IMP: Integrative Multi-species Prediction

Drosophila melanogaster

3 genes annotated in fly

negative regulation of erk1 and erk2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of erk1 and erk2 cascade"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of erk1 and erk2 cascade" (in gray)

Name	Description	Probability	Func Analog Organism
Dsor1	Downstream of raf1	0.243
prod	proliferation disrupter	0.163
Pp2B-14D	Protein phosphatase 2B at 14D	0.163
rl	rolled	0.115
Ras64B	Ras oncogene at 64B	0.114
dos	daughter of sevenless	0.111
PTP-ER	Protein tyrosine phosphatase-ERK/Enhancer of Ras1	0.104
ksr	kinase suppressor of ras	0.095
pigeon	CG10739 gene product from transcript CG10739-RB	0.091
X11L	CG5675 gene product from transcript CG5675-RB	0.086
Socs36E	Suppressor of cytokine signaling at 36E	0.079
Sry-delta	Serendipity delta	0.077
drk	downstream of receptor kinase	0.073
chp	chaoptic	0.070
dwg	deformed wings	0.068
cnk	connector enhancer of ksr	0.067	Mouse
gek	genghis khan	0.066
Sos	Son of sevenless	0.061
CG10267	CG10267 gene product from transcript CG10267-RB	0.059	Fly
CycJ	Cyclin J	0.058
Apc	APC-like	0.057
CG2662	CG2662 gene product from transcript CG2662-RA	0.056
CdsA	CDP diglyceride synthetase	0.056
C3G	CG42328 gene product from transcript CG42328-RC	0.053
CG6792	CG6792 gene product from transcript CG6792-RA	0.051
grp	grapes	0.050
mbt	mushroom bodies tiny	0.042
CG5794	CG5794 gene product from transcript CG5794-RB	0.040
Hs6st	Heparan sulfate 6-O-sulfotransferase	0.040
enok	enoki mushroom	0.039
MAN1	CG3167 gene product from transcript CG3167-RA	0.039
CG12299	CG12299 gene product from transcript CG12299-RA	0.039
Gap1	GTPase-activating protein 1	0.038
sbb	scribbler	0.037
CG7928	CG7928 gene product from transcript CG7928-RA	0.037
trem	trade embargo	0.036	Fly
CG5180	CG5180 gene product from transcript CG5180-RB	0.036
cdc2c	CG10498 gene product from transcript CG10498-RC	0.035
pnt	pointed	0.035
mol	moladietz	0.034
Ubqn	Ubiquilin	0.034
tan	tantalus	0.034
rdgC	retinal degeneration C	0.033
Mkp3	Mitogen-activated protein kinase phosphatase 3	0.032	Human
CG11560	CG11560 gene product from transcript CG11560-RA	0.032
R	Roughened	0.032
CG14667	CG14667 gene product from transcript CG14667-RA	0.031
Rgl	Ral guanine nucleotide exchange factor	0.031
ed	echinoid	0.031
trp	transient receptor potential	0.030
S6kII	RPS6-protein kinase-II	0.030	Mouse
CG15436	CG15436 gene product from transcript CG15436-RA	0.029
Dip3	Dorsal interacting protein 3	0.029
ast	asteroid	0.028
rdgB	retinal degeneration B	0.028
CG15601	CG15601 gene product from transcript CG15601-RA	0.028
CG4424	CG4424 gene product from transcript CG4424-RA	0.027	Fly
mip120	Myb-interacting protein 120	0.026
CG11403	CG11403 gene product from transcript CG11403-RA	0.026
YL-1	CG4621 gene product from transcript CG4621-RA	0.026
boss	bride of sevenless	0.026
sra	sarah	0.026
CG4853	CG4853 gene product from transcript CG4853-RA	0.026
Zyx102EF	CG32018 gene product from transcript CG32018-RA	0.026
Arr2	Arrestin 2	0.026	Rat
Arr1	Arrestin 1	0.026	Rat
CG6985	CG6985 gene product from transcript CG6985-RA	0.025
GluClalpha	CG7535 gene product from transcript CG7535-RG	0.025
CG4294	CG4294 gene product from transcript CG4294-RB	0.025
fs(2)ltoPP43	female sterile (2) ltoPP43	0.025
A2bp1	Ataxin-2 binding protein 1	0.025
CG31365	CG31365 gene product from transcript CG31365-RA	0.024
sinu	sinuous	0.024
cg	combgap	0.024
ninaB	neither inactivation nor afterpotential B	0.024
CG11866	CG11866 gene product from transcript CG11866-RA	0.023
ru	roughoid	0.023
Shc	SHC-adaptor protein	0.023
GckIII	Germinal centre kinase III	0.023
Rh6	Rhodopsin 6	0.023
fray	frayed	0.022
retn	retained	0.022
spn-B	spindle B	0.022
CG1792	CG1792 gene product from transcript CG1792-RA	0.022
CrebB-17A	Cyclic-AMP response element binding protein B at 17A	0.022
NFAT	NFAT homolog	0.022
CG2712	CG2712 gene product from transcript CG2712-RA	0.021
cutlet	CG33122 gene product from transcript CG33122-RA	0.021
Sara	Smad anchor for receptor activation	0.021
B-H1	BarH1	0.021
CG12713	CG12713 gene product from transcript CG12713-RA	0.020
spen	split ends	0.020
CG5199	CG5199 gene product from transcript CG5199-RA	0.020
CG7239	CG7239 gene product from transcript CG7239-RA	0.020
Sra-1	specifically Rac1-associated protein 1	0.020
Smr	Smrter	0.020
CG2129	CG2129 gene product from transcript CG2129-RA	0.019
Src42A	Src oncogene at 42A	0.019
CG13830	CG13830 gene product from transcript CG13830-RD	0.019
btl	breathless	0.019
CG17568	CG17568 gene product from transcript CG17568-RA	0.019
SF1	Splicing factor 1	0.019
tadr	torn and diminished rhabdomeres	0.019
betaInt-nu	beta[nu] integrin	0.019
Chi	Chip	0.019
klg	klingon	0.019
Taf6	TBP-associated factor 6	0.018
Taf7	TBP-associated factor 7	0.018
CG4813	CG4813 gene product from transcript CG4813-RA	0.018
DJ-1alpha	CG6646 gene product from transcript CG6646-RA	0.018
CG2865	CG2865 gene product from transcript CG2865-RA	0.018
Galpha49B	G protein alpha49B	0.018
Taspase1	Taspase 1	0.018
Xe7	CG2179 gene product from transcript CG2179-RA	0.018
CG15107	CG15107 gene product from transcript CG15107-RA	0.018
heph	hephaestus	0.018
CG11970	CG11970 gene product from transcript CG11970-RA	0.018
CG14546	CG14546 gene product from transcript CG14546-RA	0.017
CG17107	CG17107 gene product from transcript CG17107-RA	0.017
CG18616	CG18616 gene product from transcript CG18616-RA	0.017
CG3995	CG3995 gene product from transcript CG3995-RA	0.017
stumps	CG31317 gene product from transcript CG31317-RC	0.017
CG8298	CG8298 gene product from transcript CG8298-RA	0.017
CG2617	CG2617 gene product from transcript CG2617-RA	0.017
CG7879	CG7879 gene product from transcript CG7879-RB	0.017
inaD	inactivation no afterpotential D	0.017
sev	sevenless	0.016
Trf	TBP-related factor	0.016
CG8965	CG8965 gene product from transcript CG8965-RA	0.016
A16	CG9933 gene product from transcript CG9933-RA	0.016
CG17802	CG17802 gene product from transcript CG17802-RA	0.016
CG4854	CG4854 gene product from transcript CG4854-RA	0.016	Fly
CG14711	CG14711 gene product from transcript CG14711-RA	0.016	Fly
CG5491	CG5491 gene product from transcript CG5491-RA	0.016
CG1024	CG1024 gene product from transcript CG1024-RB	0.016
CG4730	CG4730 gene product from transcript CG4730-RA	0.016
cdc14	CG7134 gene product from transcript CG7134-RB	0.016
CoRest	CG42687 gene product from transcript CG42687-RC	0.016
CG16972	CG16972 gene product from transcript CG16972-RA	0.016
RanBPM	Ran-binding protein M	0.016
Rh3	Rhodopsin 3	0.016
sty	sprouty	0.016	Mouse
CG10366	CG10366 gene product from transcript CG10366-RA	0.016
pita	CG3941 gene product from transcript CG3941-RA	0.016
CG11093	CG11093 gene product from transcript CG11093-RB	0.015
cindr	CIN85 and CD2AP orthologue	0.015
dgo	diego	0.015
tinc	tincar	0.015
pex2	peroxin 2	0.015
hig	hikaru genki	0.015
jar	jaguar	0.015
lin-52	CG15929 gene product from transcript CG15929-RA	0.015
CG5098	CG5098 gene product from transcript CG5098-RA	0.015
CG6506	CG6506 gene product from transcript CG6506-RA	0.015
CG6015	CG6015 gene product from transcript CG6015-RA	0.015
kek1	kekkon-1	0.015
PP2A-B'	CG7913 gene product from transcript CG7913-RK	0.015
CG8273	CG8273 gene product from transcript CG8273-RA	0.015
hipk	homeodomain interacting protein kinase	0.015
Syt4	Synaptotagmin 4	0.015
ninaC	neither inactivation nor afterpotential C	0.015
Pis	Phosphatidylinositol synthase	0.015
luna	CG33473 gene product from transcript CG33473-RB	0.015
CG16812	CG16812 gene product from transcript CG16812-RA	0.015
nito	spenito	0.015
sofe	sister of feo	0.014
hppy	happyhour	0.014
CG12207	CG12207 gene product from transcript CG12207-RB	0.014
Bub1	Bub1 homologue	0.014
CG6353	CG6353 gene product from transcript CG6353-RA	0.014
Gem2	Gemin2	0.014
pex12	peroxin 12	0.014
CG6650	CG6650 gene product from transcript CG6650-RA	0.014
Myt1	CG32417 gene product from transcript CG32417-RA	0.014
TSG101	tumor suppressor protein 101	0.014
mip130	Myb-interacting protein 130	0.014
wech	CG42396 gene product from transcript CG42396-RC	0.014
scrt	scratch	0.013
CG7974	CG7974 gene product from transcript CG7974-RA	0.013
l(2)05714	lethal (2) 05714	0.013
mrt	martik	0.013
ash2	absent, small, or homeotic discs 2	0.013
lid	little imaginal discs	0.013
CG10949	CG10949 gene product from transcript CG10949-RA	0.013
CG8455	CG8455 gene product from transcript CG8455-RA	0.013
tsg	twisted gastrulation	0.013
CG11839	CG11839 gene product from transcript CG11839-RA	0.013
CG32572	CG32572 gene product from transcript CG32572-RA	0.013
wnd	wallenda	0.013
l(3)L1231	lethal (3) L1231	0.013
CG6923	CG6923 gene product from transcript CG6923-RA	0.013
CG9650	CG9650 gene product from transcript CG9650-RG	0.013
CG10631	CG10631 gene product from transcript CG10631-RA	0.013
CG10694	CG10694 gene product from transcript CG10694-RA	0.013
Fit2	Fermitin 2	0.013
CG13344	CG13344 gene product from transcript CG13344-RA	0.013
CG17806	CG17806 gene product from transcript CG17806-RA	0.013
CG6439	CG6439 gene product from transcript CG6439-RA	0.013
cav	caravaggio	0.013
salm	spalt major	0.013
pall	pallbearer	0.013
MBD-like	CG8208 gene product from transcript CG8208-RA	0.013
APC4	Anaphase Promoting Complex 4	0.013
CG13636	CG13636 gene product from transcript CG13636-RB	0.013
Baldspot	CG3971 gene product from transcript CG3971-RA	0.012
Mgat1	UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I	0.012
coil	coilin	0.012
syd	sunday driver	0.012
RhoGAP93B	CG3421 gene product from transcript CG3421-RA	0.012
CG9996	CG9996 gene product from transcript CG9996-RB	0.012
DopEcR	CG18314 gene product from transcript CG18314-RB	0.012
CG13472	CG13472 gene product from transcript CG13472-RA	0.012
CG17446	CG17446 gene product from transcript CG17446-RB	0.012
fend	forked end	0.012
CG7745	CG7745 gene product from transcript CG7745-RA	0.012
CG13367	CG13367 gene product from transcript CG13367-RA	0.012
CG1602	CG1602 gene product from transcript CG1602-RA	0.012
MED1	Mediator complex subunit 1	0.012
Acp62F	Accessory gland peptide 62F	0.012
isopeptidase-T-3	CG11025 gene product from transcript CG11025-RA	0.012
Dh	Diuretic hormone	0.012
CG7357	CG7357 gene product from transcript CG7357-RA	0.012
CG1553	CG1553 gene product from transcript CG1553-RA	0.012
Atx-1	Ataxin 1	0.012
l(3)73Ah	lethal (3) 73Ah	0.012
CG1663	CG1663 gene product from transcript CG1663-RA	0.012
CG12162	CG12162 gene product from transcript CG12162-RA	0.012
tna	tonalli	0.012
CG14509	CG14509 gene product from transcript CG14509-RB	0.012
Lhr	Lethal hybrid rescue	0.012
CG15577	CG15577 gene product from transcript CG15577-RA	0.012
4EHP	CG33100 gene product from transcript CG33100-RA	0.012
SP2637	CG5473 gene product from transcript CG5473-RC	0.012
Nrx-1	Neurexin 1	0.012
Taf1	TBP-associated factor 1	0.012
CG9941	CG9941 gene product from transcript CG9941-RA	0.012
Nup58	Nucleoporin 58	0.012
Tehao	CG7121 gene product from transcript CG7121-RA	0.012
mei-S332	meiotic from via Salaria 332	0.012
Ack	CG14992 gene product from transcript CG14992-RA	0.012
NaCP60E	Na channel protein 60E	0.012
Gld	Glucose dehydrogenase	0.012
synj	synaptojanin	0.012
EDTP	Egg-derived tyrosine phosphatase	0.012
CG12253	CG12253 gene product from transcript CG12253-RA	0.012
5-HT1A	Serotonin receptor 1A	0.012
kat-60L1	katanin p60-like 1	0.012
CG14182	CG14182 gene product from transcript CG14182-RA	0.011
CG9090	CG9090 gene product from transcript CG9090-RA	0.011
Cerk	Ceramide kinase	0.011
CycH	Cyclin H	0.011
png	pan gu	0.011
CG30417	CG30417 gene product from transcript CG30417-RA	0.011
CG8079	CG8079 gene product from transcript CG8079-RA	0.011
CG31140	CG31140 gene product from transcript CG31140-RF	0.011
CG16778	CG16778 gene product from transcript CG16778-RA	0.011
onecut	CG1922 gene product from transcript CG1922-RA	0.011
ninaA	neither inactivation nor afterpotential A	0.011
rg	rugose	0.011
raps	rapsynoid	0.011
sqz	squeeze	0.011
CG10133	CG10133 gene product from transcript CG10133-RA	0.011
CG15345	CG15345 gene product from transcript CG15345-RA	0.011
n-syb	n-synaptobrevin	0.011
CG3645	CG3645 gene product from transcript CG3645-RA	0.011
Buffy	CG8238 gene product from transcript CG8238-RA	0.011
rod	rough deal	0.011
CG4674	CG4674 gene product from transcript CG4674-RA	0.011
dpr9	CG33485 gene product from transcript CG33485-RA	0.011
CG14414	CG14414 gene product from transcript CG14414-RD	0.011
MBD-R2	CG10042 gene product from transcript CG10042-RB	0.011
csw	corkscrew	0.011
Slu7	CG1420 gene product from transcript CG1420-RA	0.011
CG4291	CG4291 gene product from transcript CG4291-RA	0.011
DnaJ-1	DnaJ-like-1	0.011
flfl	falafel	0.011
CG7685	CG7685 gene product from transcript CG7685-RA	0.011
CG31714	CG31714 gene product from transcript CG31714-RB	0.011
inaE	inactivation no afterpotential E	0.011
Rh4	Rhodopsin 4	0.011
l(2)k16918	lethal (2) k16918	0.011
tara	taranis	0.011
CG13197	CG13197 gene product from transcript CG13197-RA	0.011
Top3alpha	Topoisomerase 3alpha	0.011
cln3	CG5582 gene product from transcript CG5582-RA	0.011
Taf8	TBP-associated factor 8	0.011
lat	latheo	0.011
Sas	Sialic acid phosphate synthase	0.011
Rcd5	Reduction in Cnn dots 5	0.011
Klp68D	Kinesin-like protein at 68D	0.011
Grip75	CG6176 gene product from transcript CG6176-RA	0.011
Eip71CD	Ecdysone-induced protein 28/29kD	0.011
Sox21b	CG32139 gene product from transcript CG32139-RA	0.011
CG9293	CG9293 gene product from transcript CG9293-RB	0.011
CG9413	CG9413 gene product from transcript CG9413-RA	0.011
CG14814	CG14814 gene product from transcript CG14814-RA	0.011
CG30103	CG30103 gene product from transcript CG30103-RA	0.010
dimm	dimmed	0.010
poe	purity of essence	0.010
CG14989	CG14989 gene product from transcript CG14989-RB	0.010
gish	gilgamesh	0.010
be	ben	0.010
CG17186	CG17186 gene product from transcript CG17186-RA	0.010
CG11368	CG11368 gene product from transcript CG11368-RA	0.010
CG32154	CG32154 gene product from transcript CG32154-RA	0.010
CG1314	CG1314 gene product from transcript CG1314-RA	0.010
CLIP-190	Cytoplasmic linker protein 190	0.010
CG8197	CG8197 gene product from transcript CG8197-RA	0.010
I-2	Inhibitor-2	0.010
CG18271	CG18271 gene product from transcript CG18271-RB	0.010
CG11164	CG11164 gene product from transcript CG11164-RA	0.010
Upf3	CG11184 gene product from transcript CG11184-RB	0.010
Dhc36C	Dynein heavy chain at 36C	0.010
Act5C	Actin 5C	0.010
pie	pineapple eye	0.010
CG6424	CG6424 gene product from transcript CG6424-RA	0.010
CG13005	CG13005 gene product from transcript CG13005-RA	0.010
sdk	sidekick	0.010
CG34139	CG34139 gene product from transcript CG34139-RD	0.010
CG11982	CG11982 gene product from transcript CG11982-RA	0.010
CG10809	CG10809 gene product from transcript CG10809-RA	0.010
CG16888	CG16888 gene product from transcript CG16888-RA	0.010
CG14059	CG14059 gene product from transcript CG14059-RB	0.010
CG2052	CG2052 gene product from transcript CG2052-RB	0.010
CG2906	CG2906 gene product from transcript CG2906-RD	0.010
CG5693	CG5693 gene product from transcript CG5693-RA	0.010
CG11379	CG11379 gene product from transcript CG11379-RA	0.010
net	CG11450 gene product from transcript CG11450-RB	0.010
CG32650	CG32650 gene product from transcript CG32650-RA	0.010
jhamt	juvenile hormone acid methyltransferase	0.010
Vps45	Vacuolar protein sorting 45	0.010
CG42554	CG42554 gene product from transcript CG42554-RA	0.010
CG13526	CG13526 gene product from transcript CG13526-RA	0.010
Osi10	Osiris 10	0.010
CG32809	CG32809 gene product from transcript CG32809-RD	0.010
CG7715	CG7715 gene product from transcript CG7715-RA	0.010
CG14101	CG14101 gene product from transcript CG14101-RA	0.010
wtrw	CG31284 gene product from transcript CG31284-RB	0.010