IMP: Integrative Multi-species Prediction

Homo sapiens

22 genes annotated in human

cytoskeleton dependent cytokinesis

A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cytoskeleton dependent cytokinesis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cytoskeleton dependent cytokinesis" (in gray)

Name	Description	Probability	Func Analog Organism
KIF23	kinesin family member 23	0.973	Zebrafish Worm Fly
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.908
RACGAP1	Rac GTPase activating protein 1	0.820
TUBA1C	tubulin, alpha 1c	0.791
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.699
ACTB	actin, beta	0.593	Yeast
MYH9	myosin, heavy chain 9, non-muscle	0.581	Human Worm Fly
SNX9	sorting nexin 9	0.569
TCP1	t-complex 1	0.526
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.526
EXOC7	exocyst complex component 7	0.499
CDK1	cyclin-dependent kinase 1	0.466
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.460
RHOA	ras homolog gene family, member A	0.442
AURKB	aurora kinase B	0.367
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.349
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.339
TSG101	tumor susceptibility gene 101	0.333
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.332
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.328
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.315
DNM1	dynamin 1	0.304	Fly
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.297
IQGAP1	IQ motif containing GTPase activating protein 1	0.290
WASL	Wiskott-Aldrich syndrome-like	0.288
KIF5B	kinesin family member 5B	0.263	Worm
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.262
EZR	ezrin	0.261	Fly
ANK1	ankyrin 1, erythrocytic	0.242	Human
SEPT2	septin 2	0.236	Yeast
INCENP	inner centromere protein antigens 135/155kDa	0.224
MYL12B	myosin, light chain 12B, regulatory	0.214	Worm Fly
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.201
GAS2L3	growth arrest-specific 2 like 3	0.181
ANLN	anillin, actin binding protein	0.176
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.170
SCHIP1	schwannomin interacting protein 1	0.165
COPE	coatomer protein complex, subunit epsilon	0.161
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.147	Worm
HDAC2	histone deacetylase 2	0.147
DNM2	dynamin 2	0.139	Fly
PLK1	polo-like kinase 1	0.136
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.121
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.115
TUBB	tubulin, beta	0.114
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.114
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.112
CCNA2	cyclin A2	0.112
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.112
KIF20A	kinesin family member 20A	0.107	Worm
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.103	Worm Fly
KIF4A	kinesin family member 4A	0.102
TNK2	tyrosine kinase, non-receptor, 2	0.101
SPTB	spectrin, beta, erythrocytic	0.098	Human
TTK	TTK protein kinase	0.097
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.096
ACTG1	actin, gamma 1	0.094	Yeast
RFWD2	ring finger and WD repeat domain 2	0.093
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.093
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.091
PRC1	protein regulator of cytokinesis 1	0.090	Fly
CCNB1	cyclin B1	0.085	Fly
ECT2	epithelial cell transforming sequence 2 oncogene	0.084	Worm Fly
CENPE	centromere protein E, 312kDa	0.077
TP53	tumor protein p53	0.075
ANAPC5	anaphase promoting complex subunit 5	0.075
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.070
ARHGAP1	Rho GTPase activating protein 1	0.070
CDK2	cyclin-dependent kinase 2	0.067
ADAM15	ADAM metallopeptidase domain 15	0.067
RAB11A	RAB11A, member RAS oncogene family	0.064	Fly
SEC23A	Sec23 homolog A (S. cerevisiae)	0.064
CENPA	centromere protein A	0.061
ANKRD28	ankyrin repeat domain 28	0.060
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.055
RBBP4	retinoblastoma binding protein 4	0.054	Fly
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.052
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.050
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.050
FASLG	Fas ligand (TNF superfamily, member 6)	0.049
EHD1	EH-domain containing 1	0.049
CDKN3	cyclin-dependent kinase inhibitor 3	0.048
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.047
PRKCI	protein kinase C, iota	0.047
ANAPC4	anaphase promoting complex subunit 4	0.045
DSTN	destrin (actin depolymerizing factor)	0.045
TSC2	tuberous sclerosis 2	0.045
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.043
HDAC1	histone deacetylase 1	0.043
CBX5	chromobox homolog 5	0.043
NCL	nucleolin	0.042
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.041
KIF1B	kinesin family member 1B	0.041
SGOL1	shugoshin-like 1 (S. pombe)	0.040
GRB2	growth factor receptor-bound protein 2	0.038
FN1	fibronectin 1	0.038
FBF1	Fas (TNFRSF6) binding factor 1	0.038
HJURP	Holliday junction recognition protein	0.038
CKS2	CDC28 protein kinase regulatory subunit 2	0.038
NEURL4	neuralized homolog 4 (Drosophila)	0.037
CDCA2	cell division cycle associated 2	0.037
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.036
SNW1	SNW domain containing 1	0.036
ITSN1	intersectin 1 (SH3 domain protein)	0.036
CUL9	cullin 9	0.036	Human
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.036
PRNP	prion protein	0.035
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.035
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.035
PTPRN	protein tyrosine phosphatase, receptor type, N	0.035
SKA3	spindle and kinetochore associated complex subunit 3	0.034
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.034
SNX33	sorting nexin 33	0.034
SKA2	spindle and kinetochore associated complex subunit 2	0.033
HUWE1	HECT, UBA and WWE domain containing 1	0.033
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.032
KIF2C	kinesin family member 2C	0.032
SKA1	spindle and kinetochore associated complex subunit 1	0.032
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.031
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.031
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.030
APTX	aprataxin	0.030
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.030
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.030
SFN	stratifin	0.029
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.029
DEPDC1B	DEP domain containing 1B	0.029
KIF14	kinesin family member 14	0.029
EXOC2	exocyst complex component 2	0.029	Fly
DCK	deoxycytidine kinase	0.028
DEPDC1	DEP domain containing 1	0.028
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.028
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.027
RAB1A	RAB1A, member RAS oncogene family	0.027
APLP1	amyloid beta (A4) precursor-like protein 1	0.027
SPTBN1	spectrin, beta, non-erythrocytic 1	0.026
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.026
EXOC4	exocyst complex component 4	0.026	Fly
RAB6A	RAB6A, member RAS oncogene family	0.026
FLNA	filamin A, alpha	0.025
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.025
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.024
CENPF	centromere protein F, 350/400kDa (mitosin)	0.024
BIRC5	baculoviral IAP repeat containing 5	0.024
RIPK3	receptor-interacting serine-threonine kinase 3	0.024
CUL7	cullin 7	0.024
CD44	CD44 molecule (Indian blood group)	0.024
CKAP5	cytoskeleton associated protein 5	0.024
BIRC6	baculoviral IAP repeat containing 6	0.024
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.023
ANAPC11	anaphase promoting complex subunit 11	0.023
SMAD2	SMAD family member 2	0.023
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.023
SEC31A	SEC31 homolog A (S. cerevisiae)	0.023
MSN	moesin	0.023	Fly
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.023
AMPH	amphiphysin	0.023
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.023
ZMYND11	zinc finger, MYND-type containing 11	0.022
PSRC1	proline/serine-rich coiled-coil 1	0.022
INSIG1	insulin induced gene 1	0.022
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.022
FAM64A	family with sequence similarity 64, member A	0.022
KIF18A	kinesin family member 18A	0.022
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.021
RBL1	retinoblastoma-like 1 (p107)	0.021
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.021
RAB5A	RAB5A, member RAS oncogene family	0.021
CEP55	centrosomal protein 55kDa	0.020
F11R	F11 receptor	0.020
LRRK2	leucine-rich repeat kinase 2	0.020
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.020
RBBP7	retinoblastoma binding protein 7	0.020	Fly
JAM2	junctional adhesion molecule 2	0.020
CFL2	cofilin 2 (muscle)	0.019
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.019
SEPT7	septin 7	0.019	Yeast Fly
SHCBP1	SHC SH2-domain binding protein 1	0.019
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.019
PPP4C	protein phosphatase 4, catalytic subunit	0.019
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.018
CCNB2	cyclin B2	0.018	Fly
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.018
DHCR7	7-dehydrocholesterol reductase	0.018
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.018
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.018
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.018
PDCD6IP	programmed cell death 6 interacting protein	0.018
BBS2	Bardet-Biedl syndrome 2	0.018
PICALM	phosphatidylinositol binding clathrin assembly protein	0.018
ANAPC7	anaphase promoting complex subunit 7	0.018
GPSM2	G-protein signaling modulator 2	0.017
WEE1	WEE1 homolog (S. pombe)	0.017
C13orf34	chromosome 13 open reading frame 34	0.017
KRT15	keratin 15	0.017
CSNK2B	casein kinase 2, beta polypeptide	0.017
VCL	vinculin	0.017
GAS7	growth arrest-specific 7	0.017
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.017
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.017
ARHGAP11A	Rho GTPase activating protein 11A	0.017
COPG	coatomer protein complex, subunit gamma	0.017
KDM1A	lysine (K)-specific demethylase 1A	0.017
ATP8	ATP synthase F0 subunit 8	0.017
KIF11	kinesin family member 11	0.016
ANAPC1	anaphase promoting complex subunit 1	0.016
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.016
CORO1C	coronin, actin binding protein, 1C	0.016
TUBA1B	tubulin, alpha 1b	0.016
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.016
PFN1	profilin 1	0.016
ACTA2	actin, alpha 2, smooth muscle, aorta	0.016
RAB7A	RAB7A, member RAS oncogene family	0.016
MTA3	metastasis associated 1 family, member 3	0.016
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.015
NCF1	neutrophil cytosolic factor 1	0.015
COPS8	COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)	0.015
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.015
ACACA	acetyl-CoA carboxylase alpha	0.015
MARK2	MAP/microtubule affinity-regulating kinase 2	0.015
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.015
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.015
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.015
CHD4	chromodomain helicase DNA binding protein 4	0.015
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.014
ANXA2	annexin A2	0.014
CHMP1B	chromatin modifying protein 1B	0.014
TMSB4X	thymosin beta 4, X-linked	0.014
SEPT9	septin 9	0.014
MPRIP	myosin phosphatase Rho interacting protein	0.014
SEPT11	septin 11	0.014
SEPT6	septin 6	0.014	Fly
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.014
EXOC1	exocyst complex component 1	0.014
MARK3	MAP/microtubule affinity-regulating kinase 3	0.014
LIMK1	LIM domain kinase 1	0.013
UBE2C	ubiquitin-conjugating enzyme E2C	0.013
GTSE1	G-2 and S-phase expressed 1	0.013
MELK	maternal embryonic leucine zipper kinase	0.013
CAB39	calcium binding protein 39	0.013
SYNJ1	synaptojanin 1	0.013
ERBB2IP	erbb2 interacting protein	0.013
SEPT1	septin 1	0.013	Yeast
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.013
APC	adenomatous polyposis coli	0.013
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.013	Yeast
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.013
BABAM1	BRISC and BRCA1 A complex member 1	0.012
CENPI	centromere protein I	0.012
YBX1	Y box binding protein 1	0.012
HSPA1B	heat shock 70kDa protein 1B	0.012
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.012
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.012
SPAG5	sperm associated antigen 5	0.012
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.012
ARID1A	AT rich interactive domain 1A (SWI-like)	0.012
STRADB	STE20-related kinase adaptor beta	0.012
HSPB1	heat shock 27kDa protein 1	0.012
UBC	ubiquitin C	0.012
STAMBP	STAM binding protein	0.012
MICALL1	MICAL-like 1	0.012
PBK	PDZ binding kinase	0.012
KIF20B	kinesin family member 20B	0.012	Worm
DMAP1	DNA methyltransferase 1 associated protein 1	0.012
CDK17	cyclin-dependent kinase 17	0.012
C20orf20	chromosome 20 open reading frame 20	0.011
DYNC2H1	dynein, cytoplasmic 2, heavy chain 1	0.011
TBC1D10A	TBC1 domain family, member 10A	0.011
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.011
SERTAD4	SERTA domain containing 4	0.011
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.011
FAM83D	family with sequence similarity 83, member D	0.011
MND1	meiotic nuclear divisions 1 homolog (S. cerevisiae)	0.011
BBS9	Bardet-Biedl syndrome 9	0.011
COPB2	coatomer protein complex, subunit beta 2 (beta prime)	0.011
ZNF512B	zinc finger protein 512B	0.011
WDR1	WD repeat domain 1	0.011
BTBD2	BTB (POZ) domain containing 2	0.011
KAT2A	K(lysine) acetyltransferase 2A	0.011
NCKAP1	NCK-associated protein 1	0.011
S100A4	S100 calcium binding protein A4	0.010
CDCA3	cell division cycle associated 3	0.010
SYT1	synaptotagmin I	0.010
WDR83	WD repeat domain 83	0.010
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.010
MAPK1	mitogen-activated protein kinase 1	0.010
ZFPM1	zinc finger protein, multitype 1	0.010
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.010