7 genes annotated in humanMulti-species View
Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "calcineurin nfat signaling cascade"
|Name||Description||Probability||Func Analog Organism|
|IGF2R||insulin-like growth factor 2 receptor||0.030|
|DDX17||DEAD (Asp-Glu-Ala-Asp) box polypeptide 17||0.025|
|ITGB1BP3||integrin beta 1 binding protein 3||0.020|
|PSEN2||presenilin 2 (Alzheimer disease 4)||0.015|
|PLK3||polo-like kinase 3||0.014|