IMP: Integrative Multi-species Prediction

Drosophila melanogaster

27 genes annotated in fly

rna interference

The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rna interference"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "rna interference" (in gray)

Name	Description	Probability	Func Analog Organism
lwr	lesswright	0.510
tra	transformer	0.442
Rpd3	CG7471 gene product from transcript CG7471-RA	0.410	Worm
piwi	CG6122 gene product from transcript CG6122-RA	0.297	Worm Fly
aub	aubergine	0.282
pr-set7	CG3307 gene product from transcript CG3307-RC	0.260
SmD3	Small ribonucleoprotein particle protein SmD3	0.213
Caf1	Chromatin assembly factor 1 subunit	0.199	Worm
rept	reptin	0.189	Worm
feo	fascetto	0.175
Uba1	Ubiquitin activating enzyme 1	0.161
Pp1-87B	Protein phosphatase 1 at 87B	0.160
Ef1gamma	CG11901 gene product from transcript CG11901-RC	0.155
Hlc	Helicase	0.137
Atx2	Ataxin-2	0.133
AGO1	Argonaute-1	0.113
B52	CG10851 gene product from transcript CG10851-RB	0.107
stau	staufen	0.104	Worm
rin	rasputin	0.104
Pc	Polycomb	0.102
eIF4E-3	CG8023 gene product from transcript CG8023-RA	0.095
vas	vasa	0.095	Worm
heph	hephaestus	0.087
ird5	immune response deficient 5	0.085
CG13900	CG13900 gene product from transcript CG13900-RA	0.083
tsr	twinstar	0.077
Mov34	CG3416 gene product from transcript CG3416-RA	0.077
Iswi	Imitation SWI	0.076	Worm
eIF3-S10	CG9805 gene product from transcript CG9805-RA	0.075
Dcp-1	Death caspase-1	0.073
hts	hu li tai shao	0.072
CG2469	CG2469 gene product from transcript CG2469-RB	0.072
orb	oo18 RNA-binding protein	0.070
Spt5	CG7626 gene product from transcript CG7626-RA	0.069
Su(z)12	CG8013 gene product from transcript CG8013-RA	0.069
yps	ypsilon schachtel	0.068
Mi-2	CG8103 gene product from transcript CG8103-RA	0.067
CG32685	CG32685 gene product from transcript CG32685-RC	0.067
mip130	Myb-interacting protein 130	0.066
CTCF	CG8591 gene product from transcript CG8591-RA	0.064
CG16941	CG16941 gene product from transcript CG16941-RA	0.063	Worm
scny	scrawny	0.061
pelo	pelota	0.061
mael	maelstrom	0.058
E(z)	Enhancer of zeste	0.056
CG10107	CG10107 gene product from transcript CG10107-RA	0.056
fs(1)Yb	female sterile (1) Yb	0.056
growl	CG14648 gene product from transcript CG14648-RA	0.054
hyd	hyperplastic discs	0.054
stil	stand still	0.052
CG5642	CG5642 gene product from transcript CG5642-RA	0.052
eff	effete	0.052
crp	cropped	0.049
Hdac3	Histone deacetylase 3	0.049
osk	oskar	0.049
l(2)35Bg	lethal (2) 35Bg	0.047
Ef2b	Elongation factor 2b	0.046
HP4	Heterochromatin protein 4	0.045
klar	klarsicht	0.045
l(1)10Bb	lethal (1) 10Bb	0.045
rdx	roadkill	0.044
His3.3A	Histone H3.3A	0.044
CG18811	CG18811 gene product from transcript CG18811-RA	0.044
RanGap	Ran GTPase activating protein	0.043
Cap-G	CG34438 gene product from transcript CG34438-RF	0.042
hipk	homeodomain interacting protein kinase	0.042
CG5787	CG5787 gene product from transcript CG5787-RA	0.042
Prp31	CG6876 gene product from transcript CG6876-RA	0.042
Cbp80	cap binding protein 80	0.041
eIF3-S8	CG4954 gene product from transcript CG4954-RA	0.041
CG3605	CG3605 gene product from transcript CG3605-RA	0.040
18w	18 wheeler	0.040
Dsor1	Downstream of raf1	0.040
pont	pontin	0.039
cnk	connector enhancer of ksr	0.039
CG4849	CG4849 gene product from transcript CG4849-RA	0.039
CG11417	CG11417 gene product from transcript CG11417-RA	0.038
Cam	Calmodulin	0.038
Nopp140	CG7421 gene product from transcript CG7421-RB	0.038
Hsp83	Heat shock protein 83	0.038
ph-p	polyhomeotic proximal	0.037
CG8801	CG8801 gene product from transcript CG8801-RA	0.036
Tango6	Transport and Golgi organization 6	0.036
CG8108	CG8108 gene product from transcript CG8108-RA	0.036
tsu	tsunagi	0.036
JIL-1	CG6297 gene product from transcript CG6297-RA	0.035
mbo	members only	0.035
Rat1	CG10354 gene product from transcript CG10354-RA	0.034
CkIalpha	Casein kinase Ialpha	0.034
csul	capsuleen	0.034
tud	tudor	0.034
CG3363	CG3363 gene product from transcript CG3363-RB	0.034
egg	eggless	0.033
Sox14	Sox box protein 14	0.033
Su(var)2-HP2	CG12864 gene product from transcript CG12864-RB	0.032
MED20	Mediator complex subunit 20	0.032
eIF3-S9	CG4878 gene product from transcript CG4878-RA	0.032
Uch-L3	Ubiquitin C-terminal hydrolase	0.032
chinmo	Chronologically inappropriate morphogenesis	0.031
nocte	no circadian temperature entrainment	0.031
bam	bag of marbles	0.031
elav	embryonic lethal abnormal vision	0.030
otu	ovarian tumor	0.030
Cypl	Cyclophilin-like	0.029
tipE	temperature-induced paralytic E	0.029
Fip1	CG1078 gene product from transcript CG1078-RA	0.029
CG2199	CG2199 gene product from transcript CG2199-RB	0.029
Nap1	Nucleosome assembly protein 1	0.029	Worm
Sdc	Syndecan	0.029
l(2)35Df	lethal (2) 35Df	0.029
CG10990	CG10990 gene product from transcript CG10990-RB	0.029
kis	kismet	0.029
eIF-3p40	Eukaryotic initiation factor 3 p40 subunit	0.029
RpII15	RNA polymerase II 15kD subunit	0.028
CG9715	CG9715 gene product from transcript CG9715-RA	0.028
fs(1)N	female sterile (1) Nasrat	0.028
Caki	Calcium/calmodulin-dependent protein kinase	0.028
CG9305	CG9305 gene product from transcript CG9305-RA	0.028
Dlic	Dynein light intermediate chain	0.028
CG1677	CG1677 gene product from transcript CG1677-RB	0.028
Pabp2	CG2163 gene product from transcript CG2163-RA	0.028
drosha	CG8730 gene product from transcript CG8730-RA	0.027
Adf1	Adh transcription factor 1	0.027
MED11	Mediator complex subunit 11	0.027
Pros29	Proteasome 29kD subunit	0.026
CrebA	Cyclic-AMP response element binding protein A	0.025
Hrb27C	Heterogeneous nuclear ribonucleoprotein at 27C	0.025
CG11123	CG11123 gene product from transcript CG11123-RA	0.025
Droj2	DnaJ-like-2	0.025
Rpn6	Proteasome p44.5 subunit	0.025
MED15	Mediator complex subunit 15	0.024
exu	exuperantia	0.024
CG4973	CG4973 gene product from transcript CG4973-RA	0.024
Top1	Topoisomerase 1	0.024
spn-A	spindle A	0.024
CG9776	CG9776 gene product from transcript CG9776-RA	0.024
Moe	Moesin	0.024
Rm62	CG10279 gene product from transcript CG10279-RD	0.023
l(3)mbt	lethal (3) malignant brain tumor	0.023
Nnp-1	CG12396 gene product from transcript CG12396-RA	0.023
Nup154	Nucleoporin 154	0.023
CG7839	CG7839 gene product from transcript CG7839-RA	0.023
Rpn11	CG18174 gene product from transcript CG18174-RA	0.023
Lasp	CG3849 gene product from transcript CG3849-RB	0.023
MED30	Mediator complex subunit 30	0.023
Ge-1	CG6181 gene product from transcript CG6181-RA	0.023
eIF5B	CG10840 gene product from transcript CG10840-RB	0.023
Nedd8	CG10679 gene product from transcript CG10679-RA	0.023
Ars2	CG7843 gene product from transcript CG7843-RA	0.022
spn-E	spindle E	0.022
MED28	Mediator complex subunit 28	0.022
Mat89Ba	Maternal transcript 89Ba	0.022
CG5931	CG5931 gene product from transcript CG5931-RA	0.022
pon	partner of numb	0.022
CycB	Cyclin B	0.022
ppk25	pickpocket 25	0.022
CG12499	CG12499 gene product from transcript CG12499-RA	0.022
CG8443	CG8443 gene product from transcript CG8443-RA	0.022
Smg6	CG6369 gene product from transcript CG6369-RA	0.022
zpg	zero population growth	0.021
mip120	Myb-interacting protein 120	0.021
fne	found in neurons	0.021
CG6197	CG6197 gene product from transcript CG6197-RA	0.021
CG9821	CG9821 gene product from transcript CG9821-RB	0.021
CG1815	CG1815 gene product from transcript CG1815-RA	0.021
Tango7	Transport and Golgi organization 7	0.020
Aac11	CG6582 gene product from transcript CG6582-RA	0.020
CG7051	CG7051 gene product from transcript CG7051-RA	0.020
rhi	rhino	0.020
Dis3	CG6413 gene product from transcript CG6413-RA	0.020
pum	pumilio	0.020
Fmr1	CG6203 gene product from transcript CG6203-RC	0.020
Xpac	Xeroderma pigmentosum group A-like	0.020
Sam-S	S-adenosylmethionine Synthetase	0.020
Ten-m	Tenascin major	0.020
Cul-4	Cullin-4	0.020
alien	CG9556 gene product from transcript CG9556-RB	0.020
Jarid2	CG3654 gene product from transcript CG3654-RD	0.019
del	deadlock	0.019
CG12343	CG12343 gene product from transcript CG12343-RA	0.019
CG2807	CG2807 gene product from transcript CG2807-RA	0.019
ntc	nutcracker	0.019
CG13096	CG13096 gene product from transcript CG13096-RA	0.019
CG13597	CG13597 gene product from transcript CG13597-RA	0.019
mago	mago nashi	0.019
Su(var)2-10	Suppressor of variegation 2-10	0.019
Prp8	pre-mRNA processing factor 8	0.019
Dcp1	Decapping protein 1	0.018
Bap55	Brahma associated protein 55kD	0.018
Rme-8	Receptor mediated endocytosis 8	0.018
CG9346	CG9346 gene product from transcript CG9346-RA	0.018
CG5933	CG5933 gene product from transcript CG5933-RA	0.018
p47	CG11139 gene product from transcript CG11139-RA	0.018
CG13350	CG13350 gene product from transcript CG13350-RA	0.018
CG10418	CG10418 gene product from transcript CG10418-RA	0.018
trx	trithorax	0.018
SuUR	Suppressor of Under-Replication	0.018
Vps16A	Vacuolar protein sorting 16A	0.018
CG10777	CG10777 gene product from transcript CG10777-RB	0.018	Fly
Xe7	CG2179 gene product from transcript CG2179-RA	0.018
Psa	Puromycin sensitive aminopeptidase	0.018
Bap60	Brahma associated protein 60kD	0.018
rno	rhinoceros	0.017
pcm	pacman	0.017
Pp1alpha-96A	Protein phosphatase 1alpha at 96A	0.017
Gnf1	Germ line transcription factor 1	0.017
cup	CG11181 gene product from transcript CG11181-RB	0.017
pgant5	polypeptide GalNAc transferase 5	0.017
pic	piccolo	0.017
CG13779	CG13779 gene product from transcript CG13779-RA	0.017
cyc	cycle	0.017
Ubp64E	Ubiquitin-specific protease 64E	0.017
CG4364	CG4364 gene product from transcript CG4364-RA	0.017
CG5222	CG5222 gene product from transcript CG5222-RA	0.017
CG6693	CG6693 gene product from transcript CG6693-RA	0.017
CG11859	CG11859 gene product from transcript CG11859-RA	0.016
Caf1-180	CG12109 gene product from transcript CG12109-RB	0.016
Bin1	Bicoid interacting protein 1	0.016
Hsp60	Heat shock protein 60	0.016
RpL7A	Ribosomal protein L7A	0.016
TppII	tripeptidyl-peptidase II	0.016
l(1)G0156	lethal (1) G0156	0.016
Baldspot	CG3971 gene product from transcript CG3971-RA	0.016
CG32486	CG32486 gene product from transcript CG32486-RD	0.016
Gap1	GTPase-activating protein 1	0.016
AGO3	Argonaute 3	0.016
dre4	CG1828 gene product from transcript CG1828-RB	0.016
eIF-4a	Eukaryotic initiation factor 4a	0.016
tral	trailer hitch	0.015
CG10267	CG10267 gene product from transcript CG10267-RB	0.015
spn-B	spindle B	0.015
mts	microtubule star	0.015
CG33228	CG33228 gene product from transcript CG33228-RB	0.015
krimp	krimper	0.015
CycA	Cyclin A	0.015
BicC	Bicaudal C	0.015
Gug	Grunge	0.015
Pep	Protein on ecdysone puffs	0.015
Lam	Lamin	0.015
Tob	CG9214 gene product from transcript CG9214-RA	0.015
CG9063	CG9063 gene product from transcript CG9063-RA	0.015
stwl	stonewall	0.015
arr	arrow	0.015
CG6905	CG6905 gene product from transcript CG6905-RA	0.015
Psi	P-element somatic inhibitor	0.015	Worm
ssh	slingshot	0.015
l(2)37Cb	lethal (2) 37Cb	0.014
Hira	CG12153 gene product from transcript CG12153-RA	0.014
cic	capicua	0.014
spen	split ends	0.014
stet	stem cell tumor	0.014
CG7414	CG7414 gene product from transcript CG7414-RC	0.014
CkIIalpha	Casein kinase II alpha subunit	0.014
fs(1)M3	female sterile (1) M3	0.014
Smox	Smad on X	0.014
Karybeta3	Karyopherin beta 3	0.014
Gr39a	Gustatory receptor 39a	0.014
dbr	debra	0.014
emb	embargoed	0.014
RpL3	Ribosomal protein L3	0.014
Pros26.4	Proteasome 26S subunit subunit 4 ATPase	0.014
tth	toothrin	0.014
bgcn	benign gonial cell neoplasm	0.014
Lhr	Lethal hybrid rescue	0.014
dare	defective in the avoidance of repellents	0.014
CG7946	CG7946 gene product from transcript CG7946-RA	0.014
Mmp1	Matrix metalloproteinase 1	0.014
east	enhanced adult sensory threshold	0.014
ash1	absent, small, or homeotic discs 1	0.014
sop	string of pearls	0.014
E(var)3-9	Enhancer of variegation 3-9	0.014
CG9246	CG9246 gene product from transcript CG9246-RA	0.013
Liprin-alpha	CG11199 gene product from transcript CG11199-RB	0.013
enc	encore	0.013
ogre	optic ganglion reduced	0.013
CG10341	CG10341 gene product from transcript CG10341-RB	0.013
TER94	CG2331 gene product from transcript CG2331-RA	0.013
pasha	partner of drosha	0.013
CG4266	CG4266 gene product from transcript CG4266-RA	0.013
mod(mdg4)	modifier of mdg4	0.013
RhoGAP71E	CG32149 gene product from transcript CG32149-RD	0.013
CG12301	CG12301 gene product from transcript CG12301-RA	0.013
CG8545	CG8545 gene product from transcript CG8545-RA	0.013
CG32344	CG32344 gene product from transcript CG32344-RA	0.013
Pros45	CG1489 gene product from transcript CG1489-RA	0.013
spag4	sperm-associated antigen 4	0.013
CG4610	CG4610 gene product from transcript CG4610-RA	0.013
CG9925	CG9925 gene product from transcript CG9925-RA	0.013
pie	pineapple eye	0.013
jub	Ajuba LIM protein	0.013
crol	crooked legs	0.013
D1	D1 chromosomal protein	0.013
SmF	Small ribonucleoprotein particle protein SmF	0.013
Mcm6	Minichromosome maintenance 6	0.013
Rbf	Retinoblastoma-family protein	0.012
MED18	Mediator complex subunit 18	0.012
Prosalpha7	Proteasome alpha7 subunit	0.012
mus301	mutagen-sensitive 301	0.012
Su(var)205	Suppressor of variegation 205	0.012
His3.3B	Histone H3.3B	0.012
AttA	Attacin-A	0.012
Dredd	Death related ced-3/Nedd2-like protein	0.012
row	relative of woc	0.012
Hsc70Cb	CG6603 gene product from transcript CG6603-RG	0.012
l(3)76BDm	lethal (3) 76BDm	0.012
CG18528	CG18528 gene product from transcript CG18528-RA	0.012
l(1)G0289	lethal (1) G0289	0.012
CG11943	CG11943 gene product from transcript CG11943-RB	0.012
MED8	Mediator complex subunit 8	0.012
path	pathetic	0.012
Ef1alpha48D	Elongation factor 1alpha48D	0.012
XNP	CG4548 gene product from transcript CG4548-RA	0.012
wdb	widerborst	0.012
l(2)34Fd	lethal (2) 34Fd	0.012
Nup160	Nucleoporin 160	0.012
Fad2	CG7923 gene product from transcript CG7923-RA	0.012
CG16833	CG16833 gene product from transcript CG16833-RG	0.012
CG33936	CG33936 gene product from transcript CG33936-RB	0.012
ena	enabled	0.012
SRm160	CG11274 gene product from transcript CG11274-RA	0.012
gish	gilgamesh	0.012
CG40127	CG40127 gene product from transcript CG40127-RA	0.012
homer	CG11324 gene product from transcript CG11324-RC	0.012
CG8414	CG8414 gene product from transcript CG8414-RA	0.012
Axn	Axin	0.012
CkIIalpha-i3	CKII-alpha subunit interactor-3	0.012
CG12162	CG12162 gene product from transcript CG12162-RA	0.012
hd	humpty dumpty	0.012
BRWD3	CG31132 gene product from transcript CG31132-RA	0.012
Gem2	Gemin2	0.011
CG30094	CG30094 gene product from transcript CG30094-RA	0.011
esc	extra sexcombs	0.011
NC2beta	CG4185 gene product from transcript CG4185-RA	0.011
CG1316	CG1316 gene product from transcript CG1316-RA	0.011
Hsc70-3	Heat shock protein cognate 3	0.011
per	period	0.011
l(1)G0007	lethal (1) G0007	0.011
mira	miranda	0.011
RpS19b	Ribosomal protein S19b	0.011
atms	antimeros	0.011
CycC	Cyclin C	0.011
Cap-H2	Chromosome associated protein H2	0.011
CG17508	CG17508 gene product from transcript CG17508-RA	0.011
14-3-3epsilon	CG31196 gene product from transcript CG31196-RA	0.011
CycT	Cyclin T	0.011
adat	CG16889 gene product from transcript CG16889-RA	0.011
CG4857	CG4857 gene product from transcript CG4857-RD	0.011
asun	asunder	0.011
dbe	dribble	0.011
Xpd	Xeroderma pigmentosum D	0.011
exba	extra bases	0.011
Rip11	Rab11 interacting protein	0.011
loqs	loquacious	0.011
lic	licorne	0.011
Mpp6	M-phase phosphoprotein 6	0.011
CG12493	CG12493 gene product from transcript CG12493-RA	0.011	Fly
Fpps	Farnesyl pyrophosphate synthase	0.011
Upf3	CG11184 gene product from transcript CG11184-RB	0.011
ctp	cut up	0.011
Nup50	Nucleoporin 50	0.011
Aats-ile	Isoleucyl-tRNA synthetase	0.011
CG11777	CG11777 gene product from transcript CG11777-RA	0.011
PGRP-LC	Peptidoglycan recognition protein LC	0.011
pigs	pickled eggs	0.011
CG17343	CG17343 gene product from transcript CG17343-RA	0.011
Cerk	Ceramide kinase	0.011
iav	inactive	0.011
achi	achintya	0.011
CG17650	CG17650 gene product from transcript CG17650-RA	0.011
Nup107	Nucleoporin 107	0.011
CSN7	COP9 complex homolog subunit 7	0.011
CG16753	CG16753 gene product from transcript CG16753-RA	0.011
shrb	shrub	0.011
jeb	jelly belly	0.011
Cdk4	Cyclin-dependent kinase 4	0.011
mia	meiosis I arrest	0.011
Spn28D	Serpin 28D	0.010
Pkc98E	Protein C kinase 98E	0.010
CycB3	Cyclin B3	0.010
Smg5	CG8954 gene product from transcript CG8954-RA	0.010
lqfR	liquid facets-Related	0.010
CG7375	CG7375 gene product from transcript CG7375-RA	0.010
swa	swallow	0.010
Nup153	Nucleoporin 153	0.010
CG7564	CG7564 gene product from transcript CG7564-RA	0.010
CG14712	CG14712 gene product from transcript CG14712-RA	0.010
RpS10a	Ribosomal protein S10a	0.010
CaMKII	Calcium/calmodulin-dependent protein kinase II	0.010
l(3)neo43	lethal (3) neo43	0.010
spn-F	CG12114 gene product from transcript CG12114-RA	0.010
l(1)G0045	lethal (1) G0045	0.010
CG8997	CG8997 gene product from transcript CG8997-RA	0.010
CG9839	CG9839 gene product from transcript CG9839-RA	0.010
msd5	mitotic spindle density 5	0.010
yuri	yuri gagarin	0.010
Neos	Neosin	0.010
msk	moleskin	0.010
CG4360	CG4360 gene product from transcript CG4360-RA	0.010
Top2	Topoisomerase 2	0.010	Worm
CG11334	CG11334 gene product from transcript CG11334-RA	0.010