IMP: Integrative Multi-species Prediction

Homo sapiens

21 genes annotated in human

cellular respiration

The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular respiration"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cellular respiration" (in gray)

Name	Description	Probability	Func Analog Organism
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.969
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.856	Yeast
HDAC1	histone deacetylase 1	0.851	Fly
UQCRC1	ubiquinol-cytochrome c reductase core protein I	0.841	Yeast
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.783	Yeast Worm
NDUFS3	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	0.735
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.703
COX5A	cytochrome c oxidase subunit Va	0.702	Worm
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.614
OXA1L	oxidase (cytochrome c) assembly 1-like	0.580
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.526	Rat Fly
NDUFS7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	0.442
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.439
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.422	Worm
CYC1	cytochrome c-1	0.381	Yeast
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.352
NDUFA9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	0.345
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.314
SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.303	Yeast
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.293
ATP5J	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6	0.293
DLAT	dihydrolipoamide S-acetyltransferase	0.275
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	0.267
FH	fumarate hydratase	0.264
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.263
QARS	glutaminyl-tRNA synthetase	0.205
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.190
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.188
ATP5C1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	0.187
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.169
DLD	dihydrolipoamide dehydrogenase	0.142	Mouse
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.141
PHB2	prohibitin 2	0.126
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.121
SUCLG1	succinate-CoA ligase, alpha subunit	0.117
CYCS	cytochrome c, somatic	0.113
ICT1	immature colon carcinoma transcript 1	0.110
PTN	pleiotrophin	0.100
HIGD2A	HIG1 hypoxia inducible domain family, member 2A	0.089
ATP5F1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	0.080
PDHX	pyruvate dehydrogenase complex, component X	0.076
PPARG	peroxisome proliferator-activated receptor gamma	0.076
GPI	glucose-6-phosphate isomerase	0.076
SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	0.075	Yeast
HDAC3	histone deacetylase 3	0.071
EEF2	eukaryotic translation elongation factor 2	0.066
ATP5G3	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	0.062
RBBP4	retinoblastoma binding protein 4	0.058
NDUFB7	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa	0.057
EIF3K	eukaryotic translation initiation factor 3, subunit K	0.053
AHCY	adenosylhomocysteinase	0.052
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.046
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.045
ESRRG	estrogen-related receptor gamma	0.043
IMMT	inner membrane protein, mitochondrial	0.043
VDAC1	voltage-dependent anion channel 1	0.041
ECH1	enoyl CoA hydratase 1, peroxisomal	0.041
COX5B	cytochrome c oxidase subunit Vb	0.040
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.037	Fly
AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	0.036
TUFM	Tu translation elongation factor, mitochondrial	0.036
COX7B	cytochrome c oxidase subunit VIIb	0.035
ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	0.035
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.034
CDK9	cyclin-dependent kinase 9	0.034
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.033
IDH3B	isocitrate dehydrogenase 3 (NAD+) beta	0.033	Rat
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.033
FBXO7	F-box protein 7	0.031
ENO1	enolase 1, (alpha)	0.031
C7orf36	chromosome 7 open reading frame 36	0.031
SNCAIP	synuclein, alpha interacting protein	0.029
C11orf2	chromosome 11 open reading frame 2	0.028
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.028
BAK1	BCL2-antagonist/killer 1	0.028
VDAC2	voltage-dependent anion channel 2	0.028
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.028
IGBP1	immunoglobulin (CD79A) binding protein 1	0.026
NFYA	nuclear transcription factor Y, alpha	0.026
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.026
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.025
NDUFB9	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	0.024
COX8A	cytochrome c oxidase subunit VIIIA (ubiquitous)	0.024
IDH3G	isocitrate dehydrogenase 3 (NAD+) gamma	0.024	Rat
FASTKD1	FAST kinase domains 1	0.024	Human
SREBF2	sterol regulatory element binding transcription factor 2	0.023
PPIF	peptidylprolyl isomerase F	0.023
MDH1	malate dehydrogenase 1, NAD (soluble)	0.023
NNT	nicotinamide nucleotide transhydrogenase	0.023
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.023	Worm
CHCHD10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.022
TOMM70A	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	0.021
RNF144B	ring finger protein 144B	0.021
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.020	Rat
ACO2	aconitase 2, mitochondrial	0.020
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.019
TPI1	triosephosphate isomerase 1	0.019
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.019
HIPK2	homeodomain interacting protein kinase 2	0.019
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.019	Rat
MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	0.018
PRDX3	peroxiredoxin 3	0.018
C3orf15	chromosome 3 open reading frame 15	0.018
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.018
NDUFB1	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa	0.018
PPA1	pyrophosphatase (inorganic) 1	0.017
RBBP7	retinoblastoma binding protein 7	0.017
COX6C	cytochrome c oxidase subunit VIc	0.017
STARD7	StAR-related lipid transfer (START) domain containing 7	0.017
KARS	lysyl-tRNA synthetase	0.016
MRPL12	mitochondrial ribosomal protein L12	0.016
PCCB	propionyl CoA carboxylase, beta polypeptide	0.016
SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.016
NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	0.016
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.016
MRPL35	mitochondrial ribosomal protein L35	0.016
EIF3L	eukaryotic translation initiation factor 3, subunit L	0.016
COX15	COX15 homolog, cytochrome c oxidase assembly protein (yeast)	0.015
LRPPRC	leucine-rich PPR-motif containing	0.015
USPL1	ubiquitin specific peptidase like 1	0.015
EIF4B	eukaryotic translation initiation factor 4B	0.014
HADH	hydroxyacyl-CoA dehydrogenase	0.014
PRDX2	peroxiredoxin 2	0.014
PGAM1	phosphoglycerate mutase 1 (brain)	0.014
LTA4H	leukotriene A4 hydrolase	0.014
TKT	transketolase	0.013
ACAT1	acetyl-CoA acetyltransferase 1	0.013
SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	0.013
GBAS	glioblastoma amplified sequence	0.013
DAP3	death associated protein 3	0.013
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.013
ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	0.013
ADRBK1	adrenergic, beta, receptor kinase 1	0.013
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
MAPT	microtubule-associated protein tau	0.013
NCAPD2	non-SMC condensin I complex, subunit D2	0.012
NCOR2	nuclear receptor corepressor 2	0.012
PFDN1	prefoldin subunit 1	0.012
EEF1G	eukaryotic translation elongation factor 1 gamma	0.012
BZW2	basic leucine zipper and W2 domains 2	0.012
HCCS	holocytochrome c synthase	0.012
PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	0.012
NDUFS8	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	0.012	Worm
PPARA	peroxisome proliferator-activated receptor alpha	0.012
SENP1	SUMO1/sentrin specific peptidase 1	0.011
BOP1	block of proliferation 1	0.011
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.011
COX4I1	cytochrome c oxidase subunit IV isoform 1	0.011	Worm
AKIP1	A kinase (PRKA) interacting protein 1	0.011
ERP29	endoplasmic reticulum protein 29	0.011
CBX5	chromobox homolog 5	0.011
SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.011
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.011
GHITM	growth hormone inducible transmembrane protein	0.011
SURF1	surfeit 1	0.011
RIPK2	receptor-interacting serine-threonine kinase 2	0.011
RYR2	ryanodine receptor 2 (cardiac)	0.011
SRA1	steroid receptor RNA activator 1	0.010