IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 genes annotated in fly

heart disease

DOID:114

A cardiovascular system disease that involves the heart.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "heart disease" (in gray)

Name	Description	Probability	Func Analog Organism
wupA	wings up A	0.760
Mhc	Myosin heavy chain	0.690
pnr	pannier	0.656	Human
Actn	alpha actinin	0.527
N	Notch	0.451	Human
hth	homothorax	0.320
Tm2	Tropomyosin 2	0.315	Human
up	upheld	0.304	Human
Ras85D	Ras oncogene at 85D	0.288
sls	sallimus	0.275
Prm	Paramyosin	0.194
Dl	Delta	0.154
Mlc1	Myosin alkali light chain 1	0.149
tup	tailup	0.141
Mlc2	Myosin light chain 2	0.123
scw	screw	0.122
stumps	CG31317 gene product from transcript CG31317-RC	0.121
arm	armadillo	0.113	Human
Act88F	Actin 88F	0.111
Sh3beta	CG8582 gene product from transcript CG8582-RD	0.111
Rab11	Rab-protein 11	0.095
htl	heartless	0.095
Egfr	Epidermal growth factor receptor	0.086
phl	pole hole	0.083	Human
Mlp84B	Muscle LIM protein at 84B	0.079
Zasp66	Z band alternatively spliced PDZ-motif protein 66	0.067
tld	tolloid	0.067	Human
Hsp23	Heat shock protein 23	0.067
nkd	naked cuticle	0.060
slp1	sloppy paired 1	0.058
Act57B	Actin 57B	0.058
srp	serpent	0.058
Mf	Myofilin	0.057
gbb	glass bottom boat	0.057
Hsp68	Heat shock protein 68	0.051
Trxr-1	Thioredoxin reductase-1	0.051
Ser	Serrate	0.050	Human
crb	crumbs	0.048
Zasp52	Z band alternatively spliced PDZ-motif protein 52	0.044	Human
sqh	spaghetti squash	0.042
nub	nubbin	0.042
fln	flightin	0.041
CG5177	CG5177 gene product from transcript CG5177-RA	0.041
if	inflated	0.039
aop	anterior open	0.037
wg	wingless	0.037
bowl	brother of odd with entrails limited	0.036
eya	eyes absent	0.036	Human
Mp20	Muscle protein 20	0.035
Moe	Moesin	0.035
Cg25C	Collagen type IV	0.033
lab	labial	0.033
ac	achaete	0.033
sax	saxophone	0.032
spi	spitz	0.032
wb	wing blister	0.032
dve	defective proventriculus	0.030
fng	fringe	0.030
CG9297	CG9297 gene product from transcript CG9297-RB	0.030
grn	grain	0.030
ft	fat	0.030
CG9139	CG9139 gene product from transcript CG9139-RA	0.029
shn	schnurri	0.027
Pten	CG5671 gene product from transcript CG5671-RB	0.027
fj	four-jointed	0.027
en	engrailed	0.027
cv-2	crossveinless 2	0.026
Gpo-1	Glycerophosphate oxidase-1	0.025
LanA	Laminin A	0.024	Human
lea	leak	0.024
ci	cubitus interruptus	0.024
tkv	thickveins	0.024
Pcaf	CG4107 gene product from transcript CG4107-RA	0.023
dpp	decapentaplegic	0.022
Tsp	Thrombospondin	0.022
spdo	sanpodo	0.022
stv	starvin	0.022
ush	u-shaped	0.022	Human
osp	outspread	0.022
nej	nejire	0.022
bt	bent	0.022
Rpd3	CG7471 gene product from transcript CG7471-RA	0.021
Dsor1	Downstream of raf1	0.021
kon	kon-tiki	0.021
LanB2	Laminin B2	0.021
H	Hairless	0.021
bib	big brain	0.020
frc	fringe connection	0.020
EcR	Ecdysone receptor	0.020
rig	rigor mortis	0.019
GstS1	Glutathione S transferase S1	0.019
Rya-r44F	Ryanodine receptor 44F	0.019	Human
zfh1	Zn finger homeodomain 1	0.019
Axn	Axin	0.019
coro	CG9446 gene product from transcript CG9446-RC	0.019
kibra	kibra ortholog	0.018
cno	canoe	0.018
gl	glass	0.018
Df31	Decondensation factor 31	0.018
smo	smoothened	0.018
odd	odd skipped	0.018
Vmat	Vesicular monoamine transporter	0.018
Act87E	Actin 87E	0.018
ds	dachsous	0.018
melt	melted	0.017
Ddc	Dopa decarboxylase	0.017
Pax	Paxillin	0.017
tsr	twinstar	0.017
amos	absent MD neurons and olfactory sensilla	0.017
dsh	dishevelled	0.017
fas	faint sausage	0.017
sr	stripe	0.017
mbl	muscleblind	0.016
sgg	shaggy	0.016
CG9090	CG9090 gene product from transcript CG9090-RA	0.016
tsg	twisted gastrulation	0.016
baz	bazooka	0.016
MP1	Melanization Protease 1	0.016
Psn	Presenilin	0.016	Human
CG1902	CG1902 gene product from transcript CG1902-RA	0.016
Ras64B	Ras oncogene at 64B	0.016
tara	taranis	0.015
emc	extra macrochaetae	0.015
klu	klumpfuss	0.015
ctp	cut up	0.015
BEAF-32	Boundary element-associated factor of 32kD	0.015
kn	knot	0.015
hpo	hippo	0.015
insc	inscuteable	0.015
Sema-1a	CG18405 gene product from transcript CG18405-RD	0.015
Gpdh	Glycerol 3 phosphate dehydrogenase	0.015
Antp	Antennapedia	0.015
cora	coracle	0.015
Peb	Protein ejaculatory bulb	0.015
Notum	CG13076 gene product from transcript CG13076-RB	0.015
al	aristaless	0.015
CG8709	CG8709 gene product from transcript CG8709-RK	0.015
otk	off-track	0.015
CAP	CG18408 gene product from transcript CG18408-RI	0.014
glo	glorund	0.014
vkg	viking	0.014
pb	proboscipedia	0.014
CG31352	CG31352 gene product from transcript CG31352-RA	0.014
blow	blown fuse	0.014
sog	short gastrulation	0.014
arr	arrow	0.014
sv	shaven	0.014
HspB8	CG14207 gene product from transcript CG14207-RB	0.014
egg	eggless	0.014
dy	dusky	0.014
Argk	Arginine kinase	0.014
Tom	Twin of m4	0.014
abba	another B-box affiliate	0.014
Doc2	Dorsocross2	0.014
Lam	Lamin	0.013	Human
btd	buttonhead	0.013
put	punt	0.013
eve	even skipped	0.013
TpnC47D	Troponin C at 47D	0.013
tsh	teashirt	0.013
ttk	tramtrack	0.013
tmod	tropomodulin	0.013
e(y)3	enhancer of yellow 3	0.013
gsb	gooseberry	0.013
Tom34	Translocase of outer membrane 34	0.013
E(spl)	Enhancer of split	0.013
Dfd	Deformed	0.013
opa1-like	optic atrophy 1-like	0.012
Hmgcr	HMG Coenzyme A reductase	0.012
dap	dacapo	0.012
Act79B	Actin 79B	0.012
Aos1	CG12276 gene product from transcript CG12276-RA	0.012
l(2)05510	lethal (2) 05510	0.012
Neurochondrin	CG2330 gene product from transcript CG2330-RA	0.012
noc	no ocelli	0.012
LamC	Lamin C	0.012	Human
CG5023	CG5023 gene product from transcript CG5023-RA	0.012
grh	grainy head	0.012
ptc	patched	0.012
twi	twist	0.012
stj	straightjacket	0.012
Sin3A	CG8815 gene product from transcript CG8815-RC	0.012
Rho1	CG8416 gene product from transcript CG8416-RB	0.012
Taf1	TBP-associated factor 1	0.012
Su(H)	Suppressor of Hairless	0.012
brm	brahma	0.012
Dcr-2	Dicer-2	0.012
Hem	HEM-protein	0.012
Hsp26	Heat shock protein 26	0.012	Human
ara	araucan	0.011
Hop	Hsp70/Hsp90 organizing protein homolog	0.011
Src42A	Src oncogene at 42A	0.011
sqz	squeeze	0.011
scb	scab	0.011
TpnC73F	Troponin C at 73F	0.011
sna	snail	0.011
pigs	pickled eggs	0.011
sbr	small bristles	0.011
uex	unextended	0.011
Tor	Target of rapamycin	0.011
CG13887	CG13887 gene product from transcript CG13887-RC	0.011
ap	apterous	0.011
Myo31DF	Myosin 31DF	0.011
Awh	Arrowhead	0.011
rols	rolling pebbles	0.011
Chc	Clathrin heavy chain	0.011
Hsp27	Heat shock protein 27	0.011
Gp150	CG5820 gene product from transcript CG5820-RA	0.011
Mad	Mothers against dpp	0.011
inv	invected	0.011
by	blistery	0.010
cher	cheerio	0.010
ari-1	ariadne	0.010
Ubx	Ultrabithorax	0.010
Rac1	CG2248 gene product from transcript CG2248-RA	0.010
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.010
Pvr	PDGF- and VEGF-receptor related	0.010
Mef2	Myocyte enhancer factor 2	0.010
Pdi	Protein disulfide isomerase	0.010
bdg	bedraggled	0.010
CG9338	CG9338 gene product from transcript CG9338-RA	0.010
Kr-h1	Kruppel homolog 1	0.010
Chd64	CG14996 gene product from transcript CG14996-RB	0.010