IMP
Process View
base excision repair
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "base excision repair"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RPA1 | replication protein A1, 70kDa | 1.000 | ||
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.999 | Rat | |
| PARP1 | poly (ADP-ribose) polymerase 1 | 0.995 | Mouse | |
| RPA2 | replication protein A2, 32kDa | 0.992 | ||
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.986 | ||
| PCNA | proliferating cell nuclear antigen | 0.935 | Mouse | |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.928 | ||
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.887 | Yeast | |
| BLM | Bloom syndrome, RecQ helicase-like | 0.869 | ||
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 0.865 | ||
| WRN | Werner syndrome, RecQ helicase-like | 0.847 | ||
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.797 | ||
| H2AFX | H2A histone family, member X | 0.795 | ||
| APTX | aprataxin | 0.516 | ||
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 0.514 | ||
| RPA3 | replication protein A3, 14kDa | 0.470 | ||
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.463 | ||
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.461 | ||
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.459 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.346 | ||
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 0.342 | Worm | |
| UNG | uracil-DNA glycosylase | 0.327 | Worm | |
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.319 | ||
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.221 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.218 | ||
| PNKP | polynucleotide kinase 3'-phosphatase | 0.202 | ||
| XAB2 | XPA binding protein 2 | 0.177 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.163 | ||
| LIG1 | ligase I, DNA, ATP-dependent | 0.150 | Yeast | |
| RCC1 | regulator of chromosome condensation 1 | 0.148 | ||
| BRCA1 | breast cancer 1, early onset | 0.145 | ||
| CBX1 | chromobox homolog 1 | 0.144 | ||
| FANCE | Fanconi anemia, complementation group E | 0.141 | ||
| CDCA7 | cell division cycle associated 7 | 0.130 | ||
| LIG3 | ligase III, DNA, ATP-dependent | 0.117 | Rat | |
| BRCA2 | breast cancer 2, early onset | 0.114 | ||
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.103 | ||
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.101 | ||
| PIAS4 | protein inhibitor of activated STAT, 4 | 0.099 | ||
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.098 | ||
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.095 | ||
| TIMELESS | timeless homolog (Drosophila) | 0.089 | ||
| OPTN | optineurin | 0.088 | ||
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | 0.083 | ||
| ING2 | inhibitor of growth family, member 2 | 0.080 | ||
| APLF | aprataxin and PNKP like factor | 0.078 | ||
| HMGB1 | high mobility group box 1 | 0.064 | ||
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.062 | ||
| SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.061 | ||
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.057 | ||
| MECP2 | methyl CpG binding protein 2 (Rett syndrome) | 0.053 | ||
| CHAF1B | chromatin assembly factor 1, subunit B (p60) | 0.052 | ||
| HMGB2 | high mobility group box 2 | 0.051 | ||
| KIF22 | kinesin family member 22 | 0.046 | ||
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.043 | ||
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.041 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.040 | ||
| ERCC8 | excision repair cross-complementing rodent repair deficiency, complementation group 8 | 0.039 | ||
| FKBP3 | FK506 binding protein 3, 25kDa | 0.038 | ||
| PRMT6 | protein arginine methyltransferase 6 | 0.038 | ||
| MUS81 | MUS81 endonuclease homolog (S. cerevisiae) | 0.038 | ||
| FANCG | Fanconi anemia, complementation group G | 0.038 | ||
| CBX5 | chromobox homolog 5 | 0.038 | ||
| XPA | xeroderma pigmentosum, complementation group A | 0.037 | ||
| HMGA1 | high mobility group AT-hook 1 | 0.034 | ||
| HMGN1 | high mobility group nucleosome binding domain 1 | 0.033 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.033 | ||
| MUTYH | mutY homolog (E. coli) | 0.032 | ||
| SUMO2 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) | 0.030 | ||
| PTMA | prothymosin, alpha | 0.030 | ||
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.030 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.030 | ||
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.030 | ||
| EXO1 | exonuclease 1 | 0.029 | ||
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.028 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.028 | ||
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.027 | ||
| TOP1 | topoisomerase (DNA) I | 0.027 | ||
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.027 | ||
| HMGB3 | high mobility group box 3 | 0.027 | Human | |
| DUT | deoxyuridine triphosphatase | 0.026 | ||
| USP4 | ubiquitin specific peptidase 4 (proto-oncogene) | 0.026 | ||
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.026 | ||
| FEN1 | flap structure-specific endonuclease 1 | 0.026 | Yeast | |
| KIAA0101 | KIAA0101 | 0.025 | ||
| H2AFV | H2A histone family, member V | 0.025 | ||
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.024 | ||
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.023 | ||
| SP1 | Sp1 transcription factor | 0.022 | ||
| DTL | denticleless homolog (Drosophila) | 0.022 | ||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.022 | ||
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.021 | ||
| MMS19 | MMS19 nucleotide excision repair homolog (S. cerevisiae) | 0.021 | ||
| PRDX6 | peroxiredoxin 6 | 0.021 | ||
| STMN1 | stathmin 1 | 0.020 | ||
| PPP1R14A | protein phosphatase 1, regulatory (inhibitor) subunit 14A | 0.020 | ||
| IK | IK cytokine, down-regulator of HLA II | 0.020 | ||
| RFWD3 | ring finger and WD repeat domain 3 | 0.019 | ||
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.019 | ||
| CLSPN | claspin | 0.019 | ||
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.018 | ||
| ATM | ataxia telangiectasia mutated | 0.017 | ||
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.017 | ||
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.017 | ||
| RNF11 | ring finger protein 11 | 0.016 | ||
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.016 | ||
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.016 | ||
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.016 | ||
| XPC | xeroderma pigmentosum, complementation group C | 0.015 | ||
| SUMO1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | 0.015 | ||
| MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 0.015 | ||
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.014 | ||
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.014 | ||
| POLD2 | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 0.014 | ||
| TOP3A | topoisomerase (DNA) III alpha | 0.014 | ||
| HTT | huntingtin | 0.014 | ||
| MCM5 | minichromosome maintenance complex component 5 | 0.014 | ||
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.013 | ||
| TRIM28 | tripartite motif containing 28 | 0.013 | ||
| RECQL4 | RecQ protein-like 4 | 0.013 | ||
| E2F1 | E2F transcription factor 1 | 0.013 | ||
| HN1L | hematological and neurological expressed 1-like | 0.013 | ||
| MYST2 | MYST histone acetyltransferase 2 | 0.013 | ||
| CDCA4 | cell division cycle associated 4 | 0.013 | ||
| CIT | citron (rho-interacting, serine/threonine kinase 21) | 0.013 | ||
| MSH3 | mutS homolog 3 (E. coli) | 0.013 | ||
| SHPRH | SNF2 histone linker PHD RING helicase | 0.013 | ||
| GTF2H4 | general transcription factor IIH, polypeptide 4, 52kDa | 0.012 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.012 | ||
| SAC3D1 | SAC3 domain containing 1 | 0.012 | ||
| TERF2 | telomeric repeat binding factor 2 | 0.012 | ||
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 | 0.012 | ||
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 0.012 | ||
| HIRIP3 | HIRA interacting protein 3 | 0.012 | ||
| RBL1 | retinoblastoma-like 1 (p107) | 0.012 | ||
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.012 | ||
| ASF1B | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.012 | ||
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.012 | ||
| DDX23 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | 0.012 | ||
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | 0.012 | ||
| ORC6 | origin recognition complex, subunit 6 | 0.012 | ||
| RNASEH2A | ribonuclease H2, subunit A | 0.012 | ||
| EME1 | essential meiotic endonuclease 1 homolog 1 (S. pombe) | 0.012 | ||
| RAD9A | RAD9 homolog A (S. pombe) | 0.011 | ||
| RAD51L3 | RAD51-like 3 (S. cerevisiae) | 0.011 | ||
| POLE | polymerase (DNA directed), epsilon | 0.011 | ||
| CSNK1A1 | casein kinase 1, alpha 1 | 0.011 | ||
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | 0.011 | ||
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.011 | ||
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.011 | ||
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.011 | ||
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | 0.011 | ||
| RAD54L | RAD54-like (S. cerevisiae) | 0.010 | ||
| RBM25 | RNA binding motif protein 25 | 0.010 | ||
| HOOK2 | hook homolog 2 (Drosophila) | 0.010 | ||
| PRMT7 | protein arginine methyltransferase 7 | 0.010 |