IMP: Integrative Multi-species Prediction

Drosophila melanogaster

17 genes annotated in fly

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to drug"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to drug" (in gray)

Name	Description	Probability	Func Analog Organism
Akt1	CG4006 gene product from transcript CG4006-RA	0.575
Egfr	Epidermal growth factor receptor	0.527	Rat
Ras85D	Ras oncogene at 85D	0.432
Mad	Mothers against dpp	0.205
Ugt35a	UDP-glycosyltransferase 35a	0.191	Rat
LamC	Lamin C	0.148
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.146
spi	spitz	0.112
NPFR1	neuropeptide F receptor	0.111
Rdl	Resistant to dieldrin	0.103
ftz-f1	ftz transcription factor 1	0.094
Rya-r44F	Ryanodine receptor 44F	0.093
CG42629	CG42629 gene product from transcript CG42629-RB	0.090
hipk	homeodomain interacting protein kinase	0.081
Tbh	Tyramine beta hydroxylase	0.070	Rat
Cyp9f2	CG11466 gene product from transcript CG11466-RB	0.070	Human Rat
Nmdar1	NMDA receptor 1	0.061
png	pan gu	0.061
CG13510	CG13510 gene product from transcript CG13510-RA	0.059
tipE	temperature-induced paralytic E	0.054
Cyp6a21	CG10247 gene product from transcript CG10247-RA	0.054	Human Rat
Yp2	Yolk protein 2	0.049	Rat
CG13310	CG13310 gene product from transcript CG13310-RA	0.047
gcm	glial cells missing	0.043
hig	hikaru genki	0.042
Patr-1	Protein associated with topo II related - 1	0.040
CG11055	CG11055 gene product from transcript CG11055-RB	0.040
nwk	nervous wreck	0.038
p53	CG33336 gene product from transcript CG33336-RB	0.037	Human Mouse
N	Notch	0.036
swa	swallow	0.036
EcR	Ecdysone receptor	0.035
MESK2	Misexpression suppressor of KSR 2	0.035
stmA	stambha A	0.035
ed	echinoid	0.034
Stat92E	Signal-transducer and activator of transcription protein at 92E	0.034
CaMKII	Calcium/calmodulin-dependent protein kinase II	0.033
eIF4G	eukaryotic translation initiation factor 4G	0.031
Trh	Tryptophan hydroxylase	0.031
Ilp2	Insulin-like peptide 2	0.030
cort	cortex	0.030
Nrg	Neuroglian	0.030
slo	slowpoke	0.030
CG1927	CG1927 gene product from transcript CG1927-RA	0.029
Cyp12a4	CG6042 gene product from transcript CG6042-RA	0.029
hep	hemipterous	0.029
mus309	mutagen-sensitive 309	0.028
Med	Medea	0.028
Yp3	Yolk protein 3	0.028	Rat
wgn	wengen	0.027
rut	rutabaga	0.027
kel	kelch	0.027
ap	apterous	0.027
CG6283	CG6283 gene product from transcript CG6283-RA	0.026	Rat
ple	pale	0.026
Cyp4e2	Cytochrome P450-4e2	0.026
Cyp6a23	CG10242 gene product from transcript CG10242-RA	0.026	Human Rat
CG14634	CG14634 gene product from transcript CG14634-RB	0.025
CG13253	CG13253 gene product from transcript CG13253-RB	0.025
Cyp6a9	Cytochrome P450-6a9	0.025	Human Rat
Gr28b	Gustatory receptor 28b	0.025
Epac	CG34392 gene product from transcript CG34392-RC	0.024
Cyp6d5	CG3050 gene product from transcript CG3050-RA	0.024
Shaw	Shaker cognate w	0.024
Dat	Dopamine N acetyltransferase	0.023
Cp190	Centrosomal protein 190kD	0.023
CG11151	CG11151 gene product from transcript CG11151-RA	0.023
Ace	Acetylcholine esterase	0.023
dib	disembodied	0.022
tll	tailless	0.022
Ork1	Open rectifier K[+] channel 1	0.022
Tak1	TGF-beta activated kinase 1	0.021
CG11149	CG11149 gene product from transcript CG11149-RD	0.021
RhoGAP68F	CG6811 gene product from transcript CG6811-RA	0.021
nAcRbeta-96A	nicotinic Acetylcholine Receptor beta 96A	0.021
CG6178	CG6178 gene product from transcript CG6178-RA	0.020
shd	shade	0.020
Cyp12e1	CG14680 gene product from transcript CG14680-RC	0.020
CG10979	CG10979 gene product from transcript CG10979-RA	0.020
Pkc98E	Protein C kinase 98E	0.020	Worm
Tequila	CG4821 gene product from transcript CG4821-RE	0.019
pum	pumilio	0.019
CG10562	CG10562 gene product from transcript CG10562-RA	0.019
Tao-1	CG14217 gene product from transcript CG14217-RF	0.019
yip2	yippee interacting protein 2	0.018
CG17508	CG17508 gene product from transcript CG17508-RA	0.018
gogo	golden goal	0.018
CG14815	CG14815 gene product from transcript CG14815-RA	0.018
Lsd-2	Lipid storage droplet-2	0.018
MTF-1	Metal response element-binding Transcription Factor-1	0.017
Sos	Son of sevenless	0.017
Cyp6g2	CG8859 gene product from transcript CG8859-RA	0.017	Human Rat
tamo	CG4057 gene product from transcript CG4057-RA	0.017
CG2852	CG2852 gene product from transcript CG2852-RA	0.017
CrebB-17A	Cyclic-AMP response element binding protein B at 17A	0.017
Myd88	CG2078 gene product from transcript CG2078-RA	0.017
rols	rolling pebbles	0.017
JhI-26	Juvenile hormone-inducible protein 26	0.017
GLaz	Glial Lazarillo	0.016
sina	seven in absentia	0.016
Acox57D-p	acyl-Coenzyme A oxidase at 57D proximal	0.016
CG7724	CG7724 gene product from transcript CG7724-RA	0.016
eIF-4B	Eukaryotic initiation factor 4B	0.016
BicC	Bicaudal C	0.015
Dsp1	Dorsal switch protein 1	0.015
CG8306	CG8306 gene product from transcript CG8306-RA	0.015
Tre	Trehalose-sensitivity	0.015
par-1	CG8201 gene product from transcript CG8201-RA	0.015
EDTP	Egg-derived tyrosine phosphatase	0.015
VAChT	CG32848 gene product from transcript CG32848-RA	0.015
Sec61gamma	CG14214 gene product from transcript CG14214-RA	0.015
pgc	polar granule component	0.015
Cdk5alpha	Cdk5 activator-like protein	0.015
dhd	deadhead	0.014
Liprin-alpha	CG11199 gene product from transcript CG11199-RB	0.014
Cdc6	CG5971 gene product from transcript CG5971-RA	0.014
drk	downstream of receptor kinase	0.014
dl	dorsal	0.014
Eaat1	Excitatory amino acid transporter 1	0.014
Cyp4ac1	CG14032 gene product from transcript CG14032-RA	0.014
dnc	dunce	0.014	Mouse Rat
CG18522	CG18522 gene product from transcript CG18522-RA	0.014
Prat2	Phosphoribosylamidotransferase 2	0.014
dpp	decapentaplegic	0.014
plu	plutonium	0.014
shi	shibire	0.014
neuroligin	CG13772 gene product from transcript CG13772-RA	0.014
CG17337	CG17337 gene product from transcript CG17337-RA	0.013
Gip	GIP-like	0.013
Atg9	Autophagy-specific gene 9	0.013
Mob2	CG11711 gene product from transcript CG11711-RC	0.013
CG2678	CG2678 gene product from transcript CG2678-RA	0.013
CG5335	CG5335 gene product from transcript CG5335-RA	0.013
Ilp4	Insulin-like peptide 4	0.013
CG18347	CG18347 gene product from transcript CG18347-RA	0.013
CG6126	CG6126 gene product from transcript CG6126-RA	0.013
Ten-a	Tenascin accessory	0.013
S6k	RPS6-p70-protein kinase	0.013
nAcRalpha-96Aa	nicotinic Acetylcholine Receptor alpha 96Aa	0.013
na	narrow abdomen	0.013
Ac3	CG1506 gene product from transcript CG1506-RA	0.012
Alk	CG8250 gene product from transcript CG8250-RA	0.012
shakB	shaking B	0.012
ninaB	neither inactivation nor afterpotential B	0.012
Cyp12a5	CG11821 gene product from transcript CG11821-RA	0.012
Dsor1	Downstream of raf1	0.012
Ilp5	Insulin-like peptide 5	0.012
pan	pangolin	0.012
Rpn5	CG1100 gene product from transcript CG1100-RA	0.012
CG12766	CG12766 gene product from transcript CG12766-RA	0.012	Rat
CG10672	CG10672 gene product from transcript CG10672-RA	0.012
sls	sallimus	0.012
Cyp6a13	CG2397 gene product from transcript CG2397-RA	0.012	Human Rat
Smox	Smad on X	0.012
to	takeout	0.012
CG6834	CG6834 gene product from transcript CG6834-RA	0.012
CG5789	CG5789 gene product from transcript CG5789-RA	0.012
snk	snake	0.012
CG4168	CG4168 gene product from transcript CG4168-RA	0.011
Rh50	CG7499 gene product from transcript CG7499-RA	0.011
CG31937	CG31937 gene product from transcript CG31937-RA	0.011
CG3702	CG3702 gene product from transcript CG3702-RA	0.011
Sap47	Synapse-associated protein 47kD	0.011
tld	tolloid	0.011
Ipp	Inositol polyphosphate 1-phosphatase	0.011
trh	CG42865 gene product from transcript CG42865-RC	0.011
Ugt36Bc	CG17932 gene product from transcript CG17932-RB	0.011	Rat
CG2064	CG2064 gene product from transcript CG2064-RA	0.011
Pde8	Phosphodiesterase 8	0.011
zetaTry	zetaTrypsin	0.011
CG12672	CG12672 gene product from transcript CG12672-RA	0.011
Tab2	TAK1-associated binding protein 2	0.011
osk	oskar	0.011
CG5568	CG5568 gene product from transcript CG5568-RA	0.011
18w	18 wheeler	0.011
Spf45	CG17540 gene product from transcript CG17540-RB	0.011
chico	CG5686 gene product from transcript CG5686-RB	0.011
Nrx-1	Neurexin 1	0.010
CG10550	CG10550 gene product from transcript CG10550-RB	0.010
CRMP	Collapsin Response Mediator Protein	0.010
CG1909	CG1909 gene product from transcript CG1909-RA	0.010
Cyp6d4	CG12800 gene product from transcript CG12800-RA	0.010
tin	tinman	0.010
Ca-P60A	Calcium ATPase at 60A	0.010
Aats-phe	Phenylalanyl-tRNA synthetase	0.010
GstE6	Glutathione S transferase E6	0.010
CG3556	CG3556 gene product from transcript CG3556-RA	0.010
ppk	pickpocket	0.010
LvpH	Larval visceral protein H	0.010
CG13424	CG13424 gene product from transcript CG13424-RA	0.010