IMP
Process View
mature dendritic cell differentiation
The process in which antigen-activated dendritic cells acquire the specialized features of a mature dendritic cell. Mature dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "mature dendritic cell differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CAV2 | caveolin 2 | 0.829 | ||
| MPO | myeloperoxidase | 0.603 | ||
| INADL | InaD-like (Drosophila) | 0.499 | ||
| CCR7 | chemokine (C-C motif) receptor 7 | 0.450 | Mouse | |
| CTSG | cathepsin G | 0.352 | ||
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.316 | ||
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.287 | ||
| CLC | Charcot-Leyden crystal protein | 0.174 | ||
| CCL19 | chemokine (C-C motif) ligand 19 | 0.172 | Mouse | |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.143 | ||
| CAMP | cathelicidin antimicrobial peptide | 0.137 | ||
| CLEC4G | C-type lectin domain family 4, member G | 0.115 | ||
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.105 | ||
| GPR183 | G protein-coupled receptor 183 | 0.091 | ||
| IL21R | interleukin 21 receptor | 0.087 | ||
| CCL22 | chemokine (C-C motif) ligand 22 | 0.086 | ||
| ELANE | elastase, neutrophil expressed | 0.081 | Human | |
| LTF | lactotransferrin | 0.078 | ||
| BPI | bactericidal/permeability-increasing protein | 0.077 | ||
| P2RY10 | purinergic receptor P2Y, G-protein coupled, 10 | 0.075 | ||
| IL16 | interleukin 16 (lymphocyte chemoattractant factor) | 0.067 | ||
| DEFA4 | defensin, alpha 4, corticostatin | 0.067 | ||
| CCL21 | chemokine (C-C motif) ligand 21 | 0.060 | ||
| AZU1 | azurocidin 1 | 0.060 | Human | |
| STAT4 | signal transducer and activator of transcription 4 | 0.056 | ||
| HBD | hemoglobin, delta | 0.056 | ||
| FAIM3 | Fas apoptotic inhibitory molecule 3 | 0.053 | ||
| PGLYRP1 | peptidoglycan recognition protein 1 | 0.049 | ||
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.048 | ||
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 0.044 | ||
| IRF8 | interferon regulatory factor 8 | 0.039 | ||
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.038 | ||
| PROCR | protein C receptor, endothelial | 0.037 | ||
| IL7R | interleukin 7 receptor | 0.036 | ||
| GPR171 | G protein-coupled receptor 171 | 0.035 | ||
| CYTIP | cytohesin 1 interacting protein | 0.035 | ||
| GPR18 | G protein-coupled receptor 18 | 0.033 | Human | |
| IRF4 | interferon regulatory factor 4 | 0.031 | ||
| CCR5 | chemokine (C-C motif) receptor 5 | 0.031 | ||
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.031 | ||
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.031 | ||
| RETN | resistin | 0.030 | ||
| CCR6 | chemokine (C-C motif) receptor 6 | 0.030 | ||
| CFP | complement factor properdin | 0.028 | ||
| HDC | histidine decarboxylase | 0.028 | ||
| CD27 | CD27 molecule | 0.026 | ||
| EBI3 | Epstein-Barr virus induced 3 | 0.026 | ||
| CD83 | CD83 molecule | 0.026 | ||
| IL2RA | interleukin 2 receptor, alpha | 0.025 | ||
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | 0.025 | ||
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.024 | ||
| SIGLEC5 | sialic acid binding Ig-like lectin 5 | 0.024 | ||
| PRTN3 | proteinase 3 | 0.024 | ||
| LAMP3 | lysosomal-associated membrane protein 3 | 0.023 | ||
| LYL1 | lymphoblastic leukemia derived sequence 1 | 0.023 | ||
| CIITA | class II, major histocompatibility complex, transactivator | 0.023 | ||
| MMP8 | matrix metallopeptidase 8 (neutrophil collagenase) | 0.023 | ||
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.023 | ||
| TCL1A | T-cell leukemia/lymphoma 1A | 0.023 | ||
| CXCR3 | chemokine (C-X-C motif) receptor 3 | 0.022 | ||
| IL10 | interleukin 10 | 0.022 | ||
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 0.021 | ||
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.021 | ||
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.021 | ||
| IL2RB | interleukin 2 receptor, beta | 0.021 | ||
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.021 | ||
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.021 | ||
| HBB | hemoglobin, beta | 0.021 | ||
| PF4 | platelet factor 4 | 0.021 | ||
| CD96 | CD96 molecule | 0.020 | ||
| LY9 | lymphocyte antigen 9 | 0.020 | ||
| CST7 | cystatin F (leukocystatin) | 0.019 | ||
| HP | haptoglobin | 0.019 | ||
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | 0.019 | ||
| ADD2 | adducin 2 (beta) | 0.019 | ||
| FLT3 | fms-related tyrosine kinase 3 | 0.019 | ||
| IGJ | immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides | 0.018 | ||
| ORM2 | orosomucoid 2 | 0.018 | ||
| PVRIG | poliovirus receptor related immunoglobulin domain containing | 0.018 | ||
| ICOS | inducible T-cell co-stimulator | 0.018 | ||
| VPREB1 | pre-B lymphocyte 1 | 0.018 | ||
| SLAMF7 | SLAM family member 7 | 0.018 | ||
| SELL | selectin L | 0.017 | ||
| S100A12 | S100 calcium binding protein A12 | 0.017 | ||
| AIM2 | absent in melanoma 2 | 0.017 | ||
| IL18R1 | interleukin 18 receptor 1 | 0.017 | ||
| LTC4S | leukotriene C4 synthase | 0.017 | ||
| CCR2 | chemokine (C-C motif) receptor 2 | 0.016 | ||
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.016 | ||
| ITGB7 | integrin, beta 7 | 0.016 | ||
| IL18RAP | interleukin 18 receptor accessory protein | 0.016 | ||
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.016 | ||
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.016 | ||
| CD1C | CD1c molecule | 0.016 | ||
| BTLA | B and T lymphocyte associated | 0.016 | ||
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.015 | ||
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.015 | ||
| CLEC10A | C-type lectin domain family 10, member A | 0.015 | ||
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | 0.015 | ||
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.014 | ||
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.014 | ||
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.014 | ||
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 0.014 | ||
| SIT1 | signaling threshold regulating transmembrane adaptor 1 | 0.014 | ||
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.014 | ||
| TPSB2 | tryptase beta 2 (gene/pseudogene) | 0.014 | ||
| GFER | growth factor, augmenter of liver regeneration | 0.014 | ||
| TRAF3IP3 | TRAF3 interacting protein 3 | 0.013 | ||
| CD72 | CD72 molecule | 0.013 | ||
| HAAO | 3-hydroxyanthranilate 3,4-dioxygenase | 0.013 | ||
| CD22 | CD22 molecule | 0.013 | ||
| PNOC | prepronociceptin | 0.013 | ||
| CD19 | CD19 molecule | 0.013 | ||
| RUNX3 | runt-related transcription factor 3 | 0.013 | ||
| KCNA3 | potassium voltage-gated channel, shaker-related subfamily, member 3 | 0.013 | ||
| FFAR2 | free fatty acid receptor 2 | 0.012 | ||
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.012 | ||
| LCN2 | lipocalin 2 | 0.012 | ||
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.012 | ||
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.012 | ||
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | 0.012 | ||
| ADAMDEC1 | ADAM-like, decysin 1 | 0.012 | ||
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.012 | ||
| GPR97 | G protein-coupled receptor 97 | 0.012 | ||
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 0.012 | ||
| RHOH | ras homolog gene family, member H | 0.012 | ||
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.012 | ||
| ALAS2 | aminolevulinate, delta-, synthase 2 | 0.012 | ||
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.012 | ||
| ASGR2 | asialoglycoprotein receptor 2 | 0.012 | ||
| HIST1H3C | histone cluster 1, H3c | 0.012 | ||
| PTGIR | prostaglandin I2 (prostacyclin) receptor (IP) | 0.011 | ||
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.011 | ||
| FOLR3 | folate receptor 3 (gamma) | 0.011 | ||
| CD28 | CD28 molecule | 0.011 | ||
| TPSAB1 | tryptase alpha/beta 1 | 0.011 | ||
| RDH5 | retinol dehydrogenase 5 (11-cis/9-cis) | 0.011 | ||
| HLA-DOB | major histocompatibility complex, class II, DO beta | 0.011 | ||
| HAL | histidine ammonia-lyase | 0.011 | ||
| RAB33A | RAB33A, member RAS oncogene family | 0.011 | ||
| XCL2 | chemokine (C motif) ligand 2 | 0.011 | ||
| CPA3 | carboxypeptidase A3 (mast cell) | 0.011 | ||
| CD226 | CD226 molecule | 0.011 | ||
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.011 | ||
| LBP | lipopolysaccharide binding protein | 0.011 | ||
| P2RX5 | purinergic receptor P2X, ligand-gated ion channel, 5 | 0.011 | ||
| IL2RG | interleukin 2 receptor, gamma | 0.011 | ||
| NFE2 | nuclear factor (erythroid-derived 2), 45kDa | 0.011 | ||
| DEFA1B | defensin, alpha 1B | 0.010 | ||
| ADAM28 | ADAM metallopeptidase domain 28 | 0.010 | ||
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 0.010 | ||
| SPN | sialophorin | 0.010 | ||
| CD48 | CD48 molecule | 0.010 | ||
| CHI3L2 | chitinase 3-like 2 | 0.010 | ||
| BATF | basic leucine zipper transcription factor, ATF-like | 0.010 | ||
| CEACAM4 | carcinoembryonic antigen-related cell adhesion molecule 4 | 0.010 | ||
| PIM2 | pim-2 oncogene | 0.010 | ||
| CCL13 | chemokine (C-C motif) ligand 13 | 0.010 | ||
| S100P | S100 calcium binding protein P | 0.010 |