IMP: Integrative Multi-species Prediction

Drosophila melanogaster

29 genes annotated in fly

negative regulation of epidermal growth factor receptor signaling pathway

GO:0042059

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of epidermal growth factor receptor signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of epidermal growth factor receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
S6kII	RPS6-protein kinase-II	0.444
Sulf1	Sulfated	0.427
C3G	CG42328 gene product from transcript CG42328-RC	0.389
wech	CG42396 gene product from transcript CG42396-RC	0.320
drk	downstream of receptor kinase	0.301
Pkn	Protein kinase related to protein kinase N	0.299
cindr	CIN85 and CD2AP orthologue	0.283
rl	rolled	0.260
Vps36	Vacuolar protein sorting 36	0.255
vps2	CG14542 gene product from transcript CG14542-RA	0.227
hipk	homeodomain interacting protein kinase	0.224
sdk	sidekick	0.186
Sos	Son of sevenless	0.174
Wnk	CG7177 gene product from transcript CG7177-RA	0.170
Vps20	Vacuolar protein sorting 20	0.165
Ubqn	Ubiquilin	0.116
kek1	kekkon-1	0.108
Vps25	Vacuolar protein sorting 25	0.108
Atg7	Autophagy-specific gene 7	0.107
Chmp1	CG4108 gene product from transcript CG4108-RA	0.103
CG10413	CG10413 gene product from transcript CG10413-RA	0.101
fj	four-jointed	0.089
CHMP2B	Charged multivesicular body protein 2b	0.086
shn	schnurri	0.084
mbc	myoblast city	0.079
A2bp1	Ataxin-2 binding protein 1	0.079
cos	costa	0.077
InR	Insulin-like receptor	0.076
ena	enabled	0.074
Mical	Molecule interacting with CasL	0.070
Dad	Daughters against dpp	0.069
Hrs	Hepatocyte growth factor regulated tyrosine kinase substrate	0.068
Socs36E	Suppressor of cytokine signaling at 36E	0.067
shrb	shrub	0.067
CG5794	CG5794 gene product from transcript CG5794-RB	0.067
par-1	CG8201 gene product from transcript CG8201-RA	0.066
put	punt	0.065
tara	taranis	0.064
Jra	Jun-related antigen	0.062
RYBP	Ring and YY1 Binding Protein	0.060
Atg1	Autophagy-specific gene 1	0.056
X11L	CG5675 gene product from transcript CG5675-RB	0.055
CG6191	CG6191 gene product from transcript CG6191-RA	0.053
sev	sevenless	0.053
neur	neuralized	0.052
CG3194	CG3194 gene product from transcript CG3194-RB	0.051
hang	hangover	0.050
l(3)05822	lethal (3) 05822	0.050
nmo	nemo	0.049
MAN1	CG3167 gene product from transcript CG3167-RA	0.047
cnk	connector enhancer of ksr	0.047
l(2)k16918	lethal (2) k16918	0.046
wun	wunen	0.046
ksr	kinase suppressor of ras	0.046
tan	tantalus	0.046
kirre	kin of irre	0.045
mask	multiple ankyrin repeats single KH domain	0.044
fng	fringe	0.042
Graf	CG8948 gene product from transcript CG8948-RB	0.041
svr	silver	0.041
Cul-3	Cullin-3	0.041
sba	six-banded	0.041
sty	sprouty	0.041
ast	asteroid	0.040
chico	CG5686 gene product from transcript CG5686-RB	0.040
htl	heartless	0.040
CG6051	CG6051 gene product from transcript CG6051-RB	0.040	Human
CG7967	CG7967 gene product from transcript CG7967-RA	0.040
wit	wishful thinking	0.039
rst	roughest	0.039	Fly
ro	rough	0.038
Ube3a	Ubiquitin protein ligase E3A	0.037
rols	rolling pebbles	0.037
Pka-R2	cAMP-dependent protein kinase R2	0.037
TSG101	tumor suppressor protein 101	0.036
Stam	Signal transducing adaptor molecule	0.036
unk	unkempt	0.035
Mkp3	Mitogen-activated protein kinase phosphatase 3	0.035
bves	CG32513 gene product from transcript CG32513-RA	0.035
vps24	Charged multivesicular body protein 3	0.035
Pp2B-14D	Protein phosphatase 2B at 14D	0.035
NFAT	NFAT homolog	0.034
ara	araucan	0.033
Pka-C1	cAMP-dependent protein kinase 1	0.033
klar	klarsicht	0.033
ru	roughoid	0.032
eya	eyes absent	0.032
Apc	APC-like	0.032
RhoGAP15B	CG4937 gene product from transcript CG4937-RC	0.032
pUf68	poly U binding factor 68kD	0.032
ed	echinoid	0.031
Rab5	Rab-protein 5	0.031
CG2519	CG2519 gene product from transcript CG2519-RB	0.031
Pk61C	Protein kinase 61C	0.030
Hip14	Huntingtin-interacting protein 14	0.030
Not1	CG34407 gene product from transcript CG34407-RC	0.030
Dsor1	Downstream of raf1	0.029
jar	jaguar	0.029
Gap1	GTPase-activating protein 1	0.029
Nedd4	CG42279 gene product from transcript CG42279-RJ	0.029
CG30499	CG30499 gene product from transcript CG30499-RA	0.029
SoxN	SoxNeuro	0.029
pcs	parcas	0.028
Snoo	Sno oncogene	0.028
cv	crossveinless	0.028
brat	brain tumor	0.028
Abl	Abl tyrosine kinase	0.027
wts	warts	0.026
Cbl	CG7037 gene product from transcript CG7037-RB	0.026
m4	E(spl) region transcript m4	0.026
Vrp1	Verprolin 1	0.026
l(1)G0469	lethal (1) G0469	0.026
Arf84F	ADP ribosylation factor 84F	0.025
fra	frazzled	0.025
bdg	bedraggled	0.025
scb	scab	0.024	Mouse
B-H1	BarH1	0.024
Megalin	CG42611 gene product from transcript CG42611-RA	0.024
Fas3	Fasciclin 3	0.024
CanB	Calcineurin B	0.024
rho	rhomboid	0.023
CG6912	CG6912 gene product from transcript CG6912-RA	0.023
rok	Rho-kinase	0.023
skd	skuld	0.023
Vps28	Vacuolar protein sorting 28	0.023
bowl	brother of odd with entrails limited	0.023
synj	synaptojanin	0.023
PTP-ER	Protein tyrosine phosphatase-ERK/Enhancer of Ras1	0.023
Hs6st	Heparan sulfate 6-O-sulfotransferase	0.022
CG2656	CG2656 gene product from transcript CG2656-RA	0.021
dos	daughter of sevenless	0.021
tkv	thickveins	0.021
CG2875	CG2875 gene product from transcript CG2875-RB	0.021
klg	klingon	0.021
drm	drumstick	0.020
boi	brother of iHog	0.020
sip1	septin interacting protein 1	0.020
Dhod	Dihydroorotate dehydrogenase	0.020
CG31224	CG31224 gene product from transcript CG31224-RA	0.020
caz	cabeza	0.020
amos	absent MD neurons and olfactory sensilla	0.020
heph	hephaestus	0.020
mop	myopic	0.019
cdi	center divider	0.019
Sbf	SET domain binding factor	0.019
CG5045	CG5045 gene product from transcript CG5045-RA	0.019
vav	CG7893 gene product from transcript CG7893-RB	0.019
cv-2	crossveinless 2	0.019
sav	salvador	0.019
R	Roughened	0.019
cic	capicua	0.019
sns	sticks and stones	0.019	Fly
kst	karst	0.018
CG12734	CG12734 gene product from transcript CG12734-RA	0.018
CG33523	CG33523 gene product from transcript CG33523-RD	0.018
CG3125	CG3125 gene product from transcript CG3125-RA	0.018
CG6259	CG6259 gene product from transcript CG6259-RA	0.018
CG3500	CG3500 gene product from transcript CG3500-RA	0.018
Atg6	Autophagy-specific gene 6	0.018
Nrt	Neurotactin	0.018
Gprk2	G protein-coupled receptor kinase 2	0.018
FucTA	CG6869 gene product from transcript CG6869-RA	0.018
Letm1	CG4589 gene product from transcript CG4589-RB	0.018
CG3556	CG3556 gene product from transcript CG3556-RA	0.018
CG9646	CG9646 gene product from transcript CG9646-RA	0.018
net	CG11450 gene product from transcript CG11450-RB	0.018
tinc	tincar	0.018
ClC-c	Chloride channel-c	0.018
Sema-1a	CG18405 gene product from transcript CG18405-RD	0.018
scrt	scratch	0.018
endoB	endophilin B	0.018
CG8443	CG8443 gene product from transcript CG8443-RA	0.018
kn	knot	0.018
pigeon	CG10739 gene product from transcript CG10739-RB	0.018
lmg	lemming	0.018
RhoGAP19D	CG1412 gene product from transcript CG1412-RB	0.017
CG4341	CG4341 gene product from transcript CG4341-RB	0.017
inv	invected	0.017
CG10918	CG10918 gene product from transcript CG10918-RA	0.017
Bx42	CG8264 gene product from transcript CG8264-RA	0.017
CG8336	CG8336 gene product from transcript CG8336-RB	0.017
CG10673	CG10673 gene product from transcript CG10673-RA	0.017
lsn	larsen	0.017
Fs	Follistatin	0.017
pod1	CG4532 gene product from transcript CG4532-RF	0.017
CG9339	CG9339 gene product from transcript CG9339-RG	0.017
Him	Holes in muscle	0.017
sbr	small bristles	0.017
Ptp61F	Protein tyrosine phosphatase 61F	0.017
NPFR1	neuropeptide F receptor	0.016
CG3776	CG3776 gene product from transcript CG3776-RA	0.016
exba	extra bases	0.016
rg	rugose	0.016
Cyp18a1	Cytochrome P450-18a1	0.016
DAAM	Dishevelled Associated Activator of Morphogenesis	0.016
ssp4	short spindle 4	0.016
Sara	Smad anchor for receptor activation	0.016
l(1)G0007	lethal (1) G0007	0.016
Met	Methoprene-tolerant	0.016
tou	toutatis	0.016
Actbeta	Activin-beta	0.016
RhoGAP93B	CG3421 gene product from transcript CG3421-RA	0.016
Xrp1	CG17836 gene product from transcript CG17836-RB	0.016
Six4	CG3871 gene product from transcript CG3871-RA	0.016
Eip78C	Ecdysone-induced protein 78C	0.016
CG11727	CG11727 gene product from transcript CG11727-RD	0.015
Gcn2	CG1609 gene product from transcript CG1609-RA	0.015
CG2258	CG2258 gene product from transcript CG2258-RA	0.015
CG4674	CG4674 gene product from transcript CG4674-RA	0.015
Ssdp	Sequence-specific single-stranded DNA-binding protein	0.015
slmb	supernumerary limbs	0.015
CG10803	CG10803 gene product from transcript CG10803-RA	0.015
Syn2	Syntrophin-like 2	0.015
tud	tudor	0.015
S6k	RPS6-p70-protein kinase	0.015
fred	friend of echinoid	0.015	Fly
toe	twin of eyg	0.015
MYPT-75D	CG6896 gene product from transcript CG6896-RA	0.015
pnr	pannier	0.015
l(3)neo38	lethal (3) neo38	0.015
trpm	CG34123 gene product from transcript CG34123-RG	0.015
CG1965	CG1965 gene product from transcript CG1965-RA	0.015
argos	CG4531 gene product from transcript CG4531-RA	0.015
Kr-h1	Kruppel homolog 1	0.015
step	steppke	0.015
CG10103	CG10103 gene product from transcript CG10103-RA	0.015
CG8965	CG8965 gene product from transcript CG8965-RA	0.015
Notum	CG13076 gene product from transcript CG13076-RB	0.015
dgo	diego	0.015
Cad99C	CG31009 gene product from transcript CG31009-RB	0.015
lilli	lilliputian	0.014
csw	corkscrew	0.014
CG8909	CG8909 gene product from transcript CG8909-RC	0.014
CG10426	CG10426 gene product from transcript CG10426-RA	0.014
Hip1	Huntingtin interacting protein 1	0.014
CG3704	CG3704 gene product from transcript CG3704-RA	0.014
Oatp30B	Organic anion transporting polypeptide 30B	0.014
Hcf	Host cell factor	0.014
nvy	nervy	0.014
dl	dorsal	0.014
cact	cactus	0.014
CG1291	CG1291 gene product from transcript CG1291-RA	0.014
CG12736	CG12736 gene product from transcript CG12736-RA	0.014
corto	CG2530 gene product from transcript CG2530-RA	0.014
shf	shifted	0.014
Rab4	Rab-protein 4	0.014
CG9890	CG9890 gene product from transcript CG9890-RA	0.014
gry	gryzun	0.014
Rab14	Rab-protein 14	0.014
lmd	lame duck	0.014
Syn	Synapsin	0.014
Con	Connectin	0.014
CG7607	CG7607 gene product from transcript CG7607-RA	0.014
CG8001	CG8001 gene product from transcript CG8001-RA	0.014
CG8678	CG8678 gene product from transcript CG8678-RA	0.013
mrt	martik	0.013
Tom	Twin of m4	0.013
Ten-m	Tenascin major	0.013
CG7382	CG7382 gene product from transcript CG7382-RA	0.013
Eip71CD	Ecdysone-induced protein 28/29kD	0.013
bsk	basket	0.013
Bj1	Bj1 protein	0.013
dpr8	CG32600 gene product from transcript CG32600-RA	0.013
CG17568	CG17568 gene product from transcript CG17568-RA	0.013
Prosap	CG30483 gene product from transcript CG30483-RA	0.013
X11Lbeta	CG32677 gene product from transcript CG32677-RA	0.013
CSN4	COP9 complex homolog subunit 4	0.013
UBL3	CG9038 gene product from transcript CG9038-RC	0.013
CG32676	CG32676 gene product from transcript CG32676-RA	0.013
Atu	Another transcription unit	0.013
CG1578	CG1578 gene product from transcript CG1578-RA	0.013
sno	strawberry notch	0.013
Wnt5	Wnt oncogene analog 5	0.013
aux	auxillin	0.013
CG14023	CG14023 gene product from transcript CG14023-RB	0.013
CG10289	CG10289 gene product from transcript CG10289-RA	0.013
CG13409	CG13409 gene product from transcript CG13409-RA	0.013
Src42A	Src oncogene at 42A	0.013
CG3862	CG3862 gene product from transcript CG3862-RA	0.013
sog	short gastrulation	0.013
Lar	Leukocyte-antigen-related-like	0.013	Rat
cno	canoe	0.013
ec	echinus	0.013
mRpL1	mitochondrial ribosomal protein L1	0.013
Psn	Presenilin	0.013	Mouse
slik	Sterile20-like kinase	0.013
drpr	draper	0.013
Rheb	CG1081 gene product from transcript CG1081-RA	0.013
Abi	Abelson interacting protein	0.013
zfh1	Zn finger homeodomain 1	0.013
lic	licorne	0.013
Src64B	Src oncogene at 64B	0.013	Fly
CG7611	CG7611 gene product from transcript CG7611-RJ	0.012
gatA	glutamyl-tRNA amidotransferase subunit A	0.012
Psf2	CG18013 gene product from transcript CG18013-RA	0.012
Magi	CG30388 gene product from transcript CG30388-RA	0.012
Cdk5alpha	Cdk5 activator-like protein	0.012
U2A	CG1406 gene product from transcript CG1406-RA	0.012
arr	arrow	0.012
Best1	Bestrophin 1	0.012
CG40351	CG40351 gene product from transcript CG40351-RF	0.012
CG5343	CG5343 gene product from transcript CG5343-RA	0.012
Fak56D	Focal Adhesion Kinase	0.012
CG8079	CG8079 gene product from transcript CG8079-RA	0.012
nimC4	nimrod C4	0.012
CG1115	CG1115 gene product from transcript CG1115-RA	0.012
Nrx-1	Neurexin 1	0.012
CG9335	CG9335 gene product from transcript CG9335-RA	0.012
mAcR-60C	muscarinic Acetylcholine Receptor 60C	0.012
CG6495	CG6495 gene product from transcript CG6495-RA	0.012
dimm	dimmed	0.012
CG6424	CG6424 gene product from transcript CG6424-RA	0.012
alpha-catenin-related	alpha-catenin related	0.012
p16-ARC	CG9881 gene product from transcript CG9881-RA	0.012
CG6752	CG6752 gene product from transcript CG6752-RA	0.012
CG10628	CG10628 gene product from transcript CG10628-RA	0.012
CG2224	CG2224 gene product from transcript CG2224-RA	0.012
CalpB	Calpain-B	0.012
Hydr2	alpha/beta hydrolase2	0.012
betaInt-nu	beta[nu] integrin	0.012
su(s)	suppressor of sable	0.012
Klp98A	Kinesin-like protein at 98A	0.012
Cad87A	CG6977 gene product from transcript CG6977-RA	0.012
CG2970	CG2970 gene product from transcript CG2970-RA	0.012
CG14441	CG14441 gene product from transcript CG14441-RA	0.012
DnaJ-H	DnaJ homolog	0.012
CG5521	CG5521 gene product from transcript CG5521-RB	0.012
Nhe2	Na[+]/H[+] hydrogen exchanger 2	0.012
CG6700	CG6700 gene product from transcript CG6700-RA	0.011
dpr18	CG14948 gene product from transcript CG14948-RA	0.011
hbs	hibris	0.011	Fly
CG13937	CG13937 gene product from transcript CG13937-RD	0.011
repo	reversed polarity	0.011
melt	melted	0.011
CG15784	CG15784 gene product from transcript CG15784-RA	0.011
CG4294	CG4294 gene product from transcript CG4294-RB	0.011
CG34398	CG34398 gene product from transcript CG34398-RF	0.011
f-cup	flyers-cup	0.011
Damm	Death associated molecule related to Mch2	0.011
tow	target of wingless	0.011
grk	gurken	0.011
tomosyn	CG17762 gene product from transcript CG17762-RB	0.011
nord	CG30418 gene product from transcript CG30418-RA	0.011
salr	spalt-related	0.011
Aac11	CG6582 gene product from transcript CG6582-RA	0.011
dikar	CG42799 gene product from transcript CG42799-RC	0.011
alphaTub84B	alpha-Tubulin at 84B	0.011
CG6509	CG6509 gene product from transcript CG6509-RB	0.011
ttv	tout-velu	0.011
Cchl	Cytochrome c heme lyase	0.011
CG11033	CG11033 gene product from transcript CG11033-RB	0.011
CG7049	CG7049 gene product from transcript CG7049-RA	0.011
tamo	CG4057 gene product from transcript CG4057-RA	0.011
mol	moladietz	0.011
Parp	Poly-(ADP-ribose) polymerase	0.011
Pkc98E	Protein C kinase 98E	0.011
ac	achaete	0.011
slif	slimfast	0.011
CG13096	CG13096 gene product from transcript CG13096-RA	0.011
oys	oysgedart	0.011
Trc8	CG2304 gene product from transcript CG2304-RB	0.011
CG1688	CG1688 gene product from transcript CG1688-RA	0.011
Rlb1	CG8161 gene product from transcript CG8161-RA	0.011
CG11275	CG11275 gene product from transcript CG11275-RA	0.011
pb	proboscipedia	0.011
ebi	CG4063 gene product from transcript CG4063-RA	0.011
trio	CG18214 gene product from transcript CG18214-RA	0.011
insc	inscuteable	0.011
nuf	nuclear fallout	0.011
CG2269	CG2269 gene product from transcript CG2269-RC	0.011
RASSF8	CG5053 gene product from transcript CG5053-RA	0.011
CG5282	CG5282 gene product from transcript CG5282-RA	0.011
Awh	Arrowhead	0.011
Tab2	TAK1-associated binding protein 2	0.011
mib1	mind bomb 1	0.011
lig3	DNA ligase III	0.011
CG17565	CG17565 gene product from transcript CG17565-RA	0.011
rut	rutabaga	0.011
Aats-ser	Seryl-tRNA synthetase	0.010
CG17082	CG17082 gene product from transcript CG17082-RD	0.010
Lcch3	Ligand-gated chloride channel homolog 3	0.010
ATP7	CG1886 gene product from transcript CG1886-RB	0.010
be	ben	0.010
Drep-4	DNA fragmentation factor-related protein 4	0.010
CG6498	CG6498 gene product from transcript CG6498-RA	0.010
CG9170	CG9170 gene product from transcript CG9170-RB	0.010
edl	ETS-domain lacking	0.010
CG3837	CG3837 gene product from transcript CG3837-RA	0.010
bin3	bicoid-interacting protein 3	0.010
cdc14	CG7134 gene product from transcript CG7134-RB	0.010
rost	rolling stone	0.010
RN-tre	tre oncogene-related protein	0.010
ex	expanded	0.010
HDAC4	CG1770 gene product from transcript CG1770-RE	0.010
elm	ethanol sensitive with low memory	0.010
cg	combgap	0.010
CG18754	CG18754 gene product from transcript CG18754-RB	0.010
CG10916	CG10916 gene product from transcript CG10916-RA	0.010
CG9098	CG9098 gene product from transcript CG9098-RA	0.010
CG8683	CG8683 gene product from transcript CG8683-RB	0.010
APP-BP1	beta-Amyloid precursor protein binding protein 1	0.010
Stim	Stromal interaction molecule	0.010
CG9855	CG9855 gene product from transcript CG9855-RA	0.010
CG13624	CG13624 gene product from transcript CG13624-RD	0.010
Rab1	Rab-protein 1	0.010
Pvf1	PDGF- and VEGF-related factor 1	0.010
CG7609	CG7609 gene product from transcript CG7609-RB	0.010
Arpc3B	CG8936 gene product from transcript CG8936-RA	0.010
CG3558	CG3558 gene product from transcript CG3558-RC	0.010
EcR	Ecdysone receptor	0.010