IMP: Integrative Multi-species Prediction

Homo sapiens

29 genes annotated in human

dicarboxylic acid metabolic process

The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dicarboxylic acid metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "dicarboxylic acid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
GGT1	gamma-glutamyltransferase 1	0.978
GGTLC1	gamma-glutamyltransferase light chain 1	0.919	Human
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.810
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.801
INSR	insulin receptor	0.781
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.775	Rat
ACO2	aconitase 2, mitochondrial	0.760
GCLC	glutamate-cysteine ligase, catalytic subunit	0.757
GCLM	glutamate-cysteine ligase, modifier subunit	0.757
MARS	methionyl-tRNA synthetase	0.597
FH	fumarate hydratase	0.474
PHGDH	phosphoglycerate dehydrogenase	0.472
GGT2	gamma-glutamyltransferase 2	0.392	Human
GARS	glycyl-tRNA synthetase	0.379
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.344	Rat
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.341
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.306
AARS	alanyl-tRNA synthetase	0.283
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.282
IDH3B	isocitrate dehydrogenase 3 (NAD+) beta	0.280	Rat
SUFU	suppressor of fused homolog (Drosophila)	0.261
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.212
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.184
PSAT1	phosphoserine aminotransferase 1	0.161
GHITM	growth hormone inducible transmembrane protein	0.156
UQCRC1	ubiquinol-cytochrome c reductase core protein I	0.152
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.126
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.123
TRIB3	tribbles homolog 3 (Drosophila)	0.111
GLUD2	glutamate dehydrogenase 2	0.109
GLUD1	glutamate dehydrogenase 1	0.105
TOM1L1	target of myb1 (chicken)-like 1	0.100
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.087
BCAR1	breast cancer anti-estrogen resistance 1	0.085
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.084	Human
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.083
IDE	insulin-degrading enzyme	0.082
SUCLA2	succinate-CoA ligase, ADP-forming, beta subunit	0.081
OXA1L	oxidase (cytochrome c) assembly 1-like	0.078
GFER	growth factor, augmenter of liver regeneration	0.075
AK2	adenylate kinase 2	0.068
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.063
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.054
SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	0.054
JAK2	Janus kinase 2	0.052
LONP1	lon peptidase 1, mitochondrial	0.051
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.049
ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	0.048
SORD	sorbitol dehydrogenase	0.048
PYCR1	pyrroline-5-carboxylate reductase 1	0.048
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.046
SUCLG1	succinate-CoA ligase, alpha subunit	0.043
IL2RB	interleukin 2 receptor, beta	0.042
SESN2	sestrin 2	0.040
SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.040
NQO1	NAD(P)H dehydrogenase, quinone 1	0.036
GSR	glutathione reductase	0.036
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.034
GPI	glucose-6-phosphate isomerase	0.034
ZNF277	zinc finger protein 277	0.034
HADH	hydroxyacyl-CoA dehydrogenase	0.033
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.032
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.032
CRAT	carnitine O-acetyltransferase	0.031
SOCS2	suppressor of cytokine signaling 2	0.031
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.030
MIPEP	mitochondrial intermediate peptidase	0.030
NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	0.030
BTBD1	BTB (POZ) domain containing 1	0.030
ATF2	activating transcription factor 2	0.029
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.029
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.029
DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	0.029	Yeast Rat
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.029
SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.029
EPOR	erythropoietin receptor	0.028
GCDH	glutaryl-CoA dehydrogenase	0.028
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.028
PCCB	propionyl CoA carboxylase, beta polypeptide	0.027
PRDX3	peroxiredoxin 3	0.027
YARS	tyrosyl-tRNA synthetase	0.027
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.027
DCXR	dicarbonyl/L-xylulose reductase	0.027
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.026
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.026	Rat
PIR	pirin (iron-binding nuclear protein)	0.026
BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	0.025
BRE	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.025
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.025
SARS	seryl-tRNA synthetase	0.025
DLAT	dihydrolipoamide S-acetyltransferase	0.025
ALAS1	aminolevulinate, delta-, synthase 1	0.024
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.023
ACAT1	acetyl-CoA acetyltransferase 1	0.023
SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5	0.022
CAV1	caveolin 1, caveolae protein, 22kDa	0.022
AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	0.022
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.022
TIMM44	translocase of inner mitochondrial membrane 44 homolog (yeast)	0.022
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.021	Rat
MAGEA11	melanoma antigen family A, 11	0.020
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.020
APEH	N-acylaminoacyl-peptide hydrolase	0.020
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.019
RECQL5	RecQ protein-like 5	0.019
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.019
STT3A	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	0.019
RPTOR	regulatory associated protein of MTOR, complex 1	0.018
WARS	tryptophanyl-tRNA synthetase	0.018
DPP3	dipeptidyl-peptidase 3	0.018
ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.018
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.018
ECI1	enoyl-CoA delta isomerase 1	0.018
DHTKD1	dehydrogenase E1 and transketolase domain containing 1	0.018
MECR	mitochondrial trans-2-enoyl-CoA reductase	0.017
NNT	nicotinamide nucleotide transhydrogenase	0.017
MRPL49	mitochondrial ribosomal protein L49	0.017
HAX1	HCLS1 associated protein X-1	0.017
IARS2	isoleucyl-tRNA synthetase 2, mitochondrial	0.017
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.017
CBS	cystathionine-beta-synthase	0.017
GPT2	glutamic pyruvate transaminase (alanine aminotransferase) 2	0.017
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.017
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	0.017
VDAC1	voltage-dependent anion channel 1	0.016
GSS	glutathione synthetase	0.016
MFN2	mitofusin 2	0.016
NCOA1	nuclear receptor coactivator 1	0.016
PMPCA	peptidase (mitochondrial processing) alpha	0.016
C21orf33	chromosome 21 open reading frame 33	0.016
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.016
GPS1	G protein pathway suppressor 1	0.016
NCOA2	nuclear receptor coactivator 2	0.016
UBAC1	UBA domain containing 1	0.016
TUFM	Tu translation elongation factor, mitochondrial	0.015
PC	pyruvate carboxylase	0.015	Rat
UGP2	UDP-glucose pyrophosphorylase 2	0.015
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.015
ACSL1	acyl-CoA synthetase long-chain family member 1	0.015
SC4MOL	sterol-C4-methyl oxidase-like	0.015
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.015
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.015
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.015
FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.015
PEX5	peroxisomal biogenesis factor 5	0.015
PDHX	pyruvate dehydrogenase complex, component X	0.014
APCS	amyloid P component, serum	0.014
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.014
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.013
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.013
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.013
LAT	linker for activation of T cells	0.013
NMD3	NMD3 homolog (S. cerevisiae)	0.013
APOC3	apolipoprotein C-III	0.013
SPRY2	sprouty homolog 2 (Drosophila)	0.013
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.013
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.012
CTH	cystathionase (cystathionine gamma-lyase)	0.012
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.012
ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	0.012
NSFL1C	NSFL1 (p97) cofactor (p47)	0.012
DGAT1	diacylglycerol O-acyltransferase 1	0.012
GRHPR	glyoxylate reductase/hydroxypyruvate reductase	0.012
FHOD3	formin homology 2 domain containing 3	0.012
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.012
UGDH	UDP-glucose 6-dehydrogenase	0.012
BDH1	3-hydroxybutyrate dehydrogenase, type 1	0.012
TH1L	TH1-like (Drosophila)	0.012
PEMT	phosphatidylethanolamine N-methyltransferase	0.012
HRSP12	heat-responsive protein 12	0.012
CLTC	clathrin, heavy chain (Hc)	0.012
TMEM123	transmembrane protein 123	0.012
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.012
MGST1	microsomal glutathione S-transferase 1	0.011
FOXO1	forkhead box O1	0.011
CARS	cysteinyl-tRNA synthetase	0.011
HDAC3	histone deacetylase 3	0.011
GK	glycerol kinase	0.011
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.011
LTK	leukocyte receptor tyrosine kinase	0.011
C1R	complement component 1, r subcomponent	0.011
FDX1	ferredoxin 1	0.011
RABIF	RAB interacting factor	0.011
DHRS11	dehydrogenase/reductase (SDR family) member 11	0.011
FECH	ferrochelatase	0.011
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.011
PFKM	phosphofructokinase, muscle	0.011
ERP29	endoplasmic reticulum protein 29	0.011
AQP7	aquaporin 7	0.011
ING2	inhibitor of growth family, member 2	0.011
UROS	uroporphyrinogen III synthase	0.011
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.011
ORM1	orosomucoid 1	0.010
ARG1	arginase, liver	0.010
KCTD9	potassium channel tetramerisation domain containing 9	0.010
PROSC	proline synthetase co-transcribed homolog (bacterial)	0.010
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.010
NFYC	nuclear transcription factor Y, gamma	0.010
SLC35A3	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3	0.010
GMDS	GDP-mannose 4,6-dehydratase	0.010
SEPHS2	selenophosphate synthetase 2	0.010
SCP2	sterol carrier protein 2	0.010
VTN	vitronectin	0.010
DEDD	death effector domain containing	0.010