IMP: Integrative Multi-species Prediction

Homo sapiens

28 genes annotated in human

protein homotetramerization

The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein homotetramerization"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "protein homotetramerization" (in gray)

Name	Description	Probability	Func Analog Organism
RARA	retinoic acid receptor, alpha	0.797
LIN7B	lin-7 homolog B (C. elegans)	0.571
HLCS	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	0.478
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.466
SMN1	survival of motor neuron 1, telomeric	0.408
PEX19	peroxisomal biogenesis factor 19	0.292
PEX14	peroxisomal biogenesis factor 14	0.255
ETFDH	electron-transferring-flavoprotein dehydrogenase	0.231
MED25	mediator complex subunit 25	0.206
HADH	hydroxyacyl-CoA dehydrogenase	0.188
PEX5	peroxisomal biogenesis factor 5	0.179
WDYHV1	WDYHV motif containing 1	0.137
ZYX	zyxin	0.115
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.111
PEX12	peroxisomal biogenesis factor 12	0.106
RTCD1	RNA terminal phosphate cyclase domain 1	0.098
EPT1	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	0.097
PRTFDC1	phosphoribosyl transferase domain containing 1	0.094
PEMT	phosphatidylethanolamine N-methyltransferase	0.093
CCL3	chemokine (C-C motif) ligand 3	0.091
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.090
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.089
MYOZ1	myozenin 1	0.089
FLNA	filamin A, alpha	0.083
WWOX	WW domain containing oxidoreductase	0.076
NCOA1	nuclear receptor coactivator 1	0.075
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.068
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.066
PROX1	prospero homeobox 1	0.062
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.062
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.062
SPOP	speckle-type POZ protein	0.057
ARRB1	arrestin, beta 1	0.054
PDLIM1	PDZ and LIM domain 1	0.053
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.048
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.046
FAF1	Fas (TNFRSF6) associated factor 1	0.045
TRIP13	thyroid hormone receptor interactor 13	0.042
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.040
FAM46A	family with sequence similarity 46, member A	0.040
KRT5	keratin 5	0.039
ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	0.038
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.037
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.037
STRA13	stimulated by retinoic acid 13 homolog (mouse)	0.036
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.035
SATB2	SATB homeobox 2	0.035
RXRA	retinoid X receptor, alpha	0.034
SKIV2L2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	0.034
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.034
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.033
ECI2	enoyl-CoA delta isomerase 2	0.031
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.029
RBBP8	retinoblastoma binding protein 8	0.029
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.029
PXMP2	peroxisomal membrane protein 2, 22kDa	0.028
OSBP	oxysterol binding protein	0.028
PEX13	peroxisomal biogenesis factor 13	0.027
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.027
POLR2I	polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	0.025
SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like	0.025
MYH9	myosin, heavy chain 9, non-muscle	0.025
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.024
ECH1	enoyl CoA hydratase 1, peroxisomal	0.023
YAP1	Yes-associated protein 1	0.023
SREBF2	sterol regulatory element binding transcription factor 2	0.023
TTN	titin	0.023
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.021	Human Rat
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.021
NDUFS8	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	0.021
PHYH	phytanoyl-CoA 2-hydroxylase	0.021
ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.020
PEX3	peroxisomal biogenesis factor 3	0.020
LASP1	LIM and SH3 protein 1	0.020
TMEM97	transmembrane protein 97	0.019
GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	0.019
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.019
HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14	0.019
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.019
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.018
PCTP	phosphatidylcholine transfer protein	0.018
TJP1	tight junction protein 1 (zona occludens 1)	0.018
YLPM1	YLP motif containing 1	0.018
BRAP	BRCA1 associated protein	0.017
MYD88	myeloid differentiation primary response gene (88)	0.017
DHRS4	dehydrogenase/reductase (SDR family) member 4	0.017
KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16	0.017	Human
TRIM63	tripartite motif containing 63	0.017
HIPK3	homeodomain interacting protein kinase 3	0.017
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.016
VASP	vasodilator-stimulated phosphoprotein	0.016
GCDH	glutaryl-CoA dehydrogenase	0.016
C6orf108	chromosome 6 open reading frame 108	0.016
NAMPT	nicotinamide phosphoribosyltransferase	0.016
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.016
ANXA7	annexin A7	0.016
KRT6C	keratin 6C	0.016
PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.015
CD81	CD81 molecule	0.015
ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	0.015
HSDL2	hydroxysteroid dehydrogenase like 2	0.015
CYB5A	cytochrome b5 type A (microsomal)	0.015
PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.015
RANBP2	RAN binding protein 2	0.015
ZFR	zinc finger RNA binding protein	0.015
PGM3	phosphoglucomutase 3	0.015
CAT	catalase	0.015
OMA1	OMA1 homolog, zinc metallopeptidase (S. cerevisiae)	0.015
HPX	hemopexin	0.015
GAMT	guanidinoacetate N-methyltransferase	0.015
ENDOG	endonuclease G	0.014
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.014
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.014
USO1	USO1 vesicle docking protein homolog (yeast)	0.014
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.014
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.014
DRD2	dopamine receptor D2	0.014
BDH2	3-hydroxybutyrate dehydrogenase, type 2	0.014
CLU	clusterin	0.014
PFDN1	prefoldin subunit 1	0.014
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.014
PEX16	peroxisomal biogenesis factor 16	0.013
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.013
CNN2	calponin 2	0.013
PHKB	phosphorylase kinase, beta	0.013
MPV17	MpV17 mitochondrial inner membrane protein	0.013
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.013
UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1	0.013
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.013
ESD	esterase D	0.013
PRDX3	peroxiredoxin 3	0.012
PRPS2	phosphoribosyl pyrophosphate synthetase 2	0.012
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.012
VEGFB	vascular endothelial growth factor B	0.012
RXRB	retinoid X receptor, beta	0.012	Human
DNTTIP2	deoxynucleotidyltransferase, terminal, interacting protein 2	0.012
LMNA	lamin A/C	0.012
ISOC1	isochorismatase domain containing 1	0.012
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.012
TIMP2	TIMP metallopeptidase inhibitor 2	0.012
RIPK2	receptor-interacting serine-threonine kinase 2	0.012
TRAP1	TNF receptor-associated protein 1	0.012
NDUFB10	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa	0.012
APEH	N-acylaminoacyl-peptide hydrolase	0.011
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.011
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.011
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.011
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.011
FAM35A	family with sequence similarity 35, member A	0.011
SEC24A	SEC24 family, member A (S. cerevisiae)	0.011
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.011
CPT2	carnitine palmitoyltransferase 2	0.011
BIRC3	baculoviral IAP repeat containing 3	0.011
ABHD14A	abhydrolase domain containing 14A	0.011
CSRP1	cysteine and glycine-rich protein 1	0.011
PBK	PDZ binding kinase	0.011
CXCL2	chemokine (C-X-C motif) ligand 2	0.011
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.011
NEB	nebulin	0.011
GLRX3	glutaredoxin 3	0.011
ACSL1	acyl-CoA synthetase long-chain family member 1	0.011
CD320	CD320 molecule	0.011
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.011
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.011
MRPL34	mitochondrial ribosomal protein L34	0.011
ELMOD1	ELMO/CED-12 domain containing 1	0.011
DNAJC10	DnaJ (Hsp40) homolog, subfamily C, member 10	0.011
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.011
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.011
EPHX2	epoxide hydrolase 2, cytoplasmic	0.011
JUP	junction plakoglobin	0.010
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.010
MAPK7	mitogen-activated protein kinase 7	0.010
TST	thiosulfate sulfurtransferase (rhodanese)	0.010
GUF1	GUF1 GTPase homolog (S. cerevisiae)	0.010
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.010
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.010
HMGN3	high mobility group nucleosomal binding domain 3	0.010
C17orf37	chromosome 17 open reading frame 37	0.010
FAM82B	family with sequence similarity 82, member B	0.010
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.010
UQCR10	ubiquinol-cytochrome c reductase, complex III subunit X	0.010
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.010
ACTN3	actinin, alpha 3	0.010
HNF1B	HNF1 homeobox B	0.010
LMNB1	lamin B1	0.010
DBN1	drebrin 1	0.010
FXN	frataxin	0.010
MUT	methylmalonyl CoA mutase	0.010
HRSP12	heat-responsive protein 12	0.010
PLK1	polo-like kinase 1	0.010
C11orf54	chromosome 11 open reading frame 54	0.010