IMP: Integrative Multi-species Prediction

Homo sapiens

26 genes annotated in human

regulation of mitotic metaphase anaphase transition

Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mitotic metaphase anaphase transition"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of mitotic metaphase anaphase transition" (in gray)

Name	Description	Probability	Func Analog Organism
CDC20	cell division cycle 20 homolog (S. cerevisiae)	1.000	Yeast Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	1.000
ANAPC4	anaphase promoting complex subunit 4	1.000
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.999	Fly
CDK2	cyclin-dependent kinase 2	0.999
CCNA2	cyclin A2	0.999
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.999	Fly
CCNB1	cyclin B1	0.997
ANAPC7	anaphase promoting complex subunit 7	0.996
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.995
ANAPC1	anaphase promoting complex subunit 1	0.989
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.987	Worm Fly
ANAPC5	anaphase promoting complex subunit 5	0.977
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.963
PLK1	polo-like kinase 1	0.910
RB1	retinoblastoma 1	0.880
AURKB	aurora kinase B	0.844
ANAPC11	anaphase promoting complex subunit 11	0.809
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.780
FBXO5	F-box protein 5	0.773
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.674	Fly
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.632
SKP2	S-phase kinase-associated protein 2 (p45)	0.564
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.529
CBX5	chromobox homolog 5	0.520
E2F1	E2F transcription factor 1	0.515
PTTG1	pituitary tumor-transforming 1	0.506
CDT1	chromatin licensing and DNA replication factor 1	0.478
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.453
SKA1	spindle and kinetochore associated complex subunit 1	0.428
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.384
SMC3	structural maintenance of chromosomes 3	0.329
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.261
STAG1	stromal antigen 1	0.256
TFDP1	transcription factor Dp-1	0.235
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.229
H2AFX	H2A histone family, member X	0.215
CCNB2	cyclin B2	0.209
MDC1	mediator of DNA-damage checkpoint 1	0.187
SKA2	spindle and kinetochore associated complex subunit 2	0.184
CDKN3	cyclin-dependent kinase inhibitor 3	0.179
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.171
BRCA2	breast cancer 2, early onset	0.170
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.166
TP53BP1	tumor protein p53 binding protein 1	0.157
CLSPN	claspin	0.157
SKA3	spindle and kinetochore associated complex subunit 3	0.145
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.143
RBL2	retinoblastoma-like 2 (p130)	0.137	Human
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.118
CKS2	CDC28 protein kinase regulatory subunit 2	0.103
CREBBP	CREB binding protein	0.098
INCENP	inner centromere protein antigens 135/155kDa	0.096
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.095
BIRC5	baculoviral IAP repeat containing 5	0.095
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.090
RBBP8	retinoblastoma binding protein 8	0.089
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.086
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.086
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.081
SMC6	structural maintenance of chromosomes 6	0.079
FOXM1	forkhead box M1	0.079
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.075
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.073
RAD21	RAD21 homolog (S. pombe)	0.073
PRC1	protein regulator of cytokinesis 1	0.073
CDCA8	cell division cycle associated 8	0.072
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.071
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.069
ZNF207	zinc finger protein 207	0.069
ORC1	origin recognition complex, subunit 1	0.068
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.068
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.067
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.065
UBE2C	ubiquitin-conjugating enzyme E2C	0.064	Fly
PXN	paxillin	0.062
MYST1	MYST histone acetyltransferase 1	0.060
RBL1	retinoblastoma-like 1 (p107)	0.060	Human
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.058
AXIN2	axin 2	0.058
KIF18A	kinesin family member 18A	0.058
ANAPC16	anaphase promoting complex subunit 16	0.058
MED1	mediator complex subunit 1	0.055
SGOL1	shugoshin-like 1 (S. pombe)	0.055
FXR2	fragile X mental retardation, autosomal homolog 2	0.054
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.054
ZWINT	ZW10 interactor	0.054
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.053
HDAC1	histone deacetylase 1	0.051
CCND1	cyclin D1	0.050
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.050
PRRC2C	proline-rich coiled-coil 2C	0.049
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.048
E2F4	E2F transcription factor 4, p107/p130-binding	0.048
TTK	TTK protein kinase	0.047	Yeast
SIRT2	sirtuin 2	0.047
BTBD10	BTB (POZ) domain containing 10	0.046
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.046
HERC2	hect domain and RLD 2	0.046
SMAD2	SMAD family member 2	0.045
MAK	male germ cell-associated kinase	0.045
C13orf34	chromosome 13 open reading frame 34	0.045
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.044
C19orf39	chromosome 19 open reading frame 39	0.044
AURKA	aurora kinase A	0.044
PPIG	peptidylprolyl isomerase G (cyclophilin G)	0.043
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.043
ATAD2	ATPase family, AAA domain containing 2	0.042
BRCA1	breast cancer 1, early onset	0.042
ANAPC13	anaphase promoting complex subunit 13	0.042
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.039
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.039	Yeast Fly
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.038
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.038
PPME1	protein phosphatase methylesterase 1	0.038
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.037
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.037
PARP3	poly (ADP-ribose) polymerase family, member 3	0.037
CDK1	cyclin-dependent kinase 1	0.036
LIN54	lin-54 homolog (C. elegans)	0.035
GSK3B	glycogen synthase kinase 3 beta	0.035	Fly
PTK2	PTK2 protein tyrosine kinase 2	0.035
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.035
SMC1A	structural maintenance of chromosomes 1A	0.034
POMP	proteasome maturation protein	0.033
HMGB1	high mobility group box 1	0.033
HIST1H4A	histone cluster 1, H4a	0.033
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.032
CEP55	centrosomal protein 55kDa	0.032
HIST1H1E	histone cluster 1, H1e	0.032
CUL2	cullin 2	0.031
TP53	tumor protein p53	0.031
C13orf27	chromosome 13 open reading frame 27	0.031
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.031
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.031
RFWD2	ring finger and WD repeat domain 2	0.029
PRNP	prion protein	0.029
GTSE1	G-2 and S-phase expressed 1	0.029
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.029
ATMIN	ATM interactor	0.028
ZNF420	zinc finger protein 420	0.028
TRIP13	thyroid hormone receptor interactor 13	0.028
SMC4	structural maintenance of chromosomes 4	0.028
PTEN	phosphatase and tensin homolog	0.028
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.027
E2F5	E2F transcription factor 5, p130-binding	0.027
TOP3A	topoisomerase (DNA) III alpha	0.027
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.027
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.027
CENPE	centromere protein E, 312kDa	0.026
RAD51C	RAD51 homolog C (S. cerevisiae)	0.026
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.025
HUWE1	HECT, UBA and WWE domain containing 1	0.025
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.024
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.024
USP44	ubiquitin specific peptidase 44	0.024
PLK4	polo-like kinase 4	0.024
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.024
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.024
LIN9	lin-9 homolog (C. elegans)	0.023
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.023
BTRC	beta-transducin repeat containing	0.023
TROAP	trophinin associated protein (tastin)	0.023
MKRN1	makorin ring finger protein 1	0.022
MKI67	antigen identified by monoclonal antibody Ki-67	0.022
ANKRD52	ankyrin repeat domain 52	0.022
KIF2C	kinesin family member 2C	0.022
ARIH2	ariadne homolog 2 (Drosophila)	0.021
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.021
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.021
USP49	ubiquitin specific peptidase 49	0.021	Human
PPP5C	protein phosphatase 5, catalytic subunit	0.021
NKAP	NFKB activating protein	0.020
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.020
SERTAD4	SERTA domain containing 4	0.020
NBN	nibrin	0.020
INTS12	integrator complex subunit 12	0.020
SCAF11	SR-related CTD-associated factor 11	0.020
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.020
RAD51AP1	RAD51 associated protein 1	0.019
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.019
SKP1	S-phase kinase-associated protein 1	0.019
ANAPC10	anaphase promoting complex subunit 10	0.019	Yeast
VHL	von Hippel-Lindau tumor suppressor	0.019
LMNA	lamin A/C	0.019
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.019
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.019
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.018
IGF1R	insulin-like growth factor 1 receptor	0.018
CCDC99	coiled-coil domain containing 99	0.018
UBE2S	ubiquitin-conjugating enzyme E2S	0.018
HIST1H1B	histone cluster 1, H1b	0.018
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.018
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.018
CCNF	cyclin F	0.017
DCLRE1C	DNA cross-link repair 1C	0.017
ATM	ataxia telangiectasia mutated	0.017
EML2	echinoderm microtubule associated protein like 2	0.017
MED21	mediator complex subunit 21	0.017
KDM4A	lysine (K)-specific demethylase 4A	0.017
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.017
NCAPG	non-SMC condensin I complex, subunit G	0.017
NRD1	nardilysin (N-arginine dibasic convertase)	0.017
DAXX	death-domain associated protein	0.017
HIST1H3F	histone cluster 1, H3f	0.017
MIS18BP1	MIS18 binding protein 1	0.016
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.016
SETD7	SET domain containing (lysine methyltransferase) 7	0.016
FANCI	Fanconi anemia, complementation group I	0.016
FEN1	flap structure-specific endonuclease 1	0.016
EP300	E1A binding protein p300	0.016
ZNF828	zinc finger protein 828	0.016
BAG2	BCL2-associated athanogene 2	0.016
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.016
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.015
KAT5	K(lysine) acetyltransferase 5	0.015
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.015
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.015
SNAI1	snail homolog 1 (Drosophila)	0.015
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.015
NUSAP1	nucleolar and spindle associated protein 1	0.015
CCDC101	coiled-coil domain containing 101	0.015
MYO1C	myosin IC	0.015
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.014
CCNH	cyclin H	0.014
USP9X	ubiquitin specific peptidase 9, X-linked	0.014
KIF11	kinesin family member 11	0.014
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.014
AXIN1	axin 1	0.014
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.014
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.014
NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	0.014
NKTR	natural killer-tumor recognition sequence	0.014
ING2	inhibitor of growth family, member 2	0.014
OTUD5	OTU domain containing 5	0.013
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.013
STRN4	striatin, calmodulin binding protein 4	0.013
CENPJ	centromere protein J	0.013
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.013
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.013
RNF5	ring finger protein 5	0.013
THOC2	THO complex 2	0.013
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.013
MAD2L1BP	MAD2L1 binding protein	0.012
PAK6	p21 protein (Cdc42/Rac)-activated kinase 6	0.012
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.012
SPOP	speckle-type POZ protein	0.012
CUL4A	cullin 4A	0.012
CENPF	centromere protein F, 350/400kDa (mitosin)	0.012
PIM1	pim-1 oncogene	0.012
CARD11	caspase recruitment domain family, member 11	0.012
FAM64A	family with sequence similarity 64, member A	0.012
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.012
TNPO1	transportin 1	0.012
MT1A	metallothionein 1A	0.012
E2F2	E2F transcription factor 2	0.012
PHF20	PHD finger protein 20	0.012
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.012
TOR1AIP2	torsin A interacting protein 2	0.011
ENY2	enhancer of yellow 2 homolog (Drosophila)	0.011
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.011
MMADHC	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria	0.011
ZFR	zinc finger RNA binding protein	0.011
ZNF71	zinc finger protein 71	0.011
PPP2R3B	protein phosphatase 2, regulatory subunit B'', beta	0.011
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.011
HIST1H2BB	histone cluster 1, H2bb	0.011
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.011
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.011
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.011
CASC5	cancer susceptibility candidate 5	0.011
UBASH3B	ubiquitin associated and SH3 domain containing B	0.011
ZNF148	zinc finger protein 148	0.011
MASTL	microtubule associated serine/threonine kinase-like	0.011
HIST1H4F	histone cluster 1, H4f	0.011
FANCD2	Fanconi anemia, complementation group D2	0.011
CDK7	cyclin-dependent kinase 7	0.011
DMAP1	DNA methyltransferase 1 associated protein 1	0.011
GSTM4	glutathione S-transferase mu 4	0.011
KAT2B	K(lysine) acetyltransferase 2B	0.010
CUL9	cullin 9	0.010
TUBA1C	tubulin, alpha 1c	0.010
PSRC1	proline/serine-rich coiled-coil 1	0.010
CCDC106	coiled-coil domain containing 106	0.010
KPNB1	karyopherin (importin) beta 1	0.010
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.010
SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5	0.010
CCNA1	cyclin A1	0.010
HIST1H3D	histone cluster 1, H3d	0.010
MBD1	methyl-CpG binding domain protein 1	0.010
ZNHIT3	zinc finger, HIT-type containing 3	0.010
FBXO4	F-box protein 4	0.010
HIST1H2AB	histone cluster 1, H2ab	0.010
ING4	inhibitor of growth family, member 4	0.010
VRK1	vaccinia related kinase 1	0.010
KIAA1279	KIAA1279	0.010
CCND2	cyclin D2	0.010
CENPL	centromere protein L	0.010
LIN52	lin-52 homolog (C. elegans)	0.010
BTBD2	BTB (POZ) domain containing 2	0.010