IMP: Integrative Multi-species Prediction

Homo sapiens

25 genes annotated in human

Multi-species View

gamete generation

GO:0007276

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "gamete generation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "gamete generation" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.717	Fly
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.217	Fly
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.159	Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.159	Fly
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.129	Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.094	Mouse Fly
CREBBP	CREB binding protein	0.093	Worm
ATXN1	ataxin 1	0.090
PABPC1	poly(A) binding protein, cytoplasmic 1	0.085	Worm
ATF2	activating transcription factor 2	0.074
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.071	Worm Fly
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.071	Fly
SMAD3	SMAD family member 3	0.071
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.069	Fly
ESR1	estrogen receptor 1	0.065
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.062	Rat
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.052	Worm
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.050	Worm
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.050
TCP1	t-complex 1	0.050
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.050	Fly
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.048	Worm
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.047
RB1	retinoblastoma 1	0.047
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.047	Fly
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.046
GSK3B	glycogen synthase kinase 3 beta	0.045	Worm Fly
BRCA1	breast cancer 1, early onset	0.044
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.043
SNRPD1	small nuclear ribonucleoprotein D1 polypeptide 16kDa	0.040	Worm
SNRPG	small nuclear ribonucleoprotein polypeptide G	0.038
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.038	Fly
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.038	Fly
TARDBP	TAR DNA binding protein	0.038
QKI	quaking homolog, KH domain RNA binding (mouse)	0.037	Mouse Worm Fly
EGFR	epidermal growth factor receptor	0.035	Worm Fly
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.035	Fly
BRCA2	breast cancer 2, early onset	0.035	Mouse
SP1	Sp1 transcription factor	0.034
SSB	Sjogren syndrome antigen B (autoantigen La)	0.034
SF3B1	splicing factor 3b, subunit 1, 155kDa	0.033	Worm
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.033
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.031	Worm Fly
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.031	Worm
SFN	stratifin	0.031	Fly
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.030
APC	adenomatous polyposis coli	0.029	Fly
TNRC6A	trinucleotide repeat containing 6A	0.029
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.029
MAPK14	mitogen-activated protein kinase 14	0.028
SNRPE	small nuclear ribonucleoprotein polypeptide E	0.027	Worm
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.027
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.027	Fly
EP300	E1A binding protein p300	0.027	Worm
CSNK2B	casein kinase 2, beta polypeptide	0.027
SRSF1	serine/arginine-rich splicing factor 1	0.027
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.027	Worm
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.026
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.025
EIF3H	eukaryotic translation initiation factor 3, subunit H	0.025
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.025
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.024
HDAC1	histone deacetylase 1	0.023
FLNA	filamin A, alpha	0.023	Worm Fly
PBK	PDZ binding kinase	0.023
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.023	Worm Fly
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.023	Worm Fly
WDR5	WD repeat domain 5	0.023
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.023	Mouse Fly
RHOA	ras homolog gene family, member A	0.022	Worm Fly
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.022
CDK2	cyclin-dependent kinase 2	0.022
MCM7	minichromosome maintenance complex component 7	0.021
UBC	ubiquitin C	0.021	Fly
EED	embryonic ectoderm development	0.021
IQGAP1	IQ motif containing GTPase activating protein 1	0.021
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.020
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.020	Fly
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.020
GNB2L1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.020	Fly
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.019
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.019	Fly
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.019
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.019	Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.019	Fly
PNN	pinin, desmosome associated protein	0.019
SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	0.019	Fly
JUN	jun proto-oncogene	0.018	Fly
FGFR1	fibroblast growth factor receptor 1	0.018	Fly
PRKCZ	protein kinase C, zeta	0.018
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.018	Worm
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.018	Fly
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.018
SRSF2	serine/arginine-rich splicing factor 2	0.018
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.018
RPS6	ribosomal protein S6	0.018	Mouse
JAG1	jagged 1	0.018	Human
CSNK1E	casein kinase 1, epsilon	0.018
MPRIP	myosin phosphatase Rho interacting protein	0.018
BCL3	B-cell CLL/lymphoma 3	0.018	Fly
AXIN1	axin 1	0.018	Fly
HSPA4	heat shock 70kDa protein 4	0.017
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.017	Fly
LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.017
WIPF1	WAS/WASL interacting protein family, member 1	0.017
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.017
RPL5	ribosomal protein L5	0.017
FYN	FYN oncogene related to SRC, FGR, YES	0.017	Fly
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.017
CANX	calnexin	0.017
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.017	Worm Fly
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.017
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.017
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.017
RBM8A	RNA binding motif protein 8A	0.017	Fly
EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	0.017
PCBP1	poly(rC) binding protein 1	0.017
SMAD4	SMAD family member 4	0.017	Fly
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.016	Zebrafish
PAPOLA	poly(A) polymerase alpha	0.016	Worm
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.016	Fly
TP53	tumor protein p53	0.016	Zebrafish Fly
PKM2	pyruvate kinase, muscle	0.016
SRPK2	SRSF protein kinase 2	0.016	Worm Fly
NCL	nucleolin	0.016
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.016	Worm Fly
NOTCH1	notch 1	0.016	Rat Fly
SNAP25	synaptosomal-associated protein, 25kDa	0.016
SRSF10	serine/arginine-rich splicing factor 10	0.016
FBXW11	F-box and WD repeat domain containing 11	0.016	Fly
RPL7	ribosomal protein L7	0.016
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.016
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.016
GRB2	growth factor receptor-bound protein 2	0.016
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.016	Fly
AATF	apoptosis antagonizing transcription factor	0.016
SNW1	SNW domain containing 1	0.016	Worm
BCR	breakpoint cluster region	0.015
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.015
PRPF19	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	0.015
CBX3	chromobox homolog 3	0.015	Worm
TNRC6B	trinucleotide repeat containing 6B	0.015
JUNB	jun B proto-oncogene	0.015	Fly
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.015
RIPK2	receptor-interacting serine-threonine kinase 2	0.015
HSPH1	heat shock 105kDa/110kDa protein 1	0.015
ZHX1	zinc fingers and homeoboxes 1	0.015
BTRC	beta-transducin repeat containing	0.015	Fly
CTNNBL1	catenin, beta like 1	0.015
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.015	Fly
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.015
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.015
ANAPC5	anaphase promoting complex subunit 5	0.015
C14orf1	chromosome 14 open reading frame 1	0.015
SRSF3	serine/arginine-rich splicing factor 3	0.015	Worm
CUL4A	cullin 4A	0.015
IRS1	insulin receptor substrate 1	0.015	Fly
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.014	Worm Fly
PBX1	pre-B-cell leukemia homeobox 1	0.014
EIF3L	eukaryotic translation initiation factor 3, subunit L	0.014
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.014	Fly
RNF126	ring finger protein 126	0.014
MAPK1	mitogen-activated protein kinase 1	0.014	Worm
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.014	Fly
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.014	Fly
SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	0.014	Fly
SNX9	sorting nexin 9	0.014
MEN1	multiple endocrine neoplasia I	0.014
RBM39	RNA binding motif protein 39	0.014
RPL10A	ribosomal protein L10a	0.014
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.014
BAD	BCL2-associated agonist of cell death	0.014
CNOT7	CCR4-NOT transcription complex, subunit 7	0.014
RBBP8	retinoblastoma binding protein 8	0.013
H2AFX	H2A histone family, member X	0.013	Mouse
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.013
RANBP2	RAN binding protein 2	0.013
PHC2	polyhomeotic homolog 2 (Drosophila)	0.013	Mouse Fly
MAPK8	mitogen-activated protein kinase 8	0.013	Fly
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.013
NUDC	nuclear distribution gene C homolog (A. nidulans)	0.013
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.013
UBXN7	UBX domain protein 7	0.013
PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	0.013
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.013	Fly
PDIA3	protein disulfide isomerase family A, member 3	0.013
CUL3	cullin 3	0.013
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.013
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.013
TCERG1	transcription elongation regulator 1	0.013
SRPK1	SRSF protein kinase 1	0.013	Worm Fly
SH3KBP1	SH3-domain kinase binding protein 1	0.013	Fly
FANCD2	Fanconi anemia, complementation group D2	0.012	Mouse
ARHGAP1	Rho GTPase activating protein 1	0.012
IL1RAP	interleukin 1 receptor accessory protein	0.012
RBL2	retinoblastoma-like 2 (p130)	0.012
EIF4B	eukaryotic translation initiation factor 4B	0.012
MAPK6	mitogen-activated protein kinase 6	0.012
YAP1	Yes-associated protein 1	0.012	Fly
EIF4A3	eukaryotic translation initiation factor 4A3	0.012	Worm Fly
PTBP1	polypyrimidine tract binding protein 1	0.012	Fly
RUVBL2	RuvB-like 2 (E. coli)	0.012
LAT	linker for activation of T cells	0.012
DHX15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.012	Worm
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.012
BMPR1A	bone morphogenetic protein receptor, type IA	0.012	Fly
RPL6	ribosomal protein L6	0.012
MKI67IP	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.012
CUL4B	cullin 4B	0.012	Fly
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.012
HMGB1	high mobility group box 1	0.012
TSC2	tuberous sclerosis 2	0.012	Fly
PUF60	poly-U binding splicing factor 60KDa	0.012	Worm Fly
ARF4	ADP-ribosylation factor 4	0.012	Worm
LSM6	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.012
HMGA1	high mobility group AT-hook 1	0.012	Mouse
CACYBP	calcyclin binding protein	0.012
HSPA8	heat shock 70kDa protein 8	0.012
ZNF746	zinc finger protein 746	0.012
MCMBP	minichromosome maintenance complex binding protein	0.012
SART1	squamous cell carcinoma antigen recognized by T cells	0.012	Worm
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.011
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.011
NOP56	NOP56 ribonucleoprotein homolog (yeast)	0.011
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.011	Worm
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.011	Fly
ILF3	interleukin enhancer binding factor 3, 90kDa	0.011
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.011
NOTCH3	notch 3	0.011	Fly
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.011	Worm
TRA2B	transformer 2 beta homolog (Drosophila)	0.011
PML	promyelocytic leukemia	0.011
RBPMS	RNA binding protein with multiple splicing	0.011
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.011
PSEN1	presenilin 1	0.011
JUP	junction plakoglobin	0.011	Fly
SYK	spleen tyrosine kinase	0.011	Fly
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.011
NAP1L1	nucleosome assembly protein 1-like 1	0.011
SPAG9	sperm associated antigen 9	0.011
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.011	Worm
EIF5B	eukaryotic translation initiation factor 5B	0.011
EPAS1	endothelial PAS domain protein 1	0.011	Fly
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.011
CLCN3	chloride channel 3	0.011
TNRC6C	trinucleotide repeat containing 6C	0.011
GEMIN5	gem (nuclear organelle) associated protein 5	0.011
ACTN1	actinin, alpha 1	0.011
FUBP1	far upstream element (FUSE) binding protein 1	0.011	Fly
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.011
IGF1R	insulin-like growth factor 1 receptor	0.011	Zebrafish Worm Fly
PTBP2	polypyrimidine tract binding protein 2	0.011	Fly
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.011	Worm Fly
CAND1	cullin-associated and neddylation-dissociated 1	0.011
EIF3I	eukaryotic translation initiation factor 3, subunit I	0.011
PICALM	phosphatidylinositol binding clathrin assembly protein	0.011
PTPRC	protein tyrosine phosphatase, receptor type, C	0.011
TMSB4X	thymosin beta 4, X-linked	0.011
EBNA1BP2	EBNA1 binding protein 2	0.011
KLF6	Kruppel-like factor 6	0.011
NXF1	nuclear RNA export factor 1	0.011
RPS8	ribosomal protein S8	0.011
EGR1	early growth response 1	0.011	Worm
FEN1	flap structure-specific endonuclease 1	0.011
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.011
OCRL	oculocerebrorenal syndrome of Lowe	0.011
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.011
DICER1	dicer 1, ribonuclease type III	0.011	Fly
SKP2	S-phase kinase-associated protein 2 (p45)	0.010
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.010
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.010
CHERP	calcium homeostasis endoplasmic reticulum protein	0.010
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.010
VHL	von Hippel-Lindau tumor suppressor	0.010
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.010
STIP1	stress-induced-phosphoprotein 1	0.010
WDYHV1	WDYHV motif containing 1	0.010
THOC4	THO complex 4	0.010
CD44	CD44 molecule (Indian blood group)	0.010
EIF4A2	eukaryotic translation initiation factor 4A2	0.010	Fly
TGFB1	transforming growth factor, beta 1	0.010	Mouse
TRIM28	tripartite motif containing 28	0.010
GNL2	guanine nucleotide binding protein-like 2 (nucleolar)	0.010
HDAC3	histone deacetylase 3	0.010
NUP107	nucleoporin 107kDa	0.010
RPS4X	ribosomal protein S4, X-linked	0.010
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.010
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.010
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.010
E2F4	E2F transcription factor 4, p107/p130-binding	0.010	Fly
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.010
MPDZ	multiple PDZ domain protein	0.010
CKS2	CDC28 protein kinase regulatory subunit 2	0.010
ACTR1A	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.010
BLNK	B-cell linker	0.010
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.010	Worm Fly