IMP: Integrative Multi-species Prediction

Homo sapiens

1 genes annotated in human

Multi-species View

positive regulation of granzyme b production

GO:0071663

Any process that activates or increases the frequency, rate, or extent of production of granzyme B.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of granzyme b production"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of granzyme b production" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CCL4	chemokine (C-C motif) ligand 4	0.998	Human
CCL8	chemokine (C-C motif) ligand 8	0.987	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.980
CCL5	chemokine (C-C motif) ligand 5	0.964	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.927
DPP4	dipeptidyl-peptidase 4	0.925
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.873	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.856
CCL22	chemokine (C-C motif) ligand 22	0.849	Human
IDE	insulin-degrading enzyme	0.761
CCL2	chemokine (C-C motif) ligand 2	0.732	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.732
IL8	interleukin 8	0.647
CCR7	chemokine (C-C motif) receptor 7	0.560
ICAM1	intercellular adhesion molecule 1	0.547
IL1B	interleukin 1, beta	0.532
CCL13	chemokine (C-C motif) ligand 13	0.523	Human
CCL3	chemokine (C-C motif) ligand 3	0.514	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.405
IFNG	interferon, gamma	0.399
IL6	interleukin 6 (interferon, beta 2)	0.355
CXCL13	chemokine (C-X-C motif) ligand 13	0.292
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.290
IL2RB	interleukin 2 receptor, beta	0.253
RGS1	regulator of G-protein signaling 1	0.232
CCL11	chemokine (C-C motif) ligand 11	0.232	Human
VCAM1	vascular cell adhesion molecule 1	0.229
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.189
CCL19	chemokine (C-C motif) ligand 19	0.175	Human
CCR4	chemokine (C-C motif) receptor 4	0.153
CD83	CD83 molecule	0.151
CCL7	chemokine (C-C motif) ligand 7	0.147	Human
CCR1	chemokine (C-C motif) receptor 1	0.145
IL10	interleukin 10	0.133
CH25H	cholesterol 25-hydroxylase	0.121
SELE	selectin E	0.107
LAMP3	lysosomal-associated membrane protein 3	0.102
UBD	ubiquitin D	0.100
GNLY	granulysin	0.093
CXCL5	chemokine (C-X-C motif) ligand 5	0.093
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.085
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.082
TNF	tumor necrosis factor	0.080
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.079
FPR3	formyl peptide receptor 3	0.075
IL7R	interleukin 7 receptor	0.070
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.064
CCL17	chemokine (C-C motif) ligand 17	0.059	Human
IL32	interleukin 32	0.059
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.058
ADAMDEC1	ADAM-like, decysin 1	0.053
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.052
CXCR3	chemokine (C-X-C motif) receptor 3	0.051
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.050
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.045
STAT4	signal transducer and activator of transcription 4	0.043
IL18RAP	interleukin 18 receptor accessory protein	0.042
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.040
MSC	musculin	0.038
CCR3	chemokine (C-C motif) receptor 3	0.037
IDO1	indoleamine 2,3-dioxygenase 1	0.035
IL2RG	interleukin 2 receptor, gamma	0.034
CXCR6	chemokine (C-X-C motif) receptor 6	0.033
EBI3	Epstein-Barr virus induced 3	0.032
ARRB1	arrestin, beta 1	0.031
XCL1	chemokine (C motif) ligand 1	0.030
SLAMF8	SLAM family member 8	0.029
OSMR	oncostatin M receptor	0.029
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.028
DARC	Duffy blood group, chemokine receptor	0.028
NKG7	natural killer cell group 7 sequence	0.024
CD160	CD160 molecule	0.024
XCL2	chemokine (C motif) ligand 2	0.023	Human
IL1RN	interleukin 1 receptor antagonist	0.022
APOC1	apolipoprotein C-I	0.022
C2	complement component 2	0.021
IL1R2	interleukin 1 receptor, type II	0.021
IL1A	interleukin 1, alpha	0.020
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.020
CCL20	chemokine (C-C motif) ligand 20	0.019	Human
IL18R1	interleukin 18 receptor 1	0.018
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.018
PRF1	perforin 1 (pore forming protein)	0.018
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018
RGS16	regulator of G-protein signaling 16	0.018
IL21R	interleukin 21 receptor	0.017
IL2RA	interleukin 2 receptor, alpha	0.017
GZMK	granzyme K (granzyme 3; tryptase II)	0.017
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.016
CCBP2	chemokine binding protein 2	0.016
CD80	CD80 molecule	0.015
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.015
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.015
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.015
BATF	basic leucine zipper transcription factor, ATF-like	0.015
IL10RA	interleukin 10 receptor, alpha	0.015
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.015
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.015
INHBA	inhibin, beta A	0.015
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.015
IL13	interleukin 13	0.014
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.014
IL11	interleukin 11	0.014
CD69	CD69 molecule	0.014
CTSW	cathepsin W	0.014
CCRL2	chemokine (C-C motif) receptor-like 2	0.013
CD1B	CD1b molecule	0.013
CMKLR1	chemokine-like receptor 1	0.013
SLAMF7	SLAM family member 7	0.013
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.012
MMP19	matrix metallopeptidase 19	0.012
IL7	interleukin 7	0.012
TARP	TCR gamma alternate reading frame protein	0.012
NNMT	nicotinamide N-methyltransferase	0.012
CD163	CD163 molecule	0.012
RUNX3	runt-related transcription factor 3	0.012
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.012
CLEC10A	C-type lectin domain family 10, member A	0.012
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.011
PLA1A	phospholipase A1 member A	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
GPR171	G protein-coupled receptor 171	0.011
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
BCL2A1	BCL2-related protein A1	0.011
PDPN	podoplanin	0.011
CD40	CD40 molecule, TNF receptor superfamily member 5	0.010
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.010
GPR109B	G protein-coupled receptor 109B	0.010
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.010
C1S	complement component 1, s subcomponent	0.010