IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

response to caffeine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to caffeine"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to caffeine" (in gray)

Name	Description	Probability	Func Analog Organism
GSTM1	glutathione S-transferase mu 1	1.000	Human
GSTM2	glutathione S-transferase mu 2 (muscle)	0.982
BRCA1	breast cancer 1, early onset	0.944
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.908	Rat
BRCA2	breast cancer 2, early onset	0.891
HDAC2	histone deacetylase 2	0.865
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.841	Rat
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.781
DRD2	dopamine receptor D2	0.775
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.704
GSTM4	glutathione S-transferase mu 4	0.665	Human
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.597
ACVR1B	activin A receptor, type IB	0.522
BCL2L1	BCL2-like 1	0.426
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.415
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.412
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.392
PRSS2	protease, serine, 2 (trypsin 2)	0.386
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.364
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.323	Fly
NBN	nibrin	0.315
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.309
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.270
CLSPN	claspin	0.268
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.234
INSR	insulin receptor	0.221
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.221
GRB10	growth factor receptor-bound protein 10	0.183
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.174
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.169
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.166
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.149	Fly
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.126	Fly
ATR	ataxia telangiectasia and Rad3 related	0.122	Fly
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.120
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.119
FANCD2	Fanconi anemia, complementation group D2	0.116
TGFBR1	transforming growth factor, beta receptor 1	0.115
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.111
AKAP6	A kinase (PRKA) anchor protein 6	0.111
RB1	retinoblastoma 1	0.109
MSH6	mutS homolog 6 (E. coli)	0.097
WRN	Werner syndrome, RecQ helicase-like	0.097
RBBP8	retinoblastoma binding protein 8	0.097
GSTM3	glutathione S-transferase mu 3 (brain)	0.094	Human
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.090	Fly
PARP1	poly (ADP-ribose) polymerase 1	0.089
TP53BP1	tumor protein p53 binding protein 1	0.084
ACACA	acetyl-CoA carboxylase alpha	0.082
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.069
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.062
EED	embryonic ectoderm development	0.060
ESRRG	estrogen-related receptor gamma	0.059
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.050
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.047
HDAC1	histone deacetylase 1	0.046	Rat
HIPK2	homeodomain interacting protein kinase 2	0.045
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.045
PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	0.044	Rat
MYST1	MYST histone acetyltransferase 1	0.043
RPTOR	regulatory associated protein of MTOR, complex 1	0.039
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.039
NECAB2	N-terminal EF-hand calcium binding protein 2	0.038
ND1	NADH dehydrogenase, subunit 1 (complex I)	0.037
GSTM5	glutathione S-transferase mu 5	0.036	Human
IGF1R	insulin-like growth factor 1 receptor	0.035
PGCP	plasma glutamate carboxypeptidase	0.035
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.035
RFC1	replication factor C (activator 1) 1, 145kDa	0.034
HDAC4	histone deacetylase 4	0.032
SMPX	small muscle protein, X-linked	0.032
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.032
RAD50	RAD50 homolog (S. cerevisiae)	0.032
DCLRE1C	DNA cross-link repair 1C	0.032
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.032
NDNL2	necdin-like 2	0.030
TP53BP2	tumor protein p53 binding protein, 2	0.030
NAMPT	nicotinamide phosphoribosyltransferase	0.029
RAD52	RAD52 homolog (S. cerevisiae)	0.028
HNF4A	hepatocyte nuclear factor 4, alpha	0.028
PDZK1	PDZ domain containing 1	0.028
TIMELESS	timeless homolog (Drosophila)	0.028
ABI1	abl-interactor 1	0.028
LIN7A	lin-7 homolog A (C. elegans)	0.027
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.027
TRIM27	tripartite motif containing 27	0.026
ATMIN	ATM interactor	0.026
FRS2	fibroblast growth factor receptor substrate 2	0.026
F11R	F11 receptor	0.025
SMC5	structural maintenance of chromosomes 5	0.025
ALB	albumin	0.025
PALB2	partner and localizer of BRCA2	0.024
AMOT	angiomotin	0.024
GEN1	Gen homolog 1, endonuclease (Drosophila)	0.024
AMBRA1	autophagy/beclin-1 regulator 1	0.023
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.023
C19orf39	chromosome 19 open reading frame 39	0.023
TRDN	triadin	0.022
FMO4	flavin containing monooxygenase 4	0.022
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.022
CNR1	cannabinoid receptor 1 (brain)	0.022
ADORA1	adenosine A1 receptor	0.021
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.021
SH3GL2	SH3-domain GRB2-like 2	0.021
DAXX	death-domain associated protein	0.021
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.020
RYR3	ryanodine receptor 3	0.020	Human
BAX	BCL2-associated X protein	0.020
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.020
CRYAB	crystallin, alpha B	0.020
USP42	ubiquitin specific peptidase 42	0.020
C6	complement component 6	0.019
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.019
FKBP1B	FK506 binding protein 1B, 12.6 kDa	0.019
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.019
PCNA	proliferating cell nuclear antigen	0.019
NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	0.019
MYOM1	myomesin 1, 185kDa	0.019
MYOM2	myomesin (M-protein) 2, 165kDa	0.019
S100B	S100 calcium binding protein B	0.018
GAB1	GRB2-associated binding protein 1	0.018
SETD7	SET domain containing (lysine methyltransferase) 7	0.018
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.018
ACTN2	actinin, alpha 2	0.018
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.018
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.018
MYBPC1	myosin binding protein C, slow type	0.017
PYGM	phosphorylase, glycogen, muscle	0.017
FNIP1	folliculin interacting protein 1	0.017
ING4	inhibitor of growth family, member 4	0.017
MPZL1	myelin protein zero-like 1	0.017
LGALS4	lectin, galactoside-binding, soluble, 4	0.017
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.016
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.016
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.016
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.016
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.016
RBBP7	retinoblastoma binding protein 7	0.016
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.016
ATRIP	ATR interacting protein	0.016
ASPA	aspartoacylase	0.016
FRK	fyn-related kinase	0.016
MUC1	mucin 1, cell surface associated	0.016
BLM	Bloom syndrome, RecQ helicase-like	0.016
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.016
SMC2	structural maintenance of chromosomes 2	0.016
MSH3	mutS homolog 3 (E. coli)	0.016
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.015
FAM189A2	family with sequence similarity 189, member A2	0.015
BIK	BCL2-interacting killer (apoptosis-inducing)	0.015
MYOZ2	myozenin 2	0.015
PRSS3	protease, serine, 3	0.015	Rat
SP1	Sp1 transcription factor	0.015
CCDC106	coiled-coil domain containing 106	0.015
BANP	BTG3 associated nuclear protein	0.015
TBP	TATA box binding protein	0.015
MBD2	methyl-CpG binding domain protein 2	0.015
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.015
EPS8	epidermal growth factor receptor pathway substrate 8	0.015
RAD51C	RAD51 homolog C (S. cerevisiae)	0.014
PON3	paraoxonase 3	0.014
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.014
FBXO4	F-box protein 4	0.014
S100A1	S100 calcium binding protein A1	0.014
EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.014
FTL	ferritin, light polypeptide	0.014
ATM	ataxia telangiectasia mutated	0.014	Fly
F9	coagulation factor IX	0.014
RYR2	ryanodine receptor 2 (cardiac)	0.014
PRSS1	protease, serine, 1 (trypsin 1)	0.014	Rat
GTF2I	general transcription factor IIi	0.014
GK	glycerol kinase	0.014
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.014
CMIP	c-Maf-inducing protein	0.013
MYOT	myotilin	0.013
PLIN1	perilipin 1	0.013
CHD4	chromodomain helicase DNA binding protein 4	0.013
C1orf105	chromosome 1 open reading frame 105	0.013
GAB2	GRB2-associated binding protein 2	0.013
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.013
RCOR1	REST corepressor 1	0.013
PRKG2	protein kinase, cGMP-dependent, type II	0.013
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.013
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.013
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.013
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.013
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.013
S100A4	S100 calcium binding protein A4	0.013
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.013
BAK1	BCL2-antagonist/killer 1	0.013
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.013
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.013
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.012
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.012
SAP30	Sin3A-associated protein, 30kDa	0.012
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.012
KDM1A	lysine (K)-specific demethylase 1A	0.012
AADAC	arylacetamide deacetylase (esterase)	0.012
ATOH8	atonal homolog 8 (Drosophila)	0.012
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.012
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.012
ACTC1	actin, alpha, cardiac muscle 1	0.012
PIAS2	protein inhibitor of activated STAT, 2	0.012
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E	0.012
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.012
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.012
PIK3C2B	phosphoinositide-3-kinase, class 2, beta polypeptide	0.012
HELLS	helicase, lymphoid-specific	0.012
MORC4	MORC family CW-type zinc finger 4	0.012
HSPB2	heat shock 27kDa protein 2	0.012
EGF	epidermal growth factor	0.012
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.012
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.011
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.011
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011
FHL5	four and a half LIM domains 5	0.011
HSPB3	heat shock 27kDa protein 3	0.011
CNGA1	cyclic nucleotide gated channel alpha 1	0.011
C4orf31	chromosome 4 open reading frame 31	0.011
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.011
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.011
STAC	SH3 and cysteine rich domain	0.011
SLN	sarcolipin	0.011
ZNF331	zinc finger protein 331	0.011
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.011
PLN	phospholamban	0.011
PLP1	proteolipid protein 1	0.011
TNNC1	troponin C type 1 (slow)	0.011
SMC4	structural maintenance of chromosomes 4	0.011
MT1A	metallothionein 1A	0.011
AMPD1	adenosine monophosphate deaminase 1	0.011
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.011
TIMP4	TIMP metallopeptidase inhibitor 4	0.011
ASCC3	activating signal cointegrator 1 complex subunit 3	0.011
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.011
RERGL	RERG/RAS-like	0.011
FMO2	flavin containing monooxygenase 2 (non-functional)	0.011
TLN2	talin 2	0.011
APTX	aprataxin	0.011
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.011
EID3	EP300 interacting inhibitor of differentiation 3	0.011
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.011
CUL9	cullin 9	0.011
KIF1C	kinesin family member 1C	0.010
SPINK5	serine peptidase inhibitor, Kazal type 5	0.010
BMX	BMX non-receptor tyrosine kinase	0.010
ITIH2	inter-alpha (globulin) inhibitor H2	0.010
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.010
LDHA	lactate dehydrogenase A	0.010
CKMT2	creatine kinase, mitochondrial 2 (sarcomeric)	0.010
SCRG1	stimulator of chondrogenesis 1	0.010
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.010
PGM5	phosphoglucomutase 5	0.010
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.010
MUC13	mucin 13, cell surface associated	0.010
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.010
FASTKD1	FAST kinase domains 1	0.010
NDRG2	NDRG family member 2	0.010
CTSE	cathepsin E	0.010
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.010
UVRAG	UV radiation resistance associated gene	0.010
LMO3	LIM domain only 3 (rhombotin-like 2)	0.010
LGI1	leucine-rich, glioma inactivated 1	0.010
PDZRN4	PDZ domain containing ring finger 4	0.010
FMO1	flavin containing monooxygenase 1	0.010
CNTNAP4	contactin associated protein-like 4	0.010
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.010
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.010
PPARA	peroxisome proliferator-activated receptor alpha	0.010
CLCA1	chloride channel accessory 1	0.010
TLR3	toll-like receptor 3	0.010
SCN7A	sodium channel, voltage-gated, type VII, alpha	0.010
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.010