IMP: Integrative Multi-species Prediction

Homo sapiens

6 genes annotated in human

positive regulation of mitotic cell cycle spindle assembly checkpoint

Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of mitotic cell cycle spindle assembly checkpoint"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of mitotic cell cycle spindle assembly checkpoint" (in gray)

Name	Description	Probability
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.433
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.161
UBC	ubiquitin C	0.076
RUVBL2	RuvB-like 2 (E. coli)	0.052
TP53	tumor protein p53	0.049
ICT1	immature colon carcinoma transcript 1	0.046
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.025
SUB1	SUB1 homolog (S. cerevisiae)	0.024
NDUFAB1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa	0.021
TRA2B	transformer 2 beta homolog (Drosophila)	0.018
SLBP	stem-loop binding protein	0.018
TRIP13	thyroid hormone receptor interactor 13	0.016
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.015
UQCRQ	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa	0.014
EIF3K	eukaryotic translation initiation factor 3, subunit K	0.014
ESR1	estrogen receptor 1	0.014
MCM7	minichromosome maintenance complex component 7	0.014
NDUFS3	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	0.013
SMN1	survival of motor neuron 1, telomeric	0.013
ADRM1	adhesion regulating molecule 1	0.012
GMFB	glia maturation factor, beta	0.012
MRPL4	mitochondrial ribosomal protein L4	0.012
ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	0.012
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.011
CYC1	cytochrome c-1	0.011
NHP2	NHP2 ribonucleoprotein homolog (yeast)	0.011