IMP: Integrative Multi-species Prediction

Drosophila melanogaster

1 genes annotated in fly

Multi-species View

negative regulation of insulin secretion

GO:0046676

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of insulin secretion"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of insulin secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Actbeta	Activin-beta	0.221
Eip63F-1	Ecdysone-induced protein 63F 1	0.212
cv-2	crossveinless 2	0.212
InR	Insulin-like receptor	0.192
Irk2	Inwardly rectifying potassium channel 2	0.183	Human
GABA-B-R2	metabotropic GABA-B receptor subtype 2	0.166
Dat	Dopamine N acetyltransferase	0.166
Irk3	Inwardly rectifying potassium channel 3	0.134	Human
foxo	forkhead box, sub-group O	0.124
SNF4Agamma	SNF4/AMP-activated protein kinase gamma subunit	0.102
Plc21C	Phospholipase C at 21C	0.100
myoglianin	CG1838 gene product from transcript CG1838-RD	0.093
rut	rutabaga	0.081
svr	silver	0.064
Pink1	PTEN-induced putative kinase 1	0.064
egr	eiger	0.063
CG32810	CG32810 gene product from transcript CG32810-RB	0.061
Ipp	Inositol polyphosphate 1-phosphatase	0.060
5-HT1B	Serotonin receptor 1B	0.057
drd	drop dead	0.056
Fer2LCH	Ferritin 2 light chain homologue	0.051
CG10200	CG10200 gene product from transcript CG10200-RB	0.050
Gadd45	CG11086 gene product from transcript CG11086-RA	0.049
per	period	0.046
Pp2B-14D	Protein phosphatase 2B at 14D	0.045	Rat
shn	schnurri	0.044
dnr1	defense repressor 1	0.042
Snoo	Sno oncogene	0.040
tinc	tincar	0.039
CanA1	Calcineurin A1	0.039	Rat
mtt	mangetout	0.038
Atg9	Autophagy-specific gene 9	0.037
CG42574	CG42574 gene product from transcript CG42574-RE	0.037
dally	division abnormally delayed	0.036
trk	trunk	0.036
HLH106	Helix loop helix protein 106	0.036
GLaz	Glial Lazarillo	0.035
rho-5	rhomboid-5	0.033
argos	CG4531 gene product from transcript CG4531-RA	0.033
cbt	cabut	0.032
tld	tolloid	0.031
sog	short gastrulation	0.030
Clk	Clock	0.028
Pde8	Phosphodiesterase 8	0.028	Rat
CG10426	CG10426 gene product from transcript CG10426-RA	0.026
Tbh	Tyramine beta hydroxylase	0.026
CG34139	CG34139 gene product from transcript CG34139-RD	0.025
Gr64e	Gustatory receptor 64e	0.025
klg	klingon	0.025
KCNQ	KCNQ potassium channel	0.025
PGRP-LF	Peptidoglycan recognition protein LF	0.024
IP3K2	Inositol 1,4,5-triphosphate kinase 2	0.024
disco	disconnected	0.024
CG8709	CG8709 gene product from transcript CG8709-RK	0.024
Dcr-2	Dicer-2	0.023
NPFR1	neuropeptide F receptor	0.023
Shaw	Shaker cognate w	0.023
CG42629	CG42629 gene product from transcript CG42629-RB	0.022
pdfr	PDF receptor	0.022
CG16884	CG16884 gene product from transcript CG16884-RA	0.021
tim	timeless	0.021
Atf-2	Activating transcription factor-2	0.021
Atg6	Autophagy-specific gene 6	0.020
beat-Ic	beaten path Ic	0.020
Pka-R2	cAMP-dependent protein kinase R2	0.020
ASPP	Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein	0.020
E23	Early gene at 23	0.020
Ih	I[[h]] channel	0.020
cwo	clockwork orange	0.019
tsl	torso-like	0.019
sty	sprouty	0.019
CG42369	CG42369 gene product from transcript CG42369-RA	0.019
CG9650	CG9650 gene product from transcript CG9650-RG	0.019
cln3	CG5582 gene product from transcript CG5582-RA	0.019
bab2	CG9102 gene product from transcript CG9102-RA	0.019
CG8907	CG8907 gene product from transcript CG8907-RA	0.019
be	ben	0.018
CG31191	CG31191 gene product from transcript CG31191-RA	0.018
to	takeout	0.018
Glut1	Glucose transporter 1	0.018
HDAC6	CG6170 gene product from transcript CG6170-RA	0.018
CanB	Calcineurin B	0.018
Ilp4	Insulin-like peptide 4	0.018
Gr28b	Gustatory receptor 28b	0.018
Efr	ER GDP-fucose transporter	0.018
5-HT1A	Serotonin receptor 1A	0.018
Sema-1a	CG18405 gene product from transcript CG18405-RD	0.018
CG32206	CG32206 gene product from transcript CG32206-RB	0.017
Baldspot	CG3971 gene product from transcript CG3971-RA	0.017
hoe1	hoepel1	0.017
CG6765	CG6765 gene product from transcript CG6765-RA	0.017
byn	brachyenteron	0.017
Ptp10D	Protein tyrosine phosphatase 10D	0.017
Sln	Silnoon	0.017
Pdp1	PAR-domain protein 1	0.017
RhoGAP100F	CG1976 gene product from transcript CG1976-RB	0.017
Doc2	Dorsocross2	0.016
rho	rhomboid	0.016
dnc	dunce	0.016	Rat
CG17922	CG17922 gene product from transcript CG17922-RA	0.016
nAcRalpha-80B	nicotinic Acetylcholine Receptor alpha 80B	0.016
slo	slowpoke	0.016
Ir	Inwardly rectifying potassium channel	0.016	Human
ptc	patched	0.016
Traf-like	TNF-receptor-associated factor-like	0.016
CG33289	CG33289 gene product from transcript CG33289-RA	0.016
nAcRalpha-7E	nicotinic Acetylcholine Receptor alpha 7E	0.016
CG32813	CG32813 gene product from transcript CG32813-RE	0.016
brk	brinker	0.015
Cpr73D	Cuticular protein 73D	0.015
Ric	Ras which interacts with Calmodulin	0.015
CG13743	CG13743 gene product from transcript CG13743-RA	0.015
magu	CG2264 gene product from transcript CG2264-RD	0.015
Task6	CG9637 gene product from transcript CG9637-RC	0.015
Mer	Merlin	0.015
S6k	RPS6-p70-protein kinase	0.015
CG33203	CG33203 gene product from transcript CG33203-RB	0.015
A2bp1	Ataxin-2 binding protein 1	0.015
oys	oysgedart	0.015
CG12985	CG12985 gene product from transcript CG12985-RA	0.015
CG31140	CG31140 gene product from transcript CG31140-RF	0.015
wit	wishful thinking	0.015
5-HT7	Serotonin receptor 7	0.015
jim	CG11352 gene product from transcript CG11352-RB	0.014
CG31619	CG31619 gene product from transcript CG31619-RC	0.014
CG34400	CG34400 gene product from transcript CG34400-RD	0.014
CG9413	CG9413 gene product from transcript CG9413-RA	0.014
Nha2	Na[+]/H[+] hydrogen antiporter 2	0.014
Pdf	Pigment-dispersing factor	0.014
HERC2	CG11734 gene product from transcript CG11734-RC	0.014
CG13636	CG13636 gene product from transcript CG13636-RB	0.014
CG12071	CG12071 gene product from transcript CG12071-RB	0.014
CG17065	CG17065 gene product from transcript CG17065-RA	0.014
l(2)05510	lethal (2) 05510	0.014
betaInt-nu	beta[nu] integrin	0.014
Gyc76C	Guanylyl cyclase at 76C	0.014
CG1358	CG1358 gene product from transcript CG1358-RD	0.014
tkv	thickveins	0.014
net	CG11450 gene product from transcript CG11450-RB	0.014
l(1)G0196	lethal (1) G0196	0.013
CrebB-17A	Cyclic-AMP response element binding protein B at 17A	0.013
Dh31-R1	Diuretic hormone 31 receptor 1	0.013
by	blistery	0.013
Ilp2	Insulin-like peptide 2	0.013
CG31760	CG31760 gene product from transcript CG31760-RB	0.013
kek1	kekkon-1	0.013
Sh	Shaker	0.013
CG3194	CG3194 gene product from transcript CG3194-RB	0.013
cry	cryptochrome	0.013
Spn77Ba	Serpin 77Ba	0.013
CG4857	CG4857 gene product from transcript CG4857-RD	0.013
CG11317	CG11317 gene product from transcript CG11317-RA	0.013
CG10830	CG10830 gene product from transcript CG10830-RA	0.012
sNPF-R	short neuropeptide F receptor	0.012
DopR	Dopamine receptor	0.012
CG13594	CG13594 gene product from transcript CG13594-RA	0.012
CG13792	CG13792 gene product from transcript CG13792-RA	0.012
CG7918	CG7918 gene product from transcript CG7918-RA	0.012
rtGEF	rho-type guanine exchange factor	0.012
CG10508	CG10508 gene product from transcript CG10508-RH	0.012
Fer2	48 related 2	0.012
CG33143	CG33143 gene product from transcript CG33143-RC	0.012
CG10543	CG10543 gene product from transcript CG10543-RA	0.012
pb	proboscipedia	0.012
CG32432	CG32432 gene product from transcript CG32432-RA	0.012
Pkc98E	Protein C kinase 98E	0.012
kibra	kibra ortholog	0.012
fd59A	forkhead domain 59A	0.012
Fer1HCH	Ferritin 1 heavy chain homologue	0.012
Gr43a	Gustatory receptor 43a	0.012
srpk79D	serine-arginine protein kinase at 79D	0.012
CG11638	CG11638 gene product from transcript CG11638-RA	0.012
CG4294	CG4294 gene product from transcript CG4294-RB	0.012
CG12772	CG12772 gene product from transcript CG12772-RA	0.012
rl	rolled	0.012
tey	teyrha-meyrha	0.012
GABA-B-R3	metabotropic GABA-B receptor subtype 3	0.011	Fly
Nmdar1	NMDA receptor 1	0.011
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.011
CG14299	CG14299 gene product from transcript CG14299-RC	0.011
CG4660	CG4660 gene product from transcript CG4660-RA	0.011
beat-Vb	CG31298 gene product from transcript CG31298-RA	0.011
CG10804	CG10804 gene product from transcript CG10804-RB	0.011
CG11221	CG11221 gene product from transcript CG11221-RA	0.011
dpr11	CG33202 gene product from transcript CG33202-RB	0.011
zfh2	Zn finger homeodomain 2	0.011
syd	sunday driver	0.011
Nep1	Neprilysin 1	0.011
Socs36E	Suppressor of cytokine signaling at 36E	0.011
jet	jetlag	0.011
Wnt6	CG4969 gene product from transcript CG4969-RB	0.011
Mkp3	Mitogen-activated protein kinase phosphatase 3	0.011
Sox102F	CG11153 gene product from transcript CG11153-RB	0.011
CG13062	CG13062 gene product from transcript CG13062-RB	0.011
CG9384	CG9384 gene product from transcript CG9384-RA	0.011
mol	moladietz	0.011
Takr99D	Tachykinin-like receptor at 99D	0.011
HLH4C	Helix loop helix protein 4C	0.011
Mekk1	CG7717 gene product from transcript CG7717-RB	0.011
CG31663	CG31663 gene product from transcript CG31663-RA	0.011
CG13995	CG13995 gene product from transcript CG13995-RA	0.011
CG4025	CG4025 gene product from transcript CG4025-RA	0.011
bchs	blue cheese	0.011
H15	CG6604 gene product from transcript CG6604-RA	0.011
CG16789	CG16789 gene product from transcript CG16789-RA	0.011
stg1	stargazin-like protein	0.011
Npc2c	Niemann-Pick type C-2c	0.011
bru-3	bruno-3	0.011
ATP7	CG1886 gene product from transcript CG1886-RB	0.011
CG6495	CG6495 gene product from transcript CG6495-RA	0.011
CG15088	CG15088 gene product from transcript CG15088-RC	0.011
CG11753	CG11753 gene product from transcript CG11753-RA	0.011
cv	crossveinless	0.011
Lasp	CG3849 gene product from transcript CG3849-RB	0.010
Ctr1A	Copper transporter 1A	0.010
tsg	twisted gastrulation	0.010
CG16791	CG16791 gene product from transcript CG16791-RA	0.010
mAcR-60C	muscarinic Acetylcholine Receptor 60C	0.010
e	ebony	0.010
CG15784	CG15784 gene product from transcript CG15784-RA	0.010
CG14869	CG14869 gene product from transcript CG14869-RB	0.010
Nmdar2	NMDA receptor 2	0.010
Teh3	tipE homolog 3	0.010
Rbcn-3A	Rabconnectin-3A	0.010
CG12090	CG12090 gene product from transcript CG12090-RB	0.010
SIFR	SIFamide receptor	0.010
Golgin84	CG17785 gene product from transcript CG17785-RA	0.010