IMP: Integrative Multi-species Prediction

Homo sapiens

10 genes annotated in human

ribosomal large subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ribosomal large subunit biogenesis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "ribosomal large subunit biogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
LYAR	Ly1 antibody reactive homolog (mouse)	0.990
GNL3	guanine nucleotide binding protein-like 3 (nucleolar)	0.957	Fly
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.893
BOP1	block of proliferation 1	0.694
SENP3	SUMO1/sentrin/SMT3 specific peptidase 3	0.685
GTPBP4	GTP binding protein 4	0.669	Yeast
GNL2	guanine nucleotide binding protein-like 2 (nucleolar)	0.665
RPL17	ribosomal protein L17	0.593
PELP1	proline, glutamate and leucine rich protein 1	0.450
MYBBP1A	MYB binding protein (P160) 1a	0.369
PUS1	pseudouridylate synthase 1	0.348
RBM28	RNA binding motif protein 28	0.300	Yeast
PES1	pescadillo homolog 1, containing BRCT domain (zebrafish)	0.296
RPL27A	ribosomal protein L27a	0.274
RPL3	ribosomal protein L3	0.263	Yeast
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.236
NOP56	NOP56 ribonucleoprotein homolog (yeast)	0.195
BTF3	basic transcription factor 3	0.186
RPL4	ribosomal protein L4	0.185
RPL18	ribosomal protein L18	0.180
DNTTIP2	deoxynucleotidyltransferase, terminal, interacting protein 2	0.178
RPL7A	ribosomal protein L7a	0.175	Yeast
CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta	0.169	Yeast
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.169
RPL31	ribosomal protein L31	0.158
DKC1	dyskeratosis congenita 1, dyskerin	0.155
EBNA1BP2	EBNA1 binding protein 2	0.146
ZC3H15	zinc finger CCCH-type containing 15	0.141
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.132
RPL29	ribosomal protein L29	0.128
RPF2	ribosome production factor 2 homolog (S. cerevisiae)	0.127	Yeast
BRIX1	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	0.124	Yeast
RPL6	ribosomal protein L6	0.119	Yeast
EEF1B2	eukaryotic translation elongation factor 1 beta 2	0.108
MPHOSPH10	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	0.103
NOL11	nucleolar protein 11	0.097
RPL36AL	ribosomal protein L36a-like	0.097
RPL14	ribosomal protein L14	0.094
RPS6	ribosomal protein S6	0.087
RRP15	ribosomal RNA processing 15 homolog (S. cerevisiae)	0.086
MKI67IP	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.086
RPL11	ribosomal protein L11	0.085
BMS1	BMS1 homolog, ribosome assembly protein (yeast)	0.085
DNAJC2	DnaJ (Hsp40) homolog, subfamily C, member 2	0.083
WDR12	WD repeat domain 12	0.077
RPL8	ribosomal protein L8	0.075
CCDC59	coiled-coil domain containing 59	0.071
FTSJ3	FtsJ homolog 3 (E. coli)	0.064
RPL19	ribosomal protein L19	0.063
RRP9	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	0.060
ATAD3A	ATPase family, AAA domain containing 3A	0.056
RPS7	ribosomal protein S7	0.056
C14orf166	chromosome 14 open reading frame 166	0.052
WDR43	WD repeat domain 43	0.049
RPL24	ribosomal protein L24	0.049
RPL5	ribosomal protein L5	0.048
RPL13	ribosomal protein L13	0.045
RPS10	ribosomal protein S10	0.045
RPL22	ribosomal protein L22	0.043
RPL23A	ribosomal protein L23a	0.043	Yeast
RPL10	ribosomal protein L10	0.042	Yeast
RPL15	ribosomal protein L15	0.042
C8orf33	chromosome 8 open reading frame 33	0.042
PTRH2	peptidyl-tRNA hydrolase 2	0.041
NACA	nascent polypeptide-associated complex alpha subunit	0.040
LAS1L	LAS1-like (S. cerevisiae)	0.040
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.040
EEF2	eukaryotic translation elongation factor 2	0.036
BCAS2	breast carcinoma amplified sequence 2	0.036
DHX37	DEAH (Asp-Glu-Ala-His) box polypeptide 37	0.036
NAT10	N-acetyltransferase 10 (GCN5-related)	0.035
RPP40	ribonuclease P/MRP 40kDa subunit	0.034
NCL	nucleolin	0.034
POLR1C	polymerase (RNA) I polypeptide C, 30kDa	0.034
NOP58	NOP58 ribonucleoprotein homolog (yeast)	0.033
RPLP0	ribosomal protein, large, P0	0.032	Yeast
WDR74	WD repeat domain 74	0.032
NOL7	nucleolar protein 7, 27kDa	0.031
PAK1IP1	PAK1 interacting protein 1	0.031	Yeast
WDR5	WD repeat domain 5	0.030
EEF1E1	eukaryotic translation elongation factor 1 epsilon 1	0.029
POLR1E	polymerase (RNA) I polypeptide E, 53kDa	0.028
NOL8	nucleolar protein 8	0.028
RPL10A	ribosomal protein L10a	0.027
TRMT1	TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)	0.027
WDR3	WD repeat domain 3	0.026
TEX10	testis expressed 10	0.026
CIRH1A	cirrhosis, autosomal recessive 1A (cirhin)	0.026
NOC2L	nucleolar complex associated 2 homolog (S. cerevisiae)	0.026	Yeast
SUGP1	SURP and G patch domain containing 1	0.026
RPL37A	ribosomal protein L37a	0.025
NDUFB3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa	0.025
WDR75	WD repeat domain 75	0.024
WDR46	WD repeat domain 46	0.023
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.023
RPL21	ribosomal protein L21	0.023
EIF3E	eukaryotic translation initiation factor 3, subunit E	0.023
RPL9	ribosomal protein L9	0.022
TSR1	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	0.022
OSGEP	O-sialoglycoprotein endopeptidase	0.021
ABCF2	ATP-binding cassette, sub-family F (GCN20), member 2	0.021
RRP12	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.020
SMYD5	SMYD family member 5	0.020
TPRKB	TP53RK binding protein	0.020
RPS4X	ribosomal protein S4, X-linked	0.020
RG9MTD1	RNA (guanine-9-) methyltransferase domain containing 1	0.018
RPS27A	ribosomal protein S27a	0.018
EXOSC2	exosome component 2	0.018
RPL12	ribosomal protein L12	0.017	Yeast
RIOK1	RIO kinase 1 (yeast)	0.017
PWP1	PWP1 homolog (S. cerevisiae)	0.017
GRWD1	glutamate-rich WD repeat containing 1	0.017
RPL38	ribosomal protein L38	0.016
PPRC1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	0.016
MRPS22	mitochondrial ribosomal protein S22	0.016
ATAD3B	ATPase family, AAA domain containing 3B	0.015
XPO5	exportin 5	0.015
NDUFAF2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2	0.015
IPO4	importin 4	0.014
FBL	fibrillarin	0.014
RPSA	ribosomal protein SA	0.014
NOB1	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	0.014
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.014
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.013
RPL35	ribosomal protein L35	0.013	Yeast
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.013
CUL1	cullin 1	0.013
MAK16	MAK16 homolog (S. cerevisiae)	0.013
TOMM6	translocase of outer mitochondrial membrane 6 homolog (yeast)	0.012
THOC1	THO complex 1	0.012
DPH2	DPH2 homolog (S. cerevisiae)	0.011
DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	0.011
RPL23	ribosomal protein L23	0.011
RAE1	RAE1 RNA export 1 homolog (S. pombe)	0.011
RPL26L1	ribosomal protein L26-like 1	0.011	Human
DDX27	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	0.011	Yeast
EIF2A	eukaryotic translation initiation factor 2A, 65kDa	0.011
TTC27	tetratricopeptide repeat domain 27	0.011