IMP: Integrative Multi-species Prediction

Homo sapiens

33 genes annotated in human

Multi-species View

membrane protein ectodomain proteolysis

GO:0006509

The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "membrane protein ectodomain proteolysis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "membrane protein ectodomain proteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
ADAM15	ADAM metallopeptidase domain 15	0.998	Human
FASLG	Fas ligand (TNF superfamily, member 6)	0.987
NCSTN	nicastrin	0.953
SNX9	sorting nexin 9	0.952
IL1R1	interleukin 1 receptor, type I	0.914
SNX33	sorting nexin 33	0.808
APP	amyloid beta (A4) precursor protein	0.759
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.741
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.703
PSEN1	presenilin 1	0.675
TRAF2	TNF receptor-associated factor 2	0.662
DNM1	dynamin 1	0.652
ABI2	abl-interactor 2	0.649
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.479
TRAF5	TNF receptor-associated factor 5	0.443
TRAF1	TNF receptor-associated factor 1	0.417
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.368
TRADD	TNFRSF1A-associated via death domain	0.366
BCAR1	breast cancer anti-estrogen resistance 1	0.346
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.335
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.319
CYBA	cytochrome b-245, alpha polypeptide	0.289
FLNB	filamin B, beta	0.277
DLG1	discs, large homolog 1 (Drosophila)	0.271
TRAF3	TNF receptor-associated factor 3	0.258
FYN	FYN oncogene related to SRC, FGR, YES	0.242
A2M	alpha-2-macroglobulin	0.225
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.207
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.203
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.202
NCF2	neutrophil cytosolic factor 2	0.187
FLNA	filamin A, alpha	0.184
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.142
NCF1	neutrophil cytosolic factor 1	0.137
CD63	CD63 molecule	0.132
HP	haptoglobin	0.118
UTRN	utrophin	0.108
TNF	tumor necrosis factor	0.107
IL10RA	interleukin 10 receptor, alpha	0.100
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.091
ANKRD28	ankyrin repeat domain 28	0.088
LCK	lymphocyte-specific protein tyrosine kinase	0.087
HCK	hemopoietic cell kinase	0.086
IL22RA2	interleukin 22 receptor, alpha 2	0.078
SH3D19	SH3 domain containing 19	0.076
IL22RA1	interleukin 22 receptor, alpha 1	0.074
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.073
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.070
PTPN18	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	0.070
ITK	IL2-inducible T-cell kinase	0.069
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.068
DNM2	dynamin 2	0.066
PKP4	plakophilin 4	0.063
FNBP1	formin binding protein 1	0.060
IL1R2	interleukin 1 receptor, type II	0.058
GHR	growth hormone receptor	0.057
SH3PXD2A	SH3 and PX domains 2A	0.056
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.054
AGTR2	angiotensin II receptor, type 2	0.052
ADAM12	ADAM metallopeptidase domain 12	0.051	Human
MAPT	microtubule-associated protein tau	0.051
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.050	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.049	Human
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.047
APOC1	apolipoprotein C-I	0.047
SNAP23	synaptosomal-associated protein, 23kDa	0.047
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.045
LCAT	lecithin-cholesterol acyltransferase	0.040
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.039
GRB2	growth factor receptor-bound protein 2	0.038
ACTA2	actin, alpha 2, smooth muscle, aorta	0.037
ARRDC3	arrestin domain containing 3	0.036
PSEN2	presenilin 2 (Alzheimer disease 4)	0.036
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.035
BIRC3	baculoviral IAP repeat containing 3	0.035
PLAUR	plasminogen activator, urokinase receptor	0.035
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.035	Human
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.034
MYL9	myosin, light chain 9, regulatory	0.033
ACTN1	actinin, alpha 1	0.032
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.029
BTK	Bruton agammaglobulinemia tyrosine kinase	0.029
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.029
CD2	CD2 molecule	0.028
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.028
APOC3	apolipoprotein C-III	0.028
TGOLN2	trans-golgi network protein 2	0.027
YAP1	Yes-associated protein 1	0.027
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.026
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.026
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.026
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.025
PDIA3	protein disulfide isomerase family A, member 3	0.024
ECSIT	ECSIT homolog (Drosophila)	0.024
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.024
PTPRA	protein tyrosine phosphatase, receptor type, A	0.023
MED28	mediator complex subunit 28	0.023
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.022
ALB	albumin	0.022
DDX4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.022
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.022
CTTN	cortactin	0.022
CIB1	calcium and integrin binding 1 (calmyrin)	0.022
ZMYND11	zinc finger, MYND-type containing 11	0.022
APOA1	apolipoprotein A-I	0.021	Human
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.021
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.021
PLAU	plasminogen activator, urokinase	0.021
TIFA	TRAF-interacting protein with forkhead-associated domain	0.020
RIPK2	receptor-interacting serine-threonine kinase 2	0.020
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.020
FN1	fibronectin 1	0.020
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.020
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.019
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.019	Human
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.019
TRPM7	transient receptor potential cation channel, subfamily M, member 7	0.019
TRAF6	TNF receptor-associated factor 6	0.019
ICAM1	intercellular adhesion molecule 1	0.019
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.019
TRPM6	transient receptor potential cation channel, subfamily M, member 6	0.019
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.019
PTPRB	protein tyrosine phosphatase, receptor type, B	0.018
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.018
APOE	apolipoprotein E	0.018
SRCIN1	SRC kinase signaling inhibitor 1	0.017
IQGAP1	IQ motif containing GTPase activating protein 1	0.017
TPM4	tropomyosin 4	0.016
TGFBI	transforming growth factor, beta-induced, 68kDa	0.016
LAMP1	lysosomal-associated membrane protein 1	0.016
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.015
LRP1	low density lipoprotein receptor-related protein 1	0.015
CALR	calreticulin	0.015
FYB	FYN binding protein	0.015
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.015
UBQLN4	ubiquilin 4	0.015
CD14	CD14 molecule	0.015
IGFBP3	insulin-like growth factor binding protein 3	0.015
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.015
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.014
FAS	Fas (TNF receptor superfamily, member 6)	0.014
TTR	transthyretin	0.014
ITGB5	integrin, beta 5	0.014
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.014
MATR3	matrin 3	0.014
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.014
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.014
THBS1	thrombospondin 1	0.014
HK2	hexokinase 2	0.013
TMOD3	tropomodulin 3 (ubiquitous)	0.013
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.013
DDR2	discoidin domain receptor tyrosine kinase 2	0.013
UBQLN1	ubiquilin 1	0.013
ADRB2	adrenergic, beta-2-, receptor, surface	0.013	Human
CCL8	chemokine (C-C motif) ligand 8	0.013
LAMB1	laminin, beta 1	0.013
MAP2	microtubule-associated protein 2	0.013
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.013
ZNF512B	zinc finger protein 512B	0.012
PLTP	phospholipid transfer protein	0.012
IL1A	interleukin 1, alpha	0.012	Human
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
MSN	moesin	0.012
TGFB2	transforming growth factor, beta 2	0.012
SLAMF7	SLAM family member 7	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
IL8	interleukin 8	0.012
TANK	TRAF family member-associated NFKB activator	0.012
NRP1	neuropilin 1	0.012
TGFB1	transforming growth factor, beta 1	0.012
CCL20	chemokine (C-C motif) ligand 20	0.012
DTX1	deltex homolog 1 (Drosophila)	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
RNF17	ring finger protein 17	0.011
BMP1	bone morphogenetic protein 1	0.011
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.011
CCL4	chemokine (C-C motif) ligand 4	0.011
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.011
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.011	Human
CSF1R	colony stimulating factor 1 receptor	0.011
ZYX	zyxin	0.011
KRT9	keratin 9	0.011
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.011
APOA2	apolipoprotein A-II	0.011
IL19	interleukin 19	0.011	Human
TRAF3IP2	TRAF3 interacting protein 2	0.011
IL10	interleukin 10	0.011
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.011
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.011
TRIP10	thyroid hormone receptor interactor 10	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
WWC1	WW and C2 domain containing 1	0.011
FHL2	four and a half LIM domains 2	0.011
DEFB4A	defensin, beta 4A	0.011
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.011
ESR2	estrogen receptor 2 (ER beta)	0.010
IFNG	interferon, gamma	0.010
IFNGR1	interferon gamma receptor 1	0.010
NPHP1	nephronophthisis 1 (juvenile)	0.010
LEP	leptin	0.010
FGA	fibrinogen alpha chain	0.010
TAGLN	transgelin	0.010
CPD	carboxypeptidase D	0.010
WIPF1	WAS/WASL interacting protein family, member 1	0.010
IRF4	interferon regulatory factor 4	0.010
CCL11	chemokine (C-C motif) ligand 11	0.010
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.010
CXCL9	chemokine (C-X-C motif) ligand 9	0.010