IMP: Integrative Multi-species Prediction

Drosophila melanogaster

18 genes annotated in fly

negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway

Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.

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Known genes in the process in flyInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Mad	Mothers against dpp	0.954	Fly
tkv	thickveins	0.825	Fly
Ras85D	Ras oncogene at 85D	0.786
hh	hedgehog	0.538
Egfr	Epidermal growth factor receptor	0.385
wit	wishful thinking	0.354	Fly
babo	baboon	0.250	Fly
sbb	scribbler	0.161
kay	kayak	0.160
put	punt	0.137	Worm Fly
daw	dawdle	0.134
ash1	absent, small, or homeotic discs 1	0.127
gbb	glass bottom boat	0.116
Sulf1	Sulfated	0.111
cwo	clockwork orange	0.111
cv-2	crossveinless 2	0.109
ci	cubitus interruptus	0.105
pho	pleiohomeotic	0.102
fu	fused	0.095
Dad	Daughters against dpp	0.095
CG14614	CG14614 gene product from transcript CG14614-RA	0.089
Lasp	CG3849 gene product from transcript CG3849-RB	0.087
Ubqn	Ubiquilin	0.087
wun	wunen	0.084
mof	males absent on the first	0.079
JIL-1	CG6297 gene product from transcript CG6297-RA	0.078
mxc	multi sex combs	0.073
NFAT	NFAT homolog	0.071
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.064
calypso	CG8445 gene product from transcript CG8445-RB	0.063
kis	kismet	0.059
kek5	kekkon5	0.057
endoA	endophilin A	0.055
CG9139	CG9139 gene product from transcript CG9139-RA	0.053
Hcf	Host cell factor	0.053
Suv4-20	CG13363 gene product from transcript CG13363-RA	0.053
neuroligin	CG13772 gene product from transcript CG13772-RA	0.052
mael	maelstrom	0.046
CG31122	CG31122 gene product from transcript CG31122-RA	0.045
ast	asteroid	0.043
argos	CG4531 gene product from transcript CG4531-RA	0.043
msl-2	male-specific lethal 2	0.043
park	parkin	0.042
sqz	squeeze	0.042
mei-41	meiotic 41	0.041
rl	rolled	0.040
dpn	deadpan	0.038
ey	eyeless	0.037
dpp	decapentaplegic	0.036
l(2)gl	lethal (2) giant larvae	0.036
Eip93F	CG18389 gene product from transcript CG18389-RB	0.035
stj	straightjacket	0.035
chrw	chrowded	0.034
Eip63E	Ecdysone-induced protein 63E	0.034
tok	tolkin	0.034
piwi	CG6122 gene product from transcript CG6122-RA	0.033	Zebrafish
GluRIIA	Glutamate receptor IIA	0.033
CG10200	CG10200 gene product from transcript CG10200-RB	0.032
Sara	Smad anchor for receptor activation	0.032
Med	Medea	0.032	Fly
wnd	wallenda	0.030
mys	myospheroid	0.030
CG11347	CG11347 gene product from transcript CG11347-RE	0.030
flfl	falafel	0.030
slpr	slipper	0.030
msl-3	male-specific lethal 3	0.030
Nsf2	NEM-sensitive fusion protein 2	0.029
Acsl	Acyl-CoA synthetase long-chain	0.029
gro	groucho	0.029
Atg18	Autophagy-specific gene 18	0.028
brk	brinker	0.028
nuf	nuclear fallout	0.028
zfh2	Zn finger homeodomain 2	0.028
rst	roughest	0.028
CG6051	CG6051 gene product from transcript CG6051-RB	0.028
Dap160	Dynamin associated protein 160	0.027
msl-1	male-specific lethal 1	0.027
foxo	forkhead box, sub-group O	0.027
stet	stem cell tumor	0.027
EloA	Elongin A	0.027
dm	diminutive	0.027
oys	oysgedart	0.026
CG9940	CG9940 gene product from transcript CG9940-RB	0.026
pll	pelle	0.026
aub	aubergine	0.026	Zebrafish
Irk2	Inwardly rectifying potassium channel 2	0.025
Glut1	Glucose transporter 1	0.025
cic	capicua	0.025
Su(z)2	Suppressor of zeste 2	0.025
InR	Insulin-like receptor	0.024
Dhc64C	Dynein heavy chain 64C	0.024
tamo	CG4057 gene product from transcript CG4057-RA	0.024
Fak56D	Focal Adhesion Kinase	0.023
ns2	nucleostemin 2	0.023
LamC	Lamin C	0.023
CG8090	CG8090 gene product from transcript CG8090-RB	0.022
stwl	stonewall	0.022
lkb1	CG9374 gene product from transcript CG9374-RJ	0.022
CG10103	CG10103 gene product from transcript CG10103-RA	0.022
CG30372	CG30372 gene product from transcript CG30372-RC	0.021
Chd1	Chromodomain-helicase-DNA-binding protein 1	0.021
coro	CG9446 gene product from transcript CG9446-RC	0.021
CG31038	CG31038 gene product from transcript CG31038-RA	0.021
HLHm5	E(spl) region transcript m5	0.021
zpg	zero population growth	0.020
CG6701	CG6701 gene product from transcript CG6701-RD	0.020
rempA	reduced mechanoreceptor potential A	0.020
sub	subito	0.020
Smg6	CG6369 gene product from transcript CG6369-RA	0.020
betaggt-I	beta subunit of type I geranylgeranyl transferase	0.019
Kr-h1	Kruppel homolog 1	0.019
ATP7	CG1886 gene product from transcript CG1886-RB	0.019
caz	cabeza	0.019
sog	short gastrulation	0.019	Human Zebrafish Mouse
CG31146	CG31146 gene product from transcript CG31146-RD	0.019
svr	silver	0.019
ct	cut	0.019
ab	abrupt	0.019
Mtp	Microsomal triacylglycerol transfer protein	0.018
Sdc	Syndecan	0.018
Pli	Pellino	0.018
Sir2	CG5216 gene product from transcript CG5216-RA	0.018	Mouse
CG3194	CG3194 gene product from transcript CG3194-RB	0.018
Mer	Merlin	0.018
CG9086	CG9086 gene product from transcript CG9086-RA	0.018
CG14782	CG14782 gene product from transcript CG14782-RA	0.018
alc	alicorn	0.018
tipE	temperature-induced paralytic E	0.018
mGluRA	metabotropic glutamate receptor	0.018
bam	bag of marbles	0.017
cv	crossveinless	0.017	Mouse
CG32066	CG32066 gene product from transcript CG32066-RC	0.017
mri	mrityu	0.017
betaInt-nu	beta[nu] integrin	0.017
egg	eggless	0.017
not	non-stop	0.017
rpr	reaper	0.016
mp	multiplexin	0.016
if	inflated	0.016
Su(dx)	Suppressor of deltex	0.016	Fly
alpha-Adaptin	CG4260 gene product from transcript CG4260-RA	0.015
neb	nebbish	0.015
Adar	Adenosine deaminase acting on RNA	0.015
Hr39	Hormone receptor-like in 39	0.015
eya	eyes absent	0.015
lz	lozenge	0.015
squ	squash	0.015
Taf4	TBP-associated factor 4	0.015
nan	nanchung	0.015
para	paralytic	0.015
lqf	liquid facets	0.015
trbl	tribbles	0.015
tefu	telomere fusion	0.015
CG8765	CG8765 gene product from transcript CG8765-RA	0.015
RhoGAP100F	CG1976 gene product from transcript CG1976-RB	0.015
fwd	four wheel drive	0.014
aay	astray	0.014
wds	will die slowly	0.014
Ssdp	Sequence-specific single-stranded DNA-binding protein	0.014
PGRP-LF	Peptidoglycan recognition protein LF	0.014
egh	egghead	0.014
Atg1	Autophagy-specific gene 1	0.014
Mical	Molecule interacting with CasL	0.014
Aut1	CG6877 gene product from transcript CG6877-RA	0.014
Su(var)3-7	Suppressor of variegation 3-7	0.014
Hip1	Huntingtin interacting protein 1	0.014
pon	partner of numb	0.013
Gfr	CG9620 gene product from transcript CG9620-RA	0.013
aop	anterior open	0.013
brn	brainiac	0.013
CG17184	CG17184 gene product from transcript CG17184-RB	0.013
CSN1b	COP9 complex homolog subunit 1 b	0.013
amos	absent MD neurons and olfactory sensilla	0.013
A2bp1	Ataxin-2 binding protein 1	0.013
tsg	twisted gastrulation	0.013
CG15658	CG15658 gene product from transcript CG15658-RA	0.013
Tsp68C	Tetraspanin 68C	0.012
N	Notch	0.012	Mouse
Rpn6	Proteasome p44.5 subunit	0.012
CG2950	CG2950 gene product from transcript CG2950-RD	0.012
Taz	Tafazzin	0.012
Rab3	Rab-protein 3	0.012
RagA	CG11968 gene product from transcript CG11968-RA	0.012
tan	tantalus	0.012
Dp1	Dodeca-satellite-binding protein 1	0.012
fng	fringe	0.012
Sema-1b	CG6446 gene product from transcript CG6446-RA	0.012
adp	adipose	0.012
CG8486	CG8486 gene product from transcript CG8486-RE	0.012
hts	hu li tai shao	0.012
tsh	teashirt	0.012
CG5674	CG5674 gene product from transcript CG5674-RB	0.012
Stat92E	Signal-transducer and activator of transcription protein at 92E	0.012
SNF4Agamma	SNF4/AMP-activated protein kinase gamma subunit	0.012
Nrx-1	Neurexin 1	0.011
Snap25	Synapse protein 25	0.011
Stam	Signal transducing adaptor molecule	0.011
CG3632	CG3632 gene product from transcript CG3632-RH	0.011
par-1	CG8201 gene product from transcript CG8201-RA	0.011
Socs44A	Suppressor of Cytokine Signaling at 44A	0.011
ClC-c	Chloride channel-c	0.011
wisp	wispy	0.011
CG42863	CG42863 gene product from transcript CG42863-RB	0.011
CG10431	CG10431 gene product from transcript CG10431-RA	0.011
ash2	absent, small, or homeotic discs 2	0.011
hth	homothorax	0.011
boi	brother of iHog	0.010
Pak3	CG14895 gene product from transcript CG14895-RA	0.010
MED19	Mediator complex subunit 19	0.010
krz	kurtz	0.010
Apc2	Adenomatous polyposis coli tumor suppressor homolog 2	0.010
dsh	dishevelled	0.010
milt	milton	0.010
sty	sprouty	0.010
sls	sallimus	0.010
H	Hairless	0.010
nwk	nervous wreck	0.010
CG33056	CG33056 gene product from transcript CG33056-RA	0.010
MCPH1	Microcephalin	0.010
shn	schnurri	0.010
rictor	rapamycin-insensitive companion of Tor	0.010