IMP: Integrative Multi-species Prediction

Homo sapiens

19 genes annotated in human

protein targeting to mitochondrion

The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein targeting to mitochondrion"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "protein targeting to mitochondrion" (in gray)

Name	Description	Probability	Func Analog Organism
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.999
HSPA8	heat shock 70kDa protein 8	0.705	Yeast
NUB1	negative regulator of ubiquitin-like proteins 1	0.462
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.443	Human
TOMM22	translocase of outer mitochondrial membrane 22 homolog (yeast)	0.418
TIMM10	translocase of inner mitochondrial membrane 10 homolog (yeast)	0.387
PPID	peptidylprolyl isomerase D	0.367
MARCH5	membrane-associated ring finger (C3HC4) 5	0.315
TIMM13	translocase of inner mitochondrial membrane 13 homolog (yeast)	0.258	Yeast
STIP1	stress-induced-phosphoprotein 1	0.242
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.201
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.198
TIMM8B	translocase of inner mitochondrial membrane 8 homolog B (yeast)	0.126	Yeast
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.126	Yeast
BAX	BCL2-associated X protein	0.116
MAPK8	mitogen-activated protein kinase 8	0.108
SKA3	spindle and kinetochore associated complex subunit 3	0.097
HSPH1	heat shock 105kDa/110kDa protein 1	0.090	Human
TCP1	t-complex 1	0.086
PINK1	PTEN induced putative kinase 1	0.069
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.066
PAM16	presequence translocase-associated motor 16 homolog (S. cerevisiae)	0.063	Yeast
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.060
PPIF	peptidylprolyl isomerase F	0.060
MRPL24	mitochondrial ribosomal protein L24	0.054
FKBP4	FK506 binding protein 4, 59kDa	0.054
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.052
MAP2K4	mitogen-activated protein kinase kinase 4	0.050
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.048
HSPA1A	heat shock 70kDa protein 1A	0.047	Yeast
BAK1	BCL2-antagonist/killer 1	0.045
MEOX2	mesenchyme homeobox 2	0.044
VDAC1	voltage-dependent anion channel 1	0.041
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.040
TIMM44	translocase of inner mitochondrial membrane 44 homolog (yeast)	0.038
TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	0.035
HSPA1B	heat shock 70kDa protein 1B	0.034	Yeast
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.033
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.031
PRDX5	peroxiredoxin 5	0.029
MRPS7	mitochondrial ribosomal protein S7	0.029
ATP5G3	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	0.027
BCL2L1	BCL2-like 1	0.027
BAG2	BCL2-associated athanogene 2	0.027
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.027
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.025	Yeast
BAG3	BCL2-associated athanogene 3	0.025
TOMM7	translocase of outer mitochondrial membrane 7 homolog (yeast)	0.024
TIMM23	translocase of inner mitochondrial membrane 23 homolog (yeast) and translocase of inner mitochondrial membrane 23 homolog (yeast)	0.023	Yeast
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.023
MRPL11	mitochondrial ribosomal protein L11	0.023
DNAJC19	DnaJ (Hsp40) homolog, subfamily C, member 19	0.022	Yeast
TUBA1A	tubulin, alpha 1a	0.021
ARMC6	armadillo repeat containing 6	0.021
CIAPIN1	cytokine induced apoptosis inhibitor 1	0.020
TUSC2	tumor suppressor candidate 2	0.020
C19orf70	chromosome 19 open reading frame 70	0.019
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.019
EIF5	eukaryotic translation initiation factor 5	0.019
MRPL28	mitochondrial ribosomal protein L28	0.019
BAG1	BCL2-associated athanogene	0.018
HCCS	holocytochrome c synthase	0.018
PMVK	phosphomevalonate kinase	0.018
CHCHD8	coiled-coil-helix-coiled-coil-helix domain containing 8	0.018
ROMO1	reactive oxygen species modulator 1	0.017
MRPL46	mitochondrial ribosomal protein L46	0.017
MRPS12	mitochondrial ribosomal protein S12	0.017
BAD	BCL2-associated agonist of cell death	0.016
GFM2	G elongation factor, mitochondrial 2	0.016
PHB	prohibitin	0.016
C1orf43	chromosome 1 open reading frame 43	0.016
SUPV3L1	suppressor of var1, 3-like 1 (S. cerevisiae)	0.016
DNM1L	dynamin 1-like	0.015
TTC1	tetratricopeptide repeat domain 1	0.015
ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	0.015
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.014
KIF5B	kinesin family member 5B	0.014
RPRD1A	regulation of nuclear pre-mRNA domain containing 1A	0.014
MCAT	malonyl CoA:ACP acyltransferase (mitochondrial)	0.014
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.014
CHCHD4	coiled-coil-helix-coiled-coil-helix domain containing 4	0.014
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.014
TXN2	thioredoxin 2	0.014
TUBB2B	tubulin, beta 2B	0.014
TOMM20	translocase of outer mitochondrial membrane 20 homolog (yeast)	0.013
TOMM70A	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	0.013
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.013
MRPL27	mitochondrial ribosomal protein L27	0.013
TP53BP2	tumor protein p53 binding protein, 2	0.013
NTPCR	nucleoside-triphosphatase, cancer-related	0.013
LDHA	lactate dehydrogenase A	0.013
ZNF593	zinc finger protein 593	0.013
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.013	Yeast
BZW1	basic leucine zipper and W2 domains 1	0.013
GRSF1	G-rich RNA sequence binding factor 1	0.013
PEX19	peroxisomal biogenesis factor 19	0.012
CHUK	conserved helix-loop-helix ubiquitous kinase	0.012
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.012
IARS2	isoleucyl-tRNA synthetase 2, mitochondrial	0.012
HSPBP1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	0.012
GBAS	glioblastoma amplified sequence	0.011
SERTAD4	SERTA domain containing 4	0.011
C3orf1	chromosome 3 open reading frame 1	0.011
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.011
RAB4A	RAB4A, member RAS oncogene family	0.011
GLRX3	glutaredoxin 3	0.011
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.011
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.011
XPO7	exportin 7	0.011
NCKAP1	NCK-associated protein 1	0.011
PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	0.011
CUEDC2	CUE domain containing 2	0.011
PLEKHM1	pleckstrin homology domain containing, family M (with RUN domain) member 1	0.011
TMED2	transmembrane emp24 domain trafficking protein 2	0.011
SNAPIN	SNAP-associated protein	0.010
TIMM50	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	0.010
CCNG1	cyclin G1	0.010
MARK3	MAP/microtubule affinity-regulating kinase 3	0.010