IMP
Process View
protein import into mitochondrial matrix
The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "protein import into mitochondrial matrix"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CYCS | cytochrome c, somatic | 0.978 | ||
| ETF1 | eukaryotic translation termination factor 1 | 0.956 | ||
| GRPEL1 | GrpE-like 1, mitochondrial (E. coli) | 0.829 | ||
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.819 | ||
| HSPA8 | heat shock 70kDa protein 8 | 0.683 | ||
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.497 | Yeast | |
| HSPE1 | heat shock 10kDa protein 1 (chaperonin 10) | 0.482 | ||
| IDH3A | isocitrate dehydrogenase 3 (NAD+) alpha | 0.479 | ||
| EIF5 | eukaryotic translation initiation factor 5 | 0.470 | ||
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.447 | Yeast | |
| EIF4E | eukaryotic translation initiation factor 4E | 0.398 | ||
| VDAC1 | voltage-dependent anion channel 1 | 0.354 | ||
| UBE2N | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 0.236 | ||
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.235 | ||
| HCCS | holocytochrome c synthase | 0.235 | ||
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | 0.193 | ||
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) and translocase of inner mitochondrial membrane 23 homolog (yeast) | 0.142 | Yeast | |
| TIMM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 0.132 | Yeast | |
| GSPT1 | G1 to S phase transition 1 | 0.119 | ||
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.061 | ||
| TCEB1 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | 0.060 | ||
| FASTKD5 | FAST kinase domains 5 | 0.053 | ||
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 0.049 | ||
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.048 | ||
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.043 | ||
| PPIF | peptidylprolyl isomerase F | 0.040 | ||
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | 0.039 | ||
| AMD1 | adenosylmethionine decarboxylase 1 | 0.039 | ||
| TCP1 | t-complex 1 | 0.038 | ||
| C2orf47 | chromosome 2 open reading frame 47 | 0.038 | ||
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.037 | ||
| RG9MTD1 | RNA (guanine-9-) methyltransferase domain containing 1 | 0.031 | ||
| BAG2 | BCL2-associated athanogene 2 | 0.027 | ||
| TMEM70 | transmembrane protein 70 | 0.026 | ||
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.023 | ||
| MRPL35 | mitochondrial ribosomal protein L35 | 0.022 | ||
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | 0.021 | ||
| SPG20 | spastic paraplegia 20 (Troyer syndrome) | 0.021 | ||
| EPRS | glutamyl-prolyl-tRNA synthetase | 0.020 | ||
| TSFM | Ts translation elongation factor, mitochondrial | 0.019 | ||
| NDUFAF4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 | 0.018 | ||
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.018 | ||
| GTPBP4 | GTP binding protein 4 | 0.016 | ||
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.016 | ||
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.016 | ||
| DNAJC19 | DnaJ (Hsp40) homolog, subfamily C, member 19 | 0.015 | Yeast | |
| PPID | peptidylprolyl isomerase D | 0.014 | ||
| C20orf7 | chromosome 20 open reading frame 7 | 0.014 | ||
| PGRMC1 | progesterone receptor membrane component 1 | 0.014 | ||
| COPS8 | COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) | 0.013 | ||
| TFRC | transferrin receptor (p90, CD71) | 0.013 | ||
| VDAC2 | voltage-dependent anion channel 2 | 0.013 | ||
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.012 | ||
| BZW1 | basic leucine zipper and W2 domains 1 | 0.012 | ||
| MRPL32 | mitochondrial ribosomal protein L32 | 0.012 | ||
| COPS3 | COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) | 0.011 | ||
| UBXN8 | UBX domain protein 8 | 0.011 | ||
| MRFAP1 | Morf4 family associated protein 1 | 0.011 | ||
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 0.011 | ||
| PNP | purine nucleoside phosphorylase | 0.010 | ||
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.010 | ||
| SAR1A | SAR1 homolog A (S. cerevisiae) | 0.010 |