IMP: Integrative Multi-species Prediction

Homo sapiens

4 genes annotated in human

cell junction maintenance

The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell junction maintenance"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cell junction maintenance" (in gray)

Name	Description	Probability	Func Analog Organism
CTNND1	catenin (cadherin-associated protein), delta 1	0.992
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.992
VEGFA	vascular endothelial growth factor A	0.952
MAPK1	mitogen-activated protein kinase 1	0.941	Fly
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.939
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.885
MAPK14	mitogen-activated protein kinase 14	0.871
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.864
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.857
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.707	Human
CDH5	cadherin 5, type 2 (vascular endothelium)	0.665
AMPH	amphiphysin	0.649
EGFR	epidermal growth factor receptor	0.644
MARK3	MAP/microtubule affinity-regulating kinase 3	0.639
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.610	Zebrafish
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.577
NRP1	neuropilin 1	0.563
PLCG1	phospholipase C, gamma 1	0.490
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.452
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.442
MAPK3	mitogen-activated protein kinase 3	0.438	Fly
PGF	placental growth factor	0.303
SQSTM1	sequestosome 1	0.291
SH3GL2	SH3-domain GRB2-like 2	0.283
PRKCI	protein kinase C, iota	0.282	Zebrafish
DSP	desmoplakin	0.266
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.252	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.249
DUSP1	dual specificity phosphatase 1	0.239
PTPRB	protein tyrosine phosphatase, receptor type, B	0.232
PDGFA	platelet-derived growth factor alpha polypeptide	0.221
LAT	linker for activation of T cells	0.219
PRKCZ	protein kinase C, zeta	0.218
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.215
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.196
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.187
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.179
JUP	junction plakoglobin	0.176
KRT8	keratin 8	0.171
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.168	Human
SYNJ1	synaptojanin 1	0.151
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.151
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.146
SOS1	son of sevenless homolog 1 (Drosophila)	0.133
GHR	growth hormone receptor	0.121
ITSN1	intersectin 1 (SH3 domain protein)	0.113
MAP2K1	mitogen-activated protein kinase kinase 1	0.113
FGFR1	fibroblast growth factor receptor 1	0.110
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.102	Human
DUSP3	dual specificity phosphatase 3	0.097
SPTBN1	spectrin, beta, non-erythrocytic 1	0.093
GAB1	GRB2-associated binding protein 1	0.092
OCRL	oculocerebrorenal syndrome of Lowe	0.088
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.088
LAD1	ladinin 1	0.085
PDGFC	platelet derived growth factor C	0.083
PLEKHA7	pleckstrin homology domain containing, family A member 7	0.075
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.065
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.062
PEA15	phosphoprotein enriched in astrocytes 15	0.060
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.060
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.059
DSG2	desmoglein 2	0.059
WASL	Wiskott-Aldrich syndrome-like	0.058
KRT18	keratin 18	0.056
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.053
NCKAP1	NCK-associated protein 1	0.052
NCF4	neutrophil cytosolic factor 4, 40kDa	0.050
SH3GL1	SH3-domain GRB2-like 1	0.050
MYO1E	myosin IE	0.050
GRB7	growth factor receptor-bound protein 7	0.048
EZR	ezrin	0.048
SH3RF3	SH3 domain containing ring finger 3	0.046
PTPRR	protein tyrosine phosphatase, receptor type, R	0.044
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.043
PRSS8	protease, serine, 8	0.042
SLA	Src-like-adaptor	0.042
DOCK2	dedicator of cytokinesis 2	0.040
RAB11FIP3	RAB11 family interacting protein 3 (class II)	0.040
CTTN	cortactin	0.040
SH3KBP1	SH3-domain kinase binding protein 1	0.039
CHN2	chimerin (chimaerin) 2	0.039
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.037
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.036	Human
CORO1A	coronin, actin binding protein, 1A	0.036
TYK2	tyrosine kinase 2	0.035
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.034
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.034
FNBP1	formin binding protein 1	0.034
PROM1	prominin 1	0.034
ACAP3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	0.034
DUSP7	dual specificity phosphatase 7	0.033
ARHGAP31	Rho GTPase activating protein 31	0.033
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.032
DSC2	desmocollin 2	0.031
PRKCQ	protein kinase C, theta	0.031
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.030
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.030
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.029
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.029
LDLR	low density lipoprotein receptor	0.029
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.029
TEAD3	TEA domain family member 3	0.028
ASB13	ankyrin repeat and SOCS box containing 13	0.028
NCF2	neutrophil cytosolic factor 2	0.028
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.028	Zebrafish
FRMD5	FERM domain containing 5	0.027
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.027
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.027	Fly
MAN1B1	mannosidase, alpha, class 1B, member 1	0.027
SNAP25	synaptosomal-associated protein, 25kDa	0.026
SH3BP4	SH3-domain binding protein 4	0.026
FLNB	filamin B, beta	0.025
PKP3	plakophilin 3	0.025
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.025
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.024
MAPT	microtubule-associated protein tau	0.024
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.024
PSEN1	presenilin 1	0.024
NOSTRIN	nitric oxide synthase trafficker	0.024
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.024
VAV1	vav 1 guanine nucleotide exchange factor	0.024
ARHGAP9	Rho GTPase activating protein 9	0.024
KIF3A	kinesin family member 3A	0.023
F11R	F11 receptor	0.023
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.023
C10orf118	chromosome 10 open reading frame 118	0.023
SMAD9	SMAD family member 9	0.022
GDI2	GDP dissociation inhibitor 2	0.022
YY1AP1	YY1 associated protein 1	0.022
ADAM15	ADAM metallopeptidase domain 15	0.021
ASRGL1	asparaginase like 1	0.021
ARHGEF9	Cdc42 guanine nucleotide exchange factor (GEF) 9	0.021
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.021
LOC283278	hypothetical protein LOC283278	0.021
BCAR1	breast cancer anti-estrogen resistance 1	0.020
FKBP8	FK506 binding protein 8, 38kDa	0.020
RAI1	retinoic acid induced 1	0.020
PLEKHA6	pleckstrin homology domain containing, family A member 6	0.020	Human
PHACTR3	phosphatase and actin regulator 3	0.019
HSPG2	heparan sulfate proteoglycan 2	0.019
RAB7A	RAB7A, member RAS oncogene family	0.019
ESRP1	epithelial splicing regulatory protein 1	0.019
MAP2K6	mitogen-activated protein kinase kinase 6	0.019
MAP2	microtubule-associated protein 2	0.019
SH3RF1	SH3 domain containing ring finger 1	0.019
MPEG1	macrophage expressed 1	0.019
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.019
ELK1	ELK1, member of ETS oncogene family	0.019
SH2D1A	SH2 domain containing 1A	0.019
CD93	CD93 molecule	0.018
PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.018
MBP	myelin basic protein	0.018
STK10	serine/threonine kinase 10	0.018
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.018
DOCK1	dedicator of cytokinesis 1	0.018
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.018	Human
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.018
TSC22D1	TSC22 domain family, member 1	0.018
KIAA1543	KIAA1543	0.017
AIG1	androgen-induced 1	0.017
SOCS6	suppressor of cytokine signaling 6	0.017
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.017
PTEN	phosphatase and tensin homolog	0.017
ZNF784	zinc finger protein 784	0.017
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.017
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.017
PNMA1	paraneoplastic antigen MA1	0.016
KRT19	keratin 19	0.016
KIAA1267	KIAA1267	0.016
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.016
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.016
KRT15	keratin 15	0.016
GTPBP5	GTP binding protein 5 (putative)	0.016
VEGFC	vascular endothelial growth factor C	0.016
ARHGAP15	Rho GTPase activating protein 15	0.015
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.015
NRBP2	nuclear receptor binding protein 2	0.015
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.015
KIAA0889	KIAA0889	0.015
RAB14	RAB14, member RAS oncogene family	0.015
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.015
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.015
MYL12B	myosin, light chain 12B, regulatory	0.015
ESRP2	epithelial splicing regulatory protein 2	0.015
RAB6A	RAB6A, member RAS oncogene family	0.015
GPR143	G protein-coupled receptor 143	0.015
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.014
FHOD1	formin homology 2 domain containing 1	0.014
CMIP	c-Maf-inducing protein	0.014
ARHGAP32	Rho GTPase activating protein 32	0.014
MYO5B	myosin VB	0.014
NOS3	nitric oxide synthase 3 (endothelial cell)	0.014
PTPRF	protein tyrosine phosphatase, receptor type, F	0.014
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.014
IRF8	interferon regulatory factor 8	0.014
DUSP16	dual specificity phosphatase 16	0.014
SPINT2	serine peptidase inhibitor, Kunitz type, 2	0.014
PDCD6IP	programmed cell death 6 interacting protein	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.014
SYNJ2	synaptojanin 2	0.014
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.014
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.014
IRF6	interferon regulatory factor 6	0.013
RIPK4	receptor-interacting serine-threonine kinase 4	0.013
ST14	suppression of tumorigenicity 14 (colon carcinoma)	0.013
ZNF71	zinc finger protein 71	0.013
JAM3	junctional adhesion molecule 3	0.013
PLEKHA5	pleckstrin homology domain containing, family A member 5	0.013	Human
SFN	stratifin	0.013
CFL1	cofilin 1 (non-muscle)	0.013
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.013
KRT6A	keratin 6A	0.013
JAM2	junctional adhesion molecule 2	0.013
ITGB4	integrin, beta 4	0.013
CSDA	cold shock domain protein A	0.013
EGF	epidermal growth factor	0.013
TCEA2	transcription elongation factor A (SII), 2	0.012
BSPRY	B-box and SPRY domain containing	0.012
CLDN4	claudin 4	0.012
CHGB	chromogranin B (secretogranin 1)	0.012
C1orf106	chromosome 1 open reading frame 106	0.012
FLT4	fms-related tyrosine kinase 4	0.012	Human
DAPK1	death-associated protein kinase 1	0.012
LMO4	LIM domain only 4	0.012
KDM5B	lysine (K)-specific demethylase 5B	0.012
THY1	Thy-1 cell surface antigen	0.012
SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	0.012
SNX9	sorting nexin 9	0.012
HDAC10	histone deacetylase 10	0.012
VSNL1	visinin-like 1	0.012
NINL	ninein-like	0.012
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.012
SPRED1	sprouty-related, EVH1 domain containing 1	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
NBR1	neighbor of BRCA1 gene 1	0.012
CD33	CD33 molecule	0.012
MAP2K4	mitogen-activated protein kinase kinase 4	0.012
TIAM2	T-cell lymphoma invasion and metastasis 2	0.012
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.012
KIAA1377	KIAA1377	0.011
CACNB3	calcium channel, voltage-dependent, beta 3 subunit	0.011
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.011
CXADR	coxsackie virus and adenovirus receptor	0.011
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.011
GRB10	growth factor receptor-bound protein 10	0.011
ETV1	ets variant 1	0.011
RHPN1	rhophilin, Rho GTPase binding protein 1	0.011
IGF1R	insulin-like growth factor 1 receptor	0.011
ELMO3	engulfment and cell motility 3	0.011
COL6A1	collagen, type VI, alpha 1	0.011
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.011
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.011
KRT6B	keratin 6B	0.011
SPATA2L	spermatogenesis associated 2-like	0.011
GAB2	GRB2-associated binding protein 2	0.011
UBASH3A	ubiquitin associated and SH3 domain containing A	0.011
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.011
DUSP9	dual specificity phosphatase 9	0.011
CEP350	centrosomal protein 350kDa	0.011
FHOD3	formin homology 2 domain containing 3	0.011
ADORA3	adenosine A3 receptor	0.011
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.011
DSC3	desmocollin 3	0.011
F10	coagulation factor X	0.011
REPS2	RALBP1 associated Eps domain containing 2	0.011
DUSP6	dual specificity phosphatase 6	0.011
EMILIN1	elastin microfibril interfacer 1	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
CSRNP2	cysteine-serine-rich nuclear protein 2	0.011
PLXNA3	plexin A3	0.011
MTPN	myotrophin	0.011
ITGB6	integrin, beta 6	0.011
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.011
EPN3	epsin 3	0.011
CX3CL1	chemokine (C-X3-C motif) ligand 1	0.010
STAP2	signal transducing adaptor family member 2	0.010
CRMP1	collapsin response mediator protein 1	0.010
CD24	CD24 molecule	0.010
PTH2R	parathyroid hormone 2 receptor	0.010
ENAH	enabled homolog (Drosophila)	0.010
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.010
RAB3IP	RAB3A interacting protein (rabin3)	0.010
CLDN3	claudin 3	0.010
SEMA6B	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.010
WWC1	WW and C2 domain containing 1	0.010
EVPL	envoplakin	0.010
CD2	CD2 molecule	0.010
UNKL	unkempt homolog (Drosophila)-like	0.010
GREM1	gremlin 1	0.010
MON1A	MON1 homolog A (yeast)	0.010
CLDN7	claudin 7	0.010
TBC1D14	TBC1 domain family, member 14	0.010
FYB	FYN binding protein	0.010