IMP
Process View
signal transduction downstream of smoothened
The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "signal transduction downstream of smoothened"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| ci | cubitus interruptus | 0.966 | ||
| fu | fused | 0.888 | ||
| tkv | thickveins | 0.461 | ||
| slmb | supernumerary limbs | 0.303 | ||
| cos | costa | 0.242 | ||
| ovo | CG6824 gene product from transcript CG6824-RE | 0.184 | ||
| brk | brinker | 0.110 | ||
| Bre1 | CG10542 gene product from transcript CG10542-RA | 0.098 | ||
| ptc | patched | 0.098 | ||
| dsh | dishevelled | 0.089 | ||
| R | Roughened | 0.083 | ||
| por | porcupine | 0.083 | ||
| ac | achaete | 0.040 | ||
| Su(H) | Suppressor of Hairless | 0.038 | ||
| hh | hedgehog | 0.037 | ||
| cg | combgap | 0.036 | ||
| Wnt4 | Wnt oncogene analog 4 | 0.036 | ||
| pygo | pygopus | 0.034 | ||
| fz | frizzled | 0.032 | ||
| gro | groucho | 0.030 | ||
| sll | slalom | 0.027 | ||
| csw | corkscrew | 0.024 | ||
| lilli | lilliputian | 0.022 | ||
| ttv | tout-velu | 0.020 | ||
| H | Hairless | 0.019 | ||
| en | engrailed | 0.018 | ||
| Cul-5 | Cullin-5 | 0.018 | ||
| pho | pleiohomeotic | 0.018 | ||
| nct | nicastrin | 0.016 | ||
| disp | dispatched | 0.014 | ||
| net | CG11450 gene product from transcript CG11450-RB | 0.013 | ||
| rok | Rho-kinase | 0.012 | ||
| JhI-1 | Juvenile hormone-inducible protein 1 | 0.012 | ||
| ash2 | absent, small, or homeotic discs 2 | 0.011 | ||
| kn | knot | 0.011 | ||
| tan | tantalus | 0.011 | ||
| Gef26 | CG9491 gene product from transcript CG9491-RB | 0.011 | ||
| Pka-R2 | cAMP-dependent protein kinase R2 | 0.011 | ||
| svr | silver | 0.011 | ||
| cutlet | CG33122 gene product from transcript CG33122-RA | 0.011 | ||
| ph-d | polyhomeotic distal | 0.010 | ||
| Top1 | Topoisomerase 1 | 0.010 |