IMP
Process View
nucleotide excision repair
A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nucleotide excision repair"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RPA1 | replication protein A1, 70kDa | 1.000 | ||
| SLX4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) | 0.999 | ||
| H2AFX | H2A histone family, member X | 0.999 | ||
| MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 0.998 | ||
| BRCA1 | breast cancer 1, early onset | 0.997 | ||
| PSMD13 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | 0.995 | ||
| ERCC3 | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 0.994 | ||
| RPA3 | replication protein A3, 14kDa | 0.993 | ||
| CDK7 | cyclin-dependent kinase 7 | 0.992 | ||
| GTF2H1 | general transcription factor IIH, polypeptide 1, 62kDa | 0.989 | ||
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.988 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.987 | ||
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.987 | ||
| BLM | Bloom syndrome, RecQ helicase-like | 0.986 | ||
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.983 | ||
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | 0.979 | ||
| ERCC6 | excision repair cross-complementing rodent repair deficiency, complementation group 6 | 0.968 | ||
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 0.968 | ||
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.961 | ||
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 0.955 | ||
| PCNA | proliferating cell nuclear antigen | 0.955 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.951 | ||
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.943 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.938 | ||
| RFC1 | replication factor C (activator 1) 1, 145kDa | 0.937 | ||
| NBN | nibrin | 0.935 | ||
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.932 | ||
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.914 | ||
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.908 | ||
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.892 | Yeast | |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.892 | ||
| ERCC8 | excision repair cross-complementing rodent repair deficiency, complementation group 8 | 0.862 | ||
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.839 | ||
| TP53 | tumor protein p53 | 0.780 | ||
| MSH3 | mutS homolog 3 (E. coli) | 0.779 | ||
| CCNH | cyclin H | 0.779 | ||
| THOC4 | THO complex 4 | 0.755 | Yeast | |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.745 | ||
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 0.725 | ||
| APLF | aprataxin and PNKP like factor | 0.713 | ||
| MUS81 | MUS81 endonuclease homolog (S. cerevisiae) | 0.677 | ||
| XAB2 | XPA binding protein 2 | 0.599 | ||
| EXO1 | exonuclease 1 | 0.569 | ||
| SLX1B | SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) | 0.545 | ||
| GTF2H2 | general transcription factor IIH, polypeptide 2, 44kDa | 0.536 | Yeast | |
| XPC | xeroderma pigmentosum, complementation group C | 0.486 | ||
| ERCC4 | excision repair cross-complementing rodent repair deficiency, complementation group 4 | 0.479 | ||
| SMC1A | structural maintenance of chromosomes 1A | 0.474 | ||
| POLD2 | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 0.466 | ||
| MNAT1 | menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) | 0.459 | Yeast | |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.455 | ||
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 0.448 | ||
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.416 | ||
| ERCC1 | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | 0.413 | ||
| FANCG | Fanconi anemia, complementation group G | 0.410 | ||
| WWOX | WW domain containing oxidoreductase | 0.410 | ||
| RPA2 | replication protein A2, 32kDa | 0.363 | ||
| WRN | Werner syndrome, RecQ helicase-like | 0.346 | ||
| EME1 | essential meiotic endonuclease 1 homolog 1 (S. pombe) | 0.305 | ||
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.286 | ||
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 0.280 | ||
| THOC1 | THO complex 1 | 0.279 | ||
| MLL | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 0.278 | ||
| ATM | ataxia telangiectasia mutated | 0.274 | ||
| EP300 | E1A binding protein p300 | 0.260 | ||
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 0.251 | ||
| XPA | xeroderma pigmentosum, complementation group A | 0.249 | ||
| THOC5 | THO complex 5 | 0.243 | ||
| RAD9A | RAD9 homolog A (S. pombe) | 0.242 | ||
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.240 | ||
| BRCA2 | breast cancer 2, early onset | 0.239 | ||
| PNKP | polynucleotide kinase 3'-phosphatase | 0.227 | ||
| RTF1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.202 | ||
| THOC2 | THO complex 2 | 0.201 | ||
| HUS1 | HUS1 checkpoint homolog (S. pombe) | 0.191 | ||
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.189 | ||
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.176 | ||
| C20orf94 | chromosome 20 open reading frame 94 | 0.146 | ||
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.146 | ||
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.144 | ||
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.143 | ||
| LIG1 | ligase I, DNA, ATP-dependent | 0.143 | Yeast | |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.141 | ||
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.117 | ||
| ATR | ataxia telangiectasia and Rad3 related | 0.109 | ||
| CHTOP | chromatin target of PRMT1 | 0.101 | ||
| KDM4A | lysine (K)-specific demethylase 4A | 0.101 | ||
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.096 | ||
| PARP1 | poly (ADP-ribose) polymerase 1 | 0.095 | ||
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 0.092 | ||
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.092 | ||
| TERF2 | telomeric repeat binding factor 2 | 0.083 | ||
| RBBP5 | retinoblastoma binding protein 5 | 0.077 | ||
| TP53BP1 | tumor protein p53 binding protein 1 | 0.077 | ||
| HIST1H4A | histone cluster 1, H4a | 0.077 | ||
| CCDC101 | coiled-coil domain containing 101 | 0.068 | ||
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.067 | ||
| KRT5 | keratin 5 | 0.067 | ||
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.066 | ||
| ERCC2 | excision repair cross-complementing rodent repair deficiency, complementation group 2 | 0.064 | ||
| THOC6 | THO complex 6 homolog (Drosophila) | 0.064 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.062 | ||
| RAD17 | RAD17 homolog (S. pombe) | 0.061 | Yeast | |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.060 | ||
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.058 | ||
| CBX5 | chromobox homolog 5 | 0.056 | ||
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.056 | ||
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.055 | ||
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.054 | ||
| CDK2 | cyclin-dependent kinase 2 | 0.051 | ||
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 0.051 | ||
| ECSIT | ECSIT homolog (Drosophila) | 0.049 | ||
| SSRP1 | structure specific recognition protein 1 | 0.048 | ||
| HIST1H3A | histone cluster 1, H3a | 0.048 | Yeast | |
| HLTF | helicase-like transcription factor | 0.047 | ||
| PRR11 | proline rich 11 | 0.047 | ||
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.046 | ||
| ACACA | acetyl-CoA carboxylase alpha | 0.045 | ||
| LMNA | lamin A/C | 0.045 | ||
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.044 | ||
| MED7 | mediator complex subunit 7 | 0.044 | ||
| ACYP1 | acylphosphatase 1, erythrocyte (common) type | 0.043 | ||
| RAD21 | RAD21 homolog (S. pombe) | 0.040 | ||
| SHFM1 | split hand/foot malformation (ectrodactyly) type 1 | 0.040 | ||
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | 0.039 | ||
| MEN1 | multiple endocrine neoplasia I | 0.039 | ||
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.038 | Worm | |
| SATB2 | SATB homeobox 2 | 0.038 | ||
| LRIF1 | ligand dependent nuclear receptor interacting factor 1 | 0.037 | ||
| POLE | polymerase (DNA directed), epsilon | 0.037 | ||
| UNG | uracil-DNA glycosylase | 0.037 | ||
| PRMT1 | protein arginine methyltransferase 1 | 0.037 | ||
| PSMC5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | 0.037 | Yeast | |
| HIST1H4D | histone cluster 1, H4d | 0.036 | ||
| REV1 | REV1 homolog (S. cerevisiae) | 0.036 | ||
| STRN4 | striatin, calmodulin binding protein 4 | 0.035 | ||
| PSMD9 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 0.035 | ||
| MYST3 | MYST histone acetyltransferase (monocytic leukemia) 3 | 0.034 | ||
| MYST1 | MYST histone acetyltransferase 1 | 0.034 | ||
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.034 | ||
| CBX1 | chromobox homolog 1 | 0.033 | ||
| RFC4 | replication factor C (activator 1) 4, 37kDa | 0.033 | ||
| GIN1 | gypsy retrotransposon integrase 1 | 0.032 | ||
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.031 | ||
| HIST1H2AB | histone cluster 1, H2ab | 0.031 | ||
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 0.031 | ||
| TRIM28 | tripartite motif containing 28 | 0.030 | ||
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | 0.030 | ||
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.030 | ||
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | 0.029 | ||
| DCUN1D2 | DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) | 0.029 | ||
| HIST1H1E | histone cluster 1, H1e | 0.028 | ||
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.028 | ||
| ATXN3 | ataxin 3 | 0.028 | ||
| USP11 | ubiquitin specific peptidase 11 | 0.028 | ||
| RAD1 | RAD1 homolog (S. pombe) | 0.026 | Worm | |
| UBL7 | ubiquitin-like 7 (bone marrow stromal cell-derived) | 0.026 | ||
| HIST1H2BB | histone cluster 1, H2bb | 0.026 | ||
| COPS4 | COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) | 0.026 | ||
| WDR61 | WD repeat domain 61 | 0.026 | ||
| GTF2H4 | general transcription factor IIH, polypeptide 4, 52kDa | 0.025 | Yeast | |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.025 | ||
| HIST1H1B | histone cluster 1, H1b | 0.025 | ||
| DMC1 | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 0.024 | ||
| RNF2 | ring finger protein 2 | 0.024 | ||
| FANCA | Fanconi anemia, complementation group A | 0.023 | ||
| TBCB | tubulin folding cofactor B | 0.023 | ||
| TTC35 | tetratricopeptide repeat domain 35 | 0.023 | ||
| POLH | polymerase (DNA directed), eta | 0.023 | ||
| GTF2H5 | general transcription factor IIH, polypeptide 5 | 0.023 | ||
| HIST1H4F | histone cluster 1, H4f | 0.023 | ||
| L3MBTL1 | l(3)mbt-like 1 (Drosophila) | 0.022 | ||
| APTX | aprataxin | 0.022 | ||
| BRD7 | bromodomain containing 7 | 0.022 | ||
| AIRE | autoimmune regulator | 0.022 | ||
| RAD51L1 | RAD51-like 1 (S. cerevisiae) | 0.022 | ||
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.022 | ||
| ADRM1 | adhesion regulating molecule 1 | 0.021 | ||
| MMS19 | MMS19 nucleotide excision repair homolog (S. cerevisiae) | 0.021 | ||
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 | 0.021 | ||
| PAAF1 | proteasomal ATPase-associated factor 1 | 0.020 | ||
| DHX16 | DEAH (Asp-Glu-Ala-His) box polypeptide 16 | 0.020 | ||
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | 0.020 | ||
| MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2 | 0.020 | ||
| HIRIP3 | HIRA interacting protein 3 | 0.020 | ||
| KRT6C | keratin 6C | 0.019 | ||
| YAP1 | Yes-associated protein 1 | 0.019 | ||
| CDC73 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.019 | ||
| MLL4 | myeloid/lymphoid or mixed-lineage leukemia 4 | 0.019 | ||
| PASK | PAS domain containing serine/threonine kinase | 0.019 | ||
| HIST1H4B | histone cluster 1, H4b | 0.018 | ||
| SNRPA | small nuclear ribonucleoprotein polypeptide A | 0.018 | ||
| HAUS5 | HAUS augmin-like complex, subunit 5 | 0.018 | ||
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 0.018 | ||
| GTF2E1 | general transcription factor IIE, polypeptide 1, alpha 56kDa | 0.018 | ||
| TBL3 | transducin (beta)-like 3 | 0.018 | ||
| NHEJ1 | nonhomologous end-joining factor 1 | 0.018 | ||
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.018 | ||
| HIST1H3G | histone cluster 1, H3g | 0.018 | ||
| DCLRE1A | DNA cross-link repair 1A | 0.017 | ||
| BRPF1 | bromodomain and PHD finger containing, 1 | 0.017 | ||
| CBX8 | chromobox homolog 8 | 0.017 | ||
| KAT2B | K(lysine) acetyltransferase 2B | 0.017 | ||
| CBX7 | chromobox homolog 7 | 0.017 | ||
| CBX6 | chromobox homolog 6 | 0.016 | ||
| HIST1H2BM | histone cluster 1, H2bm | 0.016 | ||
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.016 | ||
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | 0.016 | ||
| HIST1H3F | histone cluster 1, H3f | 0.016 | ||
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | 0.016 | ||
| HIST1H1D | histone cluster 1, H1d | 0.016 | ||
| MUTYH | mutY homolog (E. coli) | 0.016 | ||
| HIST1H2BG | histone cluster 1, H2bg | 0.015 | ||
| KDM5C | lysine (K)-specific demethylase 5C | 0.015 | ||
| HIST1H3I | histone cluster 1, H3i | 0.014 | Yeast | |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 0.014 | ||
| NRD1 | nardilysin (N-arginine dibasic convertase) | 0.014 | ||
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.014 | ||
| NCOA6 | nuclear receptor coactivator 6 | 0.014 | ||
| HIST2H2AC | histone cluster 2, H2ac | 0.014 | ||
| KNTC1 | kinetochore associated 1 | 0.014 | ||
| NXF1 | nuclear RNA export factor 1 | 0.014 | ||
| NUP188 | nucleoporin 188kDa | 0.014 | ||
| PCGF2 | polycomb group ring finger 2 | 0.014 | ||
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.013 | ||
| BARD1 | BRCA1 associated RING domain 1 | 0.013 | ||
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.013 | ||
| NUP210 | nucleoporin 210kDa | 0.013 | ||
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.013 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.013 | ||
| RING1 | ring finger protein 1 | 0.013 | ||
| CIT | citron (rho-interacting, serine/threonine kinase 21) | 0.013 | ||
| NDUFB1 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 0.013 | ||
| HCFC2 | host cell factor C2 | 0.013 | ||
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.013 | ||
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.013 | ||
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.012 | ||
| KAT2A | K(lysine) acetyltransferase 2A | 0.012 | ||
| HIST1H3D | histone cluster 1, H3d | 0.012 | ||
| CXXC1 | CXXC finger protein 1 | 0.012 | ||
| PHF20 | PHD finger protein 20 | 0.012 | ||
| EIF3G | eukaryotic translation initiation factor 3, subunit G | 0.012 | ||
| HIST1H2AL | histone cluster 1, H2al | 0.012 | ||
| CLSPN | claspin | 0.012 | ||
| C12orf10 | chromosome 12 open reading frame 10 | 0.012 | ||
| DCLRE1C | DNA cross-link repair 1C | 0.011 | ||
| HIST1H2AM | histone cluster 1, H2am | 0.011 | ||
| MAGOH | mago-nashi homolog, proliferation-associated (Drosophila) | 0.011 | ||
| HDGFRP2 | hepatoma-derived growth factor-related protein 2 | 0.011 | ||
| INCENP | inner centromere protein antigens 135/155kDa | 0.011 | ||
| ATP5D | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | 0.011 | ||
| FOXO3 | forkhead box O3 | 0.011 | ||
| TCEA1 | transcription elongation factor A (SII), 1 | 0.011 | ||
| GSTCD | glutathione S-transferase, C-terminal domain containing | 0.011 | ||
| HIST1H2BO | histone cluster 1, H2bo | 0.011 | ||
| HIST1H2BL | histone cluster 1, H2bl | 0.010 | ||
| GTF2F1 | general transcription factor IIF, polypeptide 1, 74kDa | 0.010 | ||
| HIST1H4E | histone cluster 1, H4e | 0.010 | ||
| SETD1A | SET domain containing 1A | 0.010 |