.013
HGTX	CG13475 gene product from transcript CG13475-RB	0.013
ns3	nucleostemin 3	0.013
pros	prospero	0.013
Mob2	CG11711 gene product from transcript CG11711-RC	0.013
tmod	tropomodulin	0.013
nimC3	nimrod C3	0.013
CG31999	CG31999 gene product from transcript CG31999-RA	0.013
Six4	CG3871 gene product from transcript CG3871-RA	0.013
Ilk	Integrin linked kinase	0.013
sqz	squeeze	0.013
CG6912	CG6912 gene product from transcript CG6912-RA	0.012
EndoGI	Endonuclease G inhibitor	0.012
Fas2	Fasciclin 2	0.012
cutlet	CG33122 gene product from transcript CG33122-RA	0.012
robo3	CG5423 gene product from transcript CG5423-RA	0.012	Zebrafish
Rme-8	Receptor mediated endocytosis 8	0.012
Eps-15	Epidermal growth factor receptor pathway substrate clone 15	0.012
kel	kelch	0.012
NPFR1	neuropeptide F receptor	0.012
numb	CG3779 gene product from transcript CG3779-RB	0.012
CG1129	CG1129 gene product from transcript CG1129-RC	0.012
Mpk2	CG5475 gene product from transcript CG5475-RB	0.012
Ten-m	Tenascin major	0.012
lace	CG4162 gene product from transcript CG4162-RA	0.012
Blimp-1	CG5249 gene product from transcript CG5249-RA	0.012
Baldspot	CG3971 gene product from transcript CG3971-RA	0.012
ird1	immune response deficient 1	0.012
scny	scrawny	0.012
elav	embryonic lethal abnormal vision	0.012
rictor	rapamycin-insensitive companion of Tor	0.012
tin	tinman	0.011
frtz	fritz	0.011
spo	spook	0.011
Gga	CG3002 gene product from transcript CG3002-RB	0.011
sim	single-minded	0.011
cpa	capping protein alpha	0.011
vnd	ventral nervous system defective	0.010
CG9650	CG9650 gene product from transcript CG9650-RG	0.010
Imp	IGF-II mRNA-binding protein	0.010
Pak	PAK-kinase	0.010
mam	mastermind	0.010