IMP
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fibroblast growth factor receptor signaling pathway involved in mammary gland specification
The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes.
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Click on a gene's description to view its network relationships with genes known to be involved in "fibroblast growth factor receptor signaling pathway involved in mammary gland specification"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| FGF10 | fibroblast growth factor 10 | 1.000 | ||
| FGFR2 | fibroblast growth factor receptor 2 | 1.000 | Mouse | |
| FGF1 | fibroblast growth factor 1 (acidic) | 1.000 | Human | |
| FGFR1 | fibroblast growth factor receptor 1 | 1.000 | ||
| FGF7 | fibroblast growth factor 7 | 1.000 | Human | |
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.996 | ||
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.992 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.964 | ||
| FGFR3 | fibroblast growth factor receptor 3 | 0.948 | ||
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.948 | ||
| FGF3 | fibroblast growth factor 3 | 0.495 | Human | |
| CTGF | connective tissue growth factor | 0.471 | ||
| FGF2 | fibroblast growth factor 2 (basic) | 0.443 | Human | |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.314 | ||
| FGF4 | fibroblast growth factor 4 | 0.257 | Human | |
| WNT1 | wingless-type MMTV integration site family, member 1 | 0.253 | ||
| FGF6 | fibroblast growth factor 6 | 0.129 | Human | |
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.109 | ||
| FGF19 | fibroblast growth factor 19 | 0.093 | ||
| THBS1 | thrombospondin 1 | 0.082 | ||
| PSG9 | pregnancy specific beta-1-glycoprotein 9 | 0.082 | ||
| PRDM8 | PR domain containing 8 | 0.082 | ||
| LHX5 | LIM homeobox 5 | 0.070 | ||
| GFAP | glial fibrillary acidic protein | 0.064 | ||
| CNTN1 | contactin 1 | 0.063 | ||
| ECEL1 | endothelin converting enzyme-like 1 | 0.061 | ||
| FGF5 | fibroblast growth factor 5 | 0.059 | Human | |
| WNT3 | wingless-type MMTV integration site family, member 3 | 0.057 | ||
| MOS | v-mos Moloney murine sarcoma viral oncogene homolog | 0.054 | ||
| NKX2-1 | NK2 homeobox 1 | 0.053 | ||
| T | T, brachyury homolog (mouse) | 0.053 | ||
| SEZ6L | seizure related 6 homolog (mouse)-like | 0.053 | ||
| PSG6 | pregnancy specific beta-1-glycoprotein 6 | 0.049 | ||
| PRDM12 | PR domain containing 12 | 0.049 | ||
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 | 0.047 | ||
| NKX6-2 | NK6 homeobox 2 | 0.046 | ||
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.043 | ||
| FOXN4 | forkhead box N4 | 0.042 | ||
| PGR | progesterone receptor | 0.042 | ||
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.042 | ||
| KAL1 | Kallmann syndrome 1 sequence | 0.041 | ||
| KRT34 | keratin 34 | 0.040 | ||
| LBX1 | ladybird homeobox 1 | 0.040 | ||
| PTH | parathyroid hormone | 0.040 | ||
| WNT9B | wingless-type MMTV integration site family, member 9B | 0.039 | ||
| VSX1 | visual system homeobox 1 | 0.039 | ||
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.036 | ||
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | 0.034 | ||
| GJC2 | gap junction protein, gamma 2, 47kDa | 0.032 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.032 | ||
| BDNF | brain-derived neurotrophic factor | 0.032 | ||
| JPH2 | junctophilin 2 | 0.030 | ||
| TMEM59L | transmembrane protein 59-like | 0.029 | ||
| ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary) | 0.028 | ||
| ERAS | ES cell expressed Ras | 0.027 | ||
| CRHR1 | corticotropin releasing hormone receptor 1 | 0.027 | ||
| ADRA1A | adrenergic, alpha-1A-, receptor | 0.026 | ||
| DGKI | diacylglycerol kinase, iota | 0.025 | ||
| ELAVL2 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) | 0.025 | ||
| GBX1 | gastrulation brain homeobox 1 | 0.025 | ||
| FOXL1 | forkhead box L1 | 0.024 | ||
| DNMT3L | DNA (cytosine-5-)-methyltransferase 3-like | 0.023 | ||
| FGFR4 | fibroblast growth factor receptor 4 | 0.023 | ||
| TMSB4Y | thymosin beta 4, Y-linked | 0.023 | ||
| GDF3 | growth differentiation factor 3 | 0.023 | ||
| ZNF536 | zinc finger protein 536 | 0.022 | ||
| RSPO3 | R-spondin 3 homolog (Xenopus laevis) | 0.022 | ||
| EVX1 | even-skipped homeobox 1 | 0.022 | ||
| OGN | osteoglycin | 0.022 | ||
| KCNK2 | potassium channel, subfamily K, member 2 | 0.022 | ||
| SIX6 | SIX homeobox 6 | 0.021 | ||
| HAS2 | hyaluronan synthase 2 | 0.021 | ||
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 0.021 | ||
| BARHL1 | BarH-like homeobox 1 | 0.021 | ||
| NEUROG2 | neurogenin 2 | 0.021 | ||
| EPHA5 | EPH receptor A5 | 0.020 | ||
| TBX5 | T-box 5 | 0.020 | ||
| DRD2 | dopamine receptor D2 | 0.020 | ||
| PAX1 | paired box 1 | 0.020 | ||
| CALB1 | calbindin 1, 28kDa | 0.020 | ||
| FOXD3 | forkhead box D3 | 0.020 | ||
| RSPO2 | R-spondin 2 homolog (Xenopus laevis) | 0.020 | ||
| NPY1R | neuropeptide Y receptor Y1 | 0.019 | ||
| TRPM3 | transient receptor potential cation channel, subfamily M, member 3 | 0.019 | ||
| NOL4 | nucleolar protein 4 | 0.019 | ||
| GSC | goosecoid homeobox | 0.019 | ||
| NTSR2 | neurotensin receptor 2 | 0.019 | ||
| PAX8 | paired box 8 | 0.018 | ||
| BHLHE23 | basic helix-loop-helix family, member e23 | 0.018 | ||
| GDNF | glial cell derived neurotrophic factor | 0.018 | ||
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.018 | ||
| HCN4 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4 | 0.018 | ||
| ESRRB | estrogen-related receptor beta | 0.018 | ||
| CCL24 | chemokine (C-C motif) ligand 24 | 0.017 | ||
| SLC5A5 | solute carrier family 5 (sodium iodide symporter), member 5 | 0.017 | ||
| DNAJB8 | DnaJ (Hsp40) homolog, subfamily B, member 8 | 0.017 | ||
| SPOCK3 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.017 | ||
| POU4F2 | POU class 4 homeobox 2 | 0.017 | ||
| DPEP3 | dipeptidase 3 | 0.017 | ||
| CDH8 | cadherin 8, type 2 | 0.016 | ||
| NKD2 | naked cuticle homolog 2 (Drosophila) | 0.016 | ||
| TLX1 | T-cell leukemia homeobox 1 | 0.016 | ||
| SHB | Src homology 2 domain containing adaptor protein B | 0.016 | ||
| AMN | amnionless homolog (mouse) | 0.016 | ||
| LHX3 | LIM homeobox 3 | 0.016 | ||
| AIPL1 | aryl hydrocarbon receptor interacting protein-like 1 | 0.016 | ||
| HES7 | hairy and enhancer of split 7 (Drosophila) | 0.016 | ||
| KCNJ14 | potassium inwardly-rectifying channel, subfamily J, member 14 | 0.016 | ||
| KCNB1 | potassium voltage-gated channel, Shab-related subfamily, member 1 | 0.015 | ||
| ABO | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 0.015 | ||
| ZFHX4 | zinc finger homeobox 4 | 0.015 | ||
| NOVA1 | neuro-oncological ventral antigen 1 | 0.015 | ||
| KIF25 | kinesin family member 25 | 0.015 | ||
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | 0.015 | ||
| MIXL1 | Mix1 homeobox-like 1 (Xenopus laevis) | 0.015 | ||
| IFNA8 | interferon, alpha 8 | 0.015 | ||
| KLHL1 | kelch-like 1 (Drosophila) | 0.015 | ||
| MYL10 | myosin, light chain 10, regulatory | 0.015 | ||
| HBZ | hemoglobin, zeta | 0.014 | ||
| FOXA2 | forkhead box A2 | 0.014 | ||
| NGF | nerve growth factor (beta polypeptide) | 0.014 | ||
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | 0.014 | ||
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.014 | ||
| FRMPD4 | FERM and PDZ domain containing 4 | 0.014 | ||
| CRH | corticotropin releasing hormone | 0.014 | ||
| SCTR | secretin receptor | 0.014 | ||
| KLF15 | Kruppel-like factor 15 | 0.013 | ||
| ALX1 | ALX homeobox 1 | 0.013 | ||
| HAND1 | heart and neural crest derivatives expressed 1 | 0.013 | ||
| HOXC5 | homeobox C5 | 0.013 | ||
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.013 | ||
| PSPN | persephin | 0.013 | ||
| ADRA1D | adrenergic, alpha-1D-, receptor | 0.013 | ||
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 0.013 | ||
| KCNQ3 | potassium voltage-gated channel, KQT-like subfamily, member 3 | 0.013 | ||
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.013 | ||
| ANGPT4 | angiopoietin 4 | 0.013 | ||
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.013 | ||
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.013 | ||
| CALCA | calcitonin-related polypeptide alpha | 0.013 | ||
| PSG3 | pregnancy specific beta-1-glycoprotein 3 | 0.013 | ||
| EGF | epidermal growth factor | 0.013 | ||
| CHRNA4 | cholinergic receptor, nicotinic, alpha 4 | 0.012 | ||
| TRPM1 | transient receptor potential cation channel, subfamily M, member 1 | 0.012 | ||
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.012 | ||
| MAB21L1 | mab-21-like 1 (C. elegans) | 0.012 | ||
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.012 | ||
| RIC3 | resistance to inhibitors of cholinesterase 3 homolog (C. elegans) | 0.012 | ||
| SLC6A19 | solute carrier family 6 (neutral amino acid transporter), member 19 | 0.012 | ||
| DRD1 | dopamine receptor D1 | 0.012 | ||
| HOXD1 | homeobox D1 | 0.012 | ||
| DCC | deleted in colorectal carcinoma | 0.012 | ||
| SLC4A4 | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.012 | ||
| RGS4 | regulator of G-protein signaling 4 | 0.012 | ||
| EPHA8 | EPH receptor A8 | 0.012 | ||
| MSTN | myostatin | 0.012 | ||
| C11orf41 | chromosome 11 open reading frame 41 | 0.012 | ||
| PSG5 | pregnancy specific beta-1-glycoprotein 5 | 0.012 | ||
| CBLN1 | cerebellin 1 precursor | 0.012 | ||
| BNC1 | basonuclin 1 | 0.012 | ||
| DPF3 | D4, zinc and double PHD fingers, family 3 | 0.011 | ||
| AFF2 | AF4/FMR2 family, member 2 | 0.011 | ||
| NAV3 | neuron navigator 3 | 0.011 | ||
| CDX4 | caudal type homeobox 4 | 0.011 | ||
| PDE10A | phosphodiesterase 10A | 0.011 | ||
| TLX3 | T-cell leukemia homeobox 3 | 0.011 | ||
| SLC16A8 | solute carrier family 16, member 8 (monocarboxylic acid transporter 3) | 0.011 | ||
| SSTR1 | somatostatin receptor 1 | 0.011 | ||
| CHRND | cholinergic receptor, nicotinic, delta | 0.011 | ||
| GRB14 | growth factor receptor-bound protein 14 | 0.011 | ||
| NOS1 | nitric oxide synthase 1 (neuronal) | 0.011 | ||
| CD70 | CD70 molecule | 0.011 | ||
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 0.011 | ||
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 0.011 | ||
| IL3 | interleukin 3 (colony-stimulating factor, multiple) | 0.011 | ||
| GALR1 | galanin receptor 1 | 0.010 | ||
| CPA1 | carboxypeptidase A1 (pancreatic) | 0.010 | ||
| SOX1 | SRY (sex determining region Y)-box 1 | 0.010 | ||
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.010 | ||
| GPR45 | G protein-coupled receptor 45 | 0.010 | ||
| TP73 | tumor protein p73 | 0.010 | ||
| BCAN | brevican | 0.010 | ||
| LRTM2 | leucine-rich repeats and transmembrane domains 2 | 0.010 | ||
| ADAMTS3 | ADAM metallopeptidase with thrombospondin type 1 motif, 3 | 0.010 | ||
| KRT83 | keratin 83 | 0.010 |