IMP: Integrative Multi-species Prediction

Homo sapiens

16 genes annotated in human

Multi-species View

positive regulation of developmental growth

GO:0048639

Any process that activates, maintains or increases the rate of developmental growth.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of developmental growth"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of developmental growth" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	0.930	Worm
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.822
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.795
SMAD4	SMAD family member 4	0.783	Worm Fly
SMAD2	SMAD family member 2	0.751	Worm
RB1	retinoblastoma 1	0.721	Worm
ARID1A	AT rich interactive domain 1A (SWI-like)	0.483
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	0.379
FGFR2	fibroblast growth factor receptor 2	0.303	Mouse
H2AFX	H2A histone family, member X	0.293
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.285
EP300	E1A binding protein p300	0.279
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.269
PDIA3	protein disulfide isomerase family A, member 3	0.267	Worm
INSR	insulin receptor	0.266
RPL27	ribosomal protein L27	0.245
CAND1	cullin-associated and neddylation-dissociated 1	0.229
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.203	Mouse
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.192	Mouse Fly
RBBP4	retinoblastoma binding protein 4	0.178
IGF1R	insulin-like growth factor 1 receptor	0.173	Human Worm Fly
ATF2	activating transcription factor 2	0.171
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.168
BCL2L1	BCL2-like 1	0.152
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.149
NRP1	neuropilin 1	0.144	Mouse
PABPC1	poly(A) binding protein, cytoplasmic 1	0.142
FN1	fibronectin 1	0.136	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.133	Human
NBN	nibrin	0.130
EEF1G	eukaryotic translation elongation factor 1 gamma	0.123
FLNA	filamin A, alpha	0.111
PDIA4	protein disulfide isomerase family A, member 4	0.106	Worm
CREBBP	CREB binding protein	0.104
ADNP	activity-dependent neuroprotector homeobox	0.101	Rat
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.100
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.099
SP1	Sp1 transcription factor	0.097
FKBP1A	FK506 binding protein 1A, 12kDa	0.094
SPTBN1	spectrin, beta, non-erythrocytic 1	0.093
ESR1	estrogen receptor 1	0.090
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.088
NCOR1	nuclear receptor corepressor 1	0.081
TP53	tumor protein p53	0.080	Fly
MBNL1	muscleblind-like (Drosophila)	0.080
ZFX	zinc finger protein, X-linked	0.079
FUS	fused in sarcoma	0.078	Fly
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.078
DLG4	discs, large homolog 4 (Drosophila)	0.074	Fly
JAK2	Janus kinase 2	0.073
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.071	Worm
TGFB1	transforming growth factor, beta 1	0.071
CCNA2	cyclin A2	0.070
SRSF10	serine/arginine-rich splicing factor 10	0.070
RPL36A	ribosomal protein L36a	0.069
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.069
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.067
BAD	BCL2-associated agonist of cell death	0.066
RPL41	ribosomal protein L41	0.066
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.062
HIPK2	homeodomain interacting protein kinase 2	0.061
BOP1	block of proliferation 1	0.060
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.059	Rat
UBE2K	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)	0.058
SMAD7	SMAD family member 7	0.058
MTA1	metastasis associated 1	0.058
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.055
TXN	thioredoxin	0.054
NHP2L1	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	0.054
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.054	Worm
TRIM28	tripartite motif containing 28	0.054
RPL34	ribosomal protein L34	0.053
MAPK8	mitogen-activated protein kinase 8	0.052
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.052
ITGB4	integrin, beta 4	0.049
ILF3	interleukin enhancer binding factor 3, 90kDa	0.048
JUN	jun proto-oncogene	0.047
PAX3	paired box 3	0.045
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.044
RPL27A	ribosomal protein L27a	0.044
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.044	Fly
GH1	growth hormone 1	0.043
ENO1	enolase 1, (alpha)	0.043	Worm
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.043
SIRT1	sirtuin 1	0.042
SH3RF1	SH3 domain containing ring finger 1	0.042
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.042
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.041
CREB1	cAMP responsive element binding protein 1	0.040	Mouse
HTT	huntingtin	0.040
SH3BP2	SH3-domain binding protein 2	0.039
E2F1	E2F transcription factor 1	0.038
BMP2	bone morphogenetic protein 2	0.038
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.037
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.037
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.037
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.037
EWSR1	Ewing sarcoma breakpoint region 1	0.037	Fly
COX6C	cytochrome c oxidase subunit VIc	0.037
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.036
PGK1	phosphoglycerate kinase 1	0.036
NUDT21	nudix (nucleoside diphosphate linked moiety X)-type motif 21	0.036
RPL37A	ribosomal protein L37a	0.035
CDK1	cyclin-dependent kinase 1	0.035	Rat
JAG1	jagged 1	0.035
NOLC1	nucleolar and coiled-body phosphoprotein 1	0.035
DHCR7	7-dehydrocholesterol reductase	0.034
PRRC2A	proline-rich coiled-coil 2A	0.033
TRIO	triple functional domain (PTPRF interacting)	0.032	Worm Fly
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.032
HNRNPR	heterogeneous nuclear ribonucleoprotein R	0.032
CSNK1A1	casein kinase 1, alpha 1	0.029
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.029
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.029
MED10	mediator complex subunit 10	0.029
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.029
SKIL	SKI-like oncogene	0.029
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.029
FANCD2	Fanconi anemia, complementation group D2	0.029
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.029	Human
EIF4B	eukaryotic translation initiation factor 4B	0.028
TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	0.028
RPL24	ribosomal protein L24	0.028
ZFYVE9	zinc finger, FYVE domain containing 9	0.027
EBNA1BP2	EBNA1 binding protein 2	0.027
COL5A1	collagen, type V, alpha 1	0.027
COL4A1	collagen, type IV, alpha 1	0.026
TMPO	thymopoietin	0.026
GDA	guanine deaminase	0.025
PRMT1	protein arginine methyltransferase 1	0.025
HNF4A	hepatocyte nuclear factor 4, alpha	0.025
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.025	Mouse
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.024
GRB10	growth factor receptor-bound protein 10	0.024
FGFR1	fibroblast growth factor receptor 1	0.024	Mouse
CHD7	chromodomain helicase DNA binding protein 7	0.024	Mouse Fly
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.024
CARM1	coactivator-associated arginine methyltransferase 1	0.023
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.023
RPL9	ribosomal protein L9	0.023
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.023
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.023
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.022
TPT1	tumor protein, translationally-controlled 1	0.022	Fly
RPL22	ribosomal protein L22	0.022	Worm
SMAD5	SMAD family member 5	0.022	Worm Fly
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.022
SOX10	SRY (sex determining region Y)-box 10	0.022
ZMYM2	zinc finger, MYM-type 2	0.022
TDG	thymine-DNA glycosylase	0.022
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.022
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.022
RPL31	ribosomal protein L31	0.021
ATXN1	ataxin 1	0.021
BCAR1	breast cancer anti-estrogen resistance 1	0.021
EIF4A1	eukaryotic translation initiation factor 4A1	0.021
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.021
PBRM1	polybromo 1	0.021
RRS1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	0.021
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.020
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.020
SORBS1	sorbin and SH3 domain containing 1	0.020
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.020	Worm
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.020
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.020
EIF2B4	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	0.020
ENOPH1	enolase-phosphatase 1	0.020
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.019
TNRC6A	trinucleotide repeat containing 6A	0.019
PAPOLA	poly(A) polymerase alpha	0.019
CNOT1	CCR4-NOT transcription complex, subunit 1	0.019
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.019
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.019
MRPL12	mitochondrial ribosomal protein L12	0.019
RPS7	ribosomal protein S7	0.019
CFL1	cofilin 1 (non-muscle)	0.019
PDIA6	protein disulfide isomerase family A, member 6	0.019
TCF12	transcription factor 12	0.018
GDF5	growth differentiation factor 5	0.018
EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	0.018
ACVR1	activin A receptor, type I	0.018	Worm Fly
RRAGC	Ras-related GTP binding C	0.018
SPAST	spastin	0.018	Zebrafish Fly
CRH	corticotropin releasing hormone	0.018
LAT	linker for activation of T cells	0.018
UQCRB	ubiquinol-cytochrome c reductase binding protein	0.018	Worm
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.018
USP9X	ubiquitin specific peptidase 9, X-linked	0.018
CSHL1	chorionic somatomammotropin hormone-like 1	0.017	Human
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.017
BCL2	B-cell CLL/lymphoma 2	0.017	Mouse
SP3	Sp3 transcription factor	0.017
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.017
MED15	mediator complex subunit 15	0.017
POLR1B	polymerase (RNA) I polypeptide B, 128kDa	0.017
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.017
PPIA	peptidylprolyl isomerase A (cyclophilin A)	0.017
QKI	quaking homolog, KH domain RNA binding (mouse)	0.017
STK39	serine threonine kinase 39	0.017
MKL2	MKL/myocardin-like 2	0.017
CAPRIN1	cell cycle associated protein 1	0.017
TH1L	TH1-like (Drosophila)	0.017
NLK	nemo-like kinase	0.017	Fly
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.017
CSH2	chorionic somatomammotropin hormone 2	0.016	Human
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.016
NONO	non-POU domain containing, octamer-binding	0.016
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.016
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.016	Fly
RPL23A	ribosomal protein L23a	0.016	Worm
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.016
DMD	dystrophin	0.016
ERO1L	ERO1-like (S. cerevisiae)	0.016
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.016
RPL32	ribosomal protein L32	0.016
MKL1	megakaryoblastic leukemia (translocation) 1	0.015
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.015	Worm
MAML1	mastermind-like 1 (Drosophila)	0.015
SUB1	SUB1 homolog (S. cerevisiae)	0.015
BPTF	bromodomain PHD finger transcription factor	0.015
KHSRP	KH-type splicing regulatory protein	0.015
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.015	Worm
RUNX1	runt-related transcription factor 1	0.015	Worm
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.015
RPL7	ribosomal protein L7	0.015
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.015
CBFB	core-binding factor, beta subunit	0.015
NCBP2	nuclear cap binding protein subunit 2, 20kDa	0.015
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.015
PTPRN	protein tyrosine phosphatase, receptor type, N	0.014
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.014	Worm
PRDX1	peroxiredoxin 1	0.014	Worm
BTF3	basic transcription factor 3	0.014
EPAS1	endothelial PAS domain protein 1	0.014
SENP3	SUMO1/sentrin/SMT3 specific peptidase 3	0.014
LRP6	low density lipoprotein receptor-related protein 6	0.014
CHD8	chromodomain helicase DNA binding protein 8	0.014	Fly
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.014
CALR	calreticulin	0.014
YY1	YY1 transcription factor	0.014
SRSF3	serine/arginine-rich splicing factor 3	0.014
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.014
OXSR1	oxidative-stress responsive 1	0.014
CALCA	calcitonin-related polypeptide alpha	0.013
CLASP1	cytoplasmic linker associated protein 1	0.013
NAV1	neuron navigator 1	0.013	Worm
MAP1A	microtubule-associated protein 1A	0.013
THOC4	THO complex 4	0.013
MAP2K4	mitogen-activated protein kinase kinase 4	0.013
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.013
ATN1	atrophin 1	0.013
PARP1	poly (ADP-ribose) polymerase 1	0.013
PABPN1	poly(A) binding protein, nuclear 1	0.013
ADORA2A	adenosine A2a receptor	0.013
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.013
TRAPPC6B	trafficking protein particle complex 6B	0.013
SMAD6	SMAD family member 6	0.013
HDAC4	histone deacetylase 4	0.013
FGF10	fibroblast growth factor 10	0.013	Human
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.012
RPS18	ribosomal protein S18	0.012
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.012
RPN1	ribophorin I	0.012	Worm
EIF4E	eukaryotic translation initiation factor 4E	0.012
PRKCZ	protein kinase C, zeta	0.012
BAX	BCL2-associated X protein	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
TRAPPC2L	trafficking protein particle complex 2-like	0.012
ZMYND11	zinc finger, MYND-type containing 11	0.012
COX7C	cytochrome c oxidase subunit VIIc	0.012
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.012
RPS29	ribosomal protein S29	0.012
NMT1	N-myristoyltransferase 1	0.012
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.012
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.012
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.012
GHR	growth hormone receptor	0.012
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.012	Worm
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.012
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.012
PUM2	pumilio homolog 2 (Drosophila)	0.012
IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2	0.012
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.012
VEGFA	vascular endothelial growth factor A	0.012	Mouse
RCC1	regulator of chromosome condensation 1	0.012
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.011
LAMB1	laminin, beta 1	0.011
MED27	mediator complex subunit 27	0.011
STAT5B	signal transducer and activator of transcription 5B	0.011	Mouse
C14orf2	chromosome 14 open reading frame 2	0.011
ZHX1	zinc fingers and homeoboxes 1	0.011
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.011
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.011
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.011
PDHX	pyruvate dehydrogenase complex, component X	0.011
PHF3	PHD finger protein 3	0.011
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.011
RPL30	ribosomal protein L30	0.011	Worm
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.011
GH2	growth hormone 2	0.011	Human
RPE	ribulose-5-phosphate-3-epimerase	0.011
SH2D4A	SH2 domain containing 4A	0.011
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.011
DTNA	dystrobrevin, alpha	0.011
STT3A	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	0.011
HDGF	hepatoma-derived growth factor	0.011
NSFL1C	NSFL1 (p97) cofactor (p47)	0.011
MRPS22	mitochondrial ribosomal protein S22	0.011
SOD1	superoxide dismutase 1, soluble	0.011
ERBB2IP	erbb2 interacting protein	0.010
FAR1	fatty acyl CoA reductase 1	0.010
ZMYM4	zinc finger, MYM-type 4	0.010
ELOVL1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.010
ING3	inhibitor of growth family, member 3	0.010
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.010
CBX5	chromobox homolog 5	0.010	Worm
RPS27	ribosomal protein S27	0.010
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.010
MED31	mediator complex subunit 31	0.010
PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	0.010