IMP: Integrative Multi-species Prediction

Drosophila melanogaster

36 genes annotated in fly

positive regulation of erk1 and erk2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of erk1 and erk2 cascade"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of erk1 and erk2 cascade" (in gray)

Name	Description	Probability	Func Analog Organism
Ras85D	Ras oncogene at 85D	0.673	Human Rat
phl	pole hole	0.581
drk	downstream of receptor kinase	0.401
rl	rolled	0.310
aop	anterior open	0.303
pnut	peanut	0.254
pnt	pointed	0.241
Rcd1	Reduction in Cnn dots 1	0.184
Dsor1	Downstream of raf1	0.174
csw	corkscrew	0.136	Mouse
mtt	mangetout	0.134
Taf6	TBP-associated factor 6	0.110
Gap1	GTPase-activating protein 1	0.102
dco	discs overgrown	0.101
spi	spitz	0.100
Src64B	Src oncogene at 64B	0.100	Mouse Rat
CG7028	CG7028 gene product from transcript CG7028-RA	0.089
l(1)G0232	lethal (1) G0232	0.085
bun	bunched	0.084
Stat92E	Signal-transducer and activator of transcription protein at 92E	0.083
stumps	CG31317 gene product from transcript CG31317-RC	0.082
Pp1alpha-96A	Protein phosphatase 1alpha at 96A	0.074	Fly
Mrtf	Myocardin-related transcription factor	0.071
mbc	myoblast city	0.067
Egfr	Epidermal growth factor receptor	0.067	Human
Vps35	Vacuolar protein sorting 35	0.065
PTP-ER	Protein tyrosine phosphatase-ERK/Enhancer of Ras1	0.064
CG15436	CG15436 gene product from transcript CG15436-RA	0.062
put	punt	0.061
InR	Insulin-like receptor	0.061	Fly
CG10139	CG10139 gene product from transcript CG10139-RA	0.061
sty	sprouty	0.060	Human
Aac11	CG6582 gene product from transcript CG6582-RA	0.057
Bap60	Brahma associated protein 60kD	0.057
Smox	Smad on X	0.056
trio	CG18214 gene product from transcript CG18214-RA	0.054
Shc	SHC-adaptor protein	0.054
Sry-beta	Serendipity beta	0.054
aPKC	atypical protein kinase C	0.053
Jra	Jun-related antigen	0.053
B4	CG9239 gene product from transcript CG9239-RA	0.052
repo	reversed polarity	0.052
CG7386	CG7386 gene product from transcript CG7386-RA	0.051
slmb	supernumerary limbs	0.051
Lis-1	Lissencephaly-1	0.050
Gug	Grunge	0.050
Sry-delta	Serendipity delta	0.050
srp	serpent	0.050
aux	auxillin	0.049
grau	grauzone	0.049
Fcp1	CG12252 gene product from transcript CG12252-RA	0.049
Taf12	TBP-associated factor 12	0.048
zfh1	Zn finger homeodomain 1	0.045
ths	thisbe	0.045
wg	wingless	0.045
CG7156	CG7156 gene product from transcript CG7156-RA	0.045
Akt1	CG4006 gene product from transcript CG4006-RA	0.044
CG1024	CG1024 gene product from transcript CG1024-RB	0.043
CstF-64	Cleavage stimulation factor 64 kilodalton subunit	0.042
Fmr1	CG6203 gene product from transcript CG6203-RC	0.042
ttv	tout-velu	0.041
14-3-3epsilon	CG31196 gene product from transcript CG31196-RA	0.041
mib2	mind bomb 2	0.041
Mad	Mothers against dpp	0.041
CG16972	CG16972 gene product from transcript CG16972-RA	0.040
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.039
sr	stripe	0.038
Dad	Daughters against dpp	0.038
CG4751	CG4751 gene product from transcript CG4751-RA	0.037
svp	seven up	0.037
CdsA	CDP diglyceride synthetase	0.037
npf	neuropeptide F	0.036
fl(2)d	female lethal d	0.036
Rbsn-5	Rabenosyn-5	0.036
scb	scab	0.035
CG6654	CG6654 gene product from transcript CG6654-RA	0.034
SF1	Splicing factor 1	0.033
pUf68	poly U binding factor 68kD	0.033
Tap42	Two A-associated protein of 42kDa	0.033
gig	gigas	0.032
CG13472	CG13472 gene product from transcript CG13472-RA	0.032
Rac2	CG8556 gene product from transcript CG8556-RA	0.031
CG9797	CG9797 gene product from transcript CG9797-RA	0.031
Ced-12	CG5336 gene product from transcript CG5336-RA	0.031
CG8176	CG8176 gene product from transcript CG8176-RD	0.031
Srp54	CG4602 gene product from transcript CG4602-RA	0.030
CG6015	CG6015 gene product from transcript CG6015-RA	0.030
TSG101	tumor suppressor protein 101	0.030
par-6	CG5884 gene product from transcript CG5884-RA	0.030
shn	schnurri	0.030
p16-ARC	CG9881 gene product from transcript CG9881-RA	0.030
lqf	liquid facets	0.030
Pk61C	Protein kinase 61C	0.030
Cdk9	Cyclin-dependent kinase 9	0.029
CG4617	CG4617 gene product from transcript CG4617-RA	0.029
CG1792	CG1792 gene product from transcript CG1792-RA	0.029	Fly
gek	genghis khan	0.029
CG9915	CG9915 gene product from transcript CG9915-RB	0.029
CG31108	CG31108 gene product from transcript CG31108-RA	0.029
rho	rhomboid	0.028
Nrt	Neurotactin	0.028
Liprin-alpha	CG11199 gene product from transcript CG11199-RB	0.028
pea	peanuts	0.027
CkIalpha	Casein kinase Ialpha	0.027
Nhe2	Na[+]/H[+] hydrogen exchanger 2	0.027
woc	without children	0.027
BRWD3	CG31132 gene product from transcript CG31132-RA	0.027
Git	CG16728 gene product from transcript CG16728-RA	0.027
Cyp18a1	Cytochrome P450-18a1	0.027
CG4854	CG4854 gene product from transcript CG4854-RA	0.027
CG14641	CG14641 gene product from transcript CG14641-RA	0.026
RpII15	RNA polymerase II 15kD subunit	0.026
az2	CG1605 gene product from transcript CG1605-RA	0.026	Fly
sev	sevenless	0.026	Fly
arm	armadillo	0.026
jeb	jelly belly	0.026
Ssl1	CG11115 gene product from transcript CG11115-RA	0.026
Pvf2	PDGF- and VEGF-related factor 2	0.025
CG6066	CG6066 gene product from transcript CG6066-RA	0.025
Slu7	CG1420 gene product from transcript CG1420-RA	0.025
CG14220	CG14220 gene product from transcript CG14220-RA	0.025
DnaJ-1	DnaJ-like-1	0.025
Ars2	CG7843 gene product from transcript CG7843-RA	0.025
pyr	pyramus	0.024
CG11188	CG11188 gene product from transcript CG11188-RA	0.024
bnl	branchless	0.024
Rab5	Rab-protein 5	0.024
Dab	Disabled	0.023
CG8569	CG8569 gene product from transcript CG8569-RA	0.023
CG12259	CG12259 gene product from transcript CG12259-RA	0.023
ksr	kinase suppressor of ras	0.023
Mad1	CG2072 gene product from transcript CG2072-RA	0.023
Taf1	TBP-associated factor 1	0.023
CG4424	CG4424 gene product from transcript CG4424-RA	0.023
ninaA	neither inactivation nor afterpotential A	0.023
mRNA-capping-enzyme	CG1810 gene product from transcript CG1810-RA	0.023
Gr28b	Gustatory receptor 28b	0.023
Mtor	Megator	0.022
CG7785	CG7785 gene product from transcript CG7785-RA	0.022
CG10209	CG10209 gene product from transcript CG10209-RA	0.022
CG18764	CG18764 gene product from transcript CG18764-RA	0.022	Fly
tkv	thickveins	0.022
dm	diminutive	0.022
CG8777	CG8777 gene product from transcript CG8777-RA	0.022
Dcp1	Decapping protein 1	0.021
tbce	tubulin-specific chaperone E	0.021
Pp2B-14D	Protein phosphatase 2B at 14D	0.021
rols	rolling pebbles	0.021
kay	kayak	0.021
I-2	Inhibitor-2	0.021
shi	shibire	0.020
eve	even skipped	0.020
inaD	inactivation no afterpotential D	0.020
CG14215	CG14215 gene product from transcript CG14215-RA	0.020
Arr2	Arrestin 2	0.020	Rat
Saf-B	Scaffold attachment factor B	0.020
CG7536	CG7536 gene product from transcript CG7536-RB	0.020
cdi	center divider	0.020
Bj1	Bj1 protein	0.020
S6k	RPS6-p70-protein kinase	0.020
l(2)k14710	lethal (2) k14710	0.019
CG5451	CG5451 gene product from transcript CG5451-RA	0.019
cnk	connector enhancer of ksr	0.019
Sos	Son of sevenless	0.019
CG6729	CG6729 gene product from transcript CG6729-RA	0.019
ex	expanded	0.019
Mkk4	MAP kinase kinase 4	0.019
ro	rough	0.019
CG8159	CG8159 gene product from transcript CG8159-RB	0.019	Fly
CG11448	CG11448 gene product from transcript CG11448-RA	0.019
CG12424	CG12424 gene product from transcript CG12424-RC	0.019
Mkp3	Mitogen-activated protein kinase phosphatase 3	0.019
CG14546	CG14546 gene product from transcript CG14546-RA	0.019
sw	short wing	0.019
CG17568	CG17568 gene product from transcript CG17568-RA	0.019
trx	trithorax	0.018
Socs36E	Suppressor of cytokine signaling at 36E	0.018
Dip3	Dorsal interacting protein 3	0.018
ric8a	CG15797 gene product from transcript CG15797-RA	0.018
CG17328	CG17328 gene product from transcript CG17328-RA	0.018
CG15514	CG15514 gene product from transcript CG15514-RA	0.018
Kmn1	kinetochore Mis12-Ndc80 network component 1	0.018
unk	unkempt	0.018
CG7928	CG7928 gene product from transcript CG7928-RA	0.018
S6kII	RPS6-protein kinase-II	0.017
RhoBTB	CG5701 gene product from transcript CG5701-RA	0.017
Src42A	Src oncogene at 42A	0.017
melt	melted	0.017
CG15525	CG15525 gene product from transcript CG15525-RA	0.017
atms	antimeros	0.017
slbo	slow border cells	0.017
baz	bazooka	0.017
Taf5	TBP-associated factor 5	0.017
aft	adrift	0.017
ru	roughoid	0.017
eya	eyes absent	0.017
dos	daughter of sevenless	0.017
PNUTS	CG33526 gene product from transcript CG33526-RD	0.017
Cpsf160	Cleavage and polyadenylation specificity factor 160	0.016
abo	abnormal oocyte	0.016
CG10107	CG10107 gene product from transcript CG10107-RA	0.016
CG4936	CG4936 gene product from transcript CG4936-RA	0.016
NiPp1	Nuclear inhibitor of Protein phosphatase 1	0.016
cdm	cadmus	0.016
CG5830	CG5830 gene product from transcript CG5830-RA	0.016
chp	chaoptic	0.016
CG1671	CG1671 gene product from transcript CG1671-RA	0.016
CG6707	CG6707 gene product from transcript CG6707-RA	0.016
CG10274	CG10274 gene product from transcript CG10274-RA	0.016
TfIIS	RNA polymerase II elongation factor	0.016
Spt5	CG7626 gene product from transcript CG7626-RA	0.016
CG7945	CG7945 gene product from transcript CG7945-RC	0.016
psidin	phagocyte signaling impaired	0.016
mael	maelstrom	0.016
spri	sprint	0.016
snRNP-U1-70K	small ribonucleoprotein particle U1 subunit 70K	0.016
Pmm45A	Phosphomannomutase 45A	0.016
rap	retina aberrant in pattern	0.016
rdgB	retinal degeneration B	0.016
Iswi	Imitation SWI	0.015
D19B	CG10270 gene product from transcript CG10270-RA	0.015
Ef1alpha48D	Elongation factor 1alpha48D	0.015
ranshi	CG9793 gene product from transcript CG9793-RA	0.015	Fly
CG9213	CG9213 gene product from transcript CG9213-RA	0.015
CG17494	CG17494 gene product from transcript CG17494-RA	0.015
ImpL2	Ecdysone-inducible gene L2	0.015
Rcd5	Reduction in Cnn dots 5	0.015
ena	enabled	0.015
CG5742	CG5742 gene product from transcript CG5742-RA	0.015
Ilp4	Insulin-like peptide 4	0.015
boss	bride of sevenless	0.015
MBD-R2	CG10042 gene product from transcript CG10042-RB	0.015
CG15764	CG15764 gene product from transcript CG15764-RA	0.015
NetB	Netrin-B	0.015
klg	klingon	0.015
tsu	tsunagi	0.015
ash2	absent, small, or homeotic discs 2	0.015
Brf	CG31256 gene product from transcript CG31256-RA	0.015
Rrp6	CG7292 gene product from transcript CG7292-RB	0.015
Bin1	Bicoid interacting protein 1	0.015
abs	abstrakt	0.015
CG12182	CG12182 gene product from transcript CG12182-RA	0.015
Gsc	Goosecoid	0.015
CG10171	CG10171 gene product from transcript CG10171-RB	0.015
CG10267	CG10267 gene product from transcript CG10267-RB	0.015
p130CAS	CG1212 gene product from transcript CG1212-RA	0.014
shg	shotgun	0.014
CG6623	CG6623 gene product from transcript CG6623-RA	0.014
Vha100-1	CG1709 gene product from transcript CG1709-RF	0.014
Stam	Signal transducing adaptor molecule	0.014
Apc	APC-like	0.014
pll	pelle	0.014
Ada1-1	CG31865 gene product from transcript CG31865-RA	0.014
CG1965	CG1965 gene product from transcript CG1965-RA	0.014
CaMKII	Calcium/calmodulin-dependent protein kinase II	0.014
jar	jaguar	0.014
CG10222	CG10222 gene product from transcript CG10222-RA	0.014
CG14667	CG14667 gene product from transcript CG14667-RA	0.014	Fly
mus81	CG3026 gene product from transcript CG3026-RA	0.014
rdgC	retinal degeneration C	0.014
chico	CG5686 gene product from transcript CG5686-RB	0.014
Med	Medea	0.014
kek1	kekkon-1	0.014
CG9902	CG9902 gene product from transcript CG9902-RA	0.014
synj	synaptojanin	0.014
CadN	Cadherin-N	0.014
Prosbeta4R1	Proteasome beta4R1 subunit	0.013
CG8735	CG8735 gene product from transcript CG8735-RA	0.013
cno	canoe	0.013
hug	hugin	0.013
toc	toucan	0.013
CG9323	CG9323 gene product from transcript CG9323-RA	0.013
CG13392	CG13392 gene product from transcript CG13392-RA	0.013
hbs	hibris	0.013
CG5872	CG5872 gene product from transcript CG5872-RA	0.013
Syx7	Syntaxin 7	0.013
Nf1	Neurofibromin 1	0.013
Ten-m	Tenascin major	0.013
CG15141	CG15141 gene product from transcript CG15141-RA	0.013
CG5890	CG5890 gene product from transcript CG5890-RB	0.013
CG8455	CG8455 gene product from transcript CG8455-RA	0.013
CG32264	CG32264 gene product from transcript CG32264-RH	0.013
CG5038	CG5038 gene product from transcript CG5038-RA	0.013
trpl	trp-like	0.013
Ube3a	Ubiquitin protein ligase E3A	0.013
CG4887	CG4887 gene product from transcript CG4887-RA	0.013
trem	trade embargo	0.013
ninaB	neither inactivation nor afterpotential B	0.013
CG5931	CG5931 gene product from transcript CG5931-RA	0.013
spn-D	spindle D	0.013
CG9134	CG9134 gene product from transcript CG9134-RB	0.013
bru-3	bruno-3	0.013
wb	wing blister	0.013
CG16940	CG16940 gene product from transcript CG16940-RB	0.013
betaInt-nu	beta[nu] integrin	0.013
CG6191	CG6191 gene product from transcript CG6191-RA	0.013
htl	heartless	0.013	Human Mouse
tra2	transformer 2	0.013
CG9425	CG9425 gene product from transcript CG9425-RB	0.013
dock	dreadlocks	0.013
vps2	CG14542 gene product from transcript CG14542-RA	0.013
lap	like-AP180	0.013
CG7927	CG7927 gene product from transcript CG7927-RA	0.012
Sk2	Sphingosine kinase 2	0.012
edl	ETS-domain lacking	0.012
BHD	Birt-Hogg-Dube homolog	0.012
Dmn	Dynamitin	0.012
stj	straightjacket	0.012
Bx42	CG8264 gene product from transcript CG8264-RA	0.012
CG4165	CG4165 gene product from transcript CG4165-RD	0.012
Rh3	Rhodopsin 3	0.012
CG31388	CG31388 gene product from transcript CG31388-RA	0.012
CG9018	CG9018 gene product from transcript CG9018-RA	0.012
fzy	fizzy	0.012
CG5276	CG5276 gene product from transcript CG5276-RA	0.012
onecut	CG1922 gene product from transcript CG1922-RA	0.012
phtf	CG3268 gene product from transcript CG3268-RA	0.012
Ilp7	Insulin-like peptide 7	0.012
trus	toys are us	0.012
Pde9	Phosphodiesterase 9	0.012
CG1603	CG1603 gene product from transcript CG1603-RA	0.012
CG8314	CG8314 gene product from transcript CG8314-RA	0.012
CG10263	CG10263 gene product from transcript CG10263-RC	0.012
Alk	CG8250 gene product from transcript CG8250-RA	0.012
tai	taiman	0.012
CG32590	CG32590 gene product from transcript CG32590-RA	0.012
g	garnet	0.012
UbcD2	Ubiquitin conjugating enzyme 2	0.012
rept	reptin	0.012
c12.1	CG12135 gene product from transcript CG12135-RA	0.012
Nipped-B	CG17704 gene product from transcript CG17704-RI	0.012
slou	slouch	0.012
NFAT	NFAT homolog	0.012
mask	multiple ankyrin repeats single KH domain	0.012
opa	odd paired	0.012
form3	formin 3	0.012
CG12042	CG12042 gene product from transcript CG12042-RA	0.012
Gga	CG3002 gene product from transcript CG3002-RB	0.012
alphaTub67C	alpha-Tubulin at 67C	0.012
Hr78	Hormone-receptor-like in 78	0.012
YT521-B	CG12076 gene product from transcript CG12076-RB	0.011
Pabp2	CG2163 gene product from transcript CG2163-RA	0.011
CG8965	CG8965 gene product from transcript CG8965-RA	0.011
CG4286	CG4286 gene product from transcript CG4286-RA	0.011
CG2014	CG2014 gene product from transcript CG2014-RA	0.011
Rh6	Rhodopsin 6	0.011
Ilp2	Insulin-like peptide 2	0.011
dally	division abnormally delayed	0.011
CG17359	CG17359 gene product from transcript CG17359-RA	0.011
CG33143	CG33143 gene product from transcript CG33143-RC	0.011
CG13488	CG13488 gene product from transcript CG13488-RA	0.011
unc-119	CG1659 gene product from transcript CG1659-RA	0.011
CG12029	CG12029 gene product from transcript CG12029-RB	0.011
fog	folded gastrulation	0.011
CG10435	CG10435 gene product from transcript CG10435-RA	0.011
frc	fringe connection	0.011
Fsn	CG4643 gene product from transcript CG4643-RA	0.011
CG11534	CG11534 gene product from transcript CG11534-RA	0.011
bdg	bedraggled	0.011
ninaC	neither inactivation nor afterpotential C	0.011
CG5380	CG5380 gene product from transcript CG5380-RA	0.011
Spt3	CG3169 gene product from transcript CG3169-RA	0.011
Lam	Lamin	0.011
CG6511	CG6511 gene product from transcript CG6511-RA	0.011
CG12721	CG12721 gene product from transcript CG12721-RA	0.011
CG11560	CG11560 gene product from transcript CG11560-RA	0.011
m-cup	mann-cup	0.011
MBD-like	CG8208 gene product from transcript CG8208-RA	0.011
CG4699	CG4699 gene product from transcript CG4699-RJ	0.011
TfIIFalpha	Transcription factor IIFalpha	0.011
PRL-1	CG4993 gene product from transcript CG4993-RB	0.011
sax	saxophone	0.011
mei-41	meiotic 41	0.011
CG16908	CG16908 gene product from transcript CG16908-RA	0.011
CG14710	CG14710 gene product from transcript CG14710-RB	0.011
crp	cropped	0.011
CycA	Cyclin A	0.011
CG6621	CG6621 gene product from transcript CG6621-RB	0.011
vlc	vulcan	0.011
CG1750	CG1750 gene product from transcript CG1750-RA	0.011
garz	gartenzwerg	0.011
bin	biniou	0.011
CG17855	CG17855 gene product from transcript CG17855-RA	0.011
CG31244	CG31244 gene product from transcript CG31244-RA	0.011
CG3078	CG3078 gene product from transcript CG3078-RA	0.011
sNPF	short neuropeptide F precursor	0.011
kek4	kekkon4	0.011
rg	rugose	0.011
CG13005	CG13005 gene product from transcript CG13005-RA	0.010
CG5491	CG5491 gene product from transcript CG5491-RA	0.010
CG34039	CG34039 gene product from transcript CG34039-RC	0.010
H15	CG6604 gene product from transcript CG6604-RA	0.010
CG6607	CG6607 gene product from transcript CG6607-RA	0.010
CG13041	CG13041 gene product from transcript CG13041-RA	0.010
Sox100B	CG15552 gene product from transcript CG15552-RA	0.010
Cbl	CG7037 gene product from transcript CG7037-RB	0.010
eIF4AIII	CG7483 gene product from transcript CG7483-RA	0.010
ci	cubitus interruptus	0.010
crb	crumbs	0.010
ds	dachsous	0.010
Actbeta	Activin-beta	0.010
CG3407	CG3407 gene product from transcript CG3407-RA	0.010
CG2469	CG2469 gene product from transcript CG2469-RB	0.010
Uch-L3	Ubiquitin C-terminal hydrolase	0.010
eIF-4a	Eukaryotic initiation factor 4a	0.010
rost	rolling stone	0.010
CG12071	CG12071 gene product from transcript CG12071-RB	0.010
CG9063	CG9063 gene product from transcript CG9063-RA	0.010
Clic	Chloride intracellular channel	0.010
Hs6st	Heparan sulfate 6-O-sulfotransferase	0.010
hrg	hiiragi	0.010
Syn	Synapsin	0.010
sNPF-R	short neuropeptide F receptor	0.010
Rtf1	CG10955 gene product from transcript CG10955-RA	0.010
l(2)s5379	lethal (2) s5379	0.010
Baldspot	CG3971 gene product from transcript CG3971-RA	0.010
CG8677	CG8677 gene product from transcript CG8677-RA	0.010
CG8783	CG8783 gene product from transcript CG8783-RB	0.010
Pp4-19C	Protein phosphatase 19C	0.010
Bet3	CG3911 gene product from transcript CG3911-RA	0.010
CG14708	CG14708 gene product from transcript CG14708-RA	0.010
Tpr2	Tetratricopeptide repeat protein 2	0.010
mbo	members only	0.010
Cnx99A	Calnexin 99A	0.010
Smg5	CG8954 gene product from transcript CG8954-RA	0.010
Sln	Silnoon	0.010
Cyp6t3	CG8457 gene product from transcript CG8457-RA	0.010
l(3)S147910	lethal (3) S147910	0.010
CG8319	CG8319 gene product from transcript CG8319-RA	0.010